ClaytonASmithMD

PubMed

• Frontline chemoimmunotherapy with nivolumab and dose-adjusted EPOCH in peripheral T-cell lymphoma: a phase 1 trial.
  Davila, E., Bradeen, X., Abbott, D., Zain, J., Kamdar, M., Neuwelt, A., Jasem, J., Porcu, P., Major, A., Major, A., Haverkos, B., Major, A., Bair, S., Smith, C.> ;Blood Advances. 2024 Feb 13
• Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium.
  Anagha Inguva Sheth, Krysta Engel, Hunter Tolison, Mark J Althoff, Maria L Amaya, Anna Krug, Tracy Young, Shanshan Pei, Sweta B Patel, Mohammad Minhajuddin, Amanda Win...> ;Biorxiv. 2023 Oct 3
• 10 citations
  A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy.
  Shanshan Pei, Ian T Shelton, Austin E Gillen, Brett M Stevens, Maura Gasparetto, Yanan Wang, Lina Liu, Jun Liu, Tonya M Brunetti, Krysta Engel, Sarah Staggs, William S...> ;Cancer Discovery. 2023 Sep 6
• 16 citations
  Venetoclax is safe and tolerable as post-transplant maintenance therapy for AML patients at high risk for relapse.
  Andrew Kent, Marc Schwartz, Christine McMahon, Maria Amaya, Clayton A Smith, Jennifer Tobin, Kelsey Marciano, Rebecca Rezac, Grace Bosma, Daniel A Pollyea, Jonathan A ...> ;Bone Marrow Transplantation. 2023 Aug 1
• 3 citations
  Higher-dose venetoclax with measurable residual disease-guided azacitidine discontinuation in newly diagnosed acute myeloid leukemia.
  Jonathan A Gutman, Amanda Winters, Andrew Kent, Maria Amaya, Christine McMahon, Clayton Smith, Craig T Jordan, Brett Stevens, Mohammad Minhajuddin, Shanshan Pei, Jeffr...> ;Haematologica. 2023 Oct 1
• 2 citations
  Generating and Imaging Mouse and Human Epithelial Organoids from Normal and Tumor Mammary Tissue Without Passaging.
  Serena L Cornelius, Megan M Colonnetta, Katherine E Lake, Clayton A Smith, Yu-An Zhang, Evanthia T Roussos-Torres, Sangeetha M Reddy, Elizabeth H Chen, Isaac S Chan> ;Journal of Visualized Experiments. 2022 Nov 11
• 3 citations
  Machine Learning-Based Exploratory Clinical Decision Support for Newly Diagnosed Patients With Acute Myeloid Leukemia Treated With 7 + 3 Type Chemotherapy or Venetocla...
  Nazmul Islam, Jamie S Reuben, Justin Dale, Jon Gutman, Christine M McMahon, Maria Amaya, Bruce Goodman, Joseph Toninato, Maura Gasparetto, Brett Stevens, Shanshan Pei,...> ;JCO Clinical Cancer Informatics. 2022 Sep 1
• 35 citations
  Venetoclax and azacitidine followed by allogeneic transplant results in excellent outcomes and may improve outcomes versus maintenance therapy among newly diagnosed AM...
  Daniel A. Pollyea, Amanda Winters, Christine McMahon, Marc Schwartz, Craig T. Jordan, Rachel Rabinovitch, Diana Abbott, Clayton A. Smith, Jonathan A. Gutman> ;Bone Marrow Transplantation. 2021 Oct 13
• 72 citations
  Venetoclax and Azacitidine Compared to Induction Chemotherapy for Newly Diagnosed Patients with Acute Myeloid Leukemia.
  Evan Cherry, Diana Abbott, Maria L. Amaya, Christine McMahon, Marc Schwartz, Julie Rosser, Audrey Sato, Jeffrey Schowinsky, Anagha Inguva, Mohd Minhajuddin, Shanshan P...> ;Blood Advances. 2021 Oct 5
• Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins.
