CharlesConwayMD

Psychiatry • Saint Louis, MO

Associate Professor of Psychiatry, Washington University St Louis

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Office
1 Barnes Jewish Hospital Plz
Ste 15340
Saint Louis, MO 63110
Phone+1 314-286-1700

Fax+1 314-362-7017
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Education & Training

Duke University HospitalResidency, Psychiatry, 1995 - 1999
University of Missouri-Columbia School of MedicineClass of 1995

Certifications & Licensure

MO State Medical License 1999 - 2025
NC State Medical License 1997 - 2000
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Treatment-Resistant Depression Registry Start of enrollment: 2006 Jan 01
Completed
Dopaminergic Effects of Adjunctive Aripiprazole on the Brain in Treatment-Resistant Depression Start of enrollment: 2009 May 01
Completed
Not Applicable
fMRI Study of Treatment Changes in Major Depression Start of enrollment: 2009 Feb 01
Completed
Not Applicable
Genomics Used to Improve DEpression Decisions Start of enrollment: 2014 Apr 01
Completed
Not Applicable
Adaptive tDCS for Treatment-Resistant MDD Start of enrollment: 2017 Apr 14
Active, not recruiting
Not Applicable
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits Start of enrollment: 2017 Jan 27
Terminated
Phase 1
Nitrous Oxide- Suicidal Ideation Start of enrollment: 2018 Oct 30
Enrolling by invitation
Phase 1
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression Start of enrollment: 2019 Sep 26
Recruiting
Not Applicable
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Publications & Presentations

