ColinDWeekesMD

Oncology • Boston, MA

Assistant Professor, Medicine, University of Colorado School of Medicine

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Office
55 Fruit Street
Boston, MA 02114
Phone+1 617-724-4000

Fax+1 617-726-0452
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Education & Training

Johns Hopkins UniversityFellowship, Hematology and Medical Oncology, 2003 - 2006
University of Alabama Medical CenterResidency, Internal Medicine, 2000 - 2003
University of Nebraska College of MedicineClass of 2000

Certifications & Licensure

MA State Medical License 2017 - 2024
CO State Medical License 2007 - 2019
MD State Medical License 2003 - 2007
AL State Medical License Active through 2003
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Dinaciclib and Akt Inhibitor MK2206 in Treating Patients With Pancreatic Cancer That Cannot Be Removed by Surgery Start of enrollment: 2013 Jan 15
Completed
Phase 1
PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Participants With Stage IV Untreated Pancreatic Cancer Start of enrollment: 2013 May 14
Completed
Phase 2
Safety and Efficacy of Combination Listeria/GVAX Pancreas Vaccine in the Pancreatic Cancer Setting Start of enrollment: 2014 Feb 05
Completed
Phase 2
Dose Escalation Study of OMP-54F28 in Combination With Nab-Paclitaxel and Gemcitabine in Patients With Previously Untreated Stage IV Pancreatic Cancer Start of enrollment: 2013 Nov 01
Completed
Phase 1
Perioperative Therapy for Resectable and Borderline-Resectable Pancreatic Adenocarcinoma With Molecular Correlates Start of enrollment: 2016 Dec 30
Active, not recruiting
Phase 2
A Study of LY2510924 and Durvalumab in Participants With Solid Tumors Start of enrollment: 2016 Sep 01
Terminated
Phase 1
A Study of Abemaciclib (LY2835219) Alone or in Combination With Other Agents in Participants With Previously Treated Pancreatic Ductal Adenocarcinoma Start of enrollment: 2017 Jan 12
Completed
Phase 2
A Phase 1/2 Study of DCC-3116 in Patients With MAPK Pathway Mutant Solid Tumors Start of enrollment: 2021 Jun 15
Recruiting
Phase 1, Phase 2
SHARON: A Clinical Trial for Metastatic Cancer With a BRCA or PALB2 Mutation Using Chemotherapy and Patients' Own Stem Cells Start of enrollment: 2021 Jan 13
Recruiting
Phase 1
Roles: Contact, Principal Investigator
FOLFIRINOX + 9-Ing-41 + Losartan In Pancreatic Cancer Start of enrollment: 2022 Mar 21
Recruiting
Phase 2
Roles: Contact, Principal Investigator, Sponsor-Investigator
FOLFIRINOX + NIS793 in Pancreatic Cancer Start of enrollment: 2022 Aug 09
Recruiting
Phase 1
Roles: Principal Investigator, Sponsor-Investigator, Contact
A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors Start of enrollment: 2021 Oct 04
Active, not recruiting
Phase 1
Roles: Contact, Principal Investigator
A Study of ELI-002 7P in Subjects With KRAS/NRAS Mutated Solid Tumors Start of enrollment: 2023 Apr 14
Recruiting
Phase 1, Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Patient-Reported Outcomes, Tumor Markers, and Survival Outcomes in Advanced GI Cancer.
Joy X Jarnagin, Anurag Saraf, Islam Baiev, Gary Chi, Emily E van Seventer, Amirkasra Mojtahed, Jill N Allen, Jeffrey W Clark, Lawrence Blaszkowsky, Bruce J Giantonio, ...> ;JAMA Network Open. 2023 Nov 1
Portal Vein or Superior Mesenteric Vein Thrombosis with Dose-Escalated Radiation for Borderline or Locally Advanced Pancreatic Cancer.
Alicia C Smart, Andrzej Niemierko, Jennifer Y Wo, Cristina R Ferrone, Kenneth K Tanabe, Keith D Lillemoe, Jeffrey W Clark, Lawrence S Blaszkowsky, Jill N Allen, Colin ...> ;Journal of Gastrointestinal Surgery. 2023 Nov 1
5 citations
Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) Versus the Standard of Care Imaging in the Diagnosis of Peritoneal Carcinomatosis.
