ChristopherChengMD

PubMed

• 21 citations
  Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases
  Moritz Schmidt, Ashish Gupta, Christien Bednarski, Stefanie Gehrig-Giannini, Florian Richter, Christian Pitzler, Michael Biag Gamalinda, Christina Galonska, Ryo Takeuc...> ;Nature Communications. 2021 Jul 9
• 325 citations
  In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.
  Kiran Musunuru, Alexandra C. Chadwick, Taiji Mizoguchi, Sara P. Garcia, Jamie E. DeNizio, Caroline W. Reiss, Kui Wang, Sowmya Iyer, Chaitali Dutta, Victoria Clendaniel...> ;Nature. 2021 May 1
• 17 citations
  miR-155 drives oncogenesis by promoting and cooperating with mutations in the c-Kit oncogene.
  Lisa W Witten, Christopher J. Cheng, Frank J. Slack> ;Oncogene. 2019 Mar 1
• 41 citations
  A "top-down" approach to actuate poly(amine-co-ester) terpolymers for potent and safe mRNA delivery.
  Yuhang Jiang, Alice Gaudin, Junwei Zhang, Tushar Agarwal, Eric Song, Amy C. Kauffman, Gregory T. Tietjen, Yongheng Wang, Zhaozhong Jiang, Christopher J. Cheng, W. Mark...> ;Biomaterials. 2018 May 25
• 26 citations
  Arginase I mRNA therapy - a novel approach to rescue arginase 1 enzyme deficiency.
  Kirtika H. Asrani, Lei Cheng, Christopher J. Cheng, Romesh R. Subramanian> ;RNA Biology. 2018 Jul 24
• 60 citations
  Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA
  Kirtika H. Asrani, Jeremiah D. Farelli, Mary R Stahley, Rebecca L Miller, Christopher J. Cheng, Romesh R. Subramanian, Jeffrey M Brown> ;RNA Biology. 2018 Mar 26
• 22 citations
  Exercise and weight loss interventions and miRNA expression in women with breast cancer.
  Brian D. Adams, Hannah Arem, Monica J. Hubal, Brenda Cartmel, Fangyong Li, Maura Harrigan, Tara Sanft, Christopher J. Cheng, Lajos Pusztai, Melinda L. Irwin> ;Breast Cancer Research and Treatment. 2018 Mar 6
• 7 citations
  Leveraging Rational Protein Engineering to Improve mRNA Therapeutics.
  Jeremiah D. Farelli, Kirtika H. Asrani, Cleo Isaacs, Joanna S deBear, Mary R Stahley, Anumeha Shah, Melissa A. Lasaro, Christopher J. Cheng, Romesh R. Subramanian> ;Nucleic Acid Therapeutics. 2018 Feb 13
• 4 citations
  AR2, a novel automatic muscle artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available sof...
  Shennan A. Weiss, Ali A. Asadi-Pooya, Sitaram Vangala, Stephanie Moy, Dale Wyeth, Iren Orosz, Michael Gibbs, Lara M. Schrader, Jason T. Lerner, Christopher K Cheng, Ed...> ;F1000research. 2017 Jan 10
• 106 citations
  In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery
  Raman Bahal, Nicole Ali McNeer, Elias Quijano, Yanfeng Liu, Parker L. Sulkowski, Audrey Turchick, Yi-Chien Lu, Dinesh Chandra Bhunia, Arunava Manna, Dale L. Greiner, M...> ;Nature Communications. 2016 Oct 26
• 117 citations
  miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer
  Brian D. Adams, Vikram B. Wali, Christopher J. Cheng, Sachi Inukai, Carmen J. Booth, Seema Agarwal, David L. Rimm, Balázs Győrffy, Libero Santarpia, Lajos Pusztai, W. ...> ;Cancer Research. 2016 Feb 15
• 9 citations
  Enhancing potency of siRNA targeting fusion genes by optimization outside of target sequence
  Kseniya Gavrilov, Young-Eun Seo, Gregory T. Tietjen, Jiajia Cui, Christopher J. Cheng, W. Mark Saltzman> ;Proceedings of the National Academy of Sciences of the United States of America. 2015 Dec 1
• 48 citations
  Systemic Delivery of Blood-Brain Barrier Targeted Polymeric Nanoparticles Enhances Delivery to Brain Tissue
  Jennifer K. Saucier-Sawyer, Yang Deng, Young-Eun Seo, Christopher J. Cheng, Junwei Zhang, Elias Quijano, W. Mark Saltzman> ;Journal of Drug Targeting. 2015 Oct 9
• 72 citations
  miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction.
