ChristopherJOttMD

PubMed

• 5 citations
  Selective targeting of MYC mRNA by stabilized antisense oligonucleotides
  Taylor Gill, Haichuan Wang, Raj Bandaru, Matthew A. Lawlor, Chenyue Lu, Linda T. Nieman, Junyan Tao, Yixian Zhang, Daniel G. Anderson, David T. Ting, Xin Chen, James E...> ;Oncogene. 2021 Oct 14
• 45 citations
  BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia
  Weimin Kong, Alexander Dimitri, Wenliang Wang, In-Young Jung, Christopher J. Ott, Maria Fasolino, Yan Wang, Irina Kulikovskaya, Minnal Gupta, Todd Yoder, Jamie E. DeNi...> ;The Journal of Clinical Investigation. 2021 Aug 17
• 7 citations
  Screening and Validation of Molecular Targeted Radiosensitizers.
  Henning Willers, Xiao Pan, Nathalie Borgeaud, Irina Korovina, Lydia Koi, Regina K. Egan, Patricia Greninger, Aliza Rosenkranz, J. H. Kung, Andrew S. Liss, Leslie A. Pa...> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Jul 31
• 21 citations
  A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
  Gregory Lazarian, Shanye Yin, Elisa Ten Hacken, Tomasz Sewastianik, Mohamed Uduman, Alba Font-Tello, Satyen H. Gohil, Shuqiang Li, Ekaterina Kim, Heather Joyal, Leah B...> ;Cancer Cell. 2021 Mar 8
• 18 citations
  Targeting oncoproteins with a positive selection assay for protein degraders.
  Vidyasagar Koduri, Leslie Duplaquet, Benjamin L. Lampson, Adam C. Wang, Amin H. Sabet, Mette Ishoey, Joshiawa Paulk, Mingxing Teng, Isaac S. Harris, Jennifer E. Endres...> ;Science Advances. 2021 Feb 5
• 42 citations
  Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins.
  Ryosuke Shirasaki, Geoffrey M. Matthews, Sara Gandolfi, Ricardo De Matos Simoes, Dennis L. Buckley, Joseline Raja Vora, Quinlan L. Sievers, Johanna Bruggenthies, Olga ...> ;Cell Reports. 2021 Jan 5
• 74 citations
  Targeted degradation of the enhancer lysine acetyltransferases CBP and p300.
  Raghu Vannam, Jan Fehmi Sayılgan, Samuel Ojeda, Barbara Karakyriakou, Eileen Hu, Johannes Kreuzer, Robert Morris, Xcanda Ixchel Herrera Lopez, Sumit Rai, Wilhelm Haas,...> ;Cell Chemical Biology. 2021 Apr 15
• 9 citations
  Circles with a Point: New Insights into Oncogenic Extrachromosomal DNA
  Christopher J. Ott> ;Cancer Cell. 2020 Feb 10
• 79 citations
  Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation
  Aaron D. Viny, Robert L. Bowman, Yu Liu, Vincent-Philippe Lavallée, Shira E. Eisman, Wenbin Xiao, Benjamin H. Durham, Anastasia Navitski, Jane Park, Stephanie Braunste...> ;Cell Stem Cell. 2019 Nov 7
• 187 citations
  Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies
  Romain Guieze, Vivian M. Liu, Daniel Rosebrock, Alexis A. Jourdain, María Hernández-Sánchez, Aina Martinez Zurita, Jing Sun, Elisa Ten Hacken, Kaitlyn Baranowski, Phil...> ;Cancer Cell. 2019 Oct 14
• 98 citations
  Small-molecule targeting of brachyury transcription factor addiction in chordoma.
  Tanaz Sharifnia, Mathias Wawer, Ting Chen, Qingyuan Huang, Barbara A. Weir, Ann E. Sizemore, Matthew A. Lawlor, Amy Goodale, Glenn S. Cowley, Francisca Vazquez, Christ...> ;Nature Medicine. 2019 Jan 21
• 11 citations
  Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma
  Mariateresa Fulciniti, Charles Y. Lin, Mehmet Kemal Samur, Michael A. Lopez, Irtisha Singh, Matthew A. Lawlor, Raphael Szalat, Christopher J. Ott, Hervé Avet-Loiseau, ...> ;Cell Reports. 2018 Dec 26
• 79 citations
  Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia.
