CharlesThomasBensonMD

PubMed

• 20 citations
  First-in-Human Study of Bamlanivimab in a Randomized Trial of Hospitalized Patients With COVID-19.
  Peter Chen, Gourab Datta, Ying Grace Li, Jenny Y. Chien, Karen L. Price, Emmanuel Chigutsa, Patricia Brown-Augsburger, Josh Poorbaugh, Jeffrey Fill, Robert J. Benschop...> ;Clinical Pharmacology and Therapeutics. 2021 Oct 16
• 45 citations
  Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
  Hugo M. Vargas, Michael G. Rolf, Todd Wisialowski, William E. Achanzar, Anthony Bahinski, Alan S. Bass, Charles Benson, Khuram W. Chaudhary, Nicolas Couvreur, Corina D...> ;Clinical Pharmacology and Therapeutics. 2021 Feb 1
• Pharmacokinetics and Pharmacodynamics of Human Regular U-500 Insulin Administered via Continuous Subcutaneous Insulin Infusion Versus Subcutaneous Injection in Adults ...
  Xiaosu Ma, Charles Benson, Randy Prescilla, Shuyu Zhang, Helle Linnebjerg, Elizabeth Smith Labell, Linda Morrow, Jeffrey A. Jackson, Alex Nguyen, Liza L. Ilag, Jennal ...> ;Journal of Diabetes Science and Technology. 2020 Nov 26
• 40 citations
  The novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide transiently delays gastric emptying simila...
  Shweta Urva, Tamer Coskun, Corina Loghin, Xuewei Cui, Emily C Beebe, Libbey S. O’Farrell, Daniel A. Briere, Charles Benson, Michael A. Nauck, Axel Haupt> ;Diabetes, Obesity & Metabolism. 2020 Oct 1
• 104 citations
  Efficacy and tolerability of tirzepatide, a dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist in patients with type 2 diabetes...
  Juan P. Frias, Michael A. Nauck, Joanna Van, Charles Benson, Ross Bray, Xuewei Cui, Zvonko Milicevic, Shweta Urva, Axel Haupt, Deborah A. Robins> ;Diabetes, Obesity & Metabolism. 2020 Jan 27
• 5 citations
  Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study.
  Borje Darpo, Charles Benson, Randy Brown, Corina Dota, Georg Ferber, Jim Ferry, Venkat Jarugula, James Keirns, Catherine Ortemann-Renon, Thuan G. Pham, Steve Riley, Ne...> ;Journal of Clinical Pharmacology. 2020 Jan 1
• Shared Learnings on the New EMA First-in-Human and Early Clinical Trial Guideline: Proceedings From a DIAlogue Session at DIA Europe 2018.
  van der Laan, J. W.,Benson, C. T.,Janssens, W.,Bos, J.,Stahl, E.,Brady, J. T.,Wändel-Liminga, U.,Corriol-Rohou, S.,Forster, R.,Hartmann, A.,Pertel, P. E.,Robertson, S....> ;Ther Innov Regul Sci. 2019 May 16
• 342 citations
  LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.
  Tamer Coskun, Kyle W. Sloop, Corina Loghin, Jorge Alsina-Fernandez, Shweta Urva, Krister Bokvist, Xuewei Cui, Daniel A. Briere, Over Cabrera, William C. Roell, Uma Kuc...> ;Molecular Metabolism. 2018 Oct 3
• 395 citations
  Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator...
  Juan P. Frias, Michael A. Nauck, Joanna Van, Mark E Kutner, Xuewei Cui, Charles Benson, Shweta Urva, Ruth E. Gimeno, Zvonko Milicevic, Deborah A. Robins, Axel Haupt> ;Lancet. 2018 Nov 17
• 30 citations
  CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion.
  Rob Wallis, Charles Benson, Borje Darpo, Gary A. Gintant, Yasunari Kanda, Krishna Prasad, David G. Strauss, Jean-Pierre Valentin> ;Journal of Pharmacological and Toxicological Methods. 2018 Sep 1
• 9 citations
  Repurposing a novel parathyroid hormone analogue to treat hypoparathyroidism
  Venkatesh Krishnan, Yanfei L. Ma, Catherine Z. Chen, Natasha Thorne, Heather A Bullock, Gregory J. Tawa, Christy Javella-Cauley, Shaoyou Chu, Weiming Li, Wayne David K...> ;British Journal of Pharmacology. 2018 Jan 1
• 40 citations
  A Phase 2 Randomized Study Investigating the Efficacy and Safety of Myostatin Antibody LY2495655 versus Placebo in Patients Undergoing Elective Total Hip Arthroplasty.
