ChadwickMckinleyHalesMDPhD

PubMed

• Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
  Rowan Saloner, Adam Staffaroni, Eric Dammer, Erik C B Johnson, Emily Paolillo, Amy Wise, Hilary Heuer, Leah Forsberg, Argentina Lario Lago, Julia Webb, Jacob Vogel, Al...> ;Research Square. 2024 Mar 28
• APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathology.
  Augustine Chemparathy, Yann Le Guen, Sunny Chen, Eun-Gyung Lee, Lesley Leong, John E Gorzynski, Tanner D Jensen, Alexis Ferrasse, Guangxue Xu, Hong Xiang, Michael E Be...> ;Neuron. 2024 Apr 3
• Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabol...
  Kamil Borkowski, Nicholas T Seyfried, Matthias Arnold, James J Lah, Allan I Levey, Chadwick M Hales, Eric B Dammer, Colette Blach, Gregory Louie, Rima Kaddurah-Daouk, ...> ;Scientific Reports. 2023 Aug 23
• 2 citations
  Literature-Based Discovery Predicts Antihistamines Are a Promising Repurposed Adjuvant Therapy for Parkinson's Disease.
  Gabriella Tandra, Amy Yoone, Rhea Mathew, Minzhi Wang, Chadwick M Hales, Cassie S Mitchell> ;International Journal of Molecular Sciences. 2023 Aug 2
• Predictors of Cognitive Decline in Healthy Middle-Aged Individuals with Asymptomatic Alzheimer's Disease.
  Raghav Tandon, Liping Zhao, Caroline M Watson, Morgan Elmor, Craig Heilman, Katherine Sanders, Chadwick M Hales, Huiying Yang, David W Loring, Felicia C Goldstein, Joh...> ;Research Square. 2023 Feb 28
• 9 citations
  A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment.
  Allan I Levey, Deqiang Qiu, Liping Zhao, William T Hu, Duc M Duong, Lenora Higginbotham, Eric B Dammer, Nicholas T Seyfried, Thomas S Wingo, Chadwick M Hales, Malú Gám...> ;Brain. 2022 Jun 30
• 7 citations
  Glial profiling of human tauopathy brain demonstrates enrichment of astrocytic transcripts in tau-related frontotemporal degeneration.
  Ashlyn G Johnson, James A Webster, Chadwick M Hales> ;Neurobiology of Aging. 2022 Apr 1
• 2 citations
  The Georgia Memory Net: Implementation of a statewide program to diagnose and treat Alzheimer's disease and related dementias.
  Alexis A Bender, Rebecca L McIntosh, Sean Sudduth, Michaela Harris, Kathy Tuckey, John C Morgan, Joanna M Jungerman, Abby Cox, Miranda A Moore, Bryshia Ingram, Ellyn P...> ;Journal of the American Geriatrics Society. 2022 Apr 1
• 4 citations
  A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy
  Laura Gutierrez-Quiceno, Eric B. Dammer, Ashlyn G. Johnson, James A. Webster, Rhythm Shah, Duc M. Duong, Luming Yin, Nicholas T. Seyfried, Victor E. Alvarez, Thor D. S...> ;Molecular Neurodegeneration. 2021 Jun 25
• 20 citations
  5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease.
  Janise N. Kuehner, Junyu Chen, Emily C. Bruggeman, Feng Wang, Yangping Li, Chongchong Xu, Zachary T. McEachin, Ziyi Li, Li Chen, Chadwick M. Hales, Zhexing Wen, Jingji...> ;Cell Reports. 2021 Apr 27
• 29 citations
  Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis
  Nisha Raj, Zachary T. McEachin, William Harousseau, Ying Zhou, Feiran Zhang, Megan E. Merritt-Garza, J. Matthew Taliaferro, Magdalena Kalinowska, Samuele G. Marro, Cha...> ;Cell Reports. 2021 Apr 13
• 3 citations
  Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain.
  Ariel Diaz, Paola Merino, Patrick McCann, Manuel A. Yepes, Laura G Quiceno, Enrique Torre, Amelia J. Tomkins, Xiaodong Zhang, Chadwick M. Hales, Frank C. Tong, Manuel ...> ;Journal of Cerebral Blood Flow and Metabolism. 2021 Mar 24
• 12 citations
  Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer's disease.
  Kamil Borkowski, Theresa L. Pedersen, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, Chadwick M. Hales, Eric B. Dammer, Colette Blach, Gregory Louie, Rima Kaddura...> ;Alzheimer's Research & Therapy. 2021 Sep 6
• 81 citations
  Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.
  Divyanshu Dubey, Michael R. Wilson, Benjamin D. S. Clarkson, Caterina Giannini, Manish J. Gandhi, John C. Cheville, Vanda A. Lennon, Scott D.Z. Eggers, Michelle F. Dev...> ;JAMA Neurology. 2020 Nov 1
• 42 citations
  Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36
  Zachary T. McEachin, Tania F. Gendron, Nisha Raj, María García-Murias, Anwesha Banerjee, Ryan H. Purcell, Patricia J. Ward, Tiffany W. Todd, Megan E. Merritt-Garza, Ka...> ;Neuron. 2020 Jul 22
• 6 citations
  CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual.
  Yeomin Yun, Sung Ah Hong, Ka Kyung Kim, Daye Baek, Dongsu Lee, Ashwini M. Londhe, Minhyung Lee, Jihyeon Yu, Zachary T. McEachin, Gary J. Bassell, Robert Bowser, Chadwi...> ;Communications Biology. 2020 Jan 20
• 23 citations
  TDP-43 cytoplasmic inclusion formation is disrupted in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal lobar degeneration.
  Samuel M. Lee, Seneshaw Asress, Chadwick M. Hales, Marla Gearing, Juan C. Vizcarra, Christina Fournier, David A. Gutman, Lih-Shen Chin, Lian Li, Jonathan D. Glass> ;Brain Communications. 2019 Jan 1
• 77 citations
  Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins.
  Srikant Rangaraju, Eric B. Dammer, Syed Ali Raza, Tianwen Gao, Hailian Xiao, Ranjita Betarbet, Duc M. Duong, James A. Webster, Chadwick M. Hales, James J. Lah, Allan I...> ;Molecular Neurodegeneration. 2018 Jun 28
• 335 citations
  TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
  Ching Chieh Chou, Yi Zhang, Mfon E. Umoh, Spencer Vaughan, Ileana Lorenzini, Feilin Liu, Melissa Sayegh, Paul G. Donlin-Asp, Yu Han Chen, Duc M. Duong, Nicholas T. Sey...> ;Nature Neuroscience. 2018 Jan 8
• 15 citations
  Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.
  Jonathan D. Cherry, Ahmad Zeineddin, Eric B. Dammer, James A. Webster, Duc M. Duong, Nicholas T. Seyfried, Allan I. Levey, Victor E. Alvarez, Bertrand R. Huber, Thor D...> ;Journal of Neuropathology and Experimental Neurology. 2018 Jan 1
• 61 citations
  Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients
  Csaba Konrad, Hibiki Kawamata, Kirsten Bredvik, Andrea J. Arreguin, Steven A. Cajamarca, Jonathan Hupf, John Ravits, Timothy M. Miller, Nicholas J. Maragakis, Chadwick...> ;Molecular Neurodegeneration. 2017 Oct 24
• 278 citations
  A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease
  Nicholas T. Seyfried, Eric B. Dammer, Vivek Swarup, Divya Nandakumar, Duc M. Duong, Luming Yin, Qiudong Deng, Tram Nguyen, Chadwick M. Hales, Thomas S. Wingo, Jonathan...> ;Cell Systems. 2017 Jan 25
• 53 citations
  Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression
  Chadwick M. Hales, Eric B. Dammer, Qiudong Deng, Duc M. Duong, Marla Gearing, Juan C. Troncoso, Madhav Thambisetty, James J. Lah, Joshua M. Shulman, Allan I. Levey, Ni...> ;Proteomics. 2016 Dec 1
• 41 citations
  A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses.
  Marcela K. Preininger, Rajneesh Jha, Joshua T. Maxwell, Qingling Wu, Monalisa Singh, Bo Wang, Aarti Dalal, Zachary T. McEachin, Wilfried Rossoll, Chadwick M. Hales, Pe...> ;Disease Models & Mechanisms. 2016 Sep 1
• 72 citations
  Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
  Christopher J. Holler, Georgia Taylor, Zachary T. McEachin, Qiudong Deng, William J. Watkins, Kathryn F. Hudson, Charles A. Easley, William T. Hu, Chadwick M. Hales, W...> ;Molecular Neurodegeneration. 2016 Jun 24
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Journal Articles

• Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis  
  Divyanshu Dubey, John Cheville, Thomas Kryzer, Chadwick Hales, Jorge Kattah, Eoin P Flanagan, Anastasia Zekeridou, Jenny J Linnoila, Andrew Mckeon, Sean J Pittock, JAMA Neurology