ChristineLisa(Megerdichian)ParseghianMD

PubMed

• Comprehensive Landscape of BRAF Variant Classes, Clonalities, and Co-Mutations in Metastatic Colorectal Cancer Using ctDNA Profiling.
  Wang, X., Dasari, A., Shen, J., Drusbosky, L., Johnson, B., Morris, V., Raghav, K., Lee, M., Huey, R., Parseghian, C., Willis, J., Wolff, R., Overman, M., Kopetz, S.> ;Cancers. 2024 Feb 9
• Sustained Disease Control in Immune Checkpoint Blockade Responders with Microsatellite Instability-high Colorectal Cancer after Treatment Termination.
  Simmons, K., Thomas, J., Ludford, K., Willis, J., Higbie, V., Raghav, K., Johnson, B., Dasari, A., Kee, B., Parseghian, C., Lee, M., Le, P., Morelli, M., Shen, J., Ben...> ;Cancer Research Communications. 2023 Dec 11
• Novel Clinical Tool to Estimate Risk of False-Negative KRAS Mutations in Circulating Tumor DNA Testing.
  Stefania Napolitano, Aparna R Parikh, Jason Henry, Christine M Parseghian, Jason Willis, Kanwal P Raghav, Van K Morris, Benny Johnson, Bryan K Kee, Arvind N Dasari, Mi...> ;JCO Precision Oncology. 2023 Sep 1
• Transcriptional Profiling and Consensus Molecular Subtype Assignment to Understand Response and Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Colorect...
  Saikat Chowdhury, Ria Gupta, Joshua Millstein, Kangyu Lin, Valsala Haridas, Christine Parseghian, Heinz-Josef Lenz, Scott Kopetz, John Paul Shen, Mohammad A Zeineddine> ;JCO Precision Oncology. 2023 Jul 1
• 13 citations
  Resistance Mechanisms to Anti-Epidermal Growth Factor Receptor Therapy inWild-Type Colorectal Cancer Vary by Regimen and Line of Therapy.
  Christine M Parseghian, Ryan Sun, Melanie Woods, Stefania Napolitano, Hey Min Lee, Jumanah Alshenaifi, Jason Willis, Shakayla Nunez, Kanwal P Raghav, Van K Morris, Joh...> ;Journal of Clinical Oncology. 2023 Jan 20
• Truncal Dynamics May Trump: Serial ctDNA to Predict Early Therapeutic Response.
  Madhulika Eluri, Scott Kopetz, Christine M Parseghian> ;Clinical Cancer Research. 2023 Jan 17
• 1 citations
  Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just genetics.
  Christine Parseghian, Madhulika Eluri, Scott Kopetz, Kanwal Raghav> ;Frontiers in Cell and Developmental Biology. 2023 Jan 1
• Association of Prediagnosis Obesity and Postdiagnosis Aspirin With Survival From Stage IV Colorectal Cancer.
  Jennifer S Davis, Janelle C Chavez, Melissa Kok, Yazmin San Miguel, Hwa Young Lee, Henry Henderson, Michael J Overman, Van Morris, Bryan Kee, David Fogelman, Shailesh ...> ;JAMA Network Open. 2022 Oct 3
• 7 citations
  Bintrafusp alfa, an anti-PD-L1:TGF-β trap fusion protein, in patients with ctDNA-positive, liver-limited metastatic colorectal cancer.
  Van K Morris, Michael J Overman, Michael Lam, Christine M Parseghian, Benny Johnson, Arvind Dasari, Kanwal Raghav, Bryan K Kee, Ryan Huey, Robert A Wolff, John Paul Sh...> ;Cancer Research Communications. 2022 Sep 1
• 7 citations
  Antibiotic Exposure Does Not Impact Immune Checkpoint Blockade Response in MSI-H/dMMR Metastatic Colorectal Cancer: A Single-Center Experience.
  Victoria Serpas Higbie, Jane Rogers, Hyunsoo Hwang, Wei Qiao, Lianchun Xiao, Arvind Dasari, Kerri Mola-Rudd, Van K Morris, Robert A Wolff, Kanwal Raghav, Ryan Huey, Ch...> ;The Oncologist. 2022 Nov 3
• 18 citations
  Phase II study of durvalumab (anti-PD-L1) and trametinib (MEKi) in microsatellite stable (MSS) metastatic colorectal cancer (mCRC).
  Benny Johnson, Cara L Haymaker, Edwin R Parra, Luisa Maren Solis Soto, Xuemei Wang, Jane V Thomas, Arvind Dasari, Van K Morris, Kanwal Raghav, Eduardo Vilar, Bryan K K...> ;Journal for Immunotherapy of Cancer. 2022 Aug 1
• 11 citations
  Prospective Study of Perioperative Circulating Tumor DNA Dynamics in Patients Undergoing Hepatectomy for Colorectal Liver Metastases.
  Timothy E Newhook, Michael J Overman, Yun Shin Chun, Arvind Dasari, Ching-Wei D Tzeng, Hop S Tran Cao, Victoria Raymond, Christine Parseghian, Benny Johnson, Yujiro Ni...> ;Annals of Surgery. 2023 May 1
• 1 citations
  Acneiform eruptions with combination targeted cancer therapy in colorectal cancer patients.
  Marina K Ibraheim, Rohit Gupta, Christine Parseghian, Anisha B Patel, Lo, J.> ;Supportive Care in Cancer. 2022 Oct 1
• 9 citations
  Overall Survival in Phase 3 Clinical Trials and the Surveillance, Epidemiology, and End Results Database in Patients With Metastatic Colorectal Cancer, 1986-2016: A Sy...
