CaryNMariashMD

Endocrinology • Indianapolis, IN

Diabetes, Lipid Metabolism, Thyroid

Indiana University Health

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Office
201 Pennsylvania Pkwy
Ste 310
Indianapolis, IN 46280
Phone+1 317-813-0000

Fax+1 317-573-4064
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Education & Training

University of MinnesotaFellowship, Endocrinology, Diabetes, and Metabolism, 1977 - 1980
University of MinnesotaResidency, Internal Medicine, 1972 - 1975
University of California San Diego School of MedicineClass of 1972
University of California Division of Agriculture and Natural ResourcesDegree, 1965 - 1968

Certifications & Licensure

CA State Medical License 1975 - Present
IN State Medical License 2008 - 2025
MN State Medical License 1973 - 2010
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

Best Doctors in America 2008
Elected Member The American Society for Clinical Investigation, 1990
Bausch & Lomb Science Award
Frederick Slate Memorial Scholarship University of California, Berkeley
Regent's Scholar University of California, Berkeley
Samuel B. Hamburger Prize University of California, San Diego
Best Paper Subspecialty Research Conference, University of Minnesota
National Research Service Award
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Clinical Trials

Effect of Vitamin D Deficiency and Vitamin D Supplementation on Glucose Metabolism Start of enrollment: 2007 Jan 01
Completed
Not Applicable
Study of Human Plasma-Derived Alpha1-Proteinase Inhibitor in Subjects With New-Onset Type 1 Diabetes Mellitus Start of enrollment: 2014 Mar 01
Terminated
Phase 2
Personalized Therapy Study - Attain Stability Quad Post-Approval Study Start of enrollment: 2017 Aug 21
Active, not recruiting

