CurtFreedMD

Emergency Medicine • Aurora, CO

Medical Toxicology

Professor of Medicine

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Office
12700 E 19th Ave
Aurora, CO 80045
Phone+1 303-724-6004

Fax+1 303-724-6012
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Education & Training

University of California (San Francisco)Residency, Internal Medicine, 1972 - 1975
Massachusetts General Hospital/McLean HospitalResidency, Psychiatry, 1971 - 1972
Los Angeles County-Harbor-UCLA Medical CenterResidency, Internal Medicine, 1970 - 1971
Los Angeles County-Harbor-UCLA Medical CenterInternship, Transitional Year, 1969 - 1970
Harvard Medical SchoolClass of 1969

Certifications & Licensure

CO State Medical License 1975 - 2025
CA State Medical License 1970 - 2023

Awards, Honors, & Recognition

Elected Member American Association of Physicians, 1997
Elected Member The American Society for Clinical Investigation, 1984

Clinical Trials

Embryonic Dopamine Cell Implants for Parkinson's Disease Start of enrollment: 1995 May 01
Completed
Phase 3
Phenylbutyrate Response as a Biomarker for Alpha-synuclein Clearance From the Brain Start of enrollment: 2014 Jan 01
Completed
Phase 1
Double-blind Placebo Surgery Trial for Treatment of Parkinson's Disease Start of enrollment: 1994 Nov 01
Completed
Not Applicable

Publications & Presentations

PubMed

8 citations
Persistent dyskinesias in patients with fetal tissue transplantation for Parkinson disease.
Paul Greene, Stanley Fahn, David Eidelberg, Kimberly B. Bjugstad, Robert E. Breeze, Curt R. Freed> ;NPJ Parkinson's Disease. 2021 Apr 23
53 citations
Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease
Wenbo Zhou, Jessica Cummiskey Barkow, Curt R. Freed> ;Plos One. 2017 Dec 22
24 citations
DJ-1 Modulates Nuclear Erythroid 2-Related Factor-2-Mediated Protection in Human Primary Alveolar Type II Cells in Smokers.
Karim Bahmed, Elise M. Messier, Wenbo Zhou, Rubin M. Tuder, Curt R. Freed, Hong Wei Chu, Steven G. Kelsen, Russell P. Bowler, Robert J. Mason, Beata Kosmider> ;American Journal of Respiratory Cell and Molecular Biology. 2016 Sep 1
21 citations
Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease
Lu Gao, Wenbo Zhou, Breanna Symmes, Curt R. Freed> ;Plos One. 2016 Aug 11
24 citations
A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.
Rui Xiong, Wenbo Zhou, David Siegel, Russell R. A. Kitson, Curt R. Freed, Christopher J. Moody, David Ross> ;Molecular Pharmacology. 2015 Dec 1
16 citations
Substantial Differentiation of Human Neural Stem Cells Into Motor Neurons on a Biomimetic Polyurea
Donghwa Yun, Young M. Lee, Melissa R. Laughter, Curt R. Freed, Daewon Park> ;Macromolecular Bioscience. 2015 Sep 1
38 citations
A nerve guidance conduit with topographical and biochemical cues: potential application using human neural stem cells.
Phillip M. Jenkins, Melissa R. Laughter, David J. Lee, Young M. Lee, Curt R. Freed, Daewon Park> ;Nanoscale Research Letters. 2015 Jun 12
12 citations
Biomimetic poly(serinol hexamethylene urea) for promotion of neurite outgrowth and guidance.
Donghwa Yun, Amin Famili, Young Mook Lee, Phillip M. Jenkins, Curt R. Freed, Daewon Park> ;Journal of Biomaterials Science. Polymer Edition. 2014 Jan 10
60 citations
Human Sensory Neurons Derived from Induced Pluripotent Stem Cells Support Varicella-Zoster Virus Infection
Katherine S. Lee, Wenbo Zhou, Jonah J. Scott-McKean, Kaitlin L. Emmerling, Guang-Yun Cai, David L. Krah, Alberto C.S. Costa, Curt R. Freed, Myron J. Levin> ;Plos One. 2012 Dec 28
40 citations
Dopamine Cell Transplantation for Parkinson’s Disease: The Importance of Controlled Clinical Trials
Curt R. Freed, Wenbo Zhou, Robert E. Breeze> ;Neurotherapeutics. 2011 Oct 15
114 citations
Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease *
Wenbo Zhou, Kathryn Bercury, Jessica Cummiskey, Nancy Luong, Jacob A. Lebin, Curt R. Freed> ;The Journal of Biological Chemistry. 2011 Apr 29
9 citations
Pallidal neuronal discharge in Parkinson's disease following intraputamenal fetal mesencephalic allograft
R. Mark Richardson, Curt R. Freed, Shoichi A Shimamoto, Philip A. Starr> ;Journal of Neurology, Neurosurgery, and Psychiatry. 2011 Mar 1
134 citations
Dopamine Cell Implantation in Parkinson's Disease: Long-Term Clinical and 18F-FDOPA PET Outcomes
Yilong Ma, Chengke Tang, Thomas Chaly, Paul Greene, Robert E. Breeze, Stanley Fahn, Curt R. Freed, Vijay Dhawan, David Eidelberg> ;Journal of Nuclear Medicine. 2010 Jan 1
20 citations
Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice.
Wenbo Zhou, Young Mook Lee, Vanessa C. Guy, Curt R. Freed> ;Stem Cells. 2009 Dec 1
347 citations
Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells.
Wenbo Zhou, Curt R. Freed> ;Stem Cells. 2009 Nov 1
58 citations
Noggin Enhances Dopamine Neuron Production from Human Embryonic Stem Cells and Improves Behavioral Outcome After Transplantation into Parkinsonian Rats
Shunmei Chiba, Young Mook Lee, Wenbo Zhou, Curt R. Freed> ;Stem Cells. 2008 Nov 1
189 citations
Placebo response in Parkinson's disease: Comparisons among 11 trials covering medical and surgical interventions
Christopher G. Goetz, Joanne Wuu, Michael P. McDermott, Charles H. Adler, Stanley Fahn, Curt R. Freed, Robert A. Hauser, Warren Olanow, Ira Shoulson, P.K. Tandon, Sue ...> ;Movement Disorders. 2008 Apr 15
40 citations
Transgenic Mice Overexpressing Tyrosine-to-Cysteine Mutant Human α-Synuclein A PROGRESSIVE NEURODEGENERATIVE MODEL OF DIFFUSE LEWY BODY DISEASE
Wenbo Zhou, Julie B. Milder, Curt R. Freed> ;The Journal of Biological Chemistry. 2008 Apr 11
5 citations
Mobilization of storage pool dopamine and late ipsilateral augmentation of striatal dopamine synthesis in the trained circling rat.
Barbara A. Bennett, Curt R. Freed> ;Journal of Neurochemistry. 2006 Oct 5
3 citations
Infant mice with glutaric acidaemia type I have increased vulnerability to 3-nitropropionic acid toxicity
Kimberly B. Bjugstad, Linda S. Crnic, Stephen I. Goodman, Curt R. Freed> ;Journal of Inherited Metabolic Disease. 2006 Aug 30
284 citations
DJ-1 Up-regulates Glutathione Synthesis during Oxidative Stress and Inhibits A53T α-Synuclein Toxicity
Wenbo Zhou, Curt R. Freed> ;The Journal of Biological Chemistry. 2005 Dec 30
62 citations
Characterization of the Bex gene family in humans, mice, and rats.
Enrique Alvarez, Wenbo Zhou, Samir E. Witta, Curt R. Freed> ;Gene. 2005 Aug 29
45 citations
Nectin-1/HveC Mediates herpes simplex virus type 1 entry into primary human sensory neurons and fibroblasts
Scott A. Simpson, Michael D. Manchak, Elizabeth J. Hager, Claude Krummenacher, J. Charles Whitbeck, Myron J. Levin, Curt R. Freed, Christine L. Wilcox, Gary H. Cohen, ...> ;Journal of Neurovirology. 2005 Apr 1
45 citations
Rapid Purification and Mass Spectrometric Characterization of Mitochondrial NADH Dehydrogenase (Complex I) from Rodent Brain and a Dopaminergic Neuronal Cell Line
Birgit Schilling, M.M. Srinivas Bharath, Richard H. Row, James Murray, Michael P. Cusack, Roderick A. Capaldi, Curt R. Freed, Kedar N. Prasad, Julie K. Andersen, Bradf...> ;Molecular & Cellular Proteomics. 2005 Jan 1
107 citations
Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF.
Kimberley A. Buytaert‐Hoefen, Enrique Alvarez, Curt R. Freed> ;Stem Cells. 2004 Sep 1
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Press Mentions

NEWS FROM THE ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE: Parkinson's Disease: The Latest Developments in Targeting Alpha-Synuclein Spread, Inhibiting Glucocerebrosidase Mutations, and Fetal Transplant AutopsiesDecember 22nd, 2016

Grant Support

Collection Of Placental Cord Blood Use In Tissue CultureNational Center For Research Resources2000–2002
Embryonic Cell Implants For Parkinsons Disease: Double Blind StudyNational Center For Research Resources1999

Hospital Affiliations

University of Colorado HospitalAurora, Colorado
UCHealth Memorial HospitalColorado Springs, Colorado
UCHealth Poudre Valley HospitalFort Collins, Colorado

CurtFreedMD

Dr. Freed is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Press Mentions

Grant Support

Hospital Affiliations

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