CeliaE.DominguezMD

PubMed

• Hormonal Profiles of Menstrual Bleeding Patterns During the Luteal-Follicular Transition
  Melanie H. Jacobson, Penelope P. Howards, James S. Kesner, Juliana W. Meadows, Celia E. Dominguez, Jessica B. Spencer, Lyndsey A. Darrow, Metrecia L. Terrell, Michele ...> ;The Journal of Clinical Endocrinology and Metabolism. 2020 May 1
• Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
  Luckhurst, C. A.,Aziz, O.,Beaumont, V.,Bürli, R. W.,Breccia, P.,Maillard, M. C.,Haughan, A. F.,Lamers, M.,Leonard, P.,Matthews, K. L.,Raphy, G.,Stott, A. J.,Munoz-Sanj...> ;Bioorg. Med. Chem. Lett.. 2018 Nov 23
• 11 citations
  A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma.
  Laura Orsatti, Roberto Speziale, Maria Vittoria Orsale, Fulvia Caretti, Maria Veneziano, Matteo Zini, Edith Monteagudo, Kathryn A. Lyons, Maria G. Beconi, Kelvin Chan,...> ;Journal of Pharmaceutical and Biomedical Analysis. 2015 Mar 25
• 12 citations
  Lead Optimization toward Proof-of-Concept Tools for Huntington’s Disease within a 4-(1H-Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors
  John Wityak, Kevin F. McGee, Michael Conlon, Ren Hua Song, Bryan Cordell Duffy, W. Brent Clayton, Michael A. Lynch, Gwen Wang, Emily Freeman, James C. Haber, Douglas B...> ;Journal of Medicinal Chemistry. 2015 Mar 19
• 49 citations
  Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease.
  Leticia Toledo-Sherman, Michael Prime, Ladislav Mrzljak, Maria Beconi, Alan Beresford, Frederick Arthur Brookfield, Christopher John Brown, Isabell Cardaun, Stephen Ma...> ;Journal of Medicinal Chemistry. 2015 Jan 23
• 22 citations
  Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis).
  J.S. Sutcliffe, Vahri Beaumont, James M. Watson, Chang Sing Chew, Maria Beconi, Daniel M. Hutcheson, Celia Dominguez, Ignacio Munoz-Sanjuan> ;Plos One. 2014 Jul 22
• 8 citations
  The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington’s Disease
  Vahri Beaumont, Larry Park, Arash Rassoulpour, Ulrike Dijkman, Taneli Heikkinen, Kimmo Lehtimäki, Outi Kontkanen, Rand Al Nackkash, Gillian P. Bates, Melanie Gleyzes, ...> ;Plos Currents. 2014 Feb 13
• 61 citations
  A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease
  Daniel A. Todd, Ian Gowers, Simon J. Dowler, Michael Wall, George McAllister, David F. Fischer, Sipke Dijkstra, Silvina A. Fratantoni, Rhea van de Bospoort, Jessica Ve...> ;Plos One. 2014 Feb 4
• 25 citations
  Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice.
  Petr Vodicka, Junghyun Lim, Dana T. Williams, Kimberly B. Kegel, Kathryn Chase, Hyunsun Park, Deanna Marchionini, Stephen Wilkinson, Tania Mead, Helen L. Birch, Dawn Y...> ;Journal of Huntington's Disease. 2014 Jan 1
• 104 citations
  Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Histone Deacetylase (Hdac) Inhibitors as a Potential Therapy for Huntington'S Disease.
  Roland Burli, Christopher A. Luckhurst, Omar Aziz, Kim L. Matthews, Dawn Yates, Kathy Lyons, Maria Beconi, George McAllister, Perla Breccia, Andrew J. Stott, Stephen D...> ;Journal of Medicinal Chemistry. 2013 Dec 5
• 12 citations
  Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).
  Dirk Winkler, Maria Beconi, Leticia Toledo-Sherman, Michael Prime, Andreas Ebneth, Celia Dominguez, Ignacio Munoz-Sanjuan> ;Journal of Biomolecular Screening. 2013 May 20
• 70 citations
  Antioxidant supplementation reduces endometriosis-related pelvic pain in humans.
