CathyEngMDFACP, FASCO

Gastrointestinal Cancer, Hematologic Oncology

Vanderbilt-Ingram Cancer Center; David H. Johnson Endowed Chair in Surgical and Medical Oncology; Professor of Medicine, Hematology and Oncology; Director for Strategic Relations; Co-Director, GI Oncology; Co-Leader, Gastrointestinal Cancer Research Program; Director, Young Adult Cancers Program; Co-Chair, NCI GI Steering Committee

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Office
2220 Pierce Avenue, 777 PRB
Nashville, TN 37232
Phone+1 615-322-5000
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Summary

Dr. Cathy Eng is an oncologist in Nashville, TN and is affiliated with Vanderbilt-Ingram Cancer Center. She received her medical degree from Drexel University College of Medicine/Hahnemann University and has been in practice 23 years. She specializes in gastrointestinal cancer clinical research.

Education & Training

University of ChicagoFellowship, Hematology and Medical Oncology, 1999 - 2002
Rush University Medical CenterResidency, Internal Medicine, 1996 - 1999
Rutgers Health/Cooperman Barnabas Medical CenterResidency, Radiology-Diagnostic, 1995 - 1996
Drexel University College of Medicine/Hahnemann University HospitalInternship, Internal Medicine, 1994 - 1995
Drexel University College of MedicineClass of 1994

Certifications & Licensure

TX State Medical License 2002 - 2026
IL State Medical License 1996 - 2026
TN State Medical License 2019 - 2025
AL State Medical License 2020 - 2020
NJ State Medical License 1995 - 1997
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

White House Cancer Moonshot Colorectal Cancer Panel: Colorectal Cancer Treatment, Innovation and support White House, 2023
Fellow Hedwig van Ameringen Executive Leadership in Academic Medicine, 2022
Regional Top Doctor Castle Connolly, 2009-2022
Top Doctor Nashville Lifestyles Magazine, 2000-2022
Exceptional Women in Medicine Castle Connolly, 2019-2021
Fellowship American Society of Clinical Oncology, 2019
Top Doctor in Oncology Houston Magazine, 2019
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Clinical Trials

Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Start of enrollment: 2004 Apr 01
Completed
Phase 2
S0408: Capecitabine, Oxaliplatin, and Bevacizumab in Pts Undergoing Surgery for Liver Mets From Colorectal Cancer Start of enrollment: 2006 Nov 01
Withdrawn
Phase 2
Prognostic Molecular and Environmental Factors in High-Risk Colon Cancer Patients Start of enrollment: 2006 Jan 01
Active, not recruiting
ARQ 197 in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer Start of enrollment: 2010 Jan 26
Completed
Phase 1, Phase 2
Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients Start of enrollment: 2013 Nov 01
Completed
Phase 2
Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors Start of enrollment: 2020 Jan 28
Completed
Phase 1
EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients Start of enrollment: 2020 Nov 17
Recruiting
Phase 3
A Study of Fruquintinib in Combination With Tislelizumab in Advanced Solid Tumors Start of enrollment: 2021 Aug 09
Active, not recruiting
Phase 1, Phase 2
An Open Label Study Evaluating the Efficacy and Safety of Etrumadenant (AB928) Based Treatment Combinations in Participants With Metastatic Colorectal Cancer. Start of enrollment: 2021 May 10
Active, not recruiting
Phase 1, Phase 2
A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer Start of enrollment: 2022 Feb 12
Active, not recruiting
Phase 2, Phase 3
Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer Start of enrollment: 2015 May 13
Active, not recruiting
Phase 2
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Publications & Presentations

