Charu Aggarwal MD MPH
Thoracic Cancer
Leslye Heisler Associate Professor for Lung Cancer Excellence, Perelman School of Medicine
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3400 Spruce StPhiladelphia, PA 19104
Phone+1 215-662-4000
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Summary
- Dr. Charu Aggarwal is the Leslye Heisler Assistant Professor of Medicine in the Hematology-Oncology Division at the University of Pennsylvania’s Perelman School of Medicine. She is an active member of the Abramson Cancer Center (ACC) where she serves as Physician Leader for the clinical research program for Airways Malignancies.
Dr. Aggarwal specializes in the management of patients with lung and head and neck cancer, with a specific and clinical research focus on the development of novel immunotherapeutic approaches, and the discovery and application of biomarkers to guide therapy and monitor treatment. She serves as the local and national principle investigator for multiple clinical trials focusing on the development of “targeted” immunotherapeutic approaches including cellular therapy and CAR-T for solid tumors. Dr. Aggarwal has led the development of a DNA plasmid based HPV specific immunotherapy for HPV associated head and neck cancers. She is actively involved in evaluating the role of plasma-based NGS in management of patients with metastatic lung cancer.
Education & Training
Temple University Hospital-Fox Chase Cancer CenterFellowship, Hematology and Medical Oncology, 2008 - 2011
University at BuffaloResidency, Internal Medicine, 2005 - 2008
Lady Hardinge Medical CollegeClass of 2003
Certifications & Licensure
PA State Medical License 2008 - 2026
American Board of Internal Medicine Medical Oncology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 2 Certification Beacon Oncology 2014 Certified Module, Epic Systems Corporation, 2012, 2014, 2016-2017
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2012, 2014, 2016-2017
- CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2012, 2014, 2016-2017
Clinical Trials
- Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancer Start of enrollment: 2012 Sep 28
- Etirinotecan Pegol (NKTR-102) in NSCLC Start of enrollment: 2013 Jan 01
- Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion Start of enrollment: 2013 Oct 01
Publications & Presentations
PubMed
- Osimertinib dose-reduction and survival in 1L EGFR-mutated metastatic non-small cell lung cancer (mNSCLC).Adam Barsouk, Alec Heidlauf, Keshav Goel, Lynn Rushkin, Anna Anran Huang
Lung Cancer. 2026-03-01 - Phase 1 study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers.Julie S Barber-Rotenberg, Andrew R Haas, Charu Aggarwal, Mark O'Hara, Elizabeth Hexner
Molecular Therapy. 2026-01-21 - A United States-Based Real-World Study on Biomarker Testing and Rebiopsy Rates Among Patients With Non-Small Cell Lung Cancer Across Lines of Therapy.Charu Aggarwal, Sophia Ng, Rajesh Kamalakar, Sue Beruti, Archana Simmons
Clinical Lung Cancer. 2026-01-01
Journal Articles
- Cisplatin Versus Cetuximab with Definitive Concurrent Radiotherapy for Head and Neck Squamous Cell Carcinoma: An Analysis of Veterans Health Affairs DataRavi Vinnakota, Keith Sigel, Joshua M Bauml, Roger B Cohen, Nevena Damjanov, Corey J Langer, Ronac Mamtani, Charu Aggarwal, Christina Knepley, Juan Wisnivesky, Cancer
- Immunotherapy Targeting HPV 16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck CancerGregory S Weinstein, Charu Aggarwal, Roger B Cohen, Joshua Bauml, Alexander Lin, Clinical Cancer Research
- Thoracic Imaging of Non-Small Cell Lung Cancer Treated with Anti-Programmed Death Receptor-1 TherapyJoshua Bauml, Stephen Bagley, Charu Aggarwal, Corey Langer, ScienceDirect
Press Mentions
Initiating Treatment in Advanced EGFR-Mutant NSCLC: Best PracticesDecember 8th, 2025- Can You Get Lung Cancer Without Smoking?November 12th, 2025
- Viral Immunotherapy May Extend Survival in Advanced NSCLC After Progression on Immune Checkpoint InhibitionSeptember 15th, 2025
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