CharisEngMDPhD

PubMed

• Exploring the neurological features of individuals with germline PTEN variants: A multicenter study.
  Sarah Baitamouni, Darren Liu, Robyn Busch, Patricia Klaas, Thomas W Frazier, Mustafa Sahin, Andrew Dhawan, Siddharth Srivastava, Sumit Parikh, Gary E Hsich, Neil R Fri...> ;Annals of Clinical and Translational Neurology. 2024 Mar 19
• 1 citations
  MRI Surveillance and Breast Cancer Mortality in Women With BRCA1 and BRCA2 Sequence Variations.
  Jan Lubinski, Joanne Kotsopoulos, Pal Moller, Tuya Pal, Andrea Eisen, Larissa Peck, Beth Y Karlan, Amber Aeilts, Charis Eng, Louise Bordeleau, William D Foulkes, Nadin...> ;JAMA Oncology. 2024 Apr 1
• 1 citations
  Bilateral Oophorectomy and All-Cause Mortality in Women With BRCA1 and BRCA2 Sequence Variations.
  Joanne Kotsopoulos, Jacek Gronwald, Tomasz Huzarski, Pål Møller, Tuya Pal, Jeanna M McCuaig, Christian F Singer, Beth Y Karlan, Amber Aeilts, Charis Eng, Andrea Eisen,...> ;JAMA Oncology. 2024 Apr 1
• 2 citations
  Structurally-informed human interactome reveals proteome-wide perturbations by disease mutations.
  Dapeng Xiong, Yadi Zhou, Dongjin Lee, Shobhita Gupta, Qiu, Y., Zhao, J., Torres, M., Lu, W., Liang, S., Kang, J., Eng, C., Cheng, F., Yu, H., Loscalzo, J.> ;Biorxiv. 2024 Feb 1
• Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
  Darren Liu, Lamis Yehia, Andrew Dhawan, Ying Ni, Charis Eng> ;Cell Reports. Medicine. 2024 Feb 20
• Characterization of immunomodulating agents from Staphylococcus aureus for priming immunotherapy in triple-negative breast cancers.
  Chin-Chih Liu, Matthew Wolf, Ruth Ortego, Dennis Grencewicz, Tammy Sadler, Charis Eng> ;Scientific Reports. 2024 Jan 8
• Genomic diversity in functionally relevant genes modifies neurodevelopmental versus neoplastic risks in individuals with germline PTEN variants.
  Kim, A., Yehia, L., Eng, C.> ;Research Square. 2023 Dec 14
• Risk-reducing mastectomy and breast cancer mortality in women with a BRCA1 or BRCA2 pathogenic variant: an international analysis.
  Kelly Metcalfe, Tomasz Huzarski, Jacek Gronwald, Joanne Kotsopoulos, Raymond Kim, Pal Moller, Tuya Pal, Amber Aeilts, Andrea Eisen, Beth Karlan, Louise Bordeleau, Nadi...> ;British Journal of Cancer. 2024 Feb 1
• Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoids.
  Shin Chung Kang, Nicholas B Sarn, Juan Venegas, Zhibing Tan, Masahiro Hitomi, Charis Eng> ;Molecular Psychiatry. 2023 Nov 29
• Physical Activity During Adolescence and Early-adulthood and Ovarian Cancer Among Women with a BRCA1 or BRCA2 Mutation.
  Emma Guyonnet, Shana J Kim, Yue Yin Xia, Vasily Giannakeas, Jan Lubinski, Susan Randall Armel, Andrea Eisen, Louise Bordeleau, Charis Eng, Olufunmilayo I Olopade, Nadi...> ;Cancer Research Communications. 2023 Nov 28
• Is thegene mutation associated with thrombosis?
  Andrew Dhawan, Charis Eng> ;Cleveland Clinic Journal of Medicine. 2023 Nov 1
• Differential cell cycle checkpoint evasion by PTEN germline mutations associated with dichotomous phenotypes of cancer versus autism spectrum disorder.
