ChristopherI.ShaffreyMD

Orthopaedic Surgery • Durham, NC

Orthopedic Spine Surgery

Professor and Chief of Spinal Surgery, Departments of Orthopedic and Neurological Surgery, Duke University

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Office
Duke Clinics (South), 40 Duke Medicine Circle, 5th Floor, Room 5316 (Orange Zone)
Durham, NC 27710
Phone+1 919-660-3006

Fax+1 919-385-9353
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Education & Training

University of Virginia Medical CenterFellowship, Orthopaedic Surgery Of The Spine, 1994 - 1995
University of Virginia Medical CenterResidency, Neurological Surgery, 1987 - 1995
Naval Medical Center (San Diego)Internship, Transitional Year, 1986 - 1987
University of Virginia School of MedicineClass of 1986

Certifications & Licensure

MI State Medical License 1997 - 2026
VA State Medical License 1993 - 2026
WA State Medical License 1999 - 2026
NC State Medical License 2018 - 2025
FL State Medical License 2014 - 2016
American Board of Neurological Surgery Neurological Surgery
American Board of Orthopaedic Surgery Orthopaedic Surgery

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2018
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
CMS Meaningful Use Stage 1 Certification EpicCare Inpatient - Core EMR, Epic Systems Corporation, 2012
Fellow (FAANS) American Association of Neurological Surgeons
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Clinical Trials

Spinal Cord Injury Registry - North American Clinical Trials Network Start of enrollment: 2005 Jul 01
Recruiting
A Multicenter Prospective Study of Quality of Life in Adult Scoliosis Start of enrollment: 2010 Apr 01
Completed
Not Applicable
Efficacy of Riluzole in Surgical Treatment for Cervical Spondylotic Myelopathy (CSM-Protect) Start of enrollment: 2012 Mar 01
Completed
Phase 3
Riluzole in Spinal Cord Injury Study Start of enrollment: 2013 Oct 01
Terminated
Phase 2, Phase 3
Prospective Evaluation of Elderly Deformity Surgery Start of enrollment: 2013 Dec 01
Completed
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Publications & Presentations

