CarolJFabianMD

Oncology • Fairway, KS

Breast Cancer, Cancer Genetics/Cancer Risk Assessment, Hematologic Oncology

Professor, Director Breast Cancer Prevention and Survivorship Centers

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Office
2650 Shawnee Mission Pkwy
Fairway, KS 66205
Phone+1 913-588-7750

Fax+1 913-588-9822
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Education & Training

University of Kansas (Wichita)Residency, Internal Medicine, 1973 - 1975
University of Kansas (Wichita)Residency, Internal Medicine, 1972 - 1972
University of Kansas School of MedicineClass of 1972

Certifications & Licensure

MO State Medical License 2021 - 2025
AZ State Medical License 2022 - 2024
KS State Medical License 1974 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Redbook Magazine: Top Breast Cancer Doctors Castle Connolly, 2001

Clinical Trials

LY353381 in Preventing Breast Cancer in Women With Hyperplasia Start of enrollment: 2000 Aug 01
Completed
Phase 2
Tamoxifen Compared With LY353381 in Treating Women With Newly Diagnosed Breast Cancer Start of enrollment: 2000 Jul 01
Completed
Phase 1
Celecoxib in Preventing Breast Cancer in At-Risk Premenopausal Women Start of enrollment: 2003 Jan 01
Completed
Phase 2
Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer Start of enrollment: 2005 Oct 01
Completed
Protocol for Women at Increased Risk of Developing Breast Cancer Start of enrollment: 1989 Aug 01
Recruiting
An Examination of Predictors of Indicators of Response to Letrozole 2.5 mg Start of enrollment: 2003 Jan 01
Completed
An Examination of Predictors of Indicators of Response to Celecoxib in Women Who Have a Diagnosis of Early Breast Cancer Start of enrollment: 2003 Jan 01
Completed
Protocol for Women at Increased Risk of Developing Breast Cancer Start of enrollment: 2003 Jan 01
Completed
Phase 2
Protocol for Women at Increased Risk of Developing Breast Cancer Start of enrollment: 2003 Apr 01
Completed
Phase 2
Protocol to Examine Methylation of Tumor Suppression Genes in Women at High Risk of Developing Breast Cancer Start of enrollment: 2005 Jun 01
Completed
A Study of Women With an Early Diagnosis of Breast Cancer, Taking Celecoxib Between the Biopsy and Lumpectomy/Mastectomy Start of enrollment: 2003 Jun 01
Completed
Phase 1
Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer Start of enrollment: 2005 May 01
Withdrawn
Study of Breast Cancer Prevention by Letrozole in High Risk Women Start of enrollment: 2006 Oct 01
Completed
Phase 2
Lapatinib in Women With Metastatic Breast Cancer Who Have Failed Prior Antihormone Therapy Start of enrollment: 2009 Mar 01
Terminated
Phase 2
Acolbifene in Preventing Cancer in Premenopausal Women at High Risk of Breast Cancer Start of enrollment: 2009 Feb 01
Completed
Phase 2
Anti-Hormone Therapy (With Anastrazole and Fulvestrant) Before Surgery to Treat Postmenopausal Women With Breast Cancer. Start of enrollment: 2009 May 01
Completed
Phase 2
Evaluate Trastuzumab Plus Standard Chemotherapy Given Before Surgery in Breast Cancer Patients With Low HER 2 Expression Start of enrollment: 2009 Jul 01
Completed
Phase 2
A Study to Look at the Combination of Chemotherapy, Trastuzumab and RAD001 in HER2 Positive Breast Cancer Start of enrollment: 2010 Jul 01
Withdrawn
Phase 2
Modulation of Breast Cancer Risk Biomarkers by High Dose Vitamin D Start of enrollment: 2009 May 01
Completed
Not Applicable
Breast Cancer Risk Biomarkers in Premenopausal Women Start of enrollment: 2010 Nov 01
Completed
Phase 2
Breast Cancer Risk Biomarkers in Postmenopausal Women Start of enrollment: 2010 Nov 01
Completed
Phase 2
Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer Start of enrollment: 2011 Jan 01
Terminated
Phase 2
Lapatinib and RAD-001 for HER2 Positive Metastatic Breast Cancer Start of enrollment: 2011 Feb 01
Unknown status
Phase 2
