ClaesWahlestedtMD

PubMed

• 8 citations
  JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference.
  C.J. Babigian, Hannah J. Wiedner, Claes Wahlestedt, Gregory C. Sartor> ;Behavioural Brain Research. 2022 Feb 10
• 4 citations
  A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer.
  Shayan Khalafi, Shoumin Zhu, Rimpi Khurana, Ines Lohse, Silvia Giordano, Simona Corso, Hassan Al-Ali, Claes Wahlestedt, Stephan C. Schürer, Wael El-Rifai> ;Translational Oncology. 2022 Jan 1
• 1 citations
  Direct Administration and Gene Modulation Using Antisense Oligonucleotides Within the CNS.
  Claes Wahlestedt, Olga Khorkova> ;Cellular and Molecular Neurobiology. 2021 Jul 1
• 4 citations
  A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory fu...
  Farzaneh Modarresi, Roya Pedram Fatemi, Seyedeh Fatemeh Razavipour, Natalie R. Ricciardi, Madina Makhmutova, Nathalie Khoury, Marco Magistri, Claude-Henry Volmar, Clae...> ;Heliyon. 2021 Jul 1
• 9 citations
  Nucleic Acid-Based Therapeutics in Orphan Neurological Disorders: Recent Developments.
  Olga Khorkova, Jane Hsiao, Claes Wahlestedt> ;Frontiers in Molecular Biosciences. 2021 Apr 28
• 15 citations
  Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma.
  Jeffim N. Kuznetsoff, Dawn A. Owens, Andy Lopez, Daniel A. Rodriguez, Nancy T. Chee, Stefan Kurtenbach, Daniel Bilbao, Evan R. Roberts, Claude-Henry Volmar, Claes Wahl...> ;Molecular Cancer Research. 2021 Feb 1
• 6 citations
  Emerging Technologies for Genome-Wide Profiling of DNA Breakage.
  Matthew J Rybin, Melina Ramic, Natalie R. Ricciardi, Philipp Kapranov, Claes Wahlestedt, Zane Zeier> ;Frontiers in Genetics. 2021 Jan 27
• 19 citations
  Alcohol use disorder causes global changes in splicing in the human brain
  Derek J. Van Booven, Mengying Li, J. Sunil Rao, Ilya O. Blokhin, R. Dayne Mayfield, Estelle Barbier, Markus Heilig, Claes Wahlestedt> ;Translational Psychiatry. 2021 Jan 5
• 33 citations
  Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical Research
  Jessica L. Dennison, Natalie R. Ricciardi, Ines Lohse, Claude-Henry Volmar, Claes Wahlestedt> ;Journal of Alzheimer's Disease. 2021 Jan 1
• 20 citations
  Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways.
  Andrea L. Johnstone, Nadja S. Andrade, Estelle Barbier, Bohdan B. Khomtchouk, Christopher A. Rienas, Kenneth Lowe, Derek J. Van Booven, Esi Domi, Rustam Esanov, Samara...> ;Addiction Biology. 2021 Jan 1
• 17 citations
  Molecular mechanisms of psychiatric diseases.
  Ilya O. Blokhin, Olga Khorkova, Radu V. Saveanu, Claes Wahlestedt> ;Neurobiology of Disease. 2020 Oct 17
• 33 citations
  Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734.
  Filippo Spriano, Eugenio Gaudio, Luciano Cascione, Chiara Tarantelli, Federica Melle, Giovanna Motta, Valdemar Priebe, Andrea Rinaldi, Gaetanina Golino, Afua Adjeiwaa ...> ;Blood Advances. 2020 Sep 8
• 7 citations
  The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling.
  Annamil Alvarez-Trotta, Zhiqiang Wang, Elena Shersher, Bin Li, Jun Long, Ines Lohse, Claes Wahlestedt, Wael El-Rifai, David J. Robbins, Anthony J. Capobianco> ;Oncotarget. 2020 Aug 18
• A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons
  Amir Bagheri, Seyedeh Fatemeh Razavipour, Claes Wahlestedt, Seyed Javad Mowla, Mohammad Ali Faghihi> ;Journal of Visualized Experiments. 2020 Aug 6