  Masahiro Hitomi, Juan Venegas, Shin Chung Kang, Charis Eng> ;Oncogene. 2023 Dec 1
• 1 citations
  Targeting NANOG and FAK via Cx26-derived Cell-penetrating Peptides in Triple-negative Breast Cancer.
  Erin E Mulkearns-Hubert, Emily Esakov Rhoades, Salma Ben-Salem, Rashmi Bharti, Nicole Hajdari, Sadie Johnson, Alex Myers, Iris Nira Smith, Smarajit Bandyopadhyay, Char...> ;Molecular Cancer Therapeutics. 2024 Jan 3
• 1 citations
  Development of webcam-collected and artificial-intelligence-derived social and cognitive performance measures for neurodevelopmental genetic syndromes.
  Thomas W Frazier, Robyn M Busch, Patricia Klaas, Katherine Lachlan, Shafali Jeste, Alexander Kolevzon, Eva Loth, Jacqueline Harris, Leslie Speer, Tom Pepper, Kristin A...> ;American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 2023 Sep 1
• ASO Visual Abstract: A Randomized Trial Comparing the Effectiveness of Pre-test Genetic Counseling Using an Artificial Intelligence Automated Chatbot and Traditional I...
  Zahraa Al-Hilli, Ryan Noss, Jennifer Dickard, Wei Wei, Anna Chichura, Vincent Wu, Kayla Renicker, Holly J Pederson, Charis Eng> ;Annals of Surgical Oncology. 2023 Oct 1
• 5 citations
  A Randomized Trial Comparing the Effectiveness of Pre-test Genetic Counseling Using an Artificial Intelligence Automated Chatbot and Traditional In-person Genetic Coun...
  Zahraa Al-Hilli, Ryan Noss, Jennifer Dickard, Wei Wei, Anna Chichura, Vincent Wu, Kayla Renicker, Holly J Pederson, Charis Eng> ;Annals of Surgical Oncology. 2023 Oct 1
• Hemizygous variants in protein phosphatase 1 regulatory subunit 3F (PPP1R3F) are associated with a neurodevelopmental disorder characterized by developmental delay, in...
  Zhigang Liu, Baozhong Xin, Iris N Smith, Valerie Sency, Julia Szekely, Anna Alkelai, Alan Shuldiner, Stephanie Efthymiou, Farrah Rajabi, Stephanie Coury, Catherine A B...> ;Human Molecular Genetics. 2023 Oct 4
• Embryonic stem cell factor FOXD3 (Genesis) defects in gastrointestinal stromal tumors.
  Fabio R Faucz, Anelia D Horvath, Guillaume Assié, Madson Q Almeida, Eva Szarek, Sosipatros Boikos, Anna Angelousi, Isaac Levy, Andrea G Maria, Ajay Chitnis, Cristina R...> ;Endocrine-Related Cancer. 2023 Oct 1
• 1 citations
  The mitochondrial genome as a modifier of autism versus cancer phenotypes inhamartoma tumor syndrome.
  Ruipeng Wei, Lamis Yehia, Ying Ni, Charis Eng> ;HGG Advances. 2023 Jul 13
• 5 citations
  Tamoxifen and the risk of breast cancer in women with a BRCA1 or BRCA2 mutation.
  Joanne Kotsopoulos, Jacek Gronwald, Tomasz Huzarski, Amber Aeilts, Susan Randall Armel, Beth Karlan, Christian F Singer, Andrea Eisen, Nadine Tung, Olufunmilayo Olopad...> ;Breast Cancer Research and Treatment. 2023 Sep 1
• Integrating somatic CNV and gene expression in breast cancers from women with PTEN hamartoma tumor syndrome.
  Takae Brewer, Lamis Yehia, Peter Bazeley, Charis Eng> ;NPJ Genomic Medicine. 2023 Jul 5
• 2 citations
  Development of informant-report neurobehavioral survey scales for PTEN hamartoma tumor syndrome and related neurodevelopmental genetic syndromes.