Weight Loss Plus Omega-3 Fatty Acids or Placebo in High Risk Women Start of enrollment: 2014 Mar 01
Completed
Not Applicable
Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens Start of enrollment: 2021 Dec 14
Recruiting
Phase 2
Roles: Principal Investigator, Contact
Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer Start of enrollment: 2024 Mar 01
Not yet recruiting
Phase 2
Roles: Contact, Principal Investigator
Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial Start of enrollment: 2024 Aug 03
Not yet recruiting
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Reduced-Frequency Endocrine Therapy and Challenges of Noninferiority Study Designs.
Carol J Fabian, Dinesh Pal Mudaranthakam> ;JAMA Oncology. 2023 May 1
A novel Bayesian adaptive design incorporating both primary and secondary endpoints for randomized IIB chemoprevention study of women at increased risk for breast cancer.
Byron J Gajewski, Bruce F Kimler, Devin C Koestler, Dinesh Pal Mudaranthakam, Kate Young, Carol J Fabian> ;Trials. 2022 Dec 5
7 citations
Rapid Escalation of High-Volume Exercise during Caloric Restriction; Change in Visceral Adipose Tissue and Adipocytokines in Obese Sedentary Breast Cancer Survivors
Carol J. Fabian, Jennifer R. Klemp, Nicholas J. Marchello, Eric D. Vidoni, Debra K. Sullivan, Jennifer L. Nydegger, Teresa A. Phillips, Amy L. Kreutzjans, Bill Hendry,...> ;Cancers. 2021 Sep 28
2 citations
Change in Blood and Benign Breast Biomarkers in Women Undergoing a Weight-Loss Intervention Randomized to High-Dose ω-3 Fatty Acids versus Placebo.
Carol J. Fabian, Christie A. Befort, Teresa A. Phillips, Jennifer L. Nydegger, Amy L. Kreutzjans, Kandy R. Powers, Trina Metheny, Jennifer R. Klemp, Susan E. Carlson, ...> ;Cancer Prevention Research. 2021 Jul 9
Tamoxifen: Will Less Equal More in Women with Precancerous Breast Disease?
Carol J. Fabian> ;Clinical Cancer Research. 2021 Apr 29
9 citations
Randomized Phase IIB Trial of the Lignan Secoisolariciresinol Diglucoside in Premenopausal Women at Increased Risk for Development of Breast Cancer.
Carol J. Fabian, Seema A. Khan, Judy Garber, William C. Dooley, Lisa D. Yee, Jennifer R. Klemp, Jennifer L. Nydegger, Kandy R. Powers, Amy L. Kreutzjans, Carola M. Zal...> ;Cancer Prevention Research. 2020 Jul 1
11 citations
Effects of Weight Loss and Weight Regain on Circulating Biomarkers in Overweight/Obese Breast Cancer Survivors Enrolled in a Weight Loss Trial in the Rural Midwest.
Christie A. Befort, Bruce F. Kimler, Leonidas E. Bantis, Teresa A. Phillips, Carol J. Fabian> ;Cancer Epidemiology, Biomarkers & Prevention. 2020 Apr 10
4 citations
Use of Endocrine Therapy for Breast Cancer Risk Reduction: ASCO Clinical Practice Guideline Update Summary
Carol J. Fabian, Kala Visvanathan, Mark R. Somerfield> ;Journal of Oncology Practice. 2019 Sep 3
83 citations
Use of Endocrine Therapy for Breast Cancer Risk Reduction: ASCO Clinical Practice Guideline Update
Kala Visvanathan, Carol J. Fabian, Elissa T. Bantug, Abenaa M. Brewster, Nancy E. Davidson, Andrea Decensi, Justin D. Floyd, Judy Garber, E Hofstatter, Seema A. Khan, ...> ;Journal of Clinical Oncology. 2019 Sep 3
15 citations
The Evolving Design of NIH-Funded Cardio-Oncology Studies to Address Cancer Treatment-Related Cardiovascular Toxicity.
Lori M. Minasian, Eileen P. Dimond, Myrtle Davis, Bishow B. Adhikari, Richard Fagerstrom, Carol J. Fabian, Justin D. Floyd, Joseph M. Unger, Pamela S. Douglas, Karen M...> ;JACC. Cardiooncology. 2019 Sep 1
Will a Low-Dose Option Improve Uptake of Tamoxifen for Breast Cancer Risk Reduction?
Carol J. Fabian> ;Journal of Clinical Oncology. 2019 May 13
4 citations
Circulating adipose stromal cells as a response biomarker in phase II energy balance trials of obese breast cancer survivors and high-risk women
Hailey A. Baker, Carol J. Fabian, Richard C. Hastings, Dan A. Dixon, Jennifer L. Nydegger, Teresa A. Phillips, Kandy R. Powers, Bruce F. Kimler> ;Breast Cancer Research and Treatment. 2019 Apr 30
37 citations
The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth.
Laura W. Bowers, Claire G. Lineberger, Nikki A. Ford, Emily L. Rossi, Arunima Punjala, Kristina K. Camp, Bruce K. Kimler, Carol J. Fabian, Stephen D. Hursting> ;Breast Cancer Research and Treatment. 2019 Feb 1
55 citations
Final Analysis of the Prevention of Early Menopause Study (POEMS)/SWOG Intergroup S0230.
Halle C. F. Moore, Joseph M. Unger, Kelly-Anne Phillips, Frances M. Boyle, Erika Hitre, Anna Moseley, David Porter, Prudence A. Francis, Lori J. Goldstein, Henry L. Go...> ;Journal of the National Cancer Institute. 2019 Feb 1
20 citations
Effect of Bazedoxifene and Conjugated Estrogen (Duavee) on Breast Cancer Risk Biomarkers in High-Risk Women: A Pilot Study.
Carol J. Fabian, Lauren Nye, Kandy R. Powers, Jennifer L. Nydegger, Amy L. Kreutzjans, Teresa A. Phillips, Trina Metheny, Onalisa Winblad, Carola M. Zalles, Christy R....> ;Cancer Prevention Research. 2019 Aug 16
5 citations
Phase II Feasibility Study of a Weight Loss Intervention in Female Breast and Colorectal Cancer Survivors (SWOG S1008).
Heather Greenlee, Danika L. Lew, Dawn L. Hershman, Vicky A. Newman, Lisa Hansen, Sheri J. Hartman, Judith Korner, Zaixing Shi, Christine L. Sardo Molmenti, Antoine Say...> ;Obesity. 2018 Oct 1
The Conundrum of Omega-3 Fatty Acids in Cancer Prevention Studies: Which One? How Much? What Biomarkers?
Carol J. Fabian, Bruce F. Kimler> ;Cancer Prevention Research. 2018 Mar 20
24 citations
Change in Physical Activity During a Weight Management Intervention for Breast Cancer Survivors: Association with Weight Outcomes.
Tera L. Fazzino, Carol J. Fabian, Christie A. Befort> ;Obesity. 2017 Nov 1
30 citations
Cognitive functioning and quality of life following chemotherapy in pre- and peri-menopausal women with breast cancer.
Jennifer R. Klemp, Jamie S. Myers, Carol J. Fabian, Bruce F. Kimler, Qamar J. Khan, Susan M. Sereika, Annette L. Stanton> ;Supportive Care in Cancer. 2018 Feb 1
26 citations
Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial
Qamar J. Khan, Bruce F. Kimler, Pavan S. Reddy, Priyanka Sharma, Jennifer R. Klemp, Jennifer L. Nydegger, Hung-Wen Yeh, Carol J. Fabian> ;Breast Cancer Research and Treatment. 2017 Aug 2
12 citations
NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer.
Hanan S. Elsarraj, Kelli E. Valdez, Yan Hong, Sandra L. Grimm, Lawrence R. Ricci, Fang Fan, Ossama Tawfik, Lisa May, Therese Cusick, Marc Inciardi, Mark Redick, Jason ...> ;Cancer Research. 2017 May 17
8 citations
An empirically derived dietary pattern associated with breast cancer risk is validated in a nested case-control cohort from a randomized primary prevention trial
Brandon H. Hidaka, Bruce F. Kimler, Carol J. Fabian, Susan E. Carlson> ;Clinical Nutrition ESPEN. 2017 Feb 1
705 citations
Prevention and monitoring of cardiac dysfunction in survivors of adult cancers: American society of clinical oncology clinical practice guideline
Saro H. Armenian, Christina Lacchetti, Ana Barac, Joseph R. Carver, Louis S. Constine, Neelima Denduluri, Susan Dent, Pamela S. Douglas, Jean-Bernard Durand, Michael S...> ;Journal of Clinical Oncology. 2017 Mar 10
5 citations
Barriers to a Career Focus in Cancer Prevention: A Report and Initial Recommendations From the American Society of Clinical Oncology Cancer Prevention Workforce Pipeli...
Carol J. Fabian, Frank L. Meyskens, Dean F. Bajorin, Thomas J. George, Joanne M. Jeter, Shakila P. Khan, Courtney Tyne, William N. William> ;Journal of Clinical Oncology. 2016 Sep 19
4 citations
Dietary Associations with a Breast Cancer Risk Biomarker Depend on Menopause Status.
Brandon H. Hidaka, Susan E. Carlson, Bruce F. Kimler, Carol J. Fabian> ;Nutrition and Cancer. 2016 Aug 11
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Journal Articles