PubMed

Factors Associated with the Maintenance of Cost-Effectiveness at 5 Years in Adult Spinal Deformity Corrective Surgery.
Peter G Passias, Jamshaid M Mir, Pooja Dave, Justin S Smith, Renaud Lafage, Jeffrey Gum, Breton G Line, Bassel Diebo, Alan H Daniels, David Kojo Hamilton, Thomas J Bue...> ;Spine. 2024 Mar 11
Analysis of tranexamic acid usage in adult spinal deformity patients with relative contraindications: does it increase the risk of complications?
Jeffrey P Mullin, Mohamed A R Soliman, Justin S Smith, Michael P Kelly, Thomas J Buell, Bassel Diebo, Justin K Scheer, Breton Line, Virginie Lafage, Renaud Lafage, Eri...> ;Journal of Neurosurgery. Spine. 2024 Mar 8
The Case for Operative Efficiency in Adult Spinal Deformity Surgery: Impact of Operative Time on Complications, Length of Stay, Alignment, Fusion Rates, and Patient-Re...
Daniels, A., Daher, M., Singh, M., Balmaceno-Criss, M., Lafage, R., Diebo, B., Hamilton, D., Smith, J., Eastlack, R., Fessler, R., Gum, J., Gupta, M., Hostin, R., Keba...> ;Spine. 2024 Mar 1
Impact of Hip and Knee Osteoarthritis on Full Body Sagittal Alignment and Compensation for Sagittal Spinal Deformity.
Balmaceno-Criss, M., Lafage, R., Alsoof, D., Daher, M., Hamilton, D., Smith, J., Eastlack, R., Fessler, R., Gum, J., Gupta, M., Hostin, R., Kebaish, K., Klineberg, E.,...> ;Spine. 2024 Feb 20
Are insufficient corrections a major factor in distal junctional kyphosis? A simulated analysis of cervical deformity correction using in-construct measurements.
Ani, F., Sissman, E., Woo, D., Soroceanu, A., Mundis, G., Eastlack, R., Smith, J., Hamilton, D., Kim, H., Daniels, A., Klineberg, E., Neuman, B., Sciubba, D., Gupta, M...> ;Journal of Neurosurgery. Spine. 2024 Feb 16
Validation of the Oswestry Disability Index in Adult Spinal Deformity.
Bess, S., Lafage, R., Lafage, V., , Jalali, O., Smith, J., Hostin, R., Shaffrey, C., Ames, C., Lenke, L., Kelly, M.> ;Spine. 2024 Feb 15
Development of a modified frailty index for adult spinal deformities independent of functional changes following surgical correction: a true baseline risk assessment t...
Peter G Passias, Katherine E Pierce, Jamshaid M Mir, Oscar Krol, Renaud Lafage, Virginie Lafage, Breton Line, Juan S Uribe, Richard Hostin, Alan Daniels, Robert Hart, ...> ;Spine Deformity. 2024 Feb 2
Patient-specific Cervical Deformity Corrections With Consideration of Associated Risk: Establishment of Risk Benefit Thresholds for Invasiveness Based on Deformity and...
Lebovic, J., Peter G Passias, Katherine E Pierce, Tyler K Williamson, Jordan Lebovic, Andrew J Schoenfeld, Renaud Lafage, Virginie Lafage, Jeffrey L Gum, Robert Eastla...> ;Clinical Spine Surgery. 2024 Feb 1
Persistent Lower Extremity Compensation for Sagittal Imbalance After Surgical Correction of Complex Adult Spinal Deformity: A Radiographic Analysis of Early Impact.
Tyler K Williamson, Pooja Dave, Jamshaid M Mir, Justin S Smith, Renaud Lafage, Breton Line, Bassel G Diebo, Alan H Daniels, Jeffrey L Gum, Themistocles S Protopsaltis,...> ;Operative Neurosurgery. 2024 Feb 1
Revision-Free Loss of Sagittal Correction Greater Than Three Years After Adult Spinal Deformity Surgery: Who and Why?
Francis Lovecchio, Renaud Lafage, Han Jo Kim, Shay Bess, Virginie Lafage, , Ames, C., Gupta, M., Passias, P., Klineberg, E., Mundis, G., Burton, D., Smith, J., Shaffre...> ;Spine. 2024 Feb 1
Impact of Educational Background on Preoperative Disease Severity and Postoperative Outcomes Among Patients With Cervical Spondylotic Myelopathy.
Nitin Agarwal, Anthony DiGiorgio, Giorgos D Michalopoulos, Vijay Letchuman, Andrew K Chan, Saman Shabani, Raj Swaroop Lavadi, Daniel C Lu, Michael Y Wang, Regis W Haid...> ;Clinical Spine Surgery. 2024 Apr 1
Compensation from mild and severe cases of early proximal junctional kyphosis may manifest as progressive cervical deformity at two year follow-up.
Peter G Passias, Sara Naessig, Renaud Lafage, Virginie Lafage, Justin S Smith, Munish C Gupta, Eric Klineberg, Douglas C Burton, Christopher Ames, Shay Bess, Frank J S...> ;Spine Deformity. 2024 Jan 1
Alterations in Magnitude and Shape of Thoracic Kyphosis Following Surgical Correction for Adult Spinal Deformity.
Renaud Lafage, Junho Song, Bassel Diebo, Alan H Daniels, Peter G Passias, Christopher P Ames, Shay Bess, Robert Eastlack, Munish C Gupta, Richard Hostin, Khaled Kebais...> ;Global Spine Journal. 2023 Nov 30
