
Costas Hadjipanayis MD PhD
Brain & Spinal Tumor, Stereotactic & Functional Neurosurgery
L. Dade Lunsford Professor of Neurosurgery, Executive Vice-Chairman, Dept. of Neurological Surgery, Director, Center For Image-Guided Neurosurgery, Co-Director, UPMC Hillman Brain Tumor Center Director, Brain Tumor Nanotechnology Laboratory, Hillman Cancer Center, University of Pittsburgh Medical Center (UPMC), University of Pittsburgh School of Medicine
200 Lothrop StSte F-158Pittsburgh, PA 15213
Phone+1 412-647-6781
Fax+1 412-647-8447
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Summary
- Dr. Costas Hadjipanayis is a neurosurgeon based in Pittsburgh, PA, specializing in brain and spinal tumors, as well as stereotactic and functional neurosurgery. He completed his medical education at Sidney Kimmel Medical College and further obtained a Ph.D. in Biochemistry/Molecular Genetics from the University of Pittsburgh School of Medicine. He has held significant roles such as the Director of Neurosurgical Oncology at Mount Sinai, and the Chair at Mount Sinai Beth Israel, along with academic appointments including Professor at Icahn School of Medicine. Dr. Hadjipanayis is experienced in deep brain stimulation and neurosurgical oncology and has contributed to numerous publications addressing topics such as gliomas and radiosurgery techniques. He has been involved in clinical trials aimed at enhancing visualization and removal of malignant brain tumors. His recognitions include CMS Meaningful Use Stage certifications.
Education & Training
UPMC Medical EducationResidency, Neurological Surgery, 1999 - 2006
University of Pittsburgh School of MedicinePost-Doctoral Fellowship, 2003 - 2005
University of Pittsburgh School of MedicinePh.D., Biochemistry/Molecular Genetics, 2005
UPMC Medical Education (Pittsburgh)Residency, Surgery, 1998 - 1999
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1998
Certifications & Licensure
FL State Medical License 2020 - Present
NY State Medical License 2015 - 2028
PA State Medical License 2022 - 2026
GA State Medical License 2007 - 2016
American Board of Neurological Surgery Neurological Surgery
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2014, 2017
- CMS Meaningful Use Stage 1 Certification PowerChart (Clinical), Cerner Corporation, 2014, 2017
- CMS Meaningful Use Stage 1 Certification Cerner Patient Portal and Powerchart, Cerner Corporation, 2014, 2017
Clinical Trials
Publications & Presentations
PubMed
- 9 citationsPredicting time to local failure after gamma knife radiosurgery for melanoma brain metastases using survival machine learning.Jheremy S Reyes, Alexandros Bouras, Ajay Niranjan, L Dade Lunsford, Constantinos G Hadjipanayis
Clinical & Translational Oncology. 2026-11-01 - Therapeutic Hybrid Intelligence with Neural and Knowledge-based Expert Reasoning for SRS (THINKERS): an AI Model for Functional Outcome Prediction After Gamma Knife Th...Jheremy S Reyes, Constantinos G Hadjipanayis, L Dade Lunsford, Ajay Niranjan
Cerebellum. 2026-10-23 - THINKERS-X: multisequence MRI radiomics in a mixture-of-experts model for outcome prediction and exploratory dose-scenario evaluation in lung cancer brain metastases t...Jheremy S Reyes, Constantinos G Hadjipanayis, Ajay Niranjan
Clinical & Experimental Metastasis. 2026-10-17
Journal Articles
- Targeted Therapy of Glioma Stem-like Cells and Tumor Non-stem Cells Using Cetuximab Conjugated Iron Oxide NanoparticlesKaluzova M, Bouras A, Machaidze R, Hadjipanayis CG, Oncotarget, 1/20/2015
- Radiosensitivity Enhancement of Radioresistant Glioblastoma by Epidermal Growth Factor Receptor Antibody-conjugated Iron-oxide NanoparticlesBouras A, Kaluzova M, Hadjipanayis CG, J Neurooncol, 1/1/2015
- Human Brat Ortholog TRIM3 Is a Tumor Suppressor and Regulates Asymmetric Cell Division in GlioblastomaChen G, Anand M, Kong J, Tucker-Burden C, Rong Y, Rahman F, Moreno CS, Van Meir EG, Hadjipanayis CG, Brat DJ, Cancer Res, 1/15/2014
Books/Book Chapters
Abstracts/Posters
- Targeted Therapy of Glioma Stem Cells and Tumor Non-stem Cells Using Cetuximab-conjugated Iron-oxide NanoparticlesKaluzova M, Platt S, Bouras A, Kent M, Machaidze R, Hadjipanayis CG, Fourth Quadrennial Meeting of the World Federation of Neuro-oncology, San Francisco, CA, 1/24/2013
- Targeted Therapy of Glioma Stem Cells and Tumor Non-stem Cells Using Cetuximab-conjugated Iron-oxide NanoparticlesKaluzova M, Platt S, Bouras A, Kent M, Machaidze R, Hadjipanayis CG, Neurooncology, 1/1/2013
- Endoscopic Endonasal Resection of Clival ChordomasOrmond RD, Wise S, Oyesiku N, Patel A, Hadjipanayis CG, 23rd Annual North American Skull Base Society Meeting, Journal of Neurological Surgery-Part B Skull Base, Miami, FL, 1/1/2013
Lectures
- Fluorescence-Guided Surgery of Malignant GliomaMadurai Neurosurgical Academy, Chennai, India - 1/28/2015
- Endoscopic Endonasal Resection of Clival ChordomaMadurai Neurosurgical Academy, Chennai, India - 1/28/2015
- Endoscopic Endonasal Approach to Pituitary TumorsMadurai Neurosurgical Academy, Chennai, India - 1/28/2015
Other
- Constantinos G Hadjipanayis MD PhD Appointed Chair of the Department of Neurosurgery at Mount Sinai Beth Israel
http://www.mountsinai.org/about-us/newsroom/press-releases/constantinos-g-hadjipanayis-mdphd-appointed-chair-of-the-department-of-neurosurgery-at-mount-sinai-beth-israel-
1/1/2015 - Photo Essay: One Couple's Brain Tumor Journey by the American Association of Neurological Surgeons (AANS)
http://aansneurosurgeon.org/features/photo-essay-one-couples-brain-tumor-journey/
1/1/2015 - Course Manual, Congress of Neurological Surgeons Oral Board Review Course
Chicago - 1/8/2014
Press Mentions
Synaptive Medical Présente Des Fonctionnalités Clefs De Sa Technologie De Microscopie Chirurgicale Robotique Modus V™ Lors Du CNS 2019October 15th, 2019
Synaptive Medical Presents Key Features of Its Modus V™ Robotic Surgical Microscopy Technology at the 2019 CNS Annual MeetingOctober 15th, 2019
FDA Approves Gliolan; Helps Patients with Glioblastoma Brain TumorsJuly 27th, 2017
Professional Memberships
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