CharlesStewartFuchsMD

Gastrointestinal Cancer, Hematologic Oncology

Director, Yale Cancer Center Physician-in-Chief, Smilow Cancer Hospital Richard and Jonathan Sackler Professor of Internal Medicine, Yale School of Medicine

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Office
333 Cedar St
Yale Cancer Center
New Haven, CT 06510
Phone+1 203-785-7870

Fax+1 203-785-4116
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 1989 - 1992
Brigham and Women's HospitalResidency, Internal Medicine, 1986 - 1989
Harvard Medical SchoolClass of 1986

Certifications & Licensure

MA State Medical License 1988 - 2025
CT State Medical License 2016 - 2025
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Boston Magazine Castle Connolly, 2008, 2010-2013

Clinical Trials

Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Start of enrollment: 1998 Oct 01
Completed
Phase 3
ZD 1839 Plus Combination Chemotherapy in Treating Patients With Locally Advanced, Locally Recurrent, or Metastatic Colorectal Cancer Start of enrollment: 2001 Nov 01
Completed
Phase 1
Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer Start of enrollment: 2002 Dec 01
Completed
Phase 3
Capecitabine and Thalidomide in Previously Treated Metastatic Colorectal Carcinoma Start of enrollment: 2001 Nov 01
Completed
Phase 2
Adjuvant Chemoradiation Therapy for Gastric or Gastroesophageal Junction Adenocarcinoma Start of enrollment: 2000 Sep 01
Completed
Early Phase 1
Gemcitabine, 5-Fluorouracil, and Radiation Therapy in the Treatment of Non-Metastatic Pancreatic Cancer Start of enrollment: 1998 Jan 01
Completed
Phase 1
Taxotere, Cisplatin, and CPT-11 in Advanced Solid Tumor Malignancies Start of enrollment: 1999 Sep 01
Completed
Phase 1
RAD001 in Previously Treated Patients With Metastatic Pancreatic Cancer Start of enrollment: 2007 Jan 01
Completed
Phase 2
Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal Cancer Start of enrollment: 2007 Oct 01
Completed
Phase 1, Phase 2
A Study of BBI503 in Adult Patients With Advanced Solid Tumors Start of enrollment: 2012 Feb 01
Completed
Phase 1
A Study of Ramucirumab Plus Pembrolizumab in Participants With Gastric or GEJ Adenocarcinoma, NSCLC, Transitional Cell Carcinoma of the Urothelium, or Biliary Tract Cancer Start of enrollment: 2015 Jul 29
Completed
Phase 1
A Study of Ramucirumab (LY3009806) in Combination With Paclitaxel in Participants With Gastric Cancer Start of enrollment: 2015 Oct 12
Completed
Phase 2
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Publications & Presentations

