CarlT.WittwerMD

Pathology • Camden, ME

Chemical Pathology, Microbiology, Molecular Genetics, Clinical Pathology

Professor, Pathology, University of Utah School of Medicine

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Office
148 Bay View Street
Camden, ME 04843
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Education & Training

University of Utah HealthResidency, Pathology-Anatomic and Clinical, 1984 - 1988
University of Michigan Medical SchoolClass of 1984

Certifications & Licensure

UT State Medical License 1985 - 2026
ME State Medical License 2021 - 2025
American Board of Pathology Anatomic Pathology & Clinical Pathology

Publications & Presentations

PubMed

DNA melting analysis.
Carl T Wittwer, Andrew C Hemmert, Jana O Kent, Nick A Rejali> ;Molecular Aspects of Medicine. 2024 Mar 14
7 citations
Nearest-neighbour transition-state analysis for nucleic acid kinetics.
Nick A Rejali, Felix D Ye, Aisha M. Zuiter, Caroline C Keller, Carl T. Wittwer> ;Nucleic Acids Research. 2021 May 7
39 citations
Cautionary Note on Contamination of Reagents Used for Molecular Detection of SARS-CoV-2.
Jim F. Huggett, Vladimir Benes, Stephen A. Bustin, Jeremy A. Garson, Kathryn A. Harris, Martin Kammel, Mikael Kubista, Timothy D. McHugh, Jacob Moran-Gilad, Tania Nola...> ;Clinical Chemistry. 2020 Nov 1
4 citations
Retrospective clinical trial experimentally validates glioblastoma genome-wide pattern of DNA copy-number alterations predictor of survival.
Sri Priya Ponnapalli, Matthew W. Bradley, Karen Devine, Jay Bowen, Sara E. Coppens, Kristen M. Leraas, Brett Milash, Fuqiang Li, Huijuan Luo, Shi Qiu, Kui Wu, Huanming...> ;APL Bioengineering. 2020 May 15
5 citations
Reverse transcriptase kinetics for one-step RT-PCR.
Nick A Rejali, Aisha M. Zuiter, John Quackenbush, Carl T. Wittwer> ;Analytical Biochemistry. 2020 Jul 15
5 citations
Removal of artifact bias from qPCR results using DNA melting curve analysis
Jan M. Ruijter, Adrián Ruiz-Villalba, Axel J. J. van den Hoff, Quinn D. Gunst, Carl T. Wittwer, Maurice J.B. van den Hoff> ;FASEB Journal. 2019 Nov 2
19 citations
The kinetic requirements of extreme qPCR.
Adam L. Millington, Jessica Anne Houskeeper, John Quackenbush, James M. Trauba, Carl T. Wittwer> ;Biomolecular Detection and Quantification. 2019 Mar 13
4 citations
Evaluation of Mass Cytometry in the Clinical Laboratory
Eugene V. Ravkov, Cheryl M Charlton, Adam P. Barker, Harry Hill, Lisa K. Peterson, Patricia R. Slev, Anne E. Tebo, Karl V. Voelkerding, Carl T. Wittwer, Nahla M. Heika...> ;Cytometry. Part B, Clinical Cytometry. 2019 Jul 1
16 citations
Integrated Extreme Real-Time PCR and High-Speed Melting Analysis in 52 to 87 Seconds.
Joseph T. Myrick, Robert J. Pryor, Robert Palais, Sean J Ison, Lindsay N. Sanford, Zachary Dwight, Jarkko J Huuskonen, Scott O. Sundberg, Carl T. Wittwer> ;Clinical Chemistry. 2019 Feb 1
16 citations
A “Culture” Shift: Broad Bacterial Detection, Identification, and Antimicrobial Susceptibility Testing Directly from Whole Blood
Nadya Andini, Anne Hu, Luming Zhou, Steven Cogill, Tza-Huei Wang, Carl T. Wittwer, Samuel Yang> ;Clinical Chemistry. 2018 Oct 1
21 citations
The effect of single mismatches on primer extension
Nick A Rejali, Endi Moric, Carl T. Wittwer> ;Clinical Chemistry. 2018 May 1
14 citations
Quantifying variant differences in DNA melting curves: Effects of length, melting rate, and curve overlay.
Mei Li, Robert Palais, Luming Zhou, Carl T. Wittwer> ;Analytical Biochemistry. 2017 Dec 15
12 citations
High-Speed Melting Analysis: The Effect of Melting Rate on Small Amplicon Microfluidic Genotyping.