  Frazier, T., Busch, R., Klaas, P., Lachlan, K., Jeste, S., Kolevzon, A., Loth, E., Harris, J., Speer, L., Pepper, T., Anthony, K., Graglia, J., Delagrammatikas, C., Be...> ;American Journal of Medical Genetics. Part A. 2023 Jul 1
• Diffuse Hamartomatous Change in the Gallbladder of a Patient With Deletion Involving PTEN and BMPR1A Genes.
  Ksenia Chezar, Darrell L Cass, Jacob A Kurowski, Kadakkal Radhakrishnan, Charis Eng, Xuefeng Zhang> ;The American Journal of Gastroenterology. 2023 Nov 1
• 4 citations
  Longitudinal Analysis of Cancer Risk in Children and Adults With Germline PTEN Variants.
  Lamis Yehia, Gilman Plitt, Ann M Tushar, Julia Joo, Carol A Burke, Steven C Campbell, Katherine Heiden, Judy Jin, Carole Macaron, Chad M Michener, Holly J Pederson, Ka...> ;JAMA Network Open. 2023 Apr 3
• 1 citations
  Are population level familial risks and germline genetics meeting each other?
  Kari Hemminki, Xinjun Li, Asta Försti, Charis Eng> ;Hereditary Cancer in Clinical Practice. 2023 Mar 8
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Journal Articles

• KLLN-Mediated DNA Damage-Induced Apoptosis Is Associated with Regulation of p53 Phosphorylation and Acetylation in Breast Cancer Cells  
  Charis Eng, MD, Nature

Books/Book Chapters

• Practical Handbook of Human Cancer Genetics 
  Foulkes WR, Hodgson SV, Eng C, Maher ERSpringerEdition 4th,2013
• Practical Handbook of Human Cancer Genetics 
  Foulkes WR, Hodgson SV, Eng C, Maher ERSpringerEdition 4th,2013
• A Clinical Approach to Endocrine and Metabolic Diseases 
  Chapter: Management of paraganglioma 
  Neumann HPH, Eng CEditors: Ladenson PW.The Endocrine Society, Chevy Case, MD2010
• Genetic Syndromes and Management 
  Chapter: PTEN hamartoma tumor syndrome 
  Edelman E, Eng CEditors: Cassidy S, Allanson JE.Wiley-Blackwell, New YorkEdition 3rd,2010
• WHO Classification of Tumours of the Digestive System 
  Chapter: Cowden syndrome 
  Eng C, Eng Ca, Burt RWEditors: Bostman FT, Carneiro F, Hruban RH, Theise ND.IARC Press, Lyon, FranceEdition 4th,2010
• A Guide to Cancer Genetics in Clinical Practice 
  Chapter: Hamartomatous polyposis syndromes 
  Leach BH, Kalady M, Eng CEditors: Clark S.tfm Publishing Ltd, Shrewsbury, UK2009
• Pediatric Endocrinology 
  Chapter: Pheochromocytoma and the multiple endocrine neoplasia syndromes 
  Chernausek SD, Eng C.Editors: Sperling M.Saunders ElsevierEdition 3rd,2008
• Hereditary Breast Cancer 
  Chapter: PTEN and Cowden syndrome 
  Zbuk KM, Stein J, Eng CEditors: Isaacs C, Rebbeck TM.Informa Healthcare, New York2007
• WHO Classification of Tumours. Pathology and Genetics of Tumours of Skin 
  Chapter: Cowden syndrome 
  Kazakov DV, Burg G, Eng CEditors: Weedon D, LeBoit P, Burg G, Sarasin A.IARC Press, Lyon, France2005
• Genetic Predisposition to Cancer 
  Chapter: Multiple endocrine neoplasia type 2 
  Eng C, Ponder BAJEditors: Eeles RA, Easton DF, Ponder BAJ, Eng C.Edward Arnold, Ltd, LondonEdition 2nd,2004
• WHO Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Organs 
  Chapter: Follicular carcinoma (Thyroid) 