  Yasen Maimaitiyiming, Qian Qian Wang, Chang Yang, Yasumitsu Ogra, Yinjun Lou, Clayton A Smith, Liaqat Hussain, Yi Ming Shao, Jiebo Lin, Jinfeng Liu, Lingfang Wang, Yon...> ;Blood Cancer Discovery. 2021 Jul 1
• 6 citations
  The propriety of upgrading responses to venetoclax + azacitidine in newly diagnosed patients with acute myeloid leukemia
  Diana Abbott, Evan Cherry, Maria L. Amaya, Christine McMahon, Marc Schwartz, Amanda Winters, Jeffrey Schowinsky, Craig T. Jordan, Clayton A. Smith, Jonathan A. Gutman,...> ;Leukemia & Lymphoma. 2021 May 12
• 4 citations
  Exploiting Protein Translation Dependence in Multiple Myeloma with Omacetaxine-Based Therapy.
  Zachary J. Walker, Beau M Idler, Lorraine N Davis, Brett M. Stevens, Michael J VanWyngarden, Denis Ohlstrom, Shelby C. Bearrows, Andrew Hammes, Clayton A. Smith, Craig...> ;Clinical Cancer Research. 2021 Feb 1
• 110 citations
  Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells
  Courtney L. Jones, Brett M. Stevens, Daniel A. Pollyea, Rachel Culp-Hill, Julie A. Reisz, Travis Nemkov, Sarah Gehrke, Fabia Gamboni, Anna Krug, Amanda Winters, Shansh...> ;Cell Stem Cell. 2020 Nov 5
• 121 citations
  Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells
  Brett M. Stevens, Courtney L. Jones, Daniel A. Pollyea, Rachel Culp-Hill, Angelo D'Alessandro, Amanda Winters, Anna Krug, Diana Abbott, Madeline Goosman, Shanshan Pei,...> ;Nature Cancer. 2020 Oct 26
• 15 citations
  Glasdegib as maintenance therapy for patients with AML and MDS patients at high risk for postallogeneic stem cell transplant relapse.
  Andrew Kent, Sumithira Vasu, Derek Schatz, Natalie Monson, Steven M. Devine, Clayton A. Smith, Jonathan A. Gutman, Daniel A. Pollyea> ;Blood Advances. 2020 Jul 14
• 35 citations
  Adult cord blood transplant results in comparable overall survival and improved GRFS vs matched related transplant.
  Prashant Sharma, Enkhtsetseg Purev, Bradley M. Haverkos, Daniel A. Pollyea, Evan Cherry, Manali Kamdar, Tomer M Mark, Peter A. Forsberg, Daniel W. Sherbenou, Andrew Ha...> ;Blood Advances. 2020 May 26
• 12 citations
  Measurement of ex vivo resistance to proteasome inhibitors, IMiDs, and daratumumab during multiple myeloma progression.
  Zachary J. Walker, Michael J VanWyngarden, Brett M. Stevens, Diana Abbott, Andrew Hammes, Christophe J. Langouët-Astrié, Clayton A. Smith, Brent E. Palmer, Peter A. Fo...> ;Blood Advances. 2020 Apr 28
• 9 citations
  Unlicensed Umbilical Cord Blood Units Provide a Safe and Effective Graft Source for a Diverse Population: A Study of 2456 Umbilical Cord Blood Recipients
  Karen K. Ballen, Brent R. Logan, Pintip Chitphakdithai, Michelle Kuxhausen, Stephen R. Spellman, Alexia Adams, Rebecca J. Drexler, Merry Duffy, Ann Kemp, Roberta King,...> ;Biology of Blood and Marrow Transplantation. 2020 Apr 1
• 185 citations
  Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia.
  Shanshan Pei, Daniel A. Pollyea, Annika Gustafson, Brett M. Stevens, Mohammad Minhajuddin, Rui Fu, Kent Riemondy, Austin E. Gillen, Ryan M. Sheridan, Jihye Kim, James ...> ;Cancer Discovery. 2020 Jan 23
• 98 citations
  Real-world experience of venetoclax with azacitidine for untreated patients with acute myeloid leukemia
  Amanda Winters, Jonathan A. Gutman, Enkhtsetseg Purev, Molly Nakic, Jennifer Tobin, Stephanie Chase, Jeff Kaiser, Lindsey Lyle, Chelsey Boggs, Keri Halsema, Jeffrey Sc...> ;Blood Advances. 2019 Oct 22
• 2 citations
  Why is the H3+ hot spot above Jupiter's Great Red Spot so hot?