PubMed

Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization.
Sontoria D King, Swathi Veliginti, Martijn C G J Brouwers, Zhewen Ren, Wei Zheng, Veronica W Setiawan, Lynne R Wilkens, Xiao-Ou Shu, Alan A Arslan, Laura E Beane Freem...> ;Cancer Epidemiology, Biomarkers & Prevention. 2023 Sep 1
Evaluation of Intratumoral Response Heterogeneity in Metastatic Colorectal Cancer and Its Impact on Patient Overall Survival: Findings from 10,551 Patients in the ARCA...
Fang-Shu Ou, Daniel H Ahn, Jesse G Dixon, Axel Grothey, Yiyue Lou, Pashtoon M Kasi, Joleen M Hubbard, Eric Van Cutsem, Leonard B Saltz, Hans-Joachim Schmoll, Richard M...> ;Cancers. 2023 Aug 15
1 citations
Baseline Quality of Life is a Strong and Independent Prognostic Factor for Overall Survival in Metastatic Colorectal Cancer.
Patrick McGarrah, Joleen Hubbard, Paul J Novotny, Megan E Branda, Daniel S Sargent, Roscoe F Morton, Charles S Fuchs, Al B Benson, Stephen K Williamson, Brian P Findla...> ;Cancer Control. 2023 Jun 20
1 citations
Marital Status, Living Arrangement, and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings from CALGB 89803 (Alliance).
Lee, S., Ma, C., Zhang, S., Ou, F., Bainter, T., Niedzwiecki, D., Saltz, L., Mayer, R., Whittom, R., Hantel, A., Benson, A., Atienza, D., Kindler, H., Gross, C., Irwin...> ;The Oncologist. 2022 Jun 8
28 citations
Association of Tumor Mutational Burden with Efficacy of Pembrolizumab±Chemotherapy as First-Line Therapy for Gastric Cancer in the Phase III KEYNOTE-062 Study.
Keun-Wook Lee, Eric Van Cutsem, Yung-Jue Bang, Charles S Fuchs, Iveta Kudaba, Marcelo Garrido, Hyun Cheol Chung, Jeeyun Lee, Hugo R Castro, Joseph Chao, Zev A Wainberg...> ;Clinical Cancer Research. 2022 Aug 15
2 citations
Age and comorbidity association with survival outcomes in metastatic colorectal cancer: CALGB 80405 analysis.
Nadine J McCleary, Sui Zhang, Chao Ma, Fang-Shu Ou, Tiffany M Bainter, Alan P Venook, Donna Niedzwiecki, Heinz-Josef Lenz, Federico Innocenti, Bert H O'Neil, Blase N P...> ;Journal of Geriatric Oncology. 2022 May 1
1 citations
Cetuximab and Irinotecan With or Without Bevacizumab in Refractory Metastatic Colorectal Cancer: BOND-3, an ACCRU Network Randomized Clinical Trial.
Marla Lipsyc-Sharf, Fang-Shu Ou, Matthew B Yurgelun, Douglas A Rubinson, Deborah Schrag, Shaker R Dakhil, Philip J Stella, Douglas J Weckstein, Donald B Wender, Meredi...> ;The Oncologist. 2022 Apr 5
5 citations
Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study.
Sohee Kwon, Wenjie Ma, David A Drew, Samuel J Klempner, Brianna M Leonardo, Jacqueline J Flynn, Yin Cao, Edward L Giovannucci, Ying Bao, Charles S Fuchs, Mingyang Song...> ;Cancer Prevention Research. 2022 Apr 1
1 citations
Long-Term Survival and Causes of Death After Diagnoses of Common Cancers in 3 Cohorts of US Health Professionals.
En Cheng, Dong Hoon Lee, Rulla M Tamimi, Susan E Hankinson, Walter C Willett, Edward L Giovannucci, A Heather Eliassen, Meir J Stampfer, Lorelei A Mucci, Charles S Fuc...> ;JNCI Cancer Spectrum. 2022 Mar 2
14 citations
Diet- and Lifestyle-Based Prediction Models to Estimate Cancer Recurrence and Death in Patients With Stage III Colon Cancer (CALGB 89803/Alliance).
En Cheng, Fang-Shu Ou, Chao Ma, Donna Spiegelman, Sui Zhang, Xin Zhou, Tiffany M Bainter, Leonard B Saltz, Donna Niedzwiecki, Robert J Mayer, Renaud Whittom, Alexander...> ;Journal of Clinical Oncology. 2022 Mar 1
1 citations
Associations Between Unprocessed Red Meat and Processed Meat With Risk of Recurrence and Mortality in Patients With Stage III Colon Cancer.
Erin L Van Blarigan, Fang-Shu Ou, Tiffany M Bainter, Charles S Fuchs, Donna Niedzwiecki, Sui Zhang, Leonard B Saltz, Robert J Mayer, Alexander Hantel, Al B Benson 3rd,...> ;JAMA Network Open. 2022 Feb 1
3 citations
Coffee Intake of Colorectal Cancer Patients and Prognosis According to Histopathologic Lymphocytic Reaction and T-Cell Infiltrates.
Tomotaka Ugai, Koichiro Haruki, Juha P Väyrynen, Jennifer Borowsky, Kenji Fujiyoshi, Mai Chan Lau, Naohiko Akimoto, Rong Zhong, Junko Kishikawa, Kota Arima, Shan-Shan ...> ;Mayo Clinic Proceedings. 2022 Jan 1
48 citations
Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers.
