ChristineMHeskeMD

PubMed

• Stress biology: Complexity and multifariousness in health and disease.
  Matthias P Mayer, Laura Blair, Gregory L Blatch, Thiago J Borges, Ahmed Chadli, Gabriela Chiosis, Aurélie de Thonel, Albena Dinkova-Kostova, Heath Ecroyd, Adrienne L E...> ;Cell Stress & Chaperones. 2024 Feb 1
• Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models.
  Grace B McKay-Corkum, Victor J Collins, Choh Yeung, Takeshi Ito, Sameer H Issaq, David Holland, Ksenia Vulikh, Yiping Zhang, Unsun Lee, Haiyan Lei, Arnulfo Mendoza, Ja...> ;Clinical Cancer Research. 2023 Nov 1
• 3 citations
  Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma.
  Srivandana Akshintala, R Taylor Sundby, Donna Bernstein, John W Glod, Rosandra N Kaplan, Marielle E Yohe, Andrea M Gross, Joanne Derdak, Haiyan Lei, Alexander Pan, Eva...> ;Clinical Cancer Research. 2023 Sep 1
• 2 citations
  Impact of race and ethnicity on presentation and outcomes of patients treated on rhabdomyosarcoma clinical trials: A report from the Children's Oncology Group.
  Senna R Munnikhuysen, Princess A Ekpo, Wei Xue, Zhengya Gao, Philip J Lupo, Rajkumar Venkatramani, Christine M Heske> ;Cancer Medicine. 2023 Jun 1
• 30 citations
  An update on rhabdomyosarcoma risk stratification and the rationale for current and future Children's Oncology Group clinical trials.
  Josephine H Haduong, Christine M Heske, Wendy Allen-Rhoades, Wei Xue, Lisa A Teot, David A Rodeberg, Sarah S Donaldson, Aaron Weiss, Douglas S Hawkins, Rajkumar Venkat...> ;Pediatric Blood & Cancer. 2022 Apr 1
• 9 citations
  Prioritization of Novel Agents for Patients with Rhabdomyosarcoma: A Report from the Children’s Oncology Group (COG) New Agents for Rhabdomyosarcoma Task Force
  Holly L Pacenta, Wendy Allen-Rhoades, David M. Langenau, Peter J. Houghton, Charles Keller, Christine M. Heske, Michael D. Deel, Corinne M. Linardic, Jack F. Shern, El...> ;Journal of Clinical Medicine. 2021 Apr 1
• 24 citations
  Relapsed Rhabdomyosarcoma.
  Christine M Heske, Leo Mascarenhas> ;Journal of Clinical Medicine. 2021 Feb 17
• 15 citations
  Survival outcomes of patients with localized FOXO1 fusion-positive rhabdomyosarcoma treated on recent clinical trials: A report from the Soft Tissue Sarcoma Committee ...
  Christine M. Heske, Yueh Yun Chi, Rajkumar Venkatramani, Minjie Li, Michael Arnold, Roshni Dasgupta, Susan M. Hiniker, Douglas S. Hawkins, Leo Mascarenhas> ;Cancer. 2021 Mar 15
• 10 citations
  Rigosertib induces mitotic arrest and apoptosis in RAS-driven rhabdomyosarcoma and neuroblastoma
  Joshua Kowalczyk, Xiaolin Wan, Edjay R. Hernandez, Ruibai Luo, Gaelyn C. Lyons, Kelli M. Wilson, Devorah C. Gallardo, Kristine A. Isanogle, Christina Robinson, Arnulfo...> ;Molecular Cancer Therapeutics. 2021 Feb 1
• 12 citations
  Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing ...
  Anna E. Gibson, Choh Yeung, Sameer H. Issaq, Victor J. Collins, Michael Gouzoulis, Yiping Zhang, Jiuping Ji, Arnulfo Mendoza, Christine M. Heske> ;Oncogenesis. 2020 Sep 10
• 18 citations
  EWS-FLI1-regulated serine synthesis and exogenous serine are necessary for Ewing sarcoma cellular proliferation and tumor growth
  Sameer H. Issaq, Arnulfo Mendoza, Ria Kidner, Tracy I. Rosales, Damien Y. Duveau, Christine M. Heske, Jason M. Rohde, Matthew B. Boxer, Craig J. Thomas, Ralph J. DeBer...> ;Molecular Cancer Therapeutics. 2020 May 5
• 58 citations
  Beyond Energy Metabolism: Exploiting the Additional Roles of NAMPT for Cancer Therapy
  Christine M. Heske> ;Frontiers in Oncology. 2020 Jan 17
• 10 citations
  Targeting metabolic dependencies in pediatric cancer.
  Sameer H. Issaq, Christine M. Heske> ;Current Opinion in Pediatrics. 2020 Feb 1
• 76 citations
  Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.
  Choh Yeung, Anna E. Gibson, Sameer H. Issaq, Nobu Oshima, Joshua T. Baumgart, Leah D. Edessa, Ganesha Rai, Daniel J. Urban, Michelle S. Johnson, Gloria A. Benavides, G...> ;Cancer Research. 2019 Oct 1
• 44 citations
  Insights into pediatric rhabdomyosarcoma research: Challenges and goals
  Marielle E. Yohe, Christine M. Heske, Elizabeth Stewart, Peter C. Adamson, Nabil Ahmed, Cristina R. Antonescu, Eleanor Y. Chen, Natalie Collins, Alan R. Ehrlich, Rene ...> ;Pediatric Blood & Cancer. 2019 Jun 21
• Site-specific electronic structure of imidazole and imidazolium in aqueous solutions.
  Meyer, F.,Blum, M.,Benkert, A.,Hauschild, D.,Jeyachandran, Y. L.,Wilks, R. G.,Yang, W.,Bär, M.,Reinert, F.,Heske, C.,Zharnikov, M.,Weinhardt, L.> ;Phys Chem Chem Phys. 2018 Mar 14
• 9 citations
  The Role of PDGFR-β Activation in Acquired Resistance to IGF-1R Blockade in Preclinical Models of Rhabdomyosarcoma.
  Christine M. Heske, Choh Yeung, Arnulfo Mendoza, Joshua T. Baumgart, Leah D. Edessa, Xiaolin Wan, Lee J. Helman> ;Translational Oncology. 2016 Dec 1
• 22 citations
  STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma
  Christine M. Heske, Arnulfo Mendoza, Leah D. Edessa, Joshua T. Baumgart, Sunmin Lee, Jane B. Trepel, David A. Proia, Len Neckers, Lee J. Helman> ;Oncotarget. 2016 Sep 6
• 35 citations
  IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma
  Xiaolin Wan, Choh Yeung, Christine M. Heske, Arnulfo Mendoza, Lee J. Helman> ;Neoplasia. 2015 Apr 1
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