PubMed

2 citations
Alternative metrics for characterizing longer-term clinical outcomes in difficult-to-treat depression: I. Association with change in quality of life.
Harold A Sackeim, A John Rush, Teresa Greco, Mei Jiang, Sarah Badejo, Mark T Bunker, Scott T Aaronson, Charles R Conway, Koen Demyttenaere, Allan H Young, R Hamish McA...> ;Psychological Medicine. 2023 Jan 5
Interventional psychiatry: the revolution has arrived.
Charles R Conway, Harold A Sackeim> ;Revista Brasileira De Psiquiatria. 2022 Nov 15
8 citations
Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus.
Yukitoshi Izumi, Fong-Fu Hsu, Charles R Conway, Peter Nagele, Steven J Mennerick, Charles F Zorumski> ;Biological Psychiatry. 2022 Dec 15
2 citations
Nitrous Oxide: an emerging novel treatment for treatment-resistant depression.
Darin F Quach, Victoria C de Leon, Charles R Conway> ;Journal of the Neurological Sciences. 2022 Mar 15
15 citations
Vagus nerve stimulation: An update on a novel treatment for treatment-resistant depression.
Lojine Y Kamel, Willa Xiong, Britt M Gott, Arun Kumar, Charles R Conway> ;Journal of the Neurological Sciences. 2022 Mar 15
26 citations
Clinical research challenges posed by difficult-to-treat depression.
A John Rush, Harold A Sackeim, Charles R Conway, Mark T Bunker, Steven D Hollon, Koen Demyttenaere, Allan H Young, Scott T Aaronson, Maxine Dibué, Michael E Thase, R H...> ;Psychological Medicine. 2022 Feb 1
37 citations
A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression
Peter Nagele, Ben J.A. Palanca, Britt M. Gott, Frank Brown, Linda D. Barnes, Thomas Nguyen, Willa Xiong, Naji C. Salloum, Gemma D. Espejo, Christina N. Lessov-Schlagga...> ;Science Translational Medicine. 2021 Jun 9
7 citations
Clinical validation of combinatorial pharmacogenomic testing and single-gene guidelines in predicting psychotropic medication blood levels and clinical outcomes in pat...
Anthony J. Rothschild, Sagar V. Parikh, Daniel T. Hain, Rebecca A. Law, Michael E. Thase, Boadie W. Dunlop, Charles DeBattista, Charles R. Conway, Brent P. Forester, R...> ;Psychiatry Research. 2021 Feb 1
15 citations
Combinatorial Pharmacogenomic Algorithm is Predictive of Citalopram and Escitalopram Metabolism in Patients with Major Depressive Disorder
Richard C. Shelton, Sagar V. Parikh, Rebecca A. Law, Anthony J. Rothschild, Michael E. Thase, Boadie W. Dunlop, Charles DeBattista, Charles R. Conway, Brent P. Foreste...> ;Psychiatry Research. 2020 Aug 1
11 citations
A prospective, multi-center randomized, controlled, blinded trial of vagus nerve stimulation for difficult to treat depression: A novel design for a novel treatment.
Charles R. Conway, Bryan Olin, Scott Aaronson, Harold A. Sackeim, Mark Bunker, Christopher Kriedt, Teresa Greco, Kristine Broglio, Matteo Vestrucci, A. John Rush> ;Contemporary Clinical Trials. 2020 Jun 19
9 citations
Combinatorial Pharmacogenomic Testing Improves Outcomes for Older Adults With Depression.
Brent P. Forester, Sagar V. Parikh, Sara L. Weisenbach, Olusola Ajilore, Ipsit V. Vahia, Anthony J. Rothschild, Michael E. Thase, Boadie W. Dunlop, Charles DeBattista,...> ;The American Journal of Geriatric Psychiatry. 2020 May 19
41 citations
Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents
Molly C. Kalmoe, Alvin M. Janski, Charles F. Zorumski, Peter Nagele, Ben J.A. Palanca, Charles R. Conway> ;Journal of the Neurological Sciences. 2020 May 15
14 citations
The effects of vagus nerve stimulation on the course and outcomes of patients with bipolar disorder in a treatment-resistant depressive episode: a 5-year prospective r...
R. Hamish McAllister-Williams, Soraia Sousa, Arun Kumar, Teresa Greco, Mark Bunker, Scott Aaronson, Charles R. Conway, A. John Rush> ;International Journal of Bipolar Disorders. 2020 May 2
13 citations
Comparing sensitivity to change using the 6-item versus the 17-item Hamilton depression rating scale in the GUIDED randomized controlled trial
Boadie W. Dunlop, Sagar V. Parikh, Anthony J. Rothschild, Michael E. Thase, Charles DeBattista, Charles R. Conway, Brent P. Forester, Francis M. Mondimore, Richard C. ...> ;BMC Psychiatry. 2019 Dec 27
33 citations
Impact of Pharmacogenomics on Clinical Outcomes for Patients Taking Medications With Gene-Drug Interactions in a Randomized Controlled Trial.
Michael E. Thase, Sagar V. Parikh, Anthony J. Rothschild, Boadie W. Dunlop, Charles DeBattista, Charles R. Conway, Brent P. Forester, Francis M. Mondimore, Richard C. ...> ;The Journal of Clinical Psychiatry. 2019 Oct 31
57 citations
The assessment of resistance to antidepressant treatment: Rationale for the Antidepressant Treatment History Form: Short Form (ATHF-SF)
Harold A. Sackeim, Scott Aaronson, Mark Bunker, Charles R. Conway, Mark A. Demitrack, Mark S. George, Joan Prudic, Michael E. Thase, A. John Rush> ;Journal of Psychiatric Research. 2019 Jun 1
1 citations
Response to: Goldberg et al. and Severance et al. Letters to the Editor: The clinical significance of improving remission over standard of care – The reality of treatm...
John F. Greden, Sagar V. Parikh, Anthony J. Rothschild, Michael E. Thase, Boadie W. Dunlop, Charles DeBattista, Charles R. Conway, Brent P. Forester, Francis M. Mondim...> ;Journal of Psychiatric Research. 2019 Apr 27
152 citations
Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and rater-blinded, randomized, controlled study.
John F. Greden, Sagar V. Parikh, Anthony J. Rothschild, Michael E. Thase, Boadie W. Dunlop, Charles DeBattista, Charles R. Conway, Brent P. Forester, Francis M. Mondim...> ;Journal of Psychiatric Research. 2019 Apr 1
23 citations
Durability of symptomatic responses obtained with adjunctive vagus nerve stimulation in treatment-resistant depression
Arun Kumar, Mark Bunker, Scott Aaronson, Charles R. Conway, Anthony J. Rothschild, Giacomo Mordenti, A. J. Rush> ;Neuropsychiatric Disease and Treatment. 2019 Feb 13
49 Combinatorial Pharmacogenomics to Guide Treatment Selection for Major Depressive Disorder: A Large, Blinded, Randomized Controlled Trial.
Greden, J. F.,Rosthschild, A. J.,Thase, M.,Dunlop, B. W.,DeBattista, D. C.,Conway, C. R.,Forester, B. P.,Mondimore, F. M.,Shelton, R. C.,Li, J.,Gilbert, A.,Burns, L.,J...> ;CNS Spectr. 2019 Mar 13
22 citations
Neurostimulation for depression in epilepsy.
Charles R. Conway, Anita Udaiyar, Steven C. Schachter> ;Epilepsy & Behavior. 2018 Jul 4
11 citations
Vagus Nerve Stimulation: Changing the Paradigm for Chronic Severe Depression?
Scott Aaronson, Charles R. Conway> ;The Psychiatric Clinics of North America. 2018 Sep 1
40 citations
Chronic Vagus Nerve Stimulation Significantly Improves Quality of Life in Treatment-Resistant Major Depression
Charles R. Conway, Arun Kumar, Willa Xiong, Mark Bunker, Scott Aaronson, A. John Rush> ;The Journal of Clinical Psychiatry. 2018 Aug 21
30 citations
The Mechanism of Action of Vagus Nerve Stimulation in Treatment-Resistant Depression: Current Conceptualizations.
Charles R. Conway, Willa Xiong> ;The Psychiatric Clinics of North America. 2018 Jul 17
24 citations
Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts.
Peter Nagele, Charles F. Zorumski, Charles R. Conway> ;Journal of Clinical Psychopharmacology. 2018 Apr 1
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Journal Articles

Neurostimulation for Depression in Epilepsy☆
Charles R Conway, Steven C Schachter, Epilepsy & Behavior

Press Mentions

Thursday: Laughing Gas Can Provide Relief for Depression, Study FindsJuly 6th, 2021
Low Doses of Nitrous Oxide May Treat DepressionJune 26th, 2021
Russian Researchers Revive Tiny Creatures Frozen for 24,000 YearsJune 24th, 2021
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