ChristineElizabethMarxMD

"Professor of Psychiatry and Behavioral Sciences Faculty Network Member of the Duke Institute for Brain Sciences Vice Chair for Faculty in Psychiatry and Behavioral Sciences Chief, Division of Translational Neuroscience"

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Office
508 Fulton St
Durham Va Medical Center, Mhsl 116a
Durham, NC 27705
Phone+1 919-286-0411

Fax+1 919-286-6811
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Summary

Dr. Christine Marx, MD is a board certified psychiatrist in Durham, North Carolina. She is currently licensed to practice medicine in North Carolina. She is affiliated with Durham Veterans Affairs Medical Center and is a "Professor of Psychiatry and Behavioral Sciences Faculty Network Member of the Duke Institute for Brain Sciences Vice Chair for Faculty in Psychiatry and Behavioral Sciences Chief at Division of Translational Neuroscience".

Education & Training

University of North Carolina HospitalsFellowship, Consultation-Liaison Psychiatry, 1997 - 1998
Duke University HospitalResidency, Psychiatry, 1994 - 1997
Duke University School of MedicineClass of 1992

Certifications & Licensure

NC State Medical License 1998 - 2025
American Board of Psychiatry and Neurology Psychiatry

Clinical Trials

Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD Start of enrollment: 2010 Jan 06
Completed
Phase 3
Schizophrenia and PTSD Project: Health, Interventions, and Risk/Resilience Evaluation(SAPPHIRE Study) Start of enrollment: 2007 Mar 01
Active, not recruiting
Targeting Cognition in PTSD: Pregnenolone Augmentation of SSRIs Start of enrollment: 2006 Apr 01
Completed
Not Applicable
Pilot Study of Pregnenolone Augmentation Targeting Cognitive Symptoms in Persistently Symptomatic Patients With Schizophrenia Start of enrollment: 2005 Jun 01
Completed
Not Applicable
Omega-3 Fatty Acids and Post Traumatic Stress Disorder (PTSD) Start of enrollment: 2008 Sep 22
Completed
Not Applicable
Pregnenolone for Cognitive and Negative Symptoms in Schizophrenia Start of enrollment: 2009 Dec 01
Completed
Phase 2
Neuroactive Steroids and Traumatic Brain Injury (TBI) in OEF/OIF Veterans Start of enrollment: 2013 Oct 01
Completed
Phase 2
Ganaxolone in Posttraumatic Stress Disorder (PTSD) Start of enrollment: 2011 Apr 01
Completed
Phase 2
Complementary Neurosteroid Intervention in Gulf War Illnesses (GWVI) Start of enrollment: 2013 Oct 01
Completed
Phase 2
Neurosteroids for PTSD in Veterans Start of enrollment: 2019 May 01
Recruiting
Phase 2
Allopregnanolone in Chronic Complex Traumatic Brain Injury Start of enrollment: 2024 Mar 01
Not yet recruiting
Phase 2
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Publications & Presentations