  Christopher J. Ott, Alexander J. Federation, Logan Schwartz, Siddha Kasar, Josephine L. Klitgaard, Romina E. Lenci, Qiyuan Li, Matthew A. Lawlor, Stacey M. Fernandes, ...> ;Cancer Cell. 2018 Dec 10
• 32 citations
  Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms
  Jan C. Peeken, Jonas S. Jutzi, Julius Wehrle, Christoph Koellerer, Hans F. Staehle, Heiko Becker, Elias Schoenwandt, Thalia S. Seeger, Daniel H. Schanne, Monika Gothwa...> ;Blood. 2018 May 3
• 151 citations
  Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
  Lara Gechijian, Dennis L. Buckley, Matthew A. Lawlor, Jaime M. Reyes, Joshiawa Paulk, Christopher J. Ott, Georg E. Winter, Michael A. Erb, Thomas G. Scott, Mousheng Xu...> ;Nature Chemical Biology. 2018 Mar 5
• Opportunities for targeting gene regulatory factors in B-cell acute lymphoblastic leukemia.
  Christopher J. Ott> ;International Journal of Hematologic Oncology. 2017 Nov 1
• 7 citations
  HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL.
  Christopher J. Ott, Catherine J. Wu> ;Cancer Cell. 2017 Jul 10
• 277 citations
  BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.
  Georg E. Winter, Andreas Mayer, Dennis L. Buckley, Michael A. Erb, Justine E. Roderick, Sarah Vittori, Jaime M. Reyes, Julia di Iulio, Amanda Souza, Christopher J. Ott...> ;Molecular Cell. 2017 Jul 6
• 62 citations
  Erratum: A chemical probe toolbox for dissecting the cancer epigenome
  Jake Shortt, Christopher J. Ott, Ricky W. Johnstone, James E. Bradner> ;Nature Reviews. Cancer. 2017 Apr 1
• 210 citations
  BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.
  Simon J. Hogg, Stephin J. Vervoort, Sumit Deswal, Christopher J. Ott, Jason Li, Leonie A. Cluse, Paul A. Beavis, Phillip K. Darcy, Benjamin P. Martin, Andrew Spencer, ...> ;Cell Reports. 2017 Feb 28
• 21 citations
  A chemical probe toolbox for dissecting the cancer epigenome.
  Jake Shortt, Christopher J Ott, Ricky W Johnstone, James E Bradner> ;Nature Reviews. Cancer. 2017 Feb 23
• 12 citations
  Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET.
  Luke W. Koblan, Dennis L. Buckley, Christopher J. Ott, Mark E. Fitzgerald, S.W. Ember, Jin-Yi Zhu, Shuai Liu, Justin M. Roberts, David Remillard, Sarah Vittori, Wei Zh...> ;Chemmedchem. 2016 Dec 6
• 58 citations
  ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication.
  Seong Joo Koo, Amaury Ernesto Fernandez-Montalvan, Volker Badock, Christopher J. Ott, Simon Holton, Oliver von Ahsen, Joern Toedling, Sarah Vittori, James E. Bradner, ...> ;Oncotarget. 2016 Sep 6
• 426 citations
  Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
  Shaokun Shu, Charles Y. Lin, Housheng Hansen He, Robert M. Witwicki, Doris P. Tabassum, Justin M. Roberts, Michalina Janiszewska, Sung Jin Huh, Yi Liang, Jeremy Ryan, ...> ;Nature. 2016 Jan 21
• 4 citations
  Chromatin immunoprecipitation and an open chromatin assay in zebrafish erythrocytes.
  Song Yang, Christopher J. Ott, Marlies P. Rossmann, Michael Superdock, Leonard I. Zon, Yi Zhou> ;Methods in Cell Biology. 2016 Jan 1
• Join now to see all