  Licia C Ray, Chris Lorch, James O'Donoghue, Japheth N. Yates, Sarah V. Badman, Clayton A. Smith, Tom Stallard> ;Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences. 2019 Sep 23
• 4 citations
  Sequential azacitidine and lenalidomide for patients with relapsed and refractory acute myeloid leukemia: Clinical results and predictive modeling using computational ...
  Brett M. Stevens, Amanda Winters, Jonathan A. Gutman, Aaron Fullerton, Gregory Hemenway, Derek Schatz, Nicholas Miltgen, Qi Wei, Taher Abbasi, Shireen Vali, Neeraj Kum...> ;Leukemia Research. 2019 Jun 1
• 21 citations
  CD123 CAR T cells for the treatment of myelodysplastic syndrome
  Brett M. Stevens, Wei Zhang, Daniel A. Pollyea, Amanda Winters, Jonathan A. Gutman, Clayton A. Smith, Elizabeth Budde, Stephen J. Forman, Craig T. Jordan, Enkhtsetseg ...> ;Experimental Hematology. 2019 Jun 1
• 17 citations
  Low ferroportin expression in AML is correlated with good risk cytogenetics, improved outcomes and increased sensitivity to chemotherapy.
  Maura Gasparetto, Shanshan Pei, Mohammad Minhajuddin, Brett M. Stevens, Clayton A. Smith, Paul Seligman> ;Leukemia Research. 2019 Feb 28
• 19 citations
  Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
  Courtney L Jones, Brett M Stevens, Angelo D'Alessandro, Julie A Reisz, Rachel Culp-Hill, Travis Nemkov, Shanshan Pei, Nabilah Khan, Biniam Adane, Haobin Ye, Anna Krug,...> ;Cancer Cell. 2019 Feb 11
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Journal Articles

• Venetoclax with Azacitidine Disrupts Energy Metabolism and Targets Leukemia Stem Cells in Patients with Acute Myeloid Leukemia  
  Daniel A Pollyea, Jonathan A Gutman, Enkhtsetseg Purev, Clayton Smith, Nature
• ALDHs in hematopoietic stem cells and leukemagenesis  
  Smith C, Gasparetto M, Jordan CT, Pollyea DA, Humphries KH, Vasiliou V, NYAS, 1/1/2014
• The significance of varying levels of aldehyde dehydrogenase activity in murine marrow  
  Gasparetto M, Sekulovic S, Zakaryan A, Kent DG, Humphries RK, and Smith C, Exp Heme, 1/1/2012
• Aldehyde Dehydrogenases: From eye crystallins to metabolic disease and stem cells  
  Vasillis V, Smith C, Thompson D, Mayumi F, Chen Y, Chem Biol Interact, 1/1/2012
• Fludarabine and cytarabine in patients with relapsed actute myeloid leukemia  
  McLaughlin B, Im A, Raptis A, Hou JZ, Redner R, Duggal S, Lin Y, Smith C, Boyiadzis M, Int J Hematol, 1/1/2012
• ALDH3A1 compensates for loss of ALDH1A1 in hematopoiesis and influences hematopoietic stem cell numbers, cell cycle status and early B-cell development  
  Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F et al, Exp Heme, 1/1/2011
• Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate  
  Jiang X, Forrest D, Nicolini F, Turhan A, Guilhot F, Yip C, Holyoake T, Jorgensen H, Lambie K, Saw KM, Pang E, Vukovic R, Lehn P, Ringrose A, Yu M, Brinkman R, Smith C..., Blood, 1/1/2010
• A role for E2F activities in determining the fate of Myc-induced lymphoagenesis  
  Rempel R, Mori S, Gasparetto M, Glozak M, Andrechek ER, Adler SB, Laakso NM, Lagoo AS, Storms R, Smith C and Nevins JR, PLOS Genetics, 1/11/2009
• Cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia are correlated with Sokal risk scores and duration of therapy but not trough ...  