En Cheng, Pamela R Soulos, Melinda L Irwin, Elizabeth M Cespedes Feliciano, Carolyn J Presley, Charles S Fuchs, Jeffrey A Meyerhardt, Cary P Gross> ;JAMA Network Open. 2021 Dec 1
Correction to: Health-related quality of life in advanced gastric/gastroesophageal junction cancer with second-line pembrolizumab in KEYNOTE-061 (Gastric Cancer, (2021...
Eric Van Cutsem, Mayur Amonkar, Charles S. Fuchs, Maria Alsina, Mustafa Ozguroglu, Yung-Jue Bang, Hyun Cheol Chung, Kei Muro, Eray Goekkurt, Al B. Benson, Weijing Sun,...> ;Gastric Cancer. 2021 Nov 1
20 citations
Survival in Young-Onset Metastatic Colorectal Cancer: Findings from Cancer and Leukemia Group B (Alliance)/SWOG 80405.
Marla Lipsyc-Sharf, Sui Zhang, Fang-Shu Ou, Chao Ma, Nadine Jackson McCleary, Donna Niedzwiecki, I-Wen Chang, Heinz-Josef Lenz, Charles D. Blanke, Sorbarikor Piawah, K...> ;Journal of the National Cancer Institute. 2021 Oct 12
3 citations
Unrestrained eating behavior and risk of mortality: A prospective cohort study.
Yin Zhang, Mingyang Song, Chen Yuan, Andrew T. Chan, Eva S. Schernhammer, Brian M. Wolpin, Meir J. Stampfer, Jeffrey A. Meyerhardt, Charles S. Fuchs, Susan B. Roberts,...> ;Clinical Nutrition. 2021 Nov 1
17 citations
Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer.
Tomotaka Ugai, Juha P. Väyrynen, Mai Chan Lau, Jennifer Borowsky, Naohiko Akimoto, Sara A. Väyrynen, Melissa Zhao, Rong Zhong, Koichiro Haruki, Andressa Dias Costa, Ke...> ;Cancer Immunology, Immunotherapy. 2021 Sep 16
63 citations
Pembrolizumab versus paclitaxel for previously treated PD-L1-positive advanced gastric or gastroesophageal junction cancer: 2-year update of the randomized phase 3 KEY...
Charles S. Fuchs, Mustafa Ozguroglu, Yung-Jue Bang, Maria Di Bartolomeo, Mario Mandalà, Min-Hee Ryu, Lorenzo Fornaro, Tomasz Olesinski, Christian Caglevic, Hyun Cheol ...> ;Gastric Cancer. 2021 Sep 1
12 citations
Phase II study of pembrolizumab in refractory esophageal cancer with correlates of response and survival.
Leonie K. de Klerk, Anuj K. Patel, Sarah Derks, Eirini Pectasides, Jeremy Augustin, Mohamed Uduman, Nihal Raman, Fahire G Akarca, Nadine Jackson McCleary, James M. Cle...> ;Journal for Immunotherapy of Cancer. 2021 Sep 1
6 citations
Trifluridine/Tipiracil and Regorafenib in Patients with Metastatic Colorectal Cancer: A Retrospective Study at a Tertiary Oncology Center.
Anuj K. Patel, Ritika Abhyankar, Lauren K. Brais, Mei Sheng Duh, Victoria Barghout, Lynn Huynh, Mihran Ara Yenikomshian, Kimmie Ng, Charles S. Fuchs> ;The Oncologist. 2021 Oct 1
6 citations
Health-related quality of life in advanced gastric/gastroesophageal junction cancer with second-line pembrolizumab in KEYNOTE-061.
Eric Van Cutsem, Mayur Amonkar, Charles S Fuchs, Maria Alsina, Mustafa Özgüroğlu, Yung-Jue Bang, Hyun Cheol Chung, Kei Muro, Eray Goekkurt, Al B Benson 3rd, Weijing Su...> ;Gastric Cancer. 2021 Nov 1
7 citations
Quality of life with first-line pembrolizumab for PD-L1-positive advanced gastric/gastroesophageal junction adenocarcinoma: results from the randomised phase III KEYNO...
E. Van Cutsem, A. Valderrama, Y-J. Bang, Charles S. Fuchs, K. Shitara, Yelena Y. Janjigian, S. Qin, T.G. Larson, Veena Shankaran, Stacey Stein, Josephine M. Norquist, ...> ;ESMO Open. 2021 Aug 1
8 citations
Unrestrained eating behavior and risk of digestive system cancers: a prospective cohort study.
Yin Zhang, Mingyang Song, Andrew T. Chan, Eva S. Schernhammer, Brian M. Wolpin, Meir J. Stampfer, Jeffrey A. Meyerhardt, Charles S. Fuchs, Susan B. Roberts, Walter C. ...> ;The American Journal of Clinical Nutrition. 2021 Nov 8
37 citations
Combining tumor deposits with the number of lymph node metastases to improve the prognostic accuracy in stage III colon cancer: a post hoc analysis of the CALGB/SWOG 8...
Romain Cohen, Q. Shi, Jeffrey P. Meyers, Zhaohui Jin, Magali Svrcek, Charles S. Fuchs, Félix Couture, P. Kuebler, Kristen K. Ciombor, Johanna C. Bendell, A. De Jesus-A...> ;Annals of Oncology. 2021 Oct 1
10 citations
Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival.
Emilie S Zoltick, Stephanie A. Smith-Warner, Chen Yuan, Molin Wang, Charles S. Fuchs, Jeffrey A. Meyerhardt, Andrew T. Chan, Kimmie Ng, Shuji Ogino, Meir J. Stampfer, ...> ;British Journal of Cancer. 2021 Jul 15
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Journal Articles