  Linda J. Woodhouse, R Gandhi, Stuart J. Warden, Serge Poiraudeau, Stephen L. Myers, Charles Benson, L Hu, Qasim I. Ahmad, P Linnemeier, Elisa Gomez, Olivier Bénichou, ...> ;The Journal of Frailty & Aging. 2016 Jan 1
• 216 citations
  Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial
  Clemens Becker, Stephen R. Lord, Stephanie A. Studenski, Stuart J. Warden, Roger A. Fielding, Christopher Recknor, Marc C. Hochberg, Serge Ferrari, Hubert Blain, Ellen...> ;The Lancet. Diabetes & Endocrinology. 2015 Dec 1
• 58 citations
  The Effect of Discontinuing Treatment With Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women With Low Bone Mineral Density.
  Christopher Recknor, Robert R. Recker, Charles Benson, Deborah A. Robins, Alan Y Chiang, Jahangir Alam, Leijun Hu, Toshio Matsumoto, Hideaki Sowa, John H. Sloan, Rober...> ;Journal of Bone and Mineral Research. 2015 Sep 1
• 134 citations
  Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase.
  Borje Darpo, Charles Benson, Corina Dota, Georg Ferber, Christine Garnett, Cynthia L. Green, Venkateswar Jarugula, Lars Johannesen, James Keirns, Kevin Krudys, Jiang L...> ;Clinical Pharmacology and Therapeutics. 2015 Apr 1
• 202 citations
  A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density
  Robert R. Recker, Charles Benson, Toshio Matsumoto, Michael A. Bolognese, Deborah A. Robins, Jahangir Alam, Alan Y Chiang, Leijun Hu, John H. Krege, Hideaki Sowa, Bruc...> ;Journal of Bone and Mineral Research. 2015 Feb 1
• 50 citations
  Cardiac Safety Research Consortium: Can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies? Scientific update and a ...
  Borje Darpo, Christine Garnett, Charles Benson, James Keirns, Derek J. Leishman, Marek Malik, Nitin Mehrotra, Krishna Prasad, Steve Riley, Ignacio Rodriguez, Philip T....> ;American Heart Journal. 2014 Sep 1
• 10 citations
  Mathematical model formulation and validation of water and solute transport in whole hamster pancreatic islets.
  James D. Benson, Charles Benson, John K. Critser> ;Mathematical Biosciences. 2014 Aug 1
• 81 citations
  The IQ‐CSRC Prospective Clinical Phase 1 Study: “Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?”
  Borje Darpo, Nenad Sarapa, Christine Garnett, Charles Benson, Corina Dota, Georg Ferber, Venkateswar Jarugula, Lars Johannesen, James Keirns, Kevin Krudys, Catherine O...> ;Annals of Noninvasive Electrocardiology. 2014 Jan 1
• 239 citations
  How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines
  H. G. Laverty, Charles Benson, Elizabeth J. Cartwright, Michael J. Cross, Christopher J. Garland, Timothy R. Hammond, Cameron J. Holloway, Nick McMahon, J. Milligan, B...> ;British Journal of Pharmacology. 2011 Jun 1
• 2 citations
  Systematic decrements in QTc between the first and second day of contiguous daily ECG recordings under controlled conditions.
  Charles M. Beasley, Charles Benson, Jessie Q. Xia, S. Stanley Young, Harry Haber, Malcolm I. Mitchell, Corina Loghin> ;Pacing and Clinical Electrophysiology. 2011 Apr 28
• Inhibition of PKC β by Ruboxistaurin Does Not Enhance the Acute Blood Pressure Response to Nitroglycerin
  Charles Benson, Mary E. Seger, J. Voelker> ;Clinical Pharmacology and Therapeutics. 2007 Aug 1
• 6 citations
  Teriparatide has no effect on the calcium-mediated pharmacodynamics of digoxin.
  Charles Benson, James R. Voelker> ;Clinical Pharmacology and Therapeutics. 2003 Jan 1
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