CarolMTroyMD

Neurology • New York, NY

Associate Professor, Pathology & Cell Biology, Columbia University College of Phys & Surg

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Office
630 W 168th St
Dept. Of Pathology
New York, NY 10032
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Education & Training

New York University School of MedicineClass of 1984

Certifications & Licensure

NY State Medical License 1985 - 2018

Publications & Presentations

PubMed

3 citations
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability.
Crystal Koralis Colón Ortiz, Anna Michelle Potenski, Jaqueline M. Lawson, Jade Smart, Carol M. Troy> ;Journal of Visualized Experiments. 2021 Aug 6
55 citations
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease.
Maria Avrutsky, Carol M. Troy> ;Frontiers in Pharmacology. 2021 Jan 1
1 citations
Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.
Maria Avrutsky, Crystal Koralis Colón Ortiz, Kendra V. Johnson, Anna Michelle Potenski, Claire W. Chen, Jacqueline Lawson, Alexandra J. White, Stephanie K. Yuen, Fatim...> ;Nature Communications. 2020 Jul 9
20 citations
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.
Maria Avrutsky, Crystal Koralis Colón Ortiz, Kendra V. Johnson, Anna Michelle Potenski, Claire W. Chen, Jacqueline Lawson, Alexandra J. White, Stephanie K. Yuen, Fatim...> ;Nature Communications. 2020 Jun 23
6 citations
Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice
Laura Ester Montroull, Deborah E. Rothbard, Hur Dolunay Kanal, Veera D'Mello, Vincent Dodson, Carol M. Troy, Juan P. Zanin, Steven W. Levison, Wilma J. Friedman> ;ASN Neuro. 2020 Jun 3
6 citations
Caspase-2 and tau-a toxic partnership?
Carol M. Troy, Michael L. Shelanski> ;Nature Medicine. 2016 Nov 8
42 citations
Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant
Nataliya Di Donato, Ying Y. Jean, A. Murat Maga, Briana D. Krewson, Alison B. Shupp, Maria I. Avrutsky, Achira Roy, Sarah Collins, Carissa Olds, Rebecca A. Willert, Ag...> ;American Journal of Human Genetics. 2016 Nov 3
7 citations
Detection of Axonally Localized mRNAs in Brain Sections Using High-Resolution In Situ Hybridization.
Jimena Baleriola, Ying Y. Jean, Carol M. Troy, Ulrich Hengst> ;Journal of Visualized Experiments. 2015 Jun 17
28 citations
Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus.
Ying Y. Jean, Jimena Baleriola, Mauro Fa, Ulrich Hengst, Carol M. Troy> ;Journal of Visualized Experiments. 2015 Jun 17
25 citations
Caspases: Therapeutic Targets in Neurologic Disease
Carol M. Troy, Ying Y. Jean> ;Neurotherapeutics. 2015 Jan 1
11 citations
Caspase-9 mediates photoreceptor death after blunt ocular trauma.
Richard J Blanch, Zubair Ahmed, Adam Thompson, Nsikan Akpan, David Snead, Martin Berry, Carol M. Troy, Robert A H Scott, Ann Logan> ;Investigative Ophthalmology & Visual Science. 2014 Sep 4
235 citations
Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions.
Jimena Baleriola, Chandler A. Walker, Ying Y. Jean, John F. Crary, Carol M. Troy, Peter L. Nagy, Ulrich Hengst> ;Cell. 2014 Aug 28
50 citations
Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling
Vasanthy Vigneswara, Nsikan Akpan, Martin Berry, Ann Logan, Carol M. Troy, Zubair Ahmed> ;Brain. 2014 Apr 10
19 citations
Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
Ying Y. Jean, Elena M. Ribe, Maria Elena Pero, Marina Moskalenko, Zarah Iqbal, Lianna J. Marks, Lloyd A. Greene, Carol M. Troy> ;The Biochemical Journal. 2013 Oct 1
72 citations
Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice
Julio Pozueta, Roger Lefort, Elena M. Ribe, Carol M. Troy, Ottavio Arancio, Michael L. Shelanski> ;Nature Communications. 2013 Jun 10
27 citations
Caspase Inhibitors Prospective Therapies for Stroke
Nsikan Akpan, Carol M. Troy> ;The Neuroscientist. 2013 Apr 1
19 citations
Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection
Robert Tamayev, Nsikan Akpan, Ottavio Arancio, Carol M. Troy, Luciano D'Adamio> ;Molecular Neurodegeneration. 2012 Dec 10
33 citations
Neuronal caspase 2 activity and function requires RAIDD, but not PIDD.
Elena M. Ribe, Ying Y. Jean, Rebecca L. Goldstein, Claudia Manzl, Leonidas Stefanis, Andreas Villunger, Carol M. Troy> ;The Biochemical Journal. 2012 Jun 15
69 citations
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.
Nsikan Akpan, Esther Serrano-Saiz, Brad E. Zacharia, Marc L. Otten, Andrew F. Ducruet, Scott J. Snipas, Wen Liu, Jennifer Velloza, Greg Cohen, Sergeyi A. Sosunov, Will...> ;The Journal of Neuroscience. 2011 Jun 15
225 citations
Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory.
Daniela Puzzo, Lucia Privitera, Mauro Fa, Agnieszka Staniszewski, Gakuji Hashimoto, Fahad Aziz, Mikako Sakurai, Elena M. Ribe, Carol M. Troy, Marc Mercken, Sonia S. Ju...> ;Annals of Neurology. 2011 May 1
38 citations
Regulation of caspases in the nervous system implications for functions in health and disease.
Carol M. Troy, Nsikan Akpan, Ying Y. Jean> ;Progress in Molecular Biology and Translational Science. 2011 Jan 1
93 citations
Cystatin C protects neuronal cells from amyloid-beta-induced toxicity
Belen Tizon, Elena M. Ribe, Weiqian Mi, Carol M. Troy, Efrat Levy> ;Journal of Alzheimer's Disease. 2010 Jan 28
Cystatin C Protects Neuronal Cells from Amyloid-beta-induced Toxicity.
> ;J Alzheimers Dis. 2009-11-17
97 citations
Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pat...
Ambreena Siddiq, Leila R. Aminova, Carol M. Troy, Kyungsun Suh, Zachary R. Messer, Gregg L. Semenza, Rajiv R. Ratan> ;The Journal of Neuroscience. 2009 Jul 8
119 citations
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of n...
Cherry Cheng Ying Ho, Hardy J. Rideout, Elena M. Ribe, Carol M. Troy, William T. Dauer> ;The Journal of Neuroscience. 2009 Jan 28
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Grant Support

Downstream Regulators Of Beta-Amyloid Induced Neuronal DeathNational Institute Of Neurological Disorders And Stroke2009–2010
Downstream Regulators Of Beta-Amyloid Induced Neuronal DeathNational Institute Of Neurological Disorders And Stroke2008
Neuronal Degeneration: Mechanisms And PreventionNational Institute Of Neurological Disorders And Stroke2004–2007
Downstream Regulators B-Amyloid Induced Neuronal DeathNational Institute Of Neurological Disorders And Stroke2001–2004
Neuronal Degeneration--Mechanisms And PreventionNational Institute Of Neurological Disorders And Stroke1997–2001
Calcium And The Cytoskeleton In Alzheimer'SNational Institute On Aging1989–1993
Role Of Peripherin In Neurological DiseaseNational Institute Of Neurological Disorders And Stroke1988