  Forrest DL, Trainor S, Brinkman RR, Barnett MJ, Hogge DE, Nevill TJ, Shepherd JD, Nantel SH, Toze CL, Sutherland HJ, Song KW, Lavoie JC, Power MM, Abou-Mourad Y and Sm..., Leuk Res, 1/1/2009
• Stem cell biomarkers in chronic myeloid leukemia  
  Jiang X, Zhao Y, Forrest D, Smith C, Eaves A and Eaves C, Disease Markers, 1/1/2008
• An approach to the management of chronic myeloid leukemia in British Columbia  
  Forrest DL, Jiang X, Eaves CJ and Smith C, Curr Oncol, 1/1/2008
• Data quality assessment in high throughput flow cytometry experiments  
  Le Meur N, Rossini A, Gasparetto M, Smith C, Brinkman R and Gentleman R, Cytometry A, 1/1/2007
• High content flow cytometry to determine predictors of GvHD following allogeneic transplantation  
  Brinkman R, Gasparetto M, Lee J and Smith C, Biology of Blood and Marrow Transplantation, 1/1/2007
• Improved purification of hematopoietic stem cells based on their elevated aldehyde dehydrogenase activity  
  Christ, O, Lucke K, Imren S, Leung K, Hamilton M, Eaves A, Smith C and Eaves C, Haematologica, 1/1/2007
• The challenges of targeting chronic myeloid leukemia stem cells  
  Jiang X, Smith C, Eaves A and Eaves C, Clinical Lymphoma and Myeloma, 1/1/2007
• Predictive value of karyotype on outcome of autotransplants for acute myeloid leukemia in second remission  
  Song KW, Molllee PN, Hogge DE, Gupta V, Barnett MJ, Forrest DL, Lavoie JC, Nevill TJ, Nantel SH, Shepherd JD, Smith CA, Sutherland HJ, Toze CCI, Crump M and Keating A, Leukemia and Lymphoma, 1/1/2005
• Stem Cells and Transplantation  
  Smith C, Cancer Control, 1/1/2004
• Identification of compounds that enhance the anti-lymphoma activity of rituximab using flow cytometric high-content screening  
  Gasparetto M, Sebti S, Bhalla K and Smith C, J Immunologic Methods, 1/1/2004
• Hematopoietic progenitors which express high levels of aldehyde dehydrogenase can be counted and enriched from mobilized peripheral blood  
  Fallon P, Kerr W, Gentry T, Balber A, Ludeman S, Storms R and Smith C, Br J Hematology, 1/1/2003
• 4-hydroperoxycyclophosphamide purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia  
  Rizzieri DA, Talbot JT, Long GW, Vredenburgh JW, Gasparetto C, Smith C, Colvin MO, Adams D, Morris A, Dodge R, Loftis J, Waters-Pick B, Reese M, Carawan H and Chao N, Biol Blood and Marrow Transplant, 1/1/2003
• Hematopoietic stem cells and hematopoiesis  
  Smith C, Cancer Control, 1/1/2003
• Mobilization of dendritic cells from patients with breast cancer into peripheral blood stem cell leukapheresis samples using Flt-3-ligand and G-CSF or GM-CSF  
  Gasparetto C, Gasparetto M, Vredenberg J, Long G, Rizzieri D, Chao N, Loftis J and Smith C, Cytokine, 1/1/2002
• The hematopoietic defect in PNH is not due to defective stroma or abnormal interactions between bone marrow progenitor cells and stroma  
  Nishimura J, Ware RE, Burnette A, Pendleton AL, Kitano K, Hirota H, Machii T, Kitani T, Smith C and Rosse WF, Blood Cells, Molecules and Diseases, 1/1/2002
• Retroviral vector gene transfer into hematopoietic stem cells: an overview  
  Elwood N and Smith C, Leukemia and Lymphoma, 1/1/2001
• Retroviral vector gene transfer of the pig-A gene into hematopoietic cells affected by paroxysmal nocturnal hemoglobinuria  
  Nishimura J, Rosse WF, Phillips K and Smith C, Blood, 1/1/2001
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Books/Book Chapters

• Surgical Research 
  Chapter: Hematopoietic stem cells: basic concepts and applications to surgical research. 
