ChristineMarieBestvinaMD

Oncology • Chicago, IL

Physician

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Office
5841 S. MARYLAND AVE.
M/C 2115
Chicago, IL 60637
Phone+1 773-702-4400

Fax+1 773-702-0963
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Education & Training

Duke University HospitalResidency, Internal Medicine, 2012 - 2015
Perelman School of Medicine at the University of PennsylvaniaClass of 2012

Certifications & Licensure

IL State Medical License 2015 - 2026
NC State Medical License 2012 - 2015
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Clinical Trials

Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease Start of enrollment: 2019 Jun 27
Terminated
Phase 1
M7824 With cCRT in Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) Start of enrollment: 2019 Apr 16
Terminated
Phase 2
A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2) Start of enrollment: 2019 Sep 19
Active, not recruiting
Phase 2
A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer Start of enrollment: 2019 Nov 05
Active, not recruiting
Phase 3
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Publications & Presentations

PubMed

Combined Stereotactic Body Radiation Therapy and Immune Checkpoint Inhibition for Liver Metastases: Safety and Outcomes in a Pooled Analysis of 3 Phase 1 Trials.
Connor Lynch, Mark C Korpics, Rohan R Katipally, Tianming Wu, Christine M Bestvina, Sean Pitroda, Steven J Chmura, Aditya Juloori> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Apr 1
Evaluation of Major Pathologic Response and Pathologic Complete Response as Surrogate End Points for Survival in Randomized Controlled Trials of Neoadjuvant Immune Che...
Jacobi B Hines, Robert B Cameron, Alessandra Esposito, Leeseul Kim, Luca Porcu, Antonio Nuccio, Giuseppe Viscardi, Roberto Ferrara, Giulia Veronesi, Patrick M Forde, J...> ;Journal of Thoracic Oncology. 2024 Mar 8
Cost of genetic testing, delayed care, and suboptimal treatment associated with polymerase chain reaction versus next-generation sequencing biomarker testing for genom...
Waters, D., Morrison, L., Emond, B., Lafeuille, M., Hilts, A., Lefebvre, P., He, A., Vanderpoel, J., Bestvina, C.> ;Journal of Medical Economics. 2024 Feb 24
1 citations
A Phase 1/2 Study to Evaluate the Safety and Activity of Nivolumab in Combination With Vorolanib, a Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor, in Pa...
Beckermann, K., El Osta, B., Sanborn, R., Selvaggi, G., Whisenant, J., Heimann-Nichols, E., Berry, L., Hsu, C., Shyr, Y., Horn, L., Bestvina, C., Borghaei, H., Lammers...> ;JTO Clinical and Research Reports. 2024 Feb 1
2 citations
Sotorasib with panitumumab in chemotherapy-refractory KRAS-mutated colorectal cancer: a phase 1b trial.
Kuboki, Y., Fakih, M., Strickler, J., Yaeger, R., Masuishi, T., Kim, E., Bestvina, C., Kopetz, S., Falchook, G., Langer, C., Krauss, J., Puri, S., Cardona, P., Chan, E...> ;Nature Medicine. 2024 Jan 1
Disparities in outcomes between Black and White patients in North America with thoracic malignancies and COVID-19 infection (TERAVOLT).
Laura Burns, Chih-Yuan Hsu, Jennifer G Whisenant, Melina E Marmarelis, Carolyn J Presley, Karen L Reckamp, Hina Khan, Mary Jo Fidler, Christine M Bestvina, Julie Brahm...> ;Lung Cancer. 2023 Dec 1
21 citations
Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC.
Marcelo V Negrao, Haniel A Araujo, Giuseppe Lamberti, Alissa J Cooper, Neal S Akhave, Teng Zhou, Lukas Delasos, J Kevin Hicks, Mihaela Aldea, Gabriele Minuti, Jacobi H...> ;Cancer Discovery. 2023 Jul 7
Abnormalities on baseline chest imaging are risk factors for immune checkpoint inhibitor associated pneumonitis.
Danielle Stahlbaum, Renea Jablonski, Mary E Strek, Christine M Bestvina, Mei-Yin Polley, Pankti Reid> ;Respiratory Medicine. 2023 Oct 1
6 citations
Early-Stage Lung Cancer: Using Circulating Tumor DNA to Get Personal.
Christine M Bestvina, Marina C Garassino, Joel W Neal, Heather A Wakelee, Maximilian Diehn, Everett E Vokes> ;Journal of Clinical Oncology. 2023 Sep 1
1 citations
The Role of MET in Resistance to EGFR Inhibition in NSCLC: A Review of Mechanisms and Treatment Implications.
Susan L Feldt, Christine M Bestvina> ;Cancers. 2023 May 31
2 citations
Targeted Toxicities: Protocols for Monitoring the Adverse Events of Targeted Therapies Used in the Treatment of Non-Small Cell Lung Cancer.
Jacobi B Hines, Benjamin Bowar, Emma Levine, Alessandra Esposito, Marina C Garassino, Christine M Bestvina> ;International Journal of Molecular Sciences. 2023 May 29
A Multicenter Retrospective Chart Review of Clinical Outcomes Among Patients With KRAS G12C Mutant Non-Small Cell Lung Cancer.
Wade T Iams, Meridith L Balbach, Sharon Phillips, Adrian Sacher, Christine Bestvina, Vamsidhar Velcheti, Xiao Wang, Melina E Marmarelis, Nan Sethakorn, Ticiana Leal, P...> ;Clinical Lung Cancer. 2023 May 1
Response to Provenzano et al. and De Carlo et al.
Or Kalchiem-Dekel, Christine M Bestvina, Justin F Gainor, Alexander Drilon, Jessica J Lin> ;Journal of Thoracic Oncology. 2023 Feb 1
3 citations
Brief Report: Discordance Between Liquid and Tissue Biopsy-Based Next-Generation Sequencing in Lung Adenocarcinoma at Disease Progression.
Misha C Tran, Garth W Strohbehn, Theodore G Karrison, Sherin J Rouhani, Jeremy P Segal, Ardaman Shergill, Philip C Hoffman, Jyoti D Patel, Marina C Garassino, Everett ...> ;Clinical Lung Cancer. 2023 May 1
What is the ideal endpoint in early-stage immunotherapy neoadjuvant trials in lung cancer?
Robert B Cameron, Jacobi B Hines, Valter Torri, Luca Porcu, Jessica Donington, Christine M Bestvina, Everett Vokes, James M Dolezal, Alessandra Esposito, Marina C Gara...> ;Therapeutic Advances in Medical Oncology. 2023 Jan 1
Inactivation Predicts Rapid Recurrence in Inoperable Early-Stage Non-Small-Cell Lung Cancer.
Rohan R Katipally, Liam F Spurr, Stanley I Gutiontov, William Tyler Turchan, Philip Connell, Aditya Juloori, Renuka Malik, Michael S Binkley, Alice L Jiang, Sherin J R...> ;JCO Precision Oncology. 2023 Jan 1
3 citations
Phase I study of anti-epidermal growth factor receptor antibody-drug conjugate serclutamab talirine: Safety, pharmacokinetics, and antitumor activity in advanced gliob...
Benedito A Carneiro, Kyriakos P Papadopoulos, John H Strickler, Andrew B Lassman, Saiama N Waqar, Young Kwang Chae, Jyoti D Patel, Einat Shacham-Shmueli, Karen Kelly, ...> ;Neuro-Oncology Advances. 2022 Dec 21
24 citations
Highly aneuploid non-small cell lung cancer shows enhanced responsiveness to concurrent radiation and immune checkpoint blockade.
Liam F Spurr, Carlos A Martinez, Wenjun Kang, Mengjie Chen, Yuanyuan Zha, Robyn Hseu, Stanley I Gutiontov, William T Turchan, Connor M Lynch, Kelli B Pointer, Paul Cha...> ;Nature Cancer. 2022 Dec 1
1 citations
Immunotherapy partners after progression: Right place, right time?
Sherin J Rouhani, Christine M Bestvina> ;Cancer. 2023 Jan 15
14 citations
Brief Report: Chylothorax and Chylous Ascites During RET Tyrosine Kinase Inhibitor Therapy.
Or Kalchiem-Dekel, Christina J Falcon, Christine M Bestvina, Dazhi Liu, Lauren A Kaplanis, Clare Wilhelm, Jordan Eichholz, Guilherme Harada, Lori J Wirth, Subba R Digu...> ;Journal of Thoracic Oncology. 2022 Sep 1
10 citations
Alliance A082002 -a randomized phase II/III trial of modern immunotherapy-based systemic therapy with or without SBRT for PD-L1-negative, advanced non-small cell lung ...
Steven E Schild, Xiaofei Wang, Christine M Bestvina, Terence Williams, Greg Masters, Anurag K Singh, Thomas E Stinchcombe, Joseph K Salama, Steven Wolf, Tyler Zemla, N...> ;Clinical Lung Cancer. 2022 Jul 1
4 citations
Predictors of Pneumonitis in Combined Thoracic Stereotactic Body Radiation Therapy and Immunotherapy.
Mark C Korpics, Rohan R Katipally, Julien Partouche, Dan Cutright, Kelli B Pointer, Christine M Bestvina, Jason J Luke, Sean P Pitroda, James J Dignam, Steven J Chmura...> ;International Journal of Radiation Oncology, Biology, Physics. 2022 Nov 15
8 citations
Antibody and T cell responses to COVID-19 vaccination in patients receiving anticancer therapies.
Sherin Juliet Rouhani, Jovian Yu, Daniel Olson, Yuanyuan Zha, Apameh Pezeshk, Alexandra Cabanov, Athalia R Pyzer, Jonathan Trujillo, Benjamin A Derman, Peter O'Donnell...> ;Journal for Immunotherapy of Cancer. 2022 Jun 1
8 citations
Coronavirus Disease 2019 Outcomes, Patient Vaccination Status, and Cancer-Related Delays During the Omicron Wave: A Brief Report From the TERAVOLT Analysis.
Christine M Bestvina, Jennifer G Whisenant, Valter Torri, Alessio Cortellini, Heather Wakelee, Solange Peters, Elisa Roca, Alessandro De Toma, Fred R Hirsch, Hirva Mam...> ;JTO Clinical and Research Reports. 2022 Aug 1
9 citations
A Definitive Prognostication System for Patients With Thoracic Malignancies Diagnosed With Coronavirus Disease 2019: An Update From the TERAVOLT Registry.
Jennifer G Whisenant, Javier Baena, Alessio Cortellini, Li-Ching Huang, Giuseppe Lo Russo, Luca Porcu, Selina K Wong, Christine M Bestvina, Matthew D Hellmann, Elisa R...> ;Journal of Thoracic Oncology. 2022 May 1
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Press Mentions

ASCO Annual Meeting Returns to Chicago, Celebrates New Progress in CancerJune 15th, 2022
Combining Immune Checkpoint and VEGF Inhibitors Improves Survival in Pretreated NSCLCJune 4th, 2022
Oncogene-Specific Advocacy Groups Bring a Patient-Centric Perspective to Studies of Lung CancerNovember 18th, 2020
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