ChuhanChungMD

PubMed

• 2 citations
  AI-based histologic scoring enables automated and reproducible assessment of enrollment criteria and endpoints in NASH clinical trials.
  Janani S Iyer, Harsha Pokkalla, Charles Biddle-Snead, Oscar Carrasco-Zevallos, Mary Lin, Zahil Shanis, Quang Le, Dinkar Juyal, Maryam Pouryahya, Aryan Pedawi, Sara Hof...> ;Medrxiv. 2023 Apr 25
• 1 citations
  Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH.
  Jake Conway, Maryam Pouryahya, Yevgeniy Gindin, David Z Pan, Oscar M Carrasco-Zevallos, Victoria Mountain, G Mani Subramanian, Michael C Montalto, Murray Resnick, Andr...> ;Cell Reports. Medicine. 2023 Apr 18
• 4 citations
  PRIMIS: design of a pivotal, randomized, phase 3 study evaluating the safety and efficacy of the nonsteroidal farnesoid X receptor agonist cilofexor in noncirrhotic pa...
  Michael Trauner, Chuhan Chung, Kate Sterling, Xiangyu Liu, Xiaomin Lu, Jun Xu, Clare Tempany-Afdhal, Zachary D Goodman, Martti Färkkilä, Atsushi Tanaka, Palak Trivedi,...> ;BMC Gastroenterology. 2023 Mar 15
• 18 citations
  Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis.
  Rohit Loomba, Daniel Q Huang, Arun J Sanyal, Quentin Mark Anstee, Michael Trauner, Eric J Lawitz, Dora Ding, Lily Ma, Catherine Jia, Andrew Billin, Ryan S Huss, Chuhan...> ;Gut. 2023 Mar 1
• 2 citations
  Acetyl-CoA carboxylase inhibitor increases LDL-apoB production rate in NASH with cirrhosis: prevention by fenofibrate.
  Mohamad Dandan, Julia Han, Sabrina Mann, Rachael Kim, Kelvin Li, Hussein Mohammed, Jen-Chieh Chuang, Kaiyi Zhu, Andrew N Billin, Ryan S Huss, Chuhan Chung, Robert P My...> ;Journal of Lipid Research. 2023 Mar 1
• 10 citations
  IL-31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH.
  Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen-Chieh Chuang, Julie Lin, Wen-Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, K...> ;Hepatology. 2023 Jan 1
• 15 citations
  Fenofibrate Mitigates Hypertriglyceridemia in Nonalcoholic Steatohepatitis Patients Treated With Cilofexor/Firsocostat.
  Eric J Lawitz, Bal Raj Bhandari, Peter J Ruane, Anita Kohli, Eliza Harting, Dora Ding, Jen-Chieh Chuang, Ryan S Huss, Chuhan Chung, Robert P Myers, Rohit Loomba> ;Clinical Gastroenterology and Hepatology. 2023 Jan 1
• 1 citations
  Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury.
  Xiaoying Liu, Mahmoud Khalafalla, Chuhan Chung, Yevgeniy Gindin, Susan Hubchak, Brian LeCuyer, Alyssa Kriegermeier, Danny Zhang, Wei Qiu, Xianzhong Ding, Deyu Fang, Ri...> ;Journal of Lipid Research. 2022 Nov 1
• 24 citations
  En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH.
  Masaki Kimura, Takuma Iguchi, Kentaro Iwasawa, Andrew Dunn, Wendy L Thompson, Yosuke Yoneyama, Praneet Chaturvedi, Aaron M Zorn, Michelle Wintzinger, Mattia Quattrocel...> ;Cell. 2022 Oct 27
• 5 citations
  Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients.
  Eric J Lawitz, Kelvin W Li, Edna Nyangau, Tyler John Field, Jen-Chieh Chuang, Andrew Billin, Lulu Wang, Ya Wang, Ryan S Huss, Chuhan Chung, G Mani Subramanian, Robert ...> ;Journal of Lipid Research. 2022 Sep 1
• 12 citations
  Safety and Sustained Efficacy of the Farnesoid X Receptor (FXR) Agonist Cilofexor Over a 96-Week Open-label Extension in Patients With PSC.
  Michael Trauner, Christopher L Bowlus, Aliya Gulamhusein, Bilal Hameed, Stephen H Caldwell, Mitchell L Shiffman, Charles Landis, Andrew J Muir, Andrew Billin, Jun Xu, ...> ;Clinical Gastroenterology and Hepatology. 2023 Jun 1
• Reply.
  Arun J Sanyal, Chuhan Chung, Robert P Myers, Jaime Bosch> ;Hepatology. 2022 Jul 1
• 55 citations
  A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological v...