  Page 207 - 214Rice H, Storms R, Smith C, and Flake AWEditors: W Souba and D Wilmore.Academic Press2001
• Gene Therapy for HIV Infection 
  Chapter: Hematopoietic stem cell transplantation: Issues in HIV gene therapy 
  Page 139 - 158Smith C and Gasparetto GEditors: Smith C.RG Landis, Inc., Austin, TX1998
• Gene Therapy for HIV Infection 
  Chapter: An overview of HIV gene therapy 
  Page 5 - 11Smith CEditors: Smith C.RG Landis, Inc., Austin, TX1998
• Molecular and Cell Biology of Human Gene Therapeutics 
  Chapter: AIDS and HIV Infection 
  Page 195 - 236Smith C and Sullenger BEditors: G Dickson.Chapman and Hall1995
• HIV: A Practical Approach 
  Chapter: Gene therapy for HIV infection 
  Bohnlein E, Smith C, and Marasco WIRL Press at Oxford University Press1995
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Abstracts/Posters

• Broad Efficacy of the Translation Inhibitor Omacetaxine in Relapsed/Refractory Multiple Myeloma Samples
  Clayton Smith, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Outcomes Following Allogeneic Stem Cell Transplantation for AML in First Completion Remission Are Comparable between MRD Negative Patients and MRD Positive Patients Re...
  Clayton Smith, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• A Phase 2 Study of Glasdegib for the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients with High Risk of Post-Allogeneic Stem Cell Transplantat...
  Clayton Smith, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Lectures

• Hematopoiesis 
  University of Colorado, 2012, 2013, 2014, 2015, 2016 - 1/1/2016
• Multiple Myeloma 
  University of Colorado, 2012, 2013, 2014, 2015, 2016 - 1/1/2016
• Amyloidosis 
  University of Colorado, 2012, 2013, 2014, 2015, 2016 - 1/1/2016
• Waldenstrom's macroglobulinemia 
  University of Colorado, 2012, 2013, 2014, 2015, 2016 - 1/1/2016
• Targeted therapies for hematologic malignancies 
  University of Colorado - 1/1/2016
• ALDH targeted therapy in AML 
  Vancouver, BC, Canada - 1/1/2013
• ALDHs in normal and malignant hematopoietic stem cells 
  University of Rochester - 1/1/2012
• Introduction to Blood and Marrow Transplantation 
  University of Colorado - 1/1/2012
• Umbilical cord blood and haploidentical donor transplantation 
  1/1/2011
• Aldehyde dehydrogenase in hematopoiesis and stem cell transplantation 
  University of Pittsburgh Cancer Center - 1/1/2010
• Umbilical cord blood transplantation in adults 
  1/1/2010
• Personalized medicine in acute myeloid leukemia: the need, the promise and the challenges 
  1/1/2010
• Acute leukemia, management and recent advances 
  1/1/2010
• Advances in chronic and acute leukemia 
  1/1/2010
• ALDHs and stem cells 
  1/1/2010
• High throughput, high content flow cytometry for drug discovery, functional genomics and clinical studies 
  San Jose, CA - 1/1/2009
• Aldehyde dehydrogenase and E2F gene families in hematopoietic stem cells 
  University of New Mexico - 1/1/2008
• Aldehyde dehydrogenase and umbilical cord blood transplantation 
  Montreal, Canada - 1/1/2008
• Graft versus host disease 
  Toronto, Canada - 1/1/2008
• Umbilical cord blood stem cells and transplantation 
  Vancouver, BC, Canada - 1/1/2008
• High throughput flow cytometric signatures of graft versus host disease 
  University of Miami - 1/1/2007
• Assessment of stem cells on the basis of ALDH activity 
  1/1/2006
• High throughput flow cytometry for developing cellular signatures for GvHD and other diseases 
  BC Cancer Center, Victoria - 1/1/2006
• The E2F and ALDH gene families in hematopoietic stem cell biology 
  Penn State Cancer Center - 1/1/2006
• E2F4 as a mediator of hematopoietic proliferation and differentiation 
  1/1/2004
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