Felipe S Furtado, Mark Z Wu, Shadi A Esfahani, Cristina R Ferrone, Lawrence S Blaszkowsky, Jeffrey W Clark, David P Ryan, Lipika Goyal, Joseph W Franses, Jennifer Y Wo...> ;Annals of Surgery. 2023 Apr 1
3 citations
Phase Ib and Expansion Study of Gemcitabine, Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer.
Kimberly Perez, Anna M Chiarella, James M Cleary, Nora Horick, Colin Weekes, Thomas Abrams, Lawrence Blaszkowsky, Peter Enzinger, Marios Giannakis, Lipika Goyal, Jeffr...> ;The Oncologist. 2023 May 8
3 citations
Tolerability, Attrition Rates, and Survival Outcomes of Neoadjuvant FOLFIRINOX for Nonmetastatic Pancreatic Adenocarcinoma: Intent-to-Treat Analysis.
Zhi Ven Fong, Fidel Lopez Verdugo, Carlos Fernandez-Del Castillo, Cristina R Ferrone, Jill N Allen, Lawrence S Blaszkowsky, Jeffrey W Clark, Aparna R Parikh, David P R...> ;Journal of the American College of Surgeons. 2023 Jun 1
1 citations
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence.
Thatcher R Heumann, Marina Baretti, Elizabeth A Sugar, Jennifer N Durham, Sheila Linden, Tamara Y Lopez-Vidal, James Leatherman, Leslie Cope, Anup Sharma, Colin D Week...> ;Clinical Epigenetics. 2022 Dec 3
3 citations
Oncologists' Perspectives on Individualizing Dose Selection for Patients With Metastatic Cancer.
Rachel B Jimenez, Caroline Schenkel, Laura A Levit, Bonnie Hu, Xiudong Jennifer Lei, R Donald Harvey, Vicki A Morrison, Teri Pollastro, David Waterhouse, Colin Weekes,...> ;JCO Oncology Practice. 2022 Nov 1
75 citations
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
William L Hwang, Karthik A Jagadeesh, Jimmy A Guo, Hannah I Hoffman, Payman Yadollahpour, Jason W Reeves, Rahul Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, ...> ;Nature Genetics. 2022 Aug 1
9 citations
Supportive Oncology Care at Home Intervention for Patients With Pancreatic Cancer.
Ryan D Nipp, Eva Gaufberg, Charu Vyas, Chinenye Azoba, Carolyn L Qian, Jordon Jaggers, Colin D Weekes, Jill N Allen, Eric J Roeland, Aparna R Parikh, Laurie Miller, Je...> ;JCO Oncology Practice. 2022 Oct 1
7 citations
The efficacy and safety of cardio-protective therapy in patients with 5-FU (Fluorouracil)-associated coronary vasospasm.
Amna Zafar, Zsofia D Drobni, Matthew Lei, Carlos A Gongora, Thiago Quinaglia, Uvette Y Lou, Ramya Mosarla, Sean P Murphy, Maeve Jones-O'Connor, Ali Mahmood, Sarah Hart...> ;Plos One. 2022 Jan 1
93 citations
Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial
Aparna Raj Parikh, Annamaria Szabolcs, Jill N. Allen, Jeffrey W. Clark, Jennifer Y. Wo, Michael J. Raabe, Hannah Thel, David Hoyos, Arnav Mehta, Sanya Arshad, David J....> ;Nature Cancer. 2021 Nov 1
2 citations
Leveraging patient-reported outcomes (PROs) in patients with pancreatic cancer: The Pancreatic Cancer Action Network (PanCAN) online patient registry experience.
Arjun Gupta, Omar Khalid, Cassadie Moravek, Anica Lamkin, Lynn M. Matrisian, Sudheer Doss, Crystal S. Denlinger, Andrew L. Coveler, Colin D. Weekes, Eric Roeland, Andr...> ;Cancer Medicine. 2021 Sep 3
29 citations
Sacituzumab Govitecan For Metastatic Triple Negative Breast Cancer: Clinical Overview And Management Of Potential Toxicities.
Laura Spring, Erika Nakajima, Jennifer Hutchinson, Elene Viscosi, Gayle C. Blouin, Colin D. Weekes, Hope S. Rugo, Beverly Moy, Aditya Bardia> ;The Oncologist. 2021 Oct 1
7 citations
Care Patterns and Overall Survival in Patients With Early-Onset Metastatic Colorectal Cancer.
Katie Kanter, Madeleine Fish, Gianluca Mauri, Nora Horick, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffrey W. Clark, David P. Ryan, Ryan D. Nipp, Bruce J. Giantonio, L...> ;JCO Oncology Practice. 2021 May 27
4 citations
Liver Metastasis-Directed Ablative Radiotherapy in Pancreatic Cancer Offers Prolonged Time Off Systemic Therapy in Selected Patients: Data From a Multi-institutional R...