  Marijana Vujkovic, Shweta Ramdas, Kim M Lorenz, Xiuqing Guo, Rebecca Darlay, Heather J Cordell, Jing He, Yevgeniy Gindin, Chuhan Chung, Robert P Myers, Carolin V Schne...> ;Nature Genetics. 2022 Jun 1
• 39 citations
  Cirrhosis Regression is Associated with Improved Clinical Outcomes in Patients with Nonalcoholic Steatohepatitis.
  Arun J. Sanyal, Quentin M. Anstee, Michael Trauner, Eric Lawitz, Manal F. Abdelmalek, D. Ding, Ling Han, Catherine Jia, Ryan S Huss, Chuhan Chung, Vincent Wai-Sun Wong...> ;Hepatology. 2021 Oct 18
• 18 citations
  A Machine Learning Approach to Liver Histological Evaluation Predicts Clinically Significant Portal Hypertension in NASH Cirrhosis
  Jaime Bosch, Chuhan Chung, Oscar Carrasco-Zevallos, Stephen A. Harrison, Manal F. Abdelmalek, Mitchell L. Shiffman, Don C. Rockey, Zahil Shanis, Dinkar Juyal, Harsha P...> ;Hepatology. 2021 Aug 1
• 23 citations
  Inter- and Intra-individual Variation, and Limited Prognostic Utility, of Serum Alkaline Phosphatase in a Trial of Patients With Primary Sclerosing Cholangitis
  Palak J. Trivedi, Andrew J. Muir, Cynthia Levy, Christopher L. Bowlus, Michael P. Manns, Xiaomin Lu, Gerald Crans, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, ...> ;Clinical Gastroenterology and Hepatology. 2021 Jun 1
• 9 citations
  A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis.
  Yevgeniy Gindin, Chuhan Chung, Zhaoshi Jiang, Jing Zhu Zhou, Jun Xu, Andrew N. Billin, Robert P. Myers, Zachary Goodman, Abdolabdolamir Landi, Michael Houghton, Richar...> ;Hepatology. 2021 Mar 1
• 70 citations
  A Machine Learning Approach Enables Quantitative Measurement of Liver Histology and Disease Monitoring in NASH.
  Amaro Taylor-Weiner, Harsha Pokkalla, Ling Han, Catherine Jia, Ryan S Huss, Chuhan Chung, Hunter L. Elliott, Benjamin Glass, Kishalve Pethia, Oscar Carrasco-Zevallos, ...> ;Hepatology. 2021 Feb 11
• 134 citations
  Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH
  Rohit Loomba, Mazen Noureddin, Kris V. Kowdley, Anita Kohli, Aasim Sheikh, Guy Neff, Bal R. Bhandari, Nadege Gunn, Stephen H. Caldwell, Zachary Goodman, Ilan Wapinski,...> ;Hepatology. 2021 Feb 1
• 190 citations
  Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial
  Keyur Patel, Stephen A. Harrison, Magdy Elkhashab, James F. Trotter, Robert Herring, Sergio Rojter, Zeid Kayali, Vincent Wai-Sun Wong, Susan Greenbloom, Saumya Jayakum...> ;Hepatology. 2020 Jul 1
• Reply to HEP‐20‐0871 Letter to the Editors: Cilofexor in patients with non‐alcoholic steatohepatitis (NASH): Is it really effective?
  Keyur Patel, Chuhan Chung, Robert P. Myers> ;Hepatology. 2020 Jun 3
• Reply to HEP‐20‐0140 Letter to the Editors: Could Butyrate Be Incorporated With Farnesoid X Receptor Agonist Cilofexor to Enhance Primary Sclerosing Cholangitis Treatm...
  Michael Trauner, Chuhan Chung, Robert P. Myers, Kris V. Kowdley> ;Hepatology. 2020 Apr 12
• 9 citations
  Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.
  Michael Trauner, Yevgeniy Gindin, Zhaoshi Jiang, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Aliya Gulamhusein, Kris V. Kowdley, Cynthia Levy, Zachary Goodman,...> ;JHEP Reports. 2020 Feb 1
• 161 citations
  The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis.
  Michael Trauner, Aliya Gulamhusein, Bilal Hameed, Stephen H. Caldwell, Mitchell L. Shiffman, Charles S. Landis, Bertus Eksteen, Kosh Agarwal, Andrew J. Muir, Simon M. ...> ;Hepatology. 2019 Sep 1
• 137 citations
  Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis.
  Eric Lawitz, Angie Coste, Fred Poordad, Naim Alkhouri, Nicole Loo, B. Mccolgan, Jacqueline M. Tarrant, T. Nguyen, Ling Han, Chuhan Chung, Adrian S. Ray, John G. McHutc...> ;Clinical Gastroenterology and Hepatology. 2018 Dec 1
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