  Maya E. Woodbury, Robert W. Freilich, Christopher J. Cheng, Hirohide Asai, Seiko Ikezu, Jonathan D. Boucher, Frank J. Slack, Tsuneya Ikezu> ;The Journal of Neuroscience. 2015 Jul 1
• 286 citations
  A holistic approach to targeting disease with polymeric nanoparticles
  Christopher J. Cheng, Gregory T. Tietjen, Jennifer K. Saucier-Sawyer, W. Mark Saltzman> ;Nature Reviews. Drug Discovery. 2015 Apr 1
• Ultra-slow frequency bands reflecting potential coherence between neocortical brain regions.
  Zhang X, Wang Y, Wang Y, Jung TP, Huang M, Cheng CK, Mandell AJ> ;Neuroscience. 2015-03-19
• 595 citations
  MicroRNA silencing for cancer therapy targeted to the tumour microenvironment
  Christopher J. Cheng, Raman Bahal, Imran A. Babar, Zachary Pincus, Francisco N. Barrera, Connie Liu, Alexander A. Svoronos, Demetrios T. Braddock, Peter M. Glazer, Don...> ;Nature. 2015 Feb 5
• 24 citations
  Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A
  Romi Gupta, Yuying Dong, Peter D. Solomon, Hiromi I. Wettersten, Christopher J. Cheng, Jin-Na Min, Jeremy D. Henson, Shaillay Kumar Dogra, Sung H. Hwang, Bruce D. Hamm...> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Jul 29
• 59 citations
  Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation
  Julie Devalliere, William G. Chang, Jillian W. Andrejecsk, Parwiz Abrahimi, Christopher J. Cheng, Dan Jane-wit, W. Mark Saltzman, Jordan S. Pober> ;FASEB Journal. 2014 Feb 1
• 35 citations
  Alterations in functional connectivity between the hippocampus and prefrontal cortex as a correlate of depressive symptoms in temporal lobe epilepsy.
  Nobuko Kemmotsu, N. Erkut Kucukboyaci, Christopher E. Cheng, Holly M. Girard, Evelyn S. Tecoma, Vicente J. Iragui, Carrie R. McDonald> ;Epilepsy & Behavior. 2013 Dec 1
• 38 citations
  Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer.
  Darryl T. Martin, Christopher J. Hoimes, Hristos Z. Kaimakliotis, Christopher J. Cheng, Ke Zhang, Jingchun Liu, Marcia A. Wheeler, W. Kevin Kelly, Greg N. Tew, W. Mark...> ;Nanomedicine. 2013 Nov 1
• 28 citations
  Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA.
  Xiaoping Du, Wei Li, Xinsheng Gao, Matthew B. West, W. Mark Saltzman, Christopher J. Cheng, Charles A. Stewart, Jie Zheng, Weihua Cheng, Richard D. Kopke> ;Hearing Research. 2013 Oct 1
• 40 citations
  Canonical and non-canonical barriers facing antimiR cancer therapeutics.
  Christopher J. Cheng, W. Mark Saltzman, Frank J. Slack> ;Current Medicinal Chemistry. 2013 Aug 31
• 61 citations
  Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo
  Nicole Ali McNeer, Erica B. Schleifman, Amy Cuthbert, Michael A. Brehm, Andrew Jackson, Christopher J. Cheng, Kavitha Anandalingam, Priti Kumar, Leonard D. Shultz, Dal...> ;Gene Therapy. 2013 Jun 1
• 1 citations
  Viral and paraneoplastic encephalitis in a patient with liver transplant with unilateral temporoparietal lobe abnormalities: a diagnostic challenge.
  Christopher K Cheng, Keith A Siller> ;BMJ Case Reports. 2013 May 31
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