CharlesQingHuangMD

PubMed

• NF-?B1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1.
  Yu, Y.,Zhang, D.,Huang, H.,Li, J.,Zhang, M.,Wan, Y.,Gao, J.,Huang, C.> ;Oncogene. 2013 Feb 11
• 7 citations
  Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6.
  Charles Q. Huang, Wilna J. Moree, Said Zamani-Kord, Bin-Feng Li, Fabio C. Tucci, Siobhan Malany, Jianyun Wen, Hua Wang, Sam R. J. Hoare, Chun Yang, Ajay Madan, Paul D....> ;Bioorganic & Medicinal Chemistry Letters. 2011 Feb 1
• 12 citations
  Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia.
  Wilna J. Moree, Bin-Feng Li, Said Zamani-Kord, Jinghua Yu, Coon Timothy Richard, Charles Q. Huang, Dragan Marinkovic, Fabio C. Tucci, Siobhan Malany, Margaret J. Bradb...> ;Bioorganic & Medicinal Chemistry Letters. 2010 Oct 1
• 63 citations
  Primary Pediatric Keratoplasty: Indications and Outcomes
  Charles Q. Huang, Mary A O'Hara, Mark J. Mannis> ;Cornea. 2009 Oct 1
• 66 citations
  Discovery of Sodium R-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamin...
  Chen Chen, Dongpei Wu, Zhiqiang Guo, Qiu Xie, Greg J. Reinhart, Ajay Madan, Jenny Wen, Takung Chen, Charles Q. Huang, Mi Chen, Yongsheng Chen, Fabio C. Tucci, Martin W...> ;Journal of Medicinal Chemistry. 2008 Nov 12
• 10 citations
  Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.
  Colin F. Regan, Zhiqiang Guo, Yongsheng Chen, Charles Q. Huang, Mi Chen, Wanlong Jiang, Jaimie K. Rueter, Coon Timothy Richard, Chen Chen, John Saunders, Michael S. Br...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Aug 15
• 11 citations
  Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.
  Chen Chen, Yongsheng Chen, Joseph Pontillo, Zhiqiang Guo, Charles Q. Huang, Dongpei Wu, Ajay Madan, Takung Chen, Jenny Wen, Qiu Xie, Fabio C. Tucci, Martin W. Rowbotto...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Jun 1
• 8 citations
  Humphrey Matrix perimetry in optic nerve and chiasmal disorders: comparison with Humphrey SITA standard 24-2.
  Charles Q. Huang, James Carolan, Daniel Redline, Parisa Taravati, K. R. Woodward, Chris A. Johnson, Michael Wall, John L. Keltner> ;Investigative Ophthalmology & Visual Science. 2008 Mar 1
• 11 citations
  Sensitivity and Specificity of the Humphrey Matrix to Detect Homonymous Hemianopias
  Parisa Taravati, K. R. Woodward, John L. Keltner, Chris A. Johnson, Daniel Redline, James Carolan, Charles Q. Huang, Michael Wall> ;Investigative Ophthalmology & Visual Science. 2008 Mar 1
• 4 citations
  Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists.
  Mi Chen, Zhiqiang Guo, Marion Lanier, Liren Zhao, Stephen F. Betz, Charles Q. Huang, Colin J. Loweth, Neil J. Ashweek, Xin-Jun Liu, R. Scott Struthers, Margaret J. Bra...> ;Bioorganic & Medicinal Chemistry Letters. 2007 Jul 15
• 27 citations
  1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists.
  Charles Q. Huang, Tracy Baker, David A. Schwarz, Jun Fan, Christopher E. Heise, Mingzhu Zhang, Val S. Goodfellow, Stacy Markison, Kathleen Gogas, Takung Chen, Xiaochua...> ;Bioorganic & Medicinal Chemistry Letters. 2005 Aug 15
• 27 citations
  Design and Synthesis of Tricyclic Corticotropin-Releasing Factor-1 Antagonists
  Raymond S. Gross, Zhiqiang Guo, Brian Dyck, Tim Coon, Charles Q. Huang, Richard Lowe, Dragan Marinkovic, Manisha Moorjani, Jodene Nelson, Said Zamani-Kord, Dimitri E. ...> ;Journal of Medicinal Chemistry. 2005 Aug 10
• 13 citations
  Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers.
  Zhiqiang Guo, Yongsheng Chen, Charles Q. Huang, Timothy D. Gross, Joseph Pontillo, Martin W. Rowbottom, John Saunders, Scott Struthers, Fabio C. Tucci, Qiu Xie, Warren...> ;Bioorganic & Medicinal Chemistry Letters. 2005 May 16
• 68 citations
  Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a seri...
  Caroline W. Chen, Keith M. Wilcoxen, Charles Q. Huang, Xie Yf, McCarthy, Thomas R. Webb, Yun-Fei Zhu, John Saunders, Xin-Jun Liu, Takung Chen, Haig Bozigian, Dimitri E...> ;Journal of Medicinal Chemistry. 2004 Aug 6
• 8 citations
  Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.
  Charles Q. Huang, Keith M. Wilcoxen, Dimitri E. Grigoriadis, Mccarthy James R, Chen Chen> ;Bioorganic & Medicinal Chemistry Letters. 2004 Aug 2
• 2 citations
  Synthesis of benzoylpyrimidines as antagonists of the corticotropin-releasing factor-1 receptor
  Thomas R. Webb, Terry Moran, Charles Q. Huang, Mccarthy James R, Dimitri E. Grigoriadis, Chen Chen> ;Bioorganic & Medicinal Chemistry Letters. 2004 Aug 2
• 13 citations
  Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility
  Chen Chen, Keith M. Wilcoxen, Charles Q. Huang, Mccarthy James R, Takung Chen, Dimitri E. Grigoriadis> ;Bioorganic & Medicinal Chemistry Letters. 2004 Jul 16
• 2 citations
  Design, synthesis, and SAR of 2-dialkylamino-4-arylpyrimidines as potent and selective corticotropin-releasing factor(1) (CRF(1)) receptor antagonists.
  Charles Q. Huang, Dimitri E. Grigoriadis, Zhengyu Liu, James R. McCarthy, John Y. Ramphal, Thomas R. Webb, Jeffrey P. Whitten, Michael Y. Xie, Chen Chen> ;Bioorganic & Medicinal Chemistry Letters. 2004 May 3
• 12 citations
  Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists.
  Charles Q. Huang, Keith M. Wilcoxen, Mccarthy James R, Mustapha Haddach, Thomas R. Webb, Jian Gu, Xie Yf, Dimitri E. Grigoriadis, Chen Chen> ;Bioorganic & Medicinal Chemistry Letters. 2003 Oct 16
• 2 citations
  Synthesis of 1-methyl-3-phenylpyrazolo[4,3-b]pyridines via a methylation of 4-phthalimino-3-phenylpyrazoles and optimization toward highly potent corticotropin-releasi...
  Charles Q. Huang, Keith M. Wilcoxen, Mccarthy James R, Mustaph Haddach, Dimitri E. Grigoriadis, Chen Chen> ;Bioorganic & Medicinal Chemistry Letters. 2003 Oct 16
• 5 citations
  Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists.
  Keith M. Wilcoxen, Charles Q. Huang, Mccarthy James R, Dimitri E. Grigoriadis, Chen Chen> ;Bioorganic & Medicinal Chemistry Letters. 2003 Oct 16
• 7 citations
  Pretransplantation soluble adhesion molecule expression predicts outcome after living donor renal transplantation
  Richard V Perez, Charles Q. Huang, Jeremy R. Johnson, Brian J. Gallay, Mehul M. Gandhi, John P. McVicar, Christoph Troppmann> ;Archives of Surgery. 2003 Oct 1
• 5 citations
  6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-po...
  Yun-Fei Zhu, Keith M. Wilcoxen, Timothy D. Gross, Patrick J. Connors, Nathalie Strack, Raymond S. Gross, Charles Q. Huang, James R. McCarthy, Qiu Xie, Nicholas Ling, C...> ;Bioorganic & Medicinal Chemistry Letters. 2003 Jun 2
• 11 citations
  Aniridia and Brachmann-de Lange syndrome: a review of ocular surface and anterior segment findings.
  W. Barry Lee, James D. Brandt, Mark J. Mannis, Charles Q. Huang, Gregory J. Rabin> ;Cornea. 2003 Mar 1
• 17 citations
  1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: novel synthesis via cyclization of N-Acyl-S-methylisothioureas with alkylhydrazines and their potent corticotropin-Releasin...
  Chen Chen, Raymond Dagnino, Charles Q. Huang, Mccarthy James R, Dimitri E. Grigoriadis> ;Bioorganic & Medicinal Chemistry Letters. 2001 Dec 17
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