Publications & Presentations

PubMed

Outcomes of Preoperative Medical Therapy for Thyroidectomy in Autoimmune Thyroid Disease.
Baumgartner, T., Allison, H., Braafladt, S., Blumenthaler, A., Ritter, H., Mariash, C., Elfenbein, D., McDow, A.> ;The Journal of Surgical Research. 2024 Mar 1
Relacorilant, a Selective Glucocorticoid Receptor Modulator in Development for the Treatment of Patients With Cushing Syndrome, Does Not Cause Prolongation of the Card...
Diane M Donegan, Rosario Pivonello, Antonio Stigliano, Pina Lardo, Tara Kearney, Emese Mezősi, Ezio Ghigo, Roberta Giordano, Cary N Mariash, Richard A Feelders, Kirste...> ;Endocrine Practice. 2024 Jan 1
1 citations
Dual Heterozygous Mutations inandin a Case of Nonclassic Congenital Adrenal Hyperplasia.
Eric D Frontera, Joshua J Brown, Hagop Ghareebian, Cary Mariash> ;AACE Clinical Case Reports. 2022 Oct 21
9 citations
COVID-19-Induced Graves' Disease.
Hagop Ghareebian, Cary Mariash> ;Cureus. 2022 Feb 1
Corrigendum: Relacorilant, a Selective Glucocorticoid Receptor Modulator, Induces Clinical Improvements in Patients With Cushing Syndrome: Results From A Prospective, ...
Rosario Pivonello, Irina Bancos, Richard A Feelders, Atil Y Kargi, Janice M Kerr, Murray B Gordon, Cary N Mariash, Massimo Terzolo, Noel Ellison, Andreas G Moraitis> ;Frontiers in Endocrinology. 2022 Jan 1
22 citations
Relacorilant, a Selective Glucocorticoid Receptor Modulator, Induces Clinical Improvements in Patients With Cushing Syndrome: Results From A Prospective, Open-Label Ph...
Rosario Pivonello, Irina Bancos, Richard A Feelders, Atil Y. Kargi, Janice M. Kerr, Murray B. Gordon, Cary N. Mariash, Massimo Terzolo, Noel Ellison, Andreas G. Moraitis> ;Frontiers in Endocrinology. 2021 Jul 14
1 citations
Hyperthyroidism in Pregnancy and Lactation: A Different Paradigm?
Jubran Rind, Cary N. Mariash> ;Journal of the Endocrine Society. 2021 Jan 7
17 citations
Development of an objective tool for the diagnosis of myxedema coma.
Yien Vickie Chiong, Elaine Bammerlin, Cary N. Mariash> ;Translational Research. 2015 Sep 1
20 citations
Temporal occurrences and recurrence patterns of hypoglycemia during hospitalization.
Brian J. Ulmer, Areeba Kara, Cary N. Mariash> ;Endocrine Practice. 2015 Feb 9
41 citations
Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice.
Rafat A. Siddiqui, Kevin A. Harvey, Candace Walker, Jeffrey D. Altenburg, Zhidong Xu, Colin L. Terry, Ignacio G. Camarillo, Yava L. Jones-Hall, Cary N. Mariash> ;BMC Cancer. 2013 Sep 13
24 citations
Thyroid hormone analogues for the treatment of metabolic disorders: new potential for unmet clinical needs?
Timothy J. Shoemaker, Tatsuyoshi Kono, Cary N. Mariash, Carmella Evans-Molina> ;Endocrine Practice. 2012 Nov 1
44 citations
Vitamin D3 supplementation improves insulin sensitivity in subjects with impaired fasting glucose.