  Sobrinho-Simoes M, Asa SL, Kroli TG, Nikiforov Y, DeLellis RA, Farid P, Kitamura Y, Noguchi SU, Eng C, Harach HR, Williams ED, Schneider AB, Fagin JA, Ghossein RA, Maz...Editors: DeLellis R, Lloyd R, Heitz PU, Eng C.IARC Press, Lyon, France2004
• WHO Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Organs 
  Chapter: Parathyroid adenoma 
  Grimelius L, DeLellis RA, Bondeson L, Akerstom G, Arnold A, Franssila KO, Hendy GN, Dupuy D, Eng CEditors: DeLellis R, Lloyd R, Heitz PU, Eng C.IARC Press, Lyon, France2004
• Familial Breast and Ovarian Cancer 
  Chapter: Cowden syndrome and related disorders 
  Eng CEditors: Morrison P, Hodgson SV, Haites N.Cambridge University Press, Cambridge2002
• Molecular Genetics of Cancer 
  Chapter: Multiple endocrine neoplasia type 2 
  Eng CEditors: Cowell JK.BIOS Scientific Publishers Ltd, Oxford2001
• Genetic Disorders of Endocrine Neoplasia 
  Chapter: Hereditary endocrine neoplasias: fundamental insights and the practice of clinical cancer genetics 
  Dahia PLM, Eng CEditors: Dahia PLM, Eng C.Karger, Basel2001
• WHO Classification of Tumours. Pathology and Genetics of Digestive Tract Tumours 
  Chapter: Cowden syndrome 
  Eng C, Burt R, Talbot ICEditors: Hamilton S, Aaltonen L.IARC Press, Lyon, France2000
• Multiple Primary Cancers 
  Chapter: Dominant genes and phacomatoses associated with multiple primary cancers 
  Eng C, Maher EREditors: Neugut AI, Robinson E, Meadows AT.Lippincott, Williams and Wilkins, Philadelphia1999
• Clinical Endocrinology 
  Chapter: Multiple endocrine neoplasia type 2 and medullary carcinoma of the thyroid 
  Eng C, Ponder BAJEditors: Grossman A.Blackwell Science, OxfordEdition 2nd,1998
• The Genetic Basis of Human Cancer 
  Chapter: Cowden syndrome 
  Eng C, Parsons REditors: Vogelstein B, Kinzler KW.McGraw Hill and Co., New York1998
• Hormonal Hypertension 
  Chapter: Multiple endocrine neoplasia type 2 
  Neumann HPH, Eng C, Bender BUEditors: Sznjderman M, Januszewicz W, Januszwicz A.Wydawnictwo Naukowe, Warsaw1997
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Abstracts/Posters

• Second primary malignancies in PTEN hamartoma tumor syndrome
  Ngeow J, Mester JL, Barnholtz-Sloan J, Eng C, J Clin Oncol, 1/1/2013
• Health information technology in clinical genetic counseling
  Doerr M, Seller Fecteau H, Eng C, Proc Natl Soc Genet Counsel, 1/1/2013
• Implementation of tumor testing for Lynch syndrome in endometrial cancers at a large academic medical center
  Moline J, Mahdi H, Yang B, Biscotti C, Roma AA, Heald B, Rose PG, Michener C, Eng C, Proc Natl Soc Genet Counsel, 1/1/2013
• CDH1 family and dynamics
  Polk J, Makar V, Walsh M, Eng C, Proc Natl Soc Genet Counsel, 1/1/2013
• Limitations in the patient’s right not-to-know genetic test results: case report and discussion
  Cook R, Nardini M, Sharp RR, Eng C, Proc Natl Soc Genet Counsel, 1/1/2013
• Risk for endometrial carcinoma, ovarian tumors and other gynecologic diagnoses in women with Cowden syndrome and germline PTEN mutation
  Mester JL, Escobar P, Roma A, Eng C, Soc Gynecol Oncol, 1/1/2012
• PTEN germline mutations in patients first tested for other hereditary cancer syndromes: Would use of risk assessment tools have reduced healthcare costs?
