
Christopher James Tignanelli MD MBA, MS, FACS, FAMIA
Trauma Surgery & Surgical Critical Care
Associate Dean of Data Science, University of Minnesota Associate Professor of Surgery (with tenure), University of Minnesota. Chief Medical Officer - Biometrica Health
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420 Delaware St SE MMC 195Minneapolis, MN 55455
Phone+1 612-625-7911
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Summary
- Christopher J. Tignanelli, MD, MS, MBA is a tenured Associate Professor of Surgery in the Division of Critical Care & Acute Care Surgery at the University of Minnesota Medical School, where he also serves as Associate Dean for Data Science. He is triple board-certified in General Surgery, Surgical Critical Care, and Clinical Informatics, and provides care for trauma, emergency general surgery, surgical critical care, and ECMO patients.
Dr. Tignanelli is a nationally recognized clinician-scientist whose work focuses on clinical informatics, artificial intelligence, machine learning–enabled decision support, and learning health systems to improve outcomes and reduce unwarranted variation in care. He has authored over 150 peer-reviewed publications and has received more than $30 million in direct research funding from NIH, AHRQ, and other federal and foundation sources. His research emphasizes the development, implementation, and real-world scaling of interoperable, evidence-based digital health tools across complex health systems.
In addition to his academic roles, Dr. Tignanelli is actively involved with MedTech 3.0, contributing clinical and informatics expertise to advance medical technology innovation, data-driven healthcare transformation, and collaboration between health systems, startups, and industry.
He also serves as Chief Medical Officer of Biometrica Health, a health technology company focused on device-agnostic remote patient monitoring and real-time biometric analytics. In this role, he provides clinical leadership to ensure Biometrica’s platforms deliver actionable insights, integrate seamlessly into clinical workflows, and support proactive, connected care across diverse patient populations.
Education & Training
University of MichiganFellowship, Surgical Critical Care, 2016 - 2017
University of North Carolina HospitalsResidency, Surgery, 2009 - 2016
Rutgers New Jersey Medical SchoolClass of 2009
Certifications & Licensure
MN State Medical License 2017 - 2026
MI State Medical License 2016 - 2020
NC State Medical License 2009 - 2016
American Board of Preventive Medicine Clinical Informatics
American Board of Surgery Surgery
American Board of Surgery Surgical Critical Care
Awards, Honors, & Recognition
- Clinical Research Winner - Michigan State Committee on Trauma Resident Paper Competition Michigan State Committee on Trauma, 2017
- Best AAS Overall Manuscript Submission by an AAS Resident or Fellow Association for Academic Surgery, 2017
- 2017 Surgical Critical Care Program Director Society (SCCPDS) - Excellence in Research Award SCCPDS - Honorable Mention, 2017
Publications & Presentations
PubMed
- Aligning cardiac monitoring with American Heart Association Guidelines: Impact on utilization, hemodynamic monitoring, and outcomes.Brian Hilliard, Tanvi Mehta, James Grace, Deborah L Pestka, Nicholas E Ingraham
Plos One. 2026-01-01 - Can Artificial Intelligence and Machine Learning help us improve motor vehicle crash trauma triage?Raymond A Jean, Akbar K Waljee, Maggie Makar, Christopher J Tignanelli, Mark R Hemmila
American Journal of Surgery. 2025-12-26 - The 21st Century Cures Act and the Patient Portal in Surgery.Michael R Phillips, Christopher J Tignanelli, Anthony G Charles
JAMA Surgery. 2025-08-13
Journal Articles
- Empirical Systemic Anticoagulation Is Associated with Decreased Venous Thromboembolism in Critically Ill Influenza A H1N1 Acute Respiratory Distress Syndrome PatientsPeter K Henke, Thomas W Wakefield, Lena M Napolitano, Andrea T Obi, Pauline K Park, Shipra Arya, Christopher J Tignanelli, ScienceDirect
- The Fragility Index in Randomized Clinical Trials as a Means of Optimizing Patient CareLena M Napolitano, Christopher J Tignanelli, JAMA
- Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology4. Jeffrey S. Damrauer, Katherine A. Hoadley, David D. Chism, Cheng Fan, Christopher J. Tignanelli, Sara E. Wobker, Jen Jen Yeh, Matthew I. Milowsky, Gopa Iyer, Joel S..., PNAS, 1/2014
Press Mentions
U of M Medical School Receives $1.4M in Funding for Research Project on AI and Patient SafetyFebruary 22nd, 2023
Losartan Fails to Reduce Lung Injury in Patients Hospitalized with COVID-19March 17th, 2022
Nation’s First Ivermectin Clinical Trial Now 50 Percent EnrolledNovember 11th, 2021
Grant Support
- Evaluation of the SCALED (SCaling AcceptabLE cDs) Approach for the Implementation of Interoperable CDS for Venous Thromboembolism PreventionUNIVERSITY OF MINNESOTA2022–2025
- Targeting Kinome Reprogramming in Pancreatic CancerWomack Surgical Research and Outreach Grant2013–2014
Research History
- Trauma Outcomes Research - MTQIP2016 - 2017
- Research Fellow - UNC Lineberger Comprehensive Cancer Center2012 - 2014
Professional Memberships
- Member
- Association for Academic Surgeons (AAS)Member
- Member
- Member
External Links
- Tignanelli UMN Profilehttps://www.surgery.umn.edu/bio/critical-care-and-acute-care-s/christopher-tignanelli
- Google Scholar Publication Listhttps://scholar.google.com/citations?hl=en&user=6PvI7vIAAAAJ&view_op=list_works&sortby=pubdate
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