Christopher L Holley MD PhD

Heart Failure & Transplantation, Non-Invasive Cardiology

Associate Professor of Medicine, Duke University

2301 Erwin RdDurham, NC 27710

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Summary

Christopher Holley, MD, is a cardiologist based in Durham, NC, specializing in heart failure, transplantation, and non-invasive cardiology. He completed his fellowship and residency at the Washington University/B-JH/SLCH Consortium, holds both an MD and a PhD in Pharmacology from Duke University. He is currently an Associate Professor with Tenure at Duke University Hospital, where he also serves as an Vice-Chair for Academic Affairs in the Department of Medicine. Holley has a wealth of experience in various heart-related conditions and has produced multiple publications in notable scientific journals, such as Nature Communications and Cell Metabolism. Among the accolades he has received are the Strong Start Physician-Scientist Award and the Health Fellow Award from Duke University School of Medicine.

Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Cardiovascular Disease, 2006 - 2012
Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 2004 - 2006
Duke University School of MedicineClass of 2004
Duke University Graduate School of Arts and SciencesPhD, Pharmacology, 2004
Duke UniversityBS, Biology, 1995

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Certifications & Licensure

MO State Medical License 2006 - 2027
NC State Medical License 2015 - 2027
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Strong Start Physician-Scientist Award Duke University School of Medicine, 2017
Health Fellow Award Duke University School of Medicine, 2016
Junior Faculty Development Award Duke Heart Center Leadership Council, 2016

Publications & Presentations

PubMed

A small nucleolar RNA dictates the structure and function of translating ribosomes in Leishmania.
K Shanmugha Rajan, Saurav Aryal, Sharanya Murugeshan, Yinzhou Zhu, Anat Bashan
Nature Communications. 2026-07-13
1 citations
Genome-wide profiling of RNA 2'--methylation in neurons and identification of orphan snoRNA targets.
Xuan Ye, Yaling Liu, Yinzhou Zhu, Sarah A Alshawi, Brittany A Elliott
Biorxiv. 2025-12-17
1 citations
snoRNAs Downregulate Smooth Muscle Cell COX4I2 and Promote Neointimal Hyperplasia.
Brittany A Elliott, Lisheng Zhang, Jiao-Hui Wu, Pei-Chen Wu, Xinhe Yin
Biorxiv. 2025-07-27

Books/Book Chapters

Washington Manual Cardiology Subspecialty Consult
Chapter: Evaluation of Acute Chest Pain
Holley CLEditors: Cuculich PS, Kates AM.Lippencott Williams & Wilkins, Philadelphia, PAEdition 3rd,2014
Washington Manual Cardiology Subspecialty Consult
Chapter: Approach to Syncope
Holley CL, Cooper DH, and Nordlicht SMEditors: Cuculich PS, Kates AM.Lippencott Williams & Wilkins, Philadelphia, PAEdition 3rd,2014
The Washington Manual of Echocardiography
Chapter: Quantification of Left Ventricular Systolic and Diastolic Function
Holley CLEditors: Rasalingam R, Makan M, Perez J.Lippencott Williams & Wilkins, Philadelphia, PA2012

Grant Support

Mechanisms by which Small Nucleolar RNAs Exacerbate AtherosclerosisDUKE UNIVERSITY2022–2026
The Role of RNA Modifications in Heart FailureDUKE UNIVERSITY2019–2025