DanAviLandauMD

PubMed

• GoT-Splice protocol for multi-omics profiling of gene expression, cell-surface proteins, mutational status, and RNA splicing in human cells.
  Saravanan Ganesan, Mariela Cortés-López, Ariel D Swett, Xiaoguang Dai, Scott Hickey, Paulina Chamely, Allegra G Hawkins, Sissel Juul, Federico Gaiti, Dan A Landau> ;STAR Protocols. 2024 Mar 20
• SON is an essential mA target for hematopoietic stem cell fate.
  Hanzhi Luo, Mariela Cortés-López, Cyrus L Tam, Michael Xiao, Isaac Wakiro, Karen L Chu, Aspen Pierson, Mandy Chan, Kathryn Chang, Xuejing Yang, Daniel Fecko, Grace Han...> ;Cell Stem Cell. 2023 Dec 7
• Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization.
  Nir Ben-Chetrit, Xiang Niu, Jesus Sotelo, Ariel D Swett, Vinagolu K Rajasekhar, Maria S Jiao, Caitlin M Stewart, Priya Bhardwaj, Sanjay Kottapalli, Saravanan Ganesan, ...> ;Biorxiv. 2023 Oct 27
• 7 citations
  Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths.
  Mariela Cortés-López, Paulina Chamely, Allegra G Hawkins, Robert F Stanley, Ariel D Swett, Saravanan Ganesan, Tarek H Mouhieddine, Xiaoguang Dai, Lloyd Kluegel, Celine...> ;Cell Stem Cell. 2023 Sep 7
• 29 citations
  Integration of whole transcriptome spatial profiling with protein markers.
  Nir Ben-Chetrit, Xiang Niu, Ariel D Swett, Jesus Sotelo, Maria S Jiao, Caitlin M Stewart, Catherine Potenski, Paulius Mielinis, Patrick Roelli, Marlon Stoeckius, Dan A...> ;Nature Biotechnology. 2023 Jun 1
• 23 citations
  Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction.
  Jesus Maria Gómez-Salinero, Franco Izzo, Yang Lin, Sean Houghton, Tomer Itkin, Fuqiang Geng, Yaron Bram, Robert P Adelson, Tyler M Lu, Giorgio Inghirami, Jenny Zhaoyin...> ;Cell Stem Cell. 2022 Apr 7
• Lightning does strike twice: leveraging phased variants to enhance minimal residual disease detection.
  Alexandre P Cheng, Dan A Landau> ;Med. 2021 Oct 8
• 83 citations
  Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states.
  Ronan Chaligne, Federico Gaiti, Dana Silverbush, Joshua S. Schiffman, Hannah R. Weisman, Lloyd Kluegel, Simon Gritsch, Sunil Deochand, L. Nicolas Gonzalez Castro, Alys...> ;Nature Genetics. 2021 Sep 30
• 12 citations
  Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.
  Johannes Bloehdorn, Andrejs Braun, Amaro Taylor-Weiner, Billy Michael Chelliah Jebaraj, Sandra Robrecht, Julia Krzykalla, Heng Pan, Adam Giza, Gulnara Akylzhanova, Kar...> ;Nature Communications. 2021 Sep 13
• 28 citations
  Smart-RRBS for single-cell methylome and transcriptome analysis.
  Hongcang Gu, Ayush T. Raman, Xiaoxue Wang, Federico Gaiti, Ronan Chaligne, Arman W. Mohammad, Aleksandra Alicja Arczewska, Zachary D. Smith, Dan A. Landau, Martin J. A...> ;Nature Protocols. 2021 Jul 9
• 54 citations
  Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
  Simon J. Hogg, Olga Motorna, Leonie A. Cluse, Timothy M. Johanson, Hannah D. Coughlan, Ramya Raviram, Robert M. Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pij...> ;Molecular Cell. 2021 May 20
• 32 citations
  Discovery of Candidate DNA Methylation Cancer Driver Genes.
  Heng Pan, Loïc Renaud, Ronan Chaligne, Johannes Bloehdorn, Eugen Tausch, Daniel Mertens, Anna-Maria Fink, Kirsten Fischer, Chao Zhang, Doron Betel, Andreas Gnirke, Mar...> ;Cancer Discovery. 2021 May 10
• 177 citations
  Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics
  Anna S. Nam, Ronan Chaligne, Dan A. Landau> ;Nature Reviews. Genetics. 2021 Jan 1
• 5 citations
  Epigenomically Bistable Regions across Neuron-Specific Genes Govern Neuron Eligibility to a Coding Ensemble in the Hippocampus.
  Shannon C. Odell, Faten A. Taki, S. Klein, Rosa J. Chen, Olivia B. Levine, Mary Jane Skelly, Anika Nabila, Elizabeth Brindley, Judit Gal Toth, Friederike Dündar, Carol...> ;Cell Reports. 2020 Jun 23
• 26 citations
  Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells
  Josephine Wesely, Andriana G. Kotini, Franco Izzo, Hanzhi Luo, Han Yuan, Jun Sun, Maria Georgomanoli, Asaf Zviran, André G. Deslauriers, Neville Dusaj, Stephen D. Nime...> ;Cell Reports. 2020 Jun 2
• 173 citations
  Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.
  Asaf Zviran, Rafael C. Schulman, Minita Shah, Steven T. K. Hill, Sunil Deochand, Cole C. Khamnei, Dillon Maloney, Kristofer Patel, Will Liao, Adam J. Widman, Phillip W...> ;Nature Medicine. 2020 Jun 1
• 21 citations
  Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1 regulated transcription.
  Jennifer Edelmann, Karlheinz Holzmann, Eugen Tausch, Emily A. Saunderson, Billy Michael Chelliah Jebaraj, Daniela Steinbrecher, Anna Dolnik, Tamara J. Blätte, Dan A. L...> ;Haematologica. 2020 May 1
• 121 citations
  DNA methylation disruption reshapes the hematopoietic differentiation landscape
  Franco Izzo, Stanley Chun-Wei Lee, Asaf Poran, Ronan Chaligne, Federico Gaiti, Baptiste Gross, Rekha R. Murali, Sunil Deochand, Chelston Ang, Philippa Wyndham Jones, A...> ;Nature Genetics. 2020 Mar 23
• 9 citations
  Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization
  Patrick O. Bolan, Asaf Zviran, Lisa Brenan, Joshua S. Schiffman, Neville Dusaj, Amy Goodale, Federica Piccioni, Cory M. Johannessen, Dan A. Landau> ;Cell Systems. 2020 Jan 22
• 25 citations
  EpiMethylTag: simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation.
  Priscillia Lhoumaud, Gunjan Sethia, Franco Izzo, Theodore Sakellaropoulos, Valentina Snetkova, Simon E. Vidal, Sana Badri, MacIntosh Cornwell, Dafne Campigli Di Giamma...> ;Genome Biology. 2019 Nov 21
• 102 citations
  m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment
  Yuanming Cheng, Hanzhi Luo, Franco Izzo, Brian F. Pickering, Diu T.T. Nguyen, Robert P. Myers, Alexandra Schurer, Saroj Gourkanti, Jens C. Brüning, Ly P. Vu, Samie R. ...> ;Cell Reports. 2019 Aug 13
• 137 citations
  Somatic mutations and cell identity linked by Genotyping of Transcriptomes
  Anna S. Nam, Kyu-Tae Kim, Ronan Chaligne, Franco Izzo, Chelston Ang, Justin Taylor, Robert M. Myers, Ghaith Abu-Zeinah, Ryan M. Brand, Nathaniel D. Omans, Alicia Alons...> ;Nature. 2019 Jul 1
• 150 citations
  Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia.
  Federico Gaiti, Ronan Chaligne, Hongcang Gu, Ryan M. Brand, Steven Kothen-Hill, Rafael C. Schulman, Kirill Grigorev, Davide Risso, Kyu-Tae Kim, Alessandro Pastore, Kev...> ;Nature. 2019 May 15
• 48 citations
  Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL.
  Alessandro Pastore, Federico Gaiti, Sydney X. Lu, Ryan M. Brand, Scott Kulm, Ronan Chaligne, Hongcang Gu, Kevin Y. Huang, Elena K. Stamenova, Wendy Béguelin, Yanwen Ji...> ;Nature Communications. 2019 Apr 23
• 18 citations
  Short telomeres are associated with inferior outcome, genomic complexity, and clonal evolution in chronic lymphocytic leukemia.
  Billy Michael Chelliah Jebaraj, Eugen Tausch, Dan A. Landau, Jasmin Bahlo, Sandra Robrecht, Amaro Taylor-Weiner, Johannes Bloehdorn, Annika Scheffold, Daniel Mertens, ...> ;Leukemia. 2019 Mar 25
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Journal Articles

• Discovery of a Periosteal Stem Cell Mediating Intramembranous Bone Formation  
  John H Healey, Mathias P Bostrom, Matthew B Greenblatt, Meera Hameed, Dan Avi Landau, Nature

Lectures

• Role and Mechanisms of Clonal Evolution in Lymphoid Malignancies 
  60th American Society of Hematology Annual Meeting - 12/2/2018
• Continuing Conversations With the Speakers on Role and Mechanisms of Clonal Evolution in Lymphoid Malignancies 
  60th American Society of Hematology Annual Meeting - 12/1/2018
• Multimodal Single-Cell Profiling Defines the Epigenetic Determinants of Chronic Lymphocytic Leukemia Evolution 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018