PubMed

3 citations
White Matter Microstructure Is Associated with Serum Neuroactive Steroids and Psychological Functioning.
Lisa F Umminger, Philine Rojczyk, Johanna Seitz-Holland, Nico Sollmann, Elisabeth Kaufmann, Philipp Kinzel, Fan Zhang, Janna Kochsiek, Mina Langhein, Cara L Kim, Tim L...> ;Journal of Neurotrauma. 2023 Apr 1
8 citations
A network analysis of risk factors for suicide in Iraq/Afghanistan-era veterans.
Robert C. Graziano, Frances M. Aunon, Stefanie T. LoSavio, Eric B. Elbogen, Jean C. Beckham, Kirsten H. Dillon, Mira Brancu, Patrick S. Calhoun, Eric A. Dedert, John A...> ;Journal of Psychiatric Research. 2021 Apr 5
6 citations
Gene Expression Analysis in Three Posttraumatic Stress Disorder Cohorts Implicates Inflammation and Innate Immunity Pathways and Uncovers Shared Genetic Risk With Majo...
Melanie E. Garrett, Xue Jun Qin, Divya Mehta, Michelle F. Dennis, Christine E. Marx, Gerald A. Grant, VA Mid-Atlantic Mirecc Workgroup, Ptsd Initiative, Injury, Murray...> ;Frontiers in Neuroscience. 2021 Jul 29
3 citations
Contributions of posttraumatic stress disorder (PTSD) and mild TBI (mTBI) history to suicidality in the INTRuST consortium.
Lauren B. Fisher, Jessica Bomyea, Garrett Thomas, Joey C. Cheung, Feng He, Sonia Jain, Laura A. Flashman, Norberto Andaluz, Raul Coimbra, Mark S. George, Gerald A. Gra...> ;Brain Injury. 2020 Aug 18
8 citations
Genetic predictors of hippocampal subfield volume in PTSD cases and trauma-exposed controls.
Rajendra A. Morey, Melanie E. Garrett, Jennifer S. Stevens, Emily K Clarke, Courtney C. Haswell, Sanne J.H. van Rooij, Negar Fani, Adriana Lori, Va Mid-Atlantic Mirecc...> ;European Journal of Psychotraumatology. 2020 Jul 29
Corrigendum to "Neuroendocrine biomarkers of prolonged exposure treatment response in military-related PTSD" [Psychoneuroendocrinology (2020) Article 104749].
Sheila A.M. Rauch, Rebecca K. Sripada, Mark Burton, Vasiliki Michopoulos, Kimberly Kerley, Christine E. Marx, Jason D. Kilts, Jennifer C. Naylor, Barbara O. Rothbaum, ...> ;Psychoneuroendocrinology. 2020 Jul 10
3 citations
Neuroendocrine biomarkers of prolonged exposure treatment response in military-related PTSD.
Sheila A.M. Rauch, Rebecca K. Sripada, Mark Burton, Vasiliki Michopoulos, Kimberly Kerley, Christine E. Marx, Jason D. Kilts, Jennifer C. Naylor, Barbara O. Rothbaum, ...> ;Psychoneuroendocrinology. 2020 Jun 8
8 citations
Serum Neurosteroid Levels Are Associated With Cortical Thickness in Individuals Diagnosed With Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury.
Philipp Kinzel, Christine E. Marx, Nico Sollmann, Elisabeth Hartl, Jeffrey P. Guenette, David Kaufmann, Sylvain Bouix, Ofer Pasternak, Yogesh Rathi, Michael J. Coleman...> ;Clinical EEG and Neuroscience. 2020 Mar 18
44 citations
An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci
Mark W. Logue, Mark W. Miller, Erika J. Wolf, Bertrand Russ Huber, Filomene G. Morrison, Zhenwei Zhou, Yuanchao Zheng, Alicia K. Smith, Nikolaos P. Daskalakis, Andrew ...> ;Clinical Epigenetics. 2020 Mar 14
10 citations
Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial.
Jennifer C. Naylor, Jason D. Kilts, Lawrence J. Shampine, Gillian Parke, H. Ryan Wagner, Steven T. Szabo, Karen D. Smith, Trina B. Allen, Emily G. Telford-Marx, Charlo...> ;JAMA Network Open. 2020 Mar 2
1 citations
Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels.
Rajendra A. Morey, Sarah L. Davis, Courtney C. Haswell, Jennifer C. Naylor, Jason D. Kilts, Steven T. Szabo, Lawrence J. Shampine, Gillian Parke, Delin Sun, Chelsea A....> ;Frontiers in Neuroscience. 2019 Nov 12
15 citations
Pain Intensity and Pain Interference in Male and Female Iraq/Afghanistan-era Veterans
Jennifer C. Naylor, H. Ryan Wagner, Cynthia Johnston, Eric E. Elbogen, Mira Brancu, Christine E. Marx, Jennifer L. Strauss> ;Women's Health Issues. 2019 Jun 25
42 citations
Resilience as a translational endpoint in the treatment of PTSD.
Gopalkumar Rakesh, Rajendra A. Morey, Anthony S. Zannas, Zainab Malik, Christine E. Marx, Ashley N. Clausen, Michael D. Kritzer, Steven T. Szabo> ;Molecular Psychiatry. 2019 Mar 13
8 citations
Associations between neuropsychiatric and health status outcomes in individuals with probable mTBI.
Jessica Bomyea, Laura A. Flashman, Ross Zafonte, Norberto Andaluz, Raul Coimbra, Mark S. George, Gerald A. Grant, Christine E. Marx, Thomas W. McAllister, Lori Shutter...> ;Psychiatry Research. 2019 Feb 1
16 citations
Neurosteroid Levels in the Orbital Frontal Cortex of Subjects with PTSD and Controls: A Preliminary Report.
Dianne A. Cruz, Leisa A. Glantz, Kara D. McGaughey, Gillian Parke, Lawrence J. Shampine, Jason D. Kilts, Jennifer C. Naylor, Christine E. Marx, Douglas E. Williamson> ;Chronic Stress. 2019 Apr 18
22 citations
Behavioral and Health Outcomes Associated With Deployment and Nondeployment Acquisition of Traumatic Brain Injury in Iraq and Afghanistan Veterans.
Sarah L. Martindale, Erica L. Epstein, Katherine H. Taber, Mira Brancu, Jean C. Beckham, Patrick S. Calhoun, Eric A. Dedert, Eric B. Elbogen, John A. Fairbank, Kimberl...> ;Archives of Physical Medicine and Rehabilitation. 2018 Dec 1
40 citations
White matter abnormalities in mild traumatic brain injury with and without post-traumatic stress disorder: a subject-specific diffusion tensor imaging study
Christian Lepage, Amicie de Pierrefeu, Inga K. Koerte, Michael J. Coleman, Ofer Pasternak, Gerald A. Grant, Christine E. Marx, Rajendra A. Morey, Laura A. Flashman, Ma...> ;Brain Imaging and Behavior. 2018 Jun 1
61 citations
Multi-site harmonization of diffusion MRI data in a registration framework
Hengameh Mirzaalian, Lipeng Ning, Peter Savadjiev, Ofer Pasternak, Sylvain Bouix, Oleg V. Michailovich, Sarina Karmacharya, Gerald A. Grant, Christine E. Marx, Rajendr...> ;Brain Imaging and Behavior. 2018 Feb 1
6 citations
Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders.
Brittany L. Mason, Erin Van Enkevort, Francesca M. Filbey, Christine E. Marx, John Park, Alyson Nakamura, Prabha Sunderajan, E. Sherwood Brown> ;Journal of Clinical Psychopharmacology. 2017 Dec 1
12 citations
Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls.
Rajendra A. Morey, Sarah L. Davis, Melanie E. Garrett, Courtney C. Haswell, Mid-Atlantic Mirecc Workgroup, Christine E. Marx, Jean C. Beckham, Gregory McCarthy, Michae...> ;Translational Psychiatry. 2017 Nov 30
14 citations
Stress-Related Mental Health Symptoms in Coast Guard: Incidence, Vulnerability, and Neurocognitive Performance.
Richard J. Servatius, Justin D. Handy, Michael J. Doria, Catherine E. Myers, Christine E. Marx, Robert H. Lipsky, Nora Ko, Pelin Avcu, W. Geoffrey Wright, Jack W. Tsao> ;Frontiers in Psychology. 2017 Sep 14
12 citations
Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning.
Jennifer C. Naylor, H. Ryan Wagner, Mira Brancu, Megan Shepherd-Banigan, Eric B. Elbogen, Michelle L. Kelley, Teresa E Fecteau, Karen M. Goldstein, Nathan A. Kimbrel, ...> ;Pain Medicine. 2017 Sep 1
34 citations
A randomized controlled trial of ganaxolone in posttraumatic stress disorder
Ann M. Rasmusson, Christine E. Marx, Sonia Jain, Gail M. Farfel, Julia Tsai, Xiaoying Sun, Thomas D. Geracioti, Mark B. Hamner, James B. Lohr, Richard B. Rosse, Lanier...> ;Psychopharmacology. 2017 Jul 1
57 citations
The Post-Deployment Mental Health (PDMH) study and repository: A multi-site study of US Afghanistan and Iraq era veterans.
Mira Brancu, H. Ryan Wagner, Rajendra A. Morey, Jean C. Beckham, Patrick S. Calhoun, Larry A. Tupler, Christine E. Marx, Katherine H. Taber, Robin A. Hurley, Jared A. ...> ;International Journal of Methods in Psychiatric Research. 2017 Jun 27
64 citations
Neuroactive steroids and PTSD treatment.
Ann M. Rasmusson, Christine E. Marx, Suzanne L. Pineles, Andrea Locci, Erica R. Scioli-Salter, Yael I. Nillni, Jennifer J. Liang, Graziano Pinna> ;Neuroscience Letters. 2017 May 10
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Press Mentions

Berlin & Brandenburg: Network Offers Help with Canceled OperationsNovember 23rd, 2020

Grant Support

Neuroactive Steroids And TBI In OEF/OIF VeteransVeterans Affairs2011
Proof-Of-Concept InvestigationsNational Institute On Drug Abuse2010–2011
Neurosteroids And SchizophreniaNational Institute Of Mental Health2001–2005

Hospital Affiliations

Durham Veterans Affairs Medical CenterDurham, North Carolina