DanielClarkFilesMD

Pulmonology • Winston Salem, NC

Critical Care Medicine, Pleural Disease

Assistant Professor, Internal Medicine, Bowman Gray School of Medicine of Wake Forest Univ

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Office
Medical Center Blvd
Winston Salem, NC 27157
Phone+1 336-716-2255
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Education & Training

Johns Hopkins UniversityFellowship, Pulmonary Disease and Critical Care Medicine, 2007 - 2011
Vanderbilt University Medical CenterResidency, Internal Medicine, 2003 - 2007
University of Mississippi School of MedicineClass of 2003

Certifications & Licensure

NC State Medical License 2011 - 2024
MD State Medical License 2007 - 2012
TN State Medical License 2005 - 2008

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Inpatient - Core EMR, Epic Systems Corporation, 2013

Clinical Trials

Strength Testing After Nitrate Delivery (STAND) in ICU Patients Start of enrollment: 2015 Jun 01
Completed
Not Applicable
A Study Promoting Critical Illness Recovery in the Elderly Start of enrollment: 2017 May 30
Active, not recruiting
Not Applicable
Nutrition and Exercise in Critical Illness Start of enrollment: 2017 Sep 28
Recruiting
Phase 2
Effect of Randomization to Neuromuscular Blockade on Physical Functional Impairment and Recovery in ARDS Start of enrollment: 2017 Jan 01
Unknown status
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Publications & Presentations

PubMed

12 citations
I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.
Sarafian, F., Files, D., Matthay, M., Calfee, C., Aggarwal, N., Asare, A., Beitler, J., Berger, P., Burnham, E., Cimino, G., Coleman, M., Crippa, A., Discacciati, A., ...> ;BMJ Open. 2022 Jun 6
10 citations
Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19.
Daniel Clark Files, Frank Tacke, Alexandra O'Sullivan, Patrick Dorr, William G Ferguson, William G Powderly> ;Plos Pathogens. 2022 Jun 1
1 citations
Excess Tidal Volume Ventilation in Critically Ill Adults Receiving Adaptive Pressure Control: A Cohort Study.
Kevin W Gibbs, Jonathan L Forbes, Nathaniel S O'Connell, R Shayn Martin, Rita N Bakhru, Jessica A Palakshappa, D Clark Files> ;Annals of the American Thoracic Society. 2022 Nov 1
372 citations
Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity.
Mark W Tenforde, Wesley H. Self, Katherine Adams, Manjusha Gaglani, Adit A. Ginde, Tresa McNeal, Shekhar Ghamande, David J. Douin, H. Keipp Talbot, Jonathan D Casey, N...> ;JAMA. 2021 Nov 23
2 citations
The Renin-Angiotensin-Aldosterone System in COVID-19-related and Non-COVID-19-related Acute Respiratory Distress Syndrome: Not So Different after All?
Sean P. Collins, Mark C. Chappell, D. Clark Files> ;American Journal of Respiratory and Critical Care Medicine. 2021 Nov 1
14 citations
Influenza Vaccine Effectiveness for Prevention of Severe Influenza-Associated Illness Among Adults in the United States, 2019-2020: A Test-Negative Study.
Carlos G. Grijalva, Leora R. Feldstein, H. Keipp Talