CharlesW. M.RobertsMDPhD

Pediatric Hematology & Oncology • Memphis, TN

Cancer Center Director and EVP, St. Jude Children's Research Hospital

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Office
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105
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Education & Training

Children's Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology, 1997 - 2000
Children's Hospital/Boston Medical CenterResidency, Pediatrics, 1995 - 1997
Washington University in St. Louis School of MedicineClass of 1995

Certifications & Licensure

TN State Medical License 2016 - 2025
MA State Medical License 1997 - 2016
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2010

Publications & Presentations

PubMed

Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine A Donovan, Moritz Hunkel...> ;Nature. 2024 Apr 1
15 citations
Mitotic bookmarking by SWI/SNF subunits.
Zhexin Zhu, Xiaolong Chen, Ao Guo, Trishabelle Manzano, Patrick J Walsh, Kendall M Wills, Rebecca Halliburton, Sandi Radko-Juettner, Raymond D Carter, Janet F Partridg...> ;Nature. 2023 Jun 1
63 citations
cBAF complex components and MYC cooperate early in CD8T cell fate.
Ao Guo, Hongling Huang, Zhexin Zhu, Mark J Chen, Hao Shi, Sujing Yuan, Piyush Sharma, Jon P Connelly, Swantje Liedmann, Yogesh Dhungana, Zhenrui Li, Dalia Haydar, Mao ...> ;Nature. 2022 Jul 1
13 citations
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.
Yiannis Drosos, Jacquelyn A Myers, Beisi Xu, Kaeli M Mathias, Emma C Beane, Sandi Radko-Juettner, Robert J Mobley, Margaret E Larsen, Federica Piccioni, Xiaotu Ma, Jon...> ;Molecular Cell. 2022 Jul 7
1 citations
Author Correction: PGBD5 promotes site-specific oncogenic mutations in human tumors.
Anton G. Henssen, Richard Koche, Jiali Zhuang, Eileen Jiang, Casie Reed, Amy Eisenberg, Eric Still, Ian C. MacArthur, Elias Rodriguez-Fos, Santiago Gonzalez, Montserra...> ;Nature Genetics. 2020 Nov 1
8 citations
Partitioning of Chemotherapeutics into Nuclear Condensates-Opening the Door to New Approaches for Drug Development.
Thomas P. Howard, Charles W. M. Roberts> ;Molecular Cell. 2020 Aug 20
11 citations
Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine
, , , , , , , , , , , , , , , , , , , , , , , , > ;Clinical Cancer Research. 2020 Jul 6
251 citations
The SWI/SNF complex in cancer — biology, biomarkers and therapy
Priya Mittal, Charles W. M. Roberts> ;Nature Reviews. Clinical Oncology. 2020 Apr 17
3 citations
Author Correction: BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors
Xiaofeng Wang, Su Wang, Emma C. Troisi, Thomas P. Howard, Jeffrey R. Haswell, Bennett K. Wolf, William H. Hawk, Pilar Ramos, Elaine M. Oberlick, Evgeni P. Tzvetkov, Aa...> ;Nature Communications. 2019 Sep 26
21 citations
Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.
Elaine M. Oberlick, Matthew G. Rees, Brinton Seashore-Ludlow, Francisca Vazquez, Geoffrey M. Nelson, Neekesh V. Dharia, Barbara A. Weir, Aviad Tsherniak, Mahmoud Ghand...> ;Cell Reports. 2019 Aug 27
35 citations
MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
, , , , , , , , , , , , , , , , , , , , , , , , , , > ;Cancer Research. 2019 May 1
100 citations
BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors
Xiaofeng Wang, Su Wang, Emma C. Troisi, Thomas P. Howard, Jeffrey R. Haswell, Bennett K. Wolf, William H. Hawk, Pilar Ramos, Elaine M. Oberlick, Evgeni P. Tzvetkov, Aa...> ;Nature Communications. 2019 Apr 23
27 citations
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Elife. 2019 Mar 12
53 citations
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.
Alessandro Carugo, Rosalba Minelli, Luigi Sapio, Melinda Soeung, Federica Carbone, Frederick S. Robinson, James Tepper, Ziheng Chen, Sara Lovisa, Maria Svelto, Samirku...> ;Cancer Cell. 2019 Feb 11
57 citations
Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation.
Serap Erkek, Pascal Johann, Martina Finetti, Yiannis Drosos, Hsien-Chao Chou, Marc Zapatka, Dominik Sturm, David T.W. Jones, Andrey Korshunov, Marina Rhyzova, Stephan ...> ;Cancer Cell. 2019 Jan 14
38 citations
TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer.
Robert M. Witwicki, Muhammad B. Ekram, Xintao Qiu, Michalina Janiszewska, Shaokun Shu, Mijung Kwon, Anne Trinh, Elizabeth Frias, Nadire Ramadan, Greg Hoffman, Kristine...> ;Cell Reports. 2018 Oct 30
260 citations
Mutational processes shape the landscape of TP53 mutations in human cancer
Andrew O. Giacomelli, Xiaoping Yang, Robert E. Lintner, James M. McFarland, Marc Duby, Jaegil Kim, Thomas P. Howard, David Y. Takeda, Seav Huong Ly, Eejung Kim, Hugh S...> ;Nature Genetics. 2018 Sep 17
High Frequency of Ovarian Cyst Development in Vhl2B/+;Snf5+/− Mice
Yasumichi Kuwahara, Leslie M. Kennedy, Anthony N. Karnezis, E. Lorena Mora-Blanco, Arlin B. Rogers, Christopher D.M. Fletcher, David G. Huntsman, Charles W. M. Roberts...> ;The American Journal of Pathology. 2018 Apr 20
240 citations
AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection
Thomas Vierbuchen, Emi Ling, Christopher J. Cowley, Cameron H. Couch, Xiaofeng Wang, David A. Harmin, Charles W. M. Roberts, Michael E. Greenberg> ;Molecular Cell. 2017 Dec 21
96 citations
CRISPR-Cas9 screen reveals a MYCN -amplified neuroblastoma dependency on EZH2
Liying Chen, Gabriela Alexe, Neekesh V. Dharia, Linda Ross, Amanda Balboni Iniguez, Amy Saur Conway, Emily Jue Wang, Veronica Veschi, Norris Lam, Jun Qi, W. Clay Gusta...> ;The Journal of Clinical Investigation. 2017 Dec 4
2 citations
Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors.
Anton G. Henssen, Richard Koche, Jiali Zhuang, Eileen Jiang, Casie Reed, Amy Eisenberg, Eric Still, Ian C. MacArthur, Elias Rodriguez-Fos, Santiago Gonzalez, Montserra...> ;Nature Genetics. 2017 Sep 27
41 citations
Renal Medullary Carcinoma: Establishing Standards in Practice
Kathryn E. Beckermann, Deva Sharma, Shruti Chaturvedi, Pavlos Msaouel, Miguel R. Abboud, Yves Allory, Franck Bourdeaut, Julien Calderaro, Aguirre A. de Cubas, Vimal K....> ;Journal of Oncology Practice. 2017 Jul 11
53 citations
PGBD5 promotes site-specific oncogenic mutations in human tumors
Anton G. Henssen, Richard Koche, Jiali Zhuang, Eileen Jiang, Casie Reed, Amy Eisenberg, Eric Still, Ian C. MacArthur, Elias Rodriguez-Fos, Santiago Gonzalez, Montserra...> ;Nature Genetics. 2017 May 15
223 citations
The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers.
Burak H. Alver, Kimberly H. Kim, Ping Lu, Xiaofeng Wang, Haley E. Manchester, Weishan Wang, Jeffrey R. Haswell, Peter J. Park, Charles W. M. Roberts> ;Nature Communications. 2017 Mar 6
90 citations
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer
Giannicola Genovese, Alessandro Carugo, James Tepper, Frederick S. Robinson, Liren Li, Maria Svelto, Luigi Nezi, Denise Corti, Rosalba Minelli, Piergiorgio Pettazzoni,...> ;Nature. 2017 Feb 16
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