ChristianCLeeMD

PubMed

• 10 citations
  Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma
  Casey J. N. Mathison, Chianelli Donatella, Paul Vincent Rucker, John Nelson, Jason Roland, Zhihong Huang, Yang Yang, Jiqing Jiang, Yun Feng Xie, Robert Epple, Badry Bu...> ;ACS Medicinal Chemistry Letters. 2020 Feb 12
• 6 citations
  Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.
  Pierre-Yves Michellys, Bei Chen, Tao Jiang, Jin Yunho, Wenshuo Lu, Thomas H. Marsilje, Wei Pei, Tetsuo Uno, Xue-Feng Zhu, Baogen Wu, Truc Ngoc Nguyen, Badry Bursulaya,...> ;Bioorganic & Medicinal Chemistry Letters. 2016 Feb 1
• 3 citations
  Orally bioavailable Syk inhibitors with activity in a rat PK/PD model
  Gebhard Thoma, Siem Jacob Veenstra, Ross Strang, Joachim Blanz, Eric Vangrevelinghe, Jörg Berghausen, Christian C. Lee, Hans-Günter Zerwes> ;Bioorganic & Medicinal Chemistry Letters. 2015 Oct 15
• 17 citations
  Discovery and profiling of a selective and efficacious syk inhibitor.
  Gebhard Thoma, Alexander Baxter Smith, Maurice Van Eis, Eric Vangrevelinghe, Joachim Blanz, Reiner Aichholz, Amanda Littlewood-Evans, Christian C. Lee, Hong Liu, Hans-...> ;Journal of Medicinal Chemistry. 2015 Feb 9
• 17 citations
  Syk inhibitors with high potency in presence of blood.
  Gebhard Thoma, Joachim Blanz, Peter Buhlmayer, Peter Drückes, Matthias Kittelmann, Alexander Baxter Smith, Maurice Van Eis, Eric Vangrevelinghe, Hans-Günter Zerwes, Ji...> ;Bioorganic & Medicinal Chemistry Letters. 2014 May 15
• 6 citations
  How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase
  Tatyana Karabencheva, Christian C. Lee, Gary W. Black, Rossen M. Donev, Christo Z. Christov> ;Molecular Biosystems. 2014 May 6
• 619 citations
  The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer
  Luc Friboulet, Nanxin Li, Ryohei Katayama, Christian C. Lee, Justin F. Gainor, Adam S. Crystal, Pierre-Yves Michellys, Mark M. Awad, Noriko Yanagitani, Sungjoon Kim, A...> ;Cancer Discovery. 2014 Mar 27
• 302 citations
  Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropox...
  Thomas H. Marsilje, Wei Pei, Bei Chen, Wenshuo Lu, Tetsuo Uno, Jin Yunho, Tao Jiang, Sungjoon Kim, Nanxin Li, Markus Warmuth, Yelena Sarkisova, Frank Sun, Auzon Steffy...> ;Journal of Medicinal Chemistry. 2013 Jun 26
• 124 citations
  Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
  Christian C. Lee, Yong Jia, Nanxin Li, Xiuying Sun, Kenneth Ng, Eileen Ambing, Mu-Yun Gao, Su Hua, Connie Chen, Sungjoon Kim, Pierre-Yves Michellys, Scott A. Lesley, J...> ;The Biochemical Journal. 2010 Sep 15
• 20 citations
  Divalent Cations Slow Activation of EAG Family K+ Channels through Direct Binding to S4
  Xiaofei Zhang, Badry Bursulaya, Christian C. Lee, Bihan Chen, Kendra Pivaroff, Timothy Jegla> ;Biophysical Journal. 2009 Jul 8
• 28 citations
  A Conserved Salt Bridge in the G Loop of Multiple Protein Kinases Is Important for Catalysis and for In Vivo Lyn Function
  Rina Barouch-Bentov, Jianwei Che, Christian C. Lee, Yating Yang, Ann E. Herman, Yong Jia, Anastasia Velentza, James Watson, Luise Sternberg, Sunjun Kim, Niusha Ziaee, ...> ;Molecular Cell. 2009 Jan 16
• 28 citations
  Discovery of selective aminothiazole aurora kinase inhibitors
  Carsten B Andersen, Yongqin Wan, Jae W. Chang, Blake Riggs, Christian C. Lee, Yi Liu, Fabio Sessa, Fabrizio Villa, Nicholas Kwiatkowski, Melissa Suzuki, Laxman Nallan,...> ;ACS Chemical Biology. 2008 Feb 29
• 1 citations
  Transesophageal echocardiography and the intraoperative diagnosis of a right pulmonary artery aneurysm.
  Christian C. Lee, Dave Adamson, Michael M. Madani, Gerard R. Manecke> ;Journal of Cardiothoracic and Vascular Anesthesia. 2006 Aug 1
• 122 citations
  A general strategy for creating "inactive-conformation" abl inhibitors
  Barun Okram, Advait Nagle, Francisco Adrian, Christian C. Lee, Pingda Ren, Xia Wang, Taebo Sim, Yongping Xie, Xing Wang, Gang Xia, Glen Spraggon, Markus Warmuth, Yi Li...> ;Chemistry & Biology. 2006 Jul 1
• 4 citations
  Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2.
  Ha-Soon Choi, Zhicheng Wang, Wendy Richmond, Xiaohui He, Kunyong Yang, Tao Jiang, Donald Karanewsky, Xiang-ju Gu, Vicki Zhou, Yi Liu, Jianwei Che, Christian C Lee, Jer...> ;Bioorganic & Medicinal Chemistry Letters. 2006 May 15
• 6 citations
  Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.
  Ha-Soon Choi, Zhicheng Wang, Wendy Richmond, Xiaohui He, Kunyong Yang, Tao Jiang, Taebo Sim, Donald Karanewsky, Xiang-ju Gu, Vicki Zhou, Yi Liu, Osamu Ohmori, Jeremy C...> ;Bioorganic & Medicinal Chemistry Letters. 2006 Apr 15
• 21 citations
  Crystal structure of an Udp‐n‐acetylmuramate‐alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 Å resolution
  Glen Spraggon, Robert Schwarzenbacher, Andreas Kreusch, Christian C. Lee, Polat Abdubek, Eileen Ambing, Tanya Biorac, Linda S. Brinen, Jaume M. Canaves, Jamison Cambel...> ;Proteins. 2004 Jun 1
• 39 citations
  Crystal Structure of the Type III Effector AvrB from Pseudomonas syringae
  Christian C. Lee, Michelle D. Wood, Kenneth Ng, Carsten B Andersen, Yi Liu, Peter Luginbuhl, Glen Spraggon, Fumiaki Katagiri> ;Structure. 2004 Mar 1
• 74 citations
  Crystal structure of the human neuropilin-1 b1 domain.
  Christian C. Lee, Andreas Kreusch, Daniel McMullan, Kenneth Ng, Glen Spraggon> ;Structure. 2003 Jan 1
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