  Nalini Santanam, Nino Kavtaradze, Ana A. Murphy, Celia E Dominguez, Sampath Parthasarathy> ;Translational Research. 2013 Mar 1
• 23 citations
  Metabolism and Pharmacokinetics of JM6 in Mice: JM6 Is Not a Prodrug for Ro-61-8048
  Maria Beconi, Dawn Yates, Kathryn Lyons, Kim L. Matthews, Steve Clifton, Tania Mead, Michael Prime, Dirk Winkler, Catherine M. O'Connell, Daryl Simon Walter, Leticia T...> ;Drug Metabolism and Disposition. 2012 Dec 1
• 26 citations
  SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease.
  John Wityak, Michael Prime, Frederick Arthur Brookfield, Stephen Martin Courtney, Sayeh Erfan, Siw F. Johnsen, Peter Johnson, Marie Li, Richard W Marston, Laura Reed, ...> ;ACS Medicinal Chemistry Letters. 2012 Oct 4
• 32 citations
  Oral Administration of the Pimelic Diphenylamide HDAC Inhibitor HDACi 4b Is Unsuitable for Chronic Inhibition of HDAC Activity in the CNS In Vivo
  Maria Beconi, Omar Aziz, Kim L. Matthews, Lara Moumné, Catherine M. O'Connell, Dawn Yates, Steven Clifton, Hannah Pett, Julie Vann, Lynsey Crowley, Alan Findlay Haugha...> ;Plos One. 2012 Sep 4
• Angiogenic and antiangiogenic factors before and after resolution of maternal mirror syndrome.
  Llurba E, Marsal G, Sanchez O, Dominguez C, Alijotas-Reig J, Carreras E, Cabero L> ;Ultrasound Obstet Gynecol. 2012-09-01
• 17 citations
  Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease
  Michael Prime, Frederick Arthur Brookfield, Stephen Martin Courtney, Simon Gaines, Richard W Marston, Osamu Ichihara, Marie Li, Darshan Gunvant Vaidya, Helen Williams,...> ;ACS Medicinal Chemistry Letters. 2012 Aug 13
• 68 citations
  Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives.
  Mark H. Norman, Longbin Liu, Matthew R. Lee, Ning Xi, Ingrid M. Fellows, Noel D'angelo, Celia Dominguez, Karen Rex, Steven F. Bellon, Tae-Seong Kim, Isabelle Dussault> ;Journal of Medicinal Chemistry. 2012 Feb 24
• 45 citations
  Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series
  Longbin Liu, Mark H. Norman, Matthew R. Lee, Ning Xi, Aaron C. Siegmund, Alessandro Boezio, Shon Booker, Debbie Choquette, Noel D'angelo, Julie Germain, Kevin Yang, Ya...> ;Journal of Medicinal Chemistry. 2012 Feb 24
• First trimester serum angiogenic/anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology.
  Sánchez O, Llurba E, Marsal G, Domínguez C, Aulesa C, Sánchez-Durán MA, Goya MM, Alijotas-Reig J, Carreras E, Cabero L> ;Hum. Reprod.. 2012-02-01
• 45 citations
  Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.
  Michael Prime, Ole A. Andersen, John J. Barker, Mark A. Brooks, Robert K. Y. Cheng, Ian Toogood-Johnson, Stephen Martin Courtney, Frederick Arthur Brookfield, Christop...> ;Journal of Medicinal Chemistry. 2012 Jan 27
• Pharmacokinetics of memantine in rats and mice.
  Beconi MG, Howland D, Park L, Lyons K, Giuliano J, Dominguez C, Munoz-Sanjuan I, Pacifici R> ;PLoS Curr. 2011-12-15
• 14 citations
  alcohol, smoking, and caffeine in relation to fecundability, with effect modification by NAT2.
  Kira C. Taylor, Chanley M. Small, Celia E. Dominguez, Lauren E. Murray, Weining Tang, Malania M. Wilson, Mark Bouzyk, Michele Marcus> ;Annals of Epidemiology. 2011 Nov 1
• 13 citations
  Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation.
  Ilka Müller, Marieke Lamers, Alison J. Ritchie, Celia Dominguez, Ignacio Munoz-Sanjuan, Alex S. Kiselyov> ;Bioorganic & Medicinal Chemistry Letters. 2011 Sep 15
• 12 citations
  A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme.
  Ilka Müller, Marieke B.A.C. Lamers, Alison J. Ritchie, Hyunsun Park, Celia Dominguez, Ignacio Munoz-Sanjuan, Michel Maillard, Alex S. Kiselyov> ;Journal of Molecular Biology. 2011 Jul 8
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