  Mester JL, Moore RA, Eng C, J Clin Oncol, 1/1/2012
• Implementation of institutional MSI and IHC testing for Lynch syndrome diagnosis: Cleveland Clinic experience
  Heald B, Plesec T, Liu X, Moline J, Burke CA, Kalady MF, Church J, Eng C, Proc Natl Soc Genet Counsel, 1/1/2012
• Implementation of institutional MSI and IHC testing for Lynch syndrome diagnosis: Cleveland Clinic experience
  Heald B, Plesec T, Liu X, Moline J, Burke CA, Kalady MF, Church J, Eng C, CGA/ISHC, 1/1/2012
• Comparison of neoplastic phenotypes in Cowden/Cowden-like syndrome characterized by germline SDHx variants, PTEN mutations versus KLLN epimutations
  Ni Y, Tan MH, Bennett K, Mester J, Chen J, Moline J, Orloff M, Eng C, Am Soc Hum Genet/Intl Congr Hum Genet, 1/1/2011
• Approach to systematic screening of endometrial cancers for Lynch syndrome: the Cleveland Clinic experience
  Moline J, Biscotti C, Drake R, Eng C, Proc Natl Soc Genet Counsel, 1/1/2011
• SDHx as novel susceptibility genes for Cowden and Cowden-like syndromes
  Ni Y, Orloff MS, Eng C, HHMI Molecular Medicine Scientific Retreat, 1/1/2010
• PTEN association with mTOR pathway activation and outcomes in bladder cancer
  Orloff M, Elson P, Yan YR, Eng C, Hansel DE, Proc Am Assoc Cancer Res, 1/1/2010
• Comparison of family health history to personal genomic screening for risk assessment of colon cancer
  Leach BH, Eng C, Collaborative Group of the Americas on Inherited Colorectal Cancer Syndromes, 1/1/2010
• Germline SDHC whole-gene deletion in a patient with malignant extraadrenal pheochromoctyoma: Reconsideration of clinical testing strategy
  Moline J, Chen JL, Eng C, Am Soc Hum Genet, 1/1/2010
• Activator protein 2 alpha-targeted methylation and silencing of relevant genes in head and neck squamous cell cancer (HNSCC) pathogenesis
  Bennett KL, Eng C, Proc Am Assoc Cancer Res, 1/1/2009
• Children and young adults with germline PTEN mutations: phenotypic description and key features to early diagnosis
  Mester J, Heald Leach B, Orloff MS, Eng C, Am Soc Hum Genet, 1/1/2009
• Genomic counseling in the setting of an institutional initiative for direct-to-consumer personal genomic testing
  Edelman EE, Sharp RR, Eng C, Am Soc Hum Genet, 1/1/2009
• Gastrointestinal polyps and PTEN mutations: an underacknowledged diagnostic criterion
  Heald Leach B, Burke C, Eng C, Am Soc Hum Genet, 1/1/2009
• Children and young adults with germline PTEN mutations: phenotypic description and key features to early diagnosis
  Mester J, Heald B, Orloff MS, Eng C, Proc Natl Soc Genet Counsel, 1/1/2009
• An association between hereditary colon cancer and sarcoma? A report of 2 families with mismatch repair mutations and rare presentation of rhabdomyosarcoma
  Heald B, Edelman E, Eng C, Proc Natl Soc Genet Counsel, 1/1/2008
• Common and cancer type-specific loss-of-heterozygosity (LOH) in the tumor stroma and epithelium of 3 carcinoma types associated with clinical outcome
  Orloff M, Xu Y, Zhang L, Eng C, Am Soc Hum Genet, 1/1/2008
• Clinical and molecular analyses of PTEN promoter variant –1084 C>T in 22 families with PTEN hamartoma tumor syndrome
  Edelman E, Eng C, Am Soc Hum Genet, 1/1/2008
• Adult-onset congenital erythropoietic porphyria: an extra challenge in the diagnosis of porphyria
  Gustafson S, Lichtin A, Eng C, Proc Natl Soc Genet Counsel, 1/1/2007
• Germline SDHB and SDHD mutations in a hospital-based series of patients with hereditary pheochromocytoma and paraganglioma
  Edelman E, Zbuk KM, Shealy A, Lorenz RR, Eng C, Am Soc Hum Genet, 1/1/2007
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