Robert J. Pryor, Joseph T. Myrick, Robert Palais, Scott O. Sundberg, Jeanette Y. Paek, Carl T. Wittwer, Ivor T. Knight> ;Clinical Chemistry. 2017 Oct 1
48 citations
MIQE: A Step Toward More Robust and Reproducible Quantitative PCR.
Stephen A. Bustin, Carl T. Wittwer> ;Clinical Chemistry. 2017 Sep 1
45 citations
Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders
Tsewang Tashi, N. Scott Reading, Tanna Wuren, Xu Zhang, Lorna G. Moore, Hao Hu, Feng Tang, Anna Shestakova, Felipe R. Lorenzo, Tatiana Burjanivova, Parvaiz A Koul, Pra...> ;Journal of Molecular Medicine. 2017 Feb 23
4 citations
Democratizing the Real-Time PCR
Carl T. Wittwer> ;Clinical Chemistry. 2017 Apr 1
2 citations
Portable Nanopore Sequencing for Viral Surveillance.
Carl T. Wittwer> ;Clinical Chemistry. 2016 Nov 1
3 citations
Genomic Copy Number Analysis of HER2-Equivocal Breast Cancers.
Katherine B. Geiersbach, Carlynn Willmore-Payne, Alexandra V. Pasi, Christian N. Paxton, Theresa L. Werner, Xinjie Xu, Carl T. Wittwer, H. Evin Gulbahce, Erinn Downs-K...> ;American Journal of Clinical Pathology. 2016 Oct 1
4 citations
Detection of chromosomal translocations in formalin-fixed paraffin-embedded (FFPE) leukemic specimens by digital expression profiling.
M. Liew, R. Mao, Carl T. Wittwer, Mohamed E. Salama> ;International Journal of Laboratory Hematology. 2015 Oct 1
9 citations
Disruptive Innovation in Laboratory Medicine
Nader Rifai, Eric J. Topol, Eugene Chan, Y.M. Dennis Lo, Carl T. Wittwer> ;Clinical Chemistry. 2015 Sep 1
5 citations
Rare event counting of CD59- red cells in human blood: A 47-month experience using PNH consensus guidelines for WBC and RBC testing in a reference lab
Michael Liew, Marjorie Farley, John Andreasen, Charles J. Parker, Carl T. Wittwer> ;Cytometry. Part B, Clinical Cytometry. 2015 Jul 8
22 citations
Copy Number Assessment by Competitive PCR with Limiting Deoxynucleotide Triphosphates and High-Resolution Melting
Luming Zhou, Robert Palais, Christian N. Paxton, Katherine B. Geiersbach, Carl T. Wittwer> ;Clinical Chemistry. 2015 May 1
116 citations
Extreme PCR: Efficient and Specific DNA Amplification in 15–60 Seconds
Jared S. Farrar, Carl T. Wittwer> ;Clinical Chemistry. 2015 Jan 1
14 citations
Molecular diagnostics: a revolution in progress.
Rossa W.K. Chiu, Y.M. Dennis Lo, Carl T. Wittwer> ;Clinical Chemistry. 2015 Jan 1
17 citations
Microfluidic Genotyping by Rapid Serial PCR and High-Speed Melting Analysis
Scott O. Sundberg, Carl T. Wittwer, Renée M. Howell, Jarkko J Huuskonen, Robert J. Pryor, Jared S. Farrar, Heather M. Stiles, Robert Palais, Ivor T. Knight> ;Clinical Chemistry. 2014 Oct 1
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Press Mentions

UVU Professor Develops New Patent to Help Treat Genetic DisordersJuly 11th, 2020
Sponsored: Pioneered in Utah – the Value of Innovative DiagnosticsSeptember 7th, 2023

Grant Support

Snapback Primers For Genotyping And Mutation ScanningNational Institute Of General Medical Sciences2008–2009
A System For Rapid PCR, Mutation Scanning And GenotypingNational Institute Of General Medical Sciences2005–2006
Homogeneous Mutation ScanningNational Institute Of General Medical Sciences2004–2006
Homogeneous Multiplex PCR By Fluorescence And TMNational Institute Of General Medical Sciences2001–2002
Homogeneous Multiplex PCR By Fluorescence And TMNational Institute Of General Medical Sciences1999
Continuous Monitoring Of Rapid Cycle PCRNational Institute Of General Medical Sciences1996–1997
Continuous Monitoring Of Rapid Cycle PCRNational Institute Of General Medical Sciences1994