Shaban Nazarian, John V. St. Peter, Raymond C. Boston, Sidney A. Jones, Cary N. Mariash> ;Translational Research. 2011 Nov 1
1 citations
Thyroid hormone actions: to Beta or not to Beta.
Cary N. Mariash> ;Thyroid. 2010 May 7
27 citations
Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis.
Derrick L. Aipoalani, Brennon L. O'Callaghan, Douglas G. Mashek, Cary N. Mariash, Howard C. Towle> ;Endocrinology. 2010 Mar 16
31 citations
The Thrsp null mouse (Thrsptm1cnm) and diet-induced obesity
Grant W. Anderson, Qihong Zhu, Jennifer K. Metkowski, Mary J. O. Stack, Sunil Gopinath, Cary N. Mariash> ;Molecular and Cellular Endocrinology. 2009 Apr 10
19 citations
Effect of Epoprostenol on the Thyroid Gland: Enlargement and Secretion of Thyroid Hormone
Chhavi Chadha, Marc R. Pritzker, Cary N. Mariash> ;Endocrine Practice. 2009 Mar 1
23 citations
Hepatic Expression of the SPOT 14 (S14) Paralog S14-Related (Mid1 Interacting Protein) Is Regulated by Dietary Carbohydrate
Nikolas G. Tsatsos, Lance B. Augustin, Grant W. Anderson, Howard C. Towle, Cary N. Mariash> ;Endocrinology. 2008 Oct 1
37 citations
Triiodo-l-thyronine Rapidly Stimulates Alveolar Fluid Clearance in Normal and Hyperoxia-injured Lungs
Maneesh Bhargava, Marie R. Runyon, Dmitri Smirnov, Jianxun Lei, Thomas J. Groppoli, Cary N. Mariash, O. Douglas Wangensteen, David H. Ingbar> ;American Journal of Respiratory and Critical Care Medicine. 2008 Sep 1
19 citations
Optimal Free Thyroxine Levels for Thyroid Hormone Replacement in Hypothyroidism
Jennifer F. Iverson, Cary N. Mariash> ;Endocrine Practice. 2008 Aug 26
48 citations
T3 increases Na-K-ATPase activity via a MAPK/ERK1/2-dependent pathway in rat adult alveolar epithelial cells.
Jianxun Lei, Cary N. Mariash, Maneesh Bhargava, Elizabeth V. Wattenberg, David H. Ingbar> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2008 Apr 1
20 citations
Thyroid hormone rapidly stimulates alveolar Na,K-ATPase by activation of phosphatidylinositol 3-kinase.
Maneesh Bhargava, Jianxun Lei, Cary N. Mariash, David H. Ingbar> ;Current Opinion in Endocrinology, Diabetes, and Obesity. 2007 Oct 1
14 citations
Developmental acquisition of T3-sensitive Na-K-ATPase stimulation by rat alveolar epithelial cells
Jianxun Lei, Christine H. Wendt, Daosheng Fan, Cary N. Mariash, David H. Ingbar> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2007 Jan 1
61 citations
S14: insights from knockout mice.
Laura LaFave, Lance B. Augustin, Cary N. Mariash> ;Endocrinology. 2006 Jun 29
2 citations
The possible contribution of anti-Gal to Graves' disease.
Joseph M. Fullmer, Arnold W. Lindall, Rebecca S. Bahn, Cary N. Mariash> ;Thyroid. 2005 Dec 15
76 citations
The Spot 14 protein is required for de novo lipid synthesis in the lactating mammary gland.
Qihong Zhu, Grant W. Anderson, Gregory T. Mucha, Elizabeth J. Parks, Jennifer K. Metkowski, Cary N. Mariash> ;Endocrinology. 2005 Aug 1
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Journal Articles

