ChristianEdwardIsaacMD, MSc, FRCSC

PubMed

• 20 citations
  Management of soft-tissue sarcomas; treatment strategies, staging, and outcomes
  Eyal Ramu, Matthew T. Houdek, Christian Isaac, Colleen Dickie, Peter C. Ferguson, Jay S. Wunder> ;SICOT-J. 2017 Jan 1
• 3 citations
  Cell Synchronization of Mouse Embryonic Fibroblasts
  Michael J. Thwaites, Courtney H. Coschi, Christian Isaac, Frederick A. Dick> ;Methods in Molecular Biology. 2016 Jan 1
• 63 citations
  Notch Signaling is Associated with ALDH Activity and an Aggressive Metastatic Phenotype in Murine Osteosarcoma Cells
  Xiaodong Mu, Christian Isaac, Nicholas Greco, Johnny Huard, Kurt R. Weiss> ;Frontiers in Oncology. 2013 Jun 11
• 43 citations
  Dystrophin and utrophin "double knockout" dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities.
  Christian Isaac, Adam Wright, Arvydas Usas, Hongshuai Li, Ying Tang, Xiaodong Mu, Nicholas Greco, Qing Dong, Nam Vo, James Kang, Bing Wang, Johnny Huard> ;Journal of Orthopaedic Research. 2013 Mar 1
• 38 citations
  Rapamycin Inhibits ALDH Activity, Resistance to Oxidative Stress, and Metastatic Potential in Murine Osteosarcoma Cells
  Xiaodong Mu, Christian Isaac, Trevor Schott, Johnny Huard, Kurt R. Weiss> ;Sarcoma. 2013 Feb 14
• 97 citations
  Biologic approaches to enhance rotator cuff healing after injury
  Christian Isaac, Burhan Gharaibeh, Michelle R. Witt, Vonda J. Wright, Johnny Huard> ;Journal of Shoulder and Elbow Surgery. 2012 Feb 1
• 44 citations
  A G1 Checkpoint Mediated by the Retinoblastoma Protein That Is Dispensable in Terminal Differentiation but Essential for Senescence
  Srikanth Talluri, Christian Isaac, Mohammad Ahmad, Shauna A. Henley, Sarah M. Francis, Alison L. Martens, Rod Bremner, Frederick A. Dick> ;Molecular and Cellular Biology. 2010 Feb 15
• 22 citations
  A Functional Connection between pRB and Transforming Growth Factor β in Growth Inhibition and Mammary Gland Development
  Sarah M. Francis, Jacqueline Bergsied, Christian Isaac, Courtney H. Coschi, Alison L. Martens, Carlo V. Hojilla, Subrata Chakrabarti, Gabriel E. DiMattia, Rama Khoka, ...> ;Molecular and Cellular Biology. 2009 Aug 15
• 124 citations
  Loss of ATRX leads to chromosome cohesion and congression defects.
  Kieran Ritchie, Claudia Seah, Jana M. Moulin, Christian Isaac, Frederick A. Dick, Nathalie G. Bérubé> ;The Journal of Cell Biology. 2008 Jan 28
• 102 citations
  The Retinoblastoma Protein Regulates Pericentric Heterochromatin
  Christian Isaac, Sarah M. Francis, Alison L. Martens, Lisa M. Julian, Laurie A. Seifried, Natalie Erdmann, Ulrich K. Binné, Lea Harrington, Piotr Sicinski, Nathalie G....> ;Molecular and Cellular Biology. 2006 May 1
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Journal Articles

• Loss of ATRX Leads to Chromosome Cohesion and Congression Defects  
  Ritchie, K., Seah, C., Moulin, J., Isaac, C., Dick, F., & Berube, N.G., The Journal of Cell Biology, 1/1/2018
• Management of soft-tissue sarcomas; treatment strategies, staging, and outcomes  
  Ramu, E., Houdek, M., Isaac, C., Dickie, C., Ferguson, P., & Wunder, J., SICOT-J, 1/1/2017
• Cell Synchronization of Mouse Embryonic Fibroblasts  
  Thwaites, Michael J., Coschi, Courtney H., Isaac, C., & Dick, F, Methods in Molecular Biology, 1/1/2016
• Dystrophin and Utrophin �Double Knockout� Dystrophic Mice Exhibit a Spectrum of Degenerative Musculoskeletal Abnormalities  
  Isaac, C., Wright, A., Usas, A., Li, H., Tang, Y., Mu, X., Greco, N., Dong, Q., Vo, N., Kang, J., Wang, B, & Huard, J., Journal of Orthopaedic Research, 1/1/2013
• Notch Signaling is Associated with ALDH Activity and An Aggressive Metastatic Phenotype in Murine Osteosarcoma Cells  
  Mu, X., Isaac, C., Greco, N., Huard, J., & Weiss, K., Frontiers in Oncology, 1/1/2013
• Biological Approaches to Enhance Rotator Cuff Healing After Injury  
  Isaac, C., Gharaibeh, B., Witt, M., Wright, V., & Huard, J., Journal of Shoulder and Elbow Surgery, 1/1/2012
• A G1 Checkpoint Mediated by the Retinoblastoma Protein That is Dispensable in Terminal Differentiation But Essential For Senescence  
  Talluri, S., Isaac, C.E., Ahmad, M., Henley, S.A., Francis, S.M., Martens, A.L., Bremner, R., & Dick, F.A., Molecular and Cellular Biology, 1/1/2010
• A Functional Connection Between pRB and Transforming Growth Factor Beta in Growth Inhibition and Mammary Gland Development  
  Francis, S.M., Bergsied, J., Isaac, C.E., Coschi, C.H., Martens, A.L., Hojilla, C.V., Chakrabarti, S., DiMattia, G.E., Khoka, R., Wang, J.Y.J., & Dick, F.A., Molecular and Cellular Biology, 1/1/2009
• The Retinoblastoma Protein Regulates Pericentric Heterochromatin  
  Isaac, C.E., Francis, S.M., Martens, A.L., Julian, L.M., Seifried, L.A., Erdmann, N., Binne, U.K., Harrington, L., Sicinski, P., Berube, N.G., Dyson, N.J., & Dick, F.A., Molecular and Cellular Biology, 1/1/2006
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Abstracts/Posters

• The Biological Significance of Tumor Growth During Preoperative Radiation
  Isaac C, Canadian Orthopedic Association Annual Meeting Ottawa, International Society of Limb Salvage, Japan, 1/1/2017

Lectures

• Bone Abnormalities and Impaired Bone Healing in Double Knockout Utrophin/Dystrophin Mice 
  San Francisco, CA - 1/1/2012