PubMed

CLO24-088: Efficacy of Fruquintinib in Less Heavily Pretreated Patients (Pts) With Metastatic Colorectal Cancer (mCRC): Profile-Matched Data From FRESCO and FRESCO-2.
Arvind Dasari, Cathy Eng, Sara Lonardi, Rocio Garcia-Carbonero, Toshiki Masuishi, Chiara Cremolini, Francois Ghiringhelli, Joleen Hubbard, Tanios Bekaii-Saab, Jeremy J...> ;Journal of the National Comprehensive Cancer Network. 2024 Apr 5
Data-driven optimization of version 9 American Joint Committee on Cancer staging system for anal cancer.
Browner, A., Cotler, J., Nelson, H., Ballman, K., LeBlanc, M., Brierley, J., Goldberg, R., Washington, M., Palis, B., Janczewski, L., Gollub, M., Eng, C., Palefsky, J....> ;Cancer. 2023 Dec 22
Mutational Signature Changes in Patients With Metastatic Squamous Cell Carcinoma of the Anal Canal.
Michael LaPelusa, Christopher Cann, Kristen K Ciombor, Cathy Eng> ;The Oncologist. 2024 Apr 4
Hepatic Metastasectomy in Squamous Cell Carcinoma of the Anal Canal: A Case Series of a Curative Approach.
Jane E Rogers, Amanda Sirisaengtaksin, Michael Leung, Van K Morris, Lianchun Xiao, Ryan Huey, Robert Wolff, Cathy Eng, Jean Nicolas Vauthey, Ching-Wei D Tzeng, Benny J...> ;Cancers. 2023 Jul 31
17 citations
Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study.
Dasari, A., Lonardi, S., Garcia-Carbonero, R., Elez, E., Yoshino, T., Sobrero, A., Yao, J., García-Alfonso, P., Kocsis, J., Cubillo Gracian, A., Sartore-Bianchi, A., S...> ;Lancet. 2023 Jul 1
6 citations
Efficacy of Systemic Chemotherapy in Patients With Low-grade Mucinous Appendiceal Adenocarcinoma: A Randomized Crossover Trial.
Shen, J., Yousef, A., Zeineddine, F., Zeineddine, M., Tidwell, R., Beaty, K., Scofield, L., Rafeeq, S., Hornstein, N., Lano, E., Eng, C., Matamoros, A., Foo, W., Uppal...> ;JAMA Network Open. 2023 Jun 1
5 citations
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gastrointestinal cancer.
Kelly, R., Bever, K., Chao, J., Ciombor, K., Eng, C., Fakih, M., Goyal, L., Hubbard, J., Iyer, R., Kemberling, H., Krishnamurthi, S., Ku, G., Mordecai, M., Morris, V.,...> ;Journal for Immunotherapy of Cancer. 2023 Jun 1
Publisher Correction: A randomized pilot study of oncology massage to treat chemotherapy-induced peripheral neuropathy.
Gabriel Lopez, Cathy Eng, Michael Overman, David Ramirez, Wenli Liu, Curtiss Beinhorn, Pamela Sumler, Sarah Prinsloo, Yisheng Li, Minxing Chen, Eduardo Bruera, Lorenzo...> ;Scientific Reports. 2023 May 23
3 citations
Survival outcomes used to generate version 9 American Joint Committee on Cancer staging system for anal cancer.
Lauren M Janczewski, Joseph Faski, Heidi Nelson, Marc J Gollub, Cathy Eng, James D Brierley, Joel M Palefsky, Richard M Goldberg, M Kay Washington, Elliot A Asare, Kar...> ;CA. 2023 Apr 28
4 citations
Differential Spatial Gene and Protein Expression Associated with Recurrence Following Chemoradiation for Localized Anal Squamous Cell Cancer.
Sharia Hernandez, Prajnan Das, Emma B Holliday, Li Shen, Wei Lu, Benny Johnson, Craig A Messick, Cullen M Taniguchi, John Skibber, Ethan B Ludmir, Y Nancy You, Grace L...> ;Cancers. 2023 Mar 10
1 citations
Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ-PBMC-HPV) in HLA-A*02+ patients with HPV16+ solid tumors.
Antonio Jimeno, Joaquina Baranda, Wade T Iams, Jong Chul Park, Monica Mita, Michael S Gordon, Matthew Taylor, Neesha Dhani, Alexis D Leal, Prakash Neupane, Cathy Eng, ...> ;Investigational New Drugs. 2023 Apr 1
79 citations
Treatment of Metastatic Colorectal Cancer: ASCO Guideline.
Van K Morris, Erin B Kennedy, Nancy N Baxter, Al B Benson 3rd, Andrea Cercek, May Cho, Kristen K Ciombor, Chiara Cremolini, Anjee Davis, Dustin A Deming, Marwan G Faki...> ;Journal of Clinical Oncology. 2023 Jan 20
1 citations
Immunotherapy in Localized Microsatellite Instability-High/Mismatch Repair Deficient Solid Tumors: Are We Ready for a New Standard of Care?