Adult Cervical Deformity Patients Have Higher Baseline Frailty, Disability, and Comorbidities Compared With Complex Adult Thoracolumbar Deformity Patients: A Comparati...
Justin S Smith, Michael P Kelly, Thomas J Buell, David Ben-Israel, Bassel Diebo, Justin K Scheer, Breton Line, Virginie Lafage, Renaud Lafage, Eric Klineberg, Han Jo K...> ;Global Spine Journal. 2023 Nov 10
Posterior-based Osteotomies for Deformity Correction.
Evan F Joiner, Praveen V Mummaneni, Christopher I Shaffrey, Andrew K Chan> ;Neurosurgery Clinics of North America. 2023 Oct 1
Adult cervical spine deformity: a state-of-the-art review.
Brendan Jackson-Fowl, Aaron Hockley, Sara Naessig, Waleed Ahmad, Katherine Pierce, Justin S Smith, Christopher Ames, Christopher Shaffrey, Claudia Bennett-Caso, Kimber...> ;Spine Deformity. 2024 Jan 1
Surgical technique of combined minimally invasive anterior column realignment at L1-L2 with open extension of prior fusion.
Stephen M Bergin, Christopher F Dibble, Ho Jin Lee, Muhammad M Abd-El-Barr, Christopher I Shaffrey, Khoi D Than> ;Journal of Spine Surgery. 2023 Sep 22
The ISSG-AO Complication Intervention Score, but Not Major/Minor Designation, is Correlated With Length of Stay Following Adult Spinal Deformity Surgery.
Joseph B Wick, Andrew Blandino, Justin S Smith, Breton G Line, Virginie Lafage, Renaud Lafage, Han Jo Kim, Peter G Passias, Jeffrey L Gum, Khaled M Kebaish, Robert K E...> ;Global Spine Journal. 2023 Sep 19
Antibiotic Use in Adult Spine Deformity Surgery: Results From the AO Spine Surveillance of the Management of Patients With Adult Spine Deformity.
Brett Rocos, So Kato, Stephen J Lewis, Christopher I Shaffrey, Lawrence G Lenke> ;Global Spine Journal. 2023 Sep 8
Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery.
Peter G Passias, Tyler K Williamson, Jamshaid M Mir, Justin S Smith, Virginie Lafage, Renaud Lafage, Breton Line, Alan H Daniels, Jeffrey L Gum, Andrew J Schoenfeld, D...> ;Journal of Clinical Medicine. 2023 Aug 26
Two-Year Clinical and Radiographic Outcomes for Percutaneous Lumbar Interbody Fusion With an Expandable Titanium Cage Through Kambin's Triangle Without Facetectomy.
Troy Q Tabarestani, Timothy Y Wang, David A W Sykes, Vikram A Mehta, Lexie Z Yang, Shein-Chung Chow, Christopher I Shaffrey, Walter F Wiggins, John H Chi, Muhammad M A...> ;International Journal of Spine Surgery. 2023 Dec 26
Predictive role of global spinopelvic alignment and upper instrumented vertebra level in symptomatic proximal junctional kyphosis in adult spinal deformity.
Jichao Ye, Sachin Gupta, Ali S Farooqi, Tsung Yin, Alex Soroceanu, Frank J Schwab, Virginie Lafage, Michael P Kelly, Khaled Kebaish, Richard Hostin, Jeffrey L Gum, Jus...> ;Journal of Neurosurgery. Spine. 2023 Dec 1
Longitudinal Assessment of Modern Spine Surgery Training: 10-Year Follow-up of a Nationwide Survey of Residency and Spine Fellowship Program Directors.
Alan H Daniels, Daniel Alsoof, Christopher L McDonald, Andrew S Zhang, Bassel G Diebo, Craig P Eberson, Eren O Kuris, William Lavelle, Christopher P Ames, Christopher ...> ;JB & JS Open Access. 2023 Aug 1
The impact of baseline cervical malalignment on the development of proximal junctional kyphosis following surgical correction of thoracolumbar adult spinal deformity.
Lara Passfall, Bailey Imbo, Virginie Lafage, Renaud Lafage, Justin S Smith, Breton Line, Andrew J Schoenfeld, Themistocles Protopsaltis, Alan H Daniels, Khaled M Kebai...> ;Journal of Neurosurgery. Spine. 2023 Dec 1
When not to Operate in Spinal Deformity: Identifying Subsets of Patients With Simultaneous Clinical Deterioration, Major Complications, and Reoperation.
Peter G Passias, Katherine E Pierce, Pooja Dave, Renaud Lafage, Virginie Lafage, Andrew J Schoenfeld, Breton Line, Juan Uribe, Richard Hostin, Alan Daniels, Robert Har...> ;Spine. 2023 Nov 1
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Journal Articles

Rod Fracture Following Apparently Solid Radiographic Fusion in Adult Spinal Deformity Patients
Alan H Daniels, Peter Passias, Han Jo Kim, Themistocles Protopsaltis, Justin S Smith, Christopher Shaffrey, Eric Klineberg, Frank Schwab, Christopher Ames, World Neurosurgery

Authored Content

Reimagining Medical Conferences for a Virtual SettingDecember 2020
Rod Fracture Following Apparently Solid Radiographic Fusion in Adult Spinal Deformity PatientsJune 2018