Germline Cancer Susceptibility Gene Variants, Somatic Second Hits, and Survival Outcomes in Patients with Resected Pancreatic Cancer
Richard F Dunne, Leona A Doyle, William C Hahn, Jason L Hornick, Andrea J Bullock, Sapna Syngal, Albert C Koong, Natalia Khalaf, Brian M Wolpin, Douglas A Rubinson, Da..., Nature

Lectures

A phase II trial of [fam-] trastuzumab deruxtecan (T-DXd, DS-8201a) in subjects with HER2-positive, unresectable, or metastatic gastric or gastroesophageal junction (G...
ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/23/2020
Pembrolizumab (pembro) vs paclitaxel (PTX) for previously treated advanced gastric or gastroesophageal junction (G/GEJ) cancer: Phase 3 KEYNOTE-061 trial.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018

Press Mentions

Lifestyle Factors & Cancer Survival Prediction ModelsFebruary 28th, 2022
A Book Draws on 50 Years of Accumulated Wisdom, Calls for “A New Deal for Cancer”December 10th, 2021
Yale Cancer Center Experts Co-Author Book on War on CancerNovember 16th, 2021
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Grant Support

A Prospective Study Of Diet And Colorectal NeoplasiaNational Cancer Institute2010–2011
Prospective Cohort Collaborative In Pancreatic Cancer Epidemiology &PathogenesisNational Cancer Institute2007–2011
Dietary And Lifestyle Determinants Of Colon Cancer Recurrence And SurvivalNational Cancer Institute2007–2011
Df/Hcc Spore In Gastrointestinal CancerNational Cancer Institute2007–2011
Defining Optimal Doses Of Vitamin D For Chemoprevention In African AmericansNational Cancer Institute2007–2011
A Prospective Study Of Diet And Colorectal NeoplasiaNational Cancer Institute2007–2009
Administration, Evaluation, And PlanningNational Cancer Institute2007
Prospective Study Of Pancreatic Cancer PathogenesisNational Cancer Institute2000–2004
Prospective Study Of Diet And Colorectal NeoplasiaNational Cancer Institute2001–2002
Family History And The Risk Of Common MalignanciesNational Cancer Institute1995–1999