Grace M. Lee, Daniel Kim, Oluwadamilola T. Oladeru, Andrzej Niemierko, Kimberly R. Gergelis, Michael G. Haddock, Diego A.S. Toesca, A. Koong, Dawn Owen, Colin D. Weeke...> ;Pancreas. 2021 May 19
132 citations
Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer.
Aparna Raj Parikh, Emily E. Van Seventer, Giulia Siravegna, Anna Hartwig, Ariel Jaimovich, Yupeng He, Katie Kanter, Madeleine Fish, Kathryn Fosbenner, Benchun Miao, Su...> ;Clinical Cancer Research. 2021 Apr 29
7 citations
Refining the molecular framework for pancreatic cancer with single-cell and spatial technologies
Jimmy A. Guo, Hannah I. Hoffman, Colin D. Weekes, Lei Zheng, David T. Ting, William L. Hwang> ;Clinical Cancer Research. 2021 Mar 2
30 citations
The Incidence, Risk Factors, and Outcomes With 5-Fluorouracil-Associated Coronary Vasospasm.
Amna Zafar, Zsofia D. Drobni, Ramya C. Mosarla, Raza M. Alvi, Matthew Lei, Uvette Lou, Vineet K. Raghu, Sean P. Murphy, Maeve Jones-O'Connor, Sarah Hartmann, Hannah K ...> ;JACC. Cardiooncology. 2021 Mar 1
44 citations
Tumor Microenvironment Immune Response in Pancreatic Ductal Adenocarcinoma Patients Treated With Neoadjuvant Therapy.
Theodoros Michelakos, Lei Cai, Vincenzo Villani, Francesco Sabbatino, Filippos Kontos, Carlos Fernandez-del Castillo, Teppei Yamada, Azfar Neyaz, Martin S. Taylor, Vik...> ;Journal of the National Cancer Institute. 2021 Feb 1
7 citations
Conditional Survival in Resected Pancreatic Ductal Adenocarcinoma Patients Treated with Total Neoadjuvant Therapy
Theodoros Michelakos, Yurie Sekigami, Filippos Kontos, Carlos Fernandez-del Castillo, Motaz Qadan, Vikram Deshpande, David T. Ting, Jeffrey W. Clark, Colin D. Weekes, ...> ;Journal of Gastrointestinal Surgery. 2021 Jan 26
31 citations
Circulating Tumor DNA Predicts Pathologic and Clinical Outcomes Following Neoadjuvant Chemoradiation and Surgery for Patients With Locally Advanced Rectal Cancer.
Susan G.R. McDuff, Karin M. Hardiman, Peter J. Ulintz, Aparna Raj Parikh, Hui Zheng, Daniel Kim, Jochen K. Lennerz, Mehlika Hazar-Rethinam, Emily E. Van Seventer, Isob...> ;JCO Precision Oncology. 2021 Jan 12
12 citations
Impact of PET/MRI in the Treatment of Pancreatic Adenocarcinoma: a Retrospective Cohort Study.
Felipe S. Furtado, Cristina R. Ferrone, Susanna I. Lee, Mark Vangel, David A. Rosman, Colin D. Weekes, Motaz Qadan, Carlos Fernandez-del Castillo, David P. Ryan, Lawre...> ;Molecular Imaging and Biology. 2021 Jan 7
5 citations
A Phase Ib Study of Single-Agent Idelalisib Followed by Idelalisib in Combination with Chemotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma.
Erkut Borazanci, Michael J. Pishvaian, John Nemunaitis, Colin D. Weekes, Julie Huang, Nishanthan Rajakumaraswamy> ;The Oncologist. 2020 Nov 1
20 citations
A Phase I Study of Dinaciclib in Combination With MK-2206 in Patients With Advanced Pancreatic Cancer.
Adrian Murphy, Marianna Zahurak, Mirat Shah, Colin D. Weekes, Aaron R. Hansen, Lillian L. Siu, Anna Spreafico, Noelle K. LoConte, Nicole M. Anders, Tearra Miles, Miche...> ;Clinical and Translational Science. 2020 Nov 1
6 citations
Prospective Phase II Trials Validate the Effect of Neoadjuvant Chemotherapy on Pattern of Recurrence in Pancreatic Adenocarcinoma.
Akhil Chawla, Motaz Qadan, Carlos Fernandez-del Castillo, Jennifer Y. Wo, Jill N. Allen, Jeffrey W. Clark, Janet E. Murphy, Onofrio A. Catalano, David P. Ryan, David T...> ;Annals of Surgery. 2020 Oct 19
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Press Mentions

Actuate Therapeutics Announces Initiation of a Multicenter Randomized Trial of Elraglusib plus FOLFIRINOX as First Line Therapy for Advanced Pancreatic CancerFebruary 7th, 2022
Hold off on Approving Anal Cancer Drug, Advisors Tell FDAJune 24th, 2021
FDA Panel: Yank Keytruda Approval in Third-Line Gastric CancerApril 29th, 2021
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