rospective Safety Surveillance of GH-deficient Adults: Comparison of GH-treated Vs Untreated Patients
Hartman ML, Xu R, Crowe BJ, Robison LL, Erfurth EM, Kleinberg DL, Zimmermann AG, Woodmansee WW, Cutler GB Jr, Chipman JJ, Melmed S; International HypoCCS Advisory Board, J Clin Endocrinol Metab, 1/1/2013
Characterization of Synergistic Anti-Cancer Effects of Docosahexaenoic Acid and Curcumin on DMBA-induced Mammary Tumorigenesis in Mice
Siddiqui RA, Harey KA, Walker C, Altenburg J, Xu Z, Terry C, Camarillo I, Jones-Hall Y, Mariash CN, BMC Cancer, 1/1/2013
Thyroid Hormone Analogues for the Treatment of Metabolic Disorders: New Potential for Unmet Clinical Needs
Shoemaker T, Kono T, Mariash CN, Evans-Molina C, Endocr Pract, 7/18/2012
Vitamin D3 Supplementation Improves Insulin Sensitivity in Subjects with Impaired Fasting Glucose
Nazarian S, St Peter J, Boston R, Jones SA, Mariash CN, Translational Research, 1/1/2011
Occurrence of Impaired Fasting Glucose in GH-deficient Adults Receiving GH Replacement Compared with Untreated Subjects
Woodmansee WW, Hartman ML, Lamberts SW, Zagar AJ, Clemmons DR; International HypoCCS Advisory Board, Clin Endocrinol (Oxf), 1/1/2010
Epoprostanol and Thyroid Disease
Mariash, CN, Endocrne Practice, 1/1/2010
The Thrsp Null Mouse (Thrsptm1cnm) and Diet Induced Obesity
Anderson GW, Zhu Q, Metkowski J, Stack MJ, Gopinath S, Mariash CN, Mol Cell Endocrinol, 1/1/2009
Optimum Free Thyroxine Levels for Thyroid Hormone Replacement in Hypothyroidism
Iverson JF and Mariash CN, Endocr Pract, 1/1/2008
Thyroid Hormone Regulates Alveolar Fluid Clearance
Bhargave M, Runyon M, Smirnov D, Lei Jianxun, Mariash CN, Podobinski J, Wangensteen OD, Ingbar DH, Curr Opin Endocrinol Diabetes Obes, 1/1/2007
Developmental Acquisition of T3 Sensitive Na,K-ATPase Stimulation by Rat Alveolar Epithelial Cells
Lei J, Wendt CH, Fan D, Mariash CN, Ingbar DH, Am J Physiol Lung Cell Mol Physiol, 1/1/2007
The Spot 14 Related Protein (MIG12) is Carbohydrate Responsive
Tsatsos N, Anderson GW, Augustin L, Mariash CN, Endocrinology, 1/1/2007
The Spot 14 Protein: Novel Insights From a Knockout Mouse
LaFave LT, Augustin LA, Mariash CN, Endocrinology, 1/1/2006
In Memoriam Dr Jack Oppenheimer: Reflections on a Scientist, Clinician, and Teacher
Mariash CN, Thyroid, 1/1/2006
The Possible Contribution of Anti-Gal to Graves’ Disease
Fullmer J, Lindall A, Bahn R, Mariash CN, Thyroid, 1/1/2005
Activation of Phosphoinositide 3-kinase Is Required for 3,3’5-triiodo-L-thyronine (T3)-induced Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial ...
Lei J, Mariash CN, Ingbar DH, J Biol Chem, 1/1/2004
Triiodothyroinine Is a Survival Factor for Developoing Oligodendrocytes
Jones SL, Cuta KK, Mariash CN, Anderson GW, Mol Cell Endocrinol, 1/1/2003
Thyroid Hormone and the Adipocyte (Editorial)
Mariash CN, J Clin Endocrinol Metab, 1/1/2003
Hypopituitarism Associated with Diabetes Insipidus and Painless Thyroiditis in a Perimenopausal Woman
Saeed A, Jones SA, Redmon JB, Mariash, CN, EndoTrends, 1/1/2001
Hashimoto’s Encephalitis
Sunil, GS and Mariash CN, J Clin Endocrinol Metab, 1/1/2001
Quantitative Assessment of Pituitary Resistnatce to Thyroid Hormone from Plots of the Log TSH versus Serum Free T4 Index
Ercan-Fang S, Schwartz HL, Mariash CN, Oppenheimer JH, J Clin Endocrinol Metab, 1/1/2000
The Orphan Nuclear Receptor Ear-2 Is a Negative Co-regulator for Thyroid Hormone Nuclear Receptor Function
Zhu X-g, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, and Cheng S-y, Mol Cell Biol, 1/1/2000
Differential Regulation of mRNAS14 in Obese versus Non-obese Subjects
Kirschner LS, Mariash CN, Thyroid, 1/1/1999
Two Different Response Elements Are Required for Carbohydrate Regulated Transcription of the S14 Gene in Rat Hepatocytes
Liu BR, Li W, Mariash CN, Mol Cell Endocrinol, 1/1/1999
Beta Receptor Isoforms Are Not Essential for Thyroid Hormone-dependent Regulation of PCP-2 and Myelin Basic Protein Gene Expression in the Developing Brains of Neonata...
Sandhofer C, Schwartz HL, Mariash CN, Forrest D, Oppenheimer JH, Mol Cell Endocrinol, 1/1/1998
Chicken Ovalbumin Upstream Promoter-Transcription Factor (COUP-TF) Modulates Expression of the Purkinje Cell Protein-2 Gene: A Potential Role for COUP-TF in Repressing...
Anderson GW, Larsen RJ, Oas DR, Sandhofer CR, Schwartz HL, Mariash CN, Oppenheimer JH, J Biol Chem, 1/1/1998
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Press Mentions

Doctor Flies for a Cause That Has PawsApril 5th, 2021

Grant Support

Training Grant In Diabetes Endocrinology &MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases2006–2007
Training Grant In Diabetes, Endocrinology, &MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2004
Regulation Of Brain Development By Thyroid HormoneNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2003
Evaluation Of New Mini-Needled Injection DeviceNational Center For Research Resources2000–2002
Core--Basic Mechanisms Of ObesityNational Institute Of Diabetes And Digestive And Kidney Diseases1996–2002
Diabetes, Endocrinology, And MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases1997–1999
S14 Gene In Obese Subjects As Compared To NON Obese SubjectsNational Center For Research Resources1996–1997
Metabolic Regulation Of Gene ExpressionNational Institute Of Diabetes And Digestive And Kidney Diseases1986–1996
Metabolic Regulation Of Gene ExpressionNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985