• 20 citations
  Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States
  Tanner Stokes, James A. Timmons, Hannah Crossland, Thomas R. Tripp, Kevin T. Murphy, Chris McGlory, Cameron J. Mitchell, Sara Y. Oikawa, Robert W. Morton, Bethan E. Ph...> ;Cell Reports. 2020 Aug 4
• 49 citations
  Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD
  Nadja S. Andrade, Melina Ramic, Rustam Esanov, Wenjun Liu, Mathew J. Rybin, Gabriel Gaidosh, Abbas Abdallah, Samuel Del’Olio, Tyler C. Huff, Nancy T. Chee, Sadhana Ana...> ;Molecular Neurodegeneration. 2020 Feb 24
• 32 citations
  Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells.
  Huifen Cao, Lorena Salazar-García, Fan Gao, Thor Wahlestedt, Chun Lin Wu, Xueer Han, Ye Cai, Dongyang Xu, Fang Wang, Lu Tang, Natalie R. Ricciardi, Ding Ding Cai, Huif...> ;Nature Communications. 2019 Dec 20
• 49 citations
  The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer.
  Yuqian Yan, Jian Ma, Dejie Wang, Dong Lin, Xiaodong Pang, Shangqian Wang, Yu Zhao, Lei Shi, Hui Xue, Yunqian Pan, Jun Zhang, Claes Wahlestedt, Francis J Giles, Yu Chen...> ;EMBO Molecular Medicine. 2019 Nov 7
• 8 citations
  Ovarian Cancer Treatment Stratification Using Ex Vivo Drug Sensitivity Testing.
  Ines Lohse, Diana J. Azzam, Hassan Al-Ali, Claude-Henry Volmar, Tan A. Ince, Claes Wahlestedt> ;Anticancer Research. 2019 Aug 1
• 19 citations
  Longevity-related molecular pathways are subject to midlife "switch" in humans.
  James A. Timmons, Claude-Henry Volmar, Hannah Crossland, Bethan E. Phillips, Sanjana Sood, Karolina J. Janczura, Timo Törmäkangas, Urho M. Kujala, William E. Kraus, Ph...> ;Aging Cell. 2019 Aug 1
• 107 citations
  Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.
  Josepmaria Argemi, Maria U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquín Cabezas, Juan José Lozano, Derek J. Van Booven, Aaron B...> ;Nature Communications. 2019 Jul 16
• 16 citations
  Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer.
  Sushmita Mustafi, Vladimir Camarena, Rehana Qureshi, Hyunho Yoon, Claude-Henry Volmar, Tyler C. Huff, David W. Sant, Lihong Zheng, Claes Wahlestedt, Joyce M. Slingerla...> ;Ebiomedicine. 2019 May 1
• 12 citations
  HDAC Inhibitors Induce BDNF Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons.
  Amir Bagheri, Parham Habibzadeh, Seyedeh Fatemeh Razavipour, Claude-Henry Volmar, Nancy T. Chee, Claes Wahlestedt, Seyed Javad Mowla, Mohammad Ali Faghihi> ;International Journal of Molecular Sciences. 2019 Mar 5
• 19 citations
  BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT.
  Sabrina Copsel, Casey O. Lightbourn, Henry Barreras, Ines Lohse, Dietlinde Wolf, Cameron S. Bader, John J. Manov, Brandon Kale, Devangi Shah, Krishna V. Komanduri, Cla...> ;Frontiers in Immunology. 2019 Jan 24
• 43 citations
  Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins
  Gregory C. Sartor, Andrea M. Malvezzi, Ashok V. Kumar, Nadja S. Andrade, Hannah J. Wiedner, Samantha J. Vilca, Karolina J. Janczura, Amir Bagheri, Hassan Al-Ali, Samue...> ;The Journal of Neuroscience. 2019 Jan 23
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Journal Articles

• Inhibition of HDAC3 Reverses Alzheimer’s Disease-Related Pathologies in Vitro and in the 3xTg-AD Mouse Model  
  Claes Wahlestedt, MD, Proceedings of the National Academy of Sciences