Final Analysis of the Prevention of Early Menopause Study (POEMS)/SWOG Intergroup S0230
Carol J Fabian, Julie R Gralow, Journal of the National Cancer Institute
The Flaxseed Lignan Secoisolariciresinol Diglucoside Decreases Local Inflammation, Suppresses NFκB Signaling, and Inhibits Mammary Tumor Growth
Carol Fabian, MD, Breast Cancer Research and Treatment

Press Mentions

How a Basic Building Block of the Body Could Prevent Breast CancerFebruary 3rd, 2015
Special Session Provides Clinical Updates on Breast Cancer Prevention and Early DetectionDecember 20th, 2023
Sessions To Examine Lifestyle Interventions in Breast Cancer Prevention and TreatmentNovember 29th, 2023

Grant Support

Breast Cancer Prevention By Letrozole In High Risk WomenNational Cancer Institute2007–2010
Breast Cancer Risk Biomarkers And Energy BalanceNational Cancer Institute2007–2008
Flaxseed Lignan For Breast Cancer ChemopreventionNational Cancer Institute2005–2007
Chemoprevention For Women At High Risk Of Breast CancerNational Cancer Institute1997–2003
Phase I Nonrandomized Study Of An Antiestrogen In WomenDivision Of Cancer Prevention And Control1998–2000
Phase 2 Clinical Trial Agent (TBN) In Breast DysplasiaDivision Of Cancer Prevention And Control1996–1999
Chemoprevention By Selective Estrogen Receptor ModulatorNational Cancer Institute1998
Manipulation Of Breast Cancer Cell Kinetics By EstrogenNational Cancer Institute1986–1988

Committees

Liason to Educational Committee, ASCO Prevention Committee 2012 - Present
Member, ASCO Breast Cancer Risk Guidelines Committee 2012 - Present
Co-Chair, Southwest Oncology Group ( SWOG) Survivorship Committee 2009 - Present
Chair Cancer Prevention, ASCO Prevention Committee 2010 to Present 2011 - 2012