Kristen K Ciombor, Cathy Eng> ;Journal of Clinical Oncology. 2023 Apr 20
Molecular and genetic targets within metastatic colorectal cancer and associated novel treatment advancements.
Christopher G Cann, Michael B LaPelusa, Sarah K Cimino, Cathy Eng> ;Frontiers in Oncology. 2023 Jan 1
15 citations
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.
Giulia Martina Cavestro, Alessandro Mannucci, Francesc Balaguer, Heather Hampel, Sonia S Kupfer, Alessandro Repici, Andrea Sartore-Bianchi, Toni T Seppälä, Vincenzo Va...> ;Clinical Gastroenterology and Hepatology. 2023 Mar 1
5 citations
Racial/Ethnic and Sex Differences in Somatic Cancer Gene Mutations among Patients with Early-Onset Colorectal Cancer.
Andreana N Holowatyj, Wanqing Wen, Timothy Gibbs, Hannah M Seagle, Samantha R Keller, Digna R Velez Edwards, Mary K Washington, Cathy Eng, Jose Perea, Wei Zheng, Xingy...> ;Cancer Discovery. 2023 Mar 1
2 citations
A phase II randomized double blinded trial evaluating the efficacy of curcumin with pre-operative chemoradiation for rectal cancer.
Jillian R Gunther, Awalpreet S Chadha, Sushovan Guha, Gottumukkala S Raju, Dipen M Maru, Mark F Munsell, Yan Jiang, Peiying Yang, Edd Felix, Marilyn Clemons, Geena Geo...> ;Journal of Gastrointestinal Oncology. 2022 Dec 1
7 citations
Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer.
Andreana N Holowatyj, Mary K Washington, Sean V Tavtigian, Cathy Eng, Carolyn Horton> ;JAMA Oncology. 2022 Nov 11
2 citations
A randomized pilot study of oncology massage to treat chemotherapy-induced peripheral neuropathy.
Gabriel Lopez, Cathy Eng, Michael Overman, David Ramirez, Wenli Liu, Curtiss Beinhorn, Pamela Sumler, Sarah Prinsloo, Yisheng Li, Minxing Chen, Eduardo Bruera, Lorenzo...> ;Scientific Reports. 2022 Nov 8
Biologics in rectal cancer.
Alexandre A Jácome, Renata D'Alpino Peixoto, Mariana V Gil, Juliana Ominelli, Gabriel Prolla, Rodrigo Dienstmann, Cathy Eng> ;Expert Opinion on Biological Therapy. 2022 Oct 1
17 citations
Phase II study of durvalumab (anti-PD-L1) and trametinib (MEKi) in microsatellite stable (MSS) metastatic colorectal cancer (mCRC).
Benny Johnson, Cara L Haymaker, Edwin R Parra, Luisa Maren Solis Soto, Xuemei Wang, Jane V Thomas, Arvind Dasari, Van K Morris, Kanwal Raghav, Eduardo Vilar, Bryan K K...> ;Journal for Immunotherapy of Cancer. 2022 Aug 1
3 citations
Variation in Treatment Patterns of Patients with Early-Onset Gastric Cancer.
Michael LaPelusa, Chan Shen, Erin A Gillaspie, Christopher Cann, Eric Lambright, A Bapsi Chakravarthy, Michael K Gibson, Cathy Eng> ;Cancers. 2022 Jul 26
11 citations
A contemporary systematic review on liver transplantation for unresectable liver metastases of colorectal cancer.
Cody M Lebeck Lee, Ioannis A Ziogas, Rajiv Agarwal, Sophoclis P Alexopoulos, Kristen K Ciombor, Lea K Matsuoka, Daniel B Brown, Cathy Eng> ;Cancer. 2022 Jun 15
1 citations
Clinical Trial Endpoints in Metastatic Cancer: Using Individual Participant Data to Inform Future Trials Methodology.
Richard M Goldberg, Richard Adams, Marc Buyse, Cathy Eng, Axel Grothey, Thierry André, Alberto F Sobrero, Stuart M Lichtman, Al B Benson, Cornelis J A Punt, Tim Maugha...> ;Journal of the National Cancer Institute. 2022 Jun 13
5 citations
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Alexandre A Jácome, Van Karlyle Morris, Cathy Eng> ;Current Treatment Options in Oncology. 2022 Aug 1
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Journal Articles

Spectrum of Somatic Cancer Gene Variations Among Adults with Appendiceal Cancer by Age at Disease Onset
Cathy Eng, MD, JAMA Network Open

Lectures

The Long-Term Impact of Neurofeedback on Symptom Burden and Interference in Patients with Chronic Chemotherapy-Induced Neuropathy: Analysis of a Randomized Controlled ...
ASCO Annual Meeting 2019 - Chicago, IL - 6/1/2019