  Chan Shen, Daniel Tannenbaum, Robert Horn, Jane Rogers, Cathy Eng, Shouhao Zhou, Benny Johnson, Scott Kopetz, Van Morris, Michael Overman, Christine Parseghian, George...> ;JAMA Network Open. 2022 May 2
• Clinical and pathologic features correlated with rare favorable survival in patients withmutated colorectal cancer.
  Van Morris, Bryan Kee, Michael Overman, Arvind Dasari, Kanwal Raghav, Benny Johnson, Christine Parseghian, Robert A Wolff, Naveen Garg, Cathy Eng, Scott Kopetz> ;Journal of Gastrointestinal Oncology. 2022 Apr 1
• 33 citations
  Comprehensive Clinical and Molecular Characterization of KRASG12C-Mutant Colorectal Cancer.
  Jason Henry, Oluwadara Coker, Saikat Chowdhury, John Paul Shen, Van K. Morris, Arvind Dasari, Kanwal Pratap Singh Raghav, Maliha Nusrat, Bryan K. Kee, Christine Megerd...> ;JCO Precision Oncology. 2021 Apr 6
• 21 citations
  Pilot Clinical Trial of Perioperative Durvalumab and Tremelimumab in the Treatment of Resectable Colorectal Cancer Liver Metastases.
  Preeti Kanikarla Marie, Cara Haymaker, Edwin R. Parra, Young Uk Kim, Rossana Lazcano, Swati Gite, Daniele Lorenzini, Ignacio I. Wistuba, Rebecca S. S. Tidwell, Xiaofei...> ;Clinical Cancer Research. 2021 Apr 2
• 2 citations
  Metastatic lung adenocarcinoma mimicking Richter transformation in a patient with chronic lymphocytic leukemia.
  Hua Jay J. Cherng, Nitin Jain, Beenu Thakral, Tariq Muzzafar, Roberto N. Miranda, Dongfeng Tan, Asif Rashid, Neda Kalhor, Andrew W. Hahn, Lauren Averett Byers, Christi...> ;Leukemia Research. 2020 Sep 13
• 15 citations
  KRAS amplification in metastatic colon cancer is associated with a history of inflammatory bowel disease and may confer resistance to anti-EGFR therapy
  Laura A. Favazza, Christine Megerdichian Parseghian, Cihan Kaya, Marina N. Nikiforova, Somak Roy, Abigail I. Wald, Michael S. Landau, Siobhan Proksell, Jeffrey Dueker,...> ;Modern Pathology. 2020 May 6
• 1 citations
  This Is Our Cells Under Pressure: Decreased DNA Damage Repair in Response to Targeted Therapies Facilitates the Emergence of Drug-Resistant Clones.
  Christine Megerdichian Parseghian, Lauren Averett Byers> ;Cancer Cell. 2020 Jan 13
• 59 citations
  Mechanisms of Innate and Acquired Resistance to Anti-EGFR therapy: A Review of Current Knowledge with a Focus on Rechallenge Therapies
  Christine Megerdichian Parseghian, Stefania Napolitano, Jonathan M. Loree, Scott Kopetz> ;Clinical Cancer Research. 2019 Dec 1
• 17 citations
  Identification of Actionable Fusions as an Anti-EGFR Resistance Mechanism Using a Circulating Tumor DNA Assay.
  Katherine Clifton, Thereasa A. Rich, Christine Megerdichian Parseghian, Victoria M. Raymond, Arvind Dasari, Allan Andresson Lima Pereira, Jason Willis, Jonathan M. Lor...> ;JCO Precision Oncology. 2019 Oct 3
• 20 citations
  Atypical, Non-V600 BRAF Mutations as a Potential Mechanism of Resistance to EGFR Inhibition in Metastatic Colorectal Cancer.
  Benny Johnson, Jonathan M. Loree, Alexandre A. Jácome, Shehara Mendis, Muddassir A. Syed, Van K. Morris, Christine Megerdichian Parseghian, Arvind Dasari, Shubham Pant...> ;JCO Precision Oncology. 2019 Aug 5
• 11 citations
  Assessment of Reported Trial Characteristics, Rate of Publication, and Inclusion of Mandatory Biopsies of Research Biopsies in Clinical Trials in Oncology
  Christine Megerdichian Parseghian, Alda L. Tam, James C. Yao, Joe Ensor, Lee M. Ellis, Kanwal Pratap Singh Raghav, Michael J. Overman> ;JAMA Oncology. 2019 Mar 1
• 67 citations
  Anti-EGFR-resistant clones decay exponentially after progression: implications for anti-EGFR re-challenge.
  C M Parseghian, J M Loree, V K Morris, X Liu, K K Clifton, S Napolitano, J T Henry, A A Pereira, E Vilar, B Johnson, B Kee, K Raghav, A Dasari, J Wu, N Garg, V M Raymo...> ;Annals of Oncology. 2019 Feb 1
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Lectures

• Circulating tumor DNA (ctDNA) heterogeneity as first- and third-line treatment in patients (pts) with metastatic colorectal cancer (mCRC) treated with panitumumab. 
  ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/25/2020
• Identifying anti-EGFR (EGFRi) response subgroups using evidence of ctDNA selective pressure. 
  2019 ASCO Annual Meeting - 6/1/2019
• Anti-EGFR resistant clones decay exponentially after progression: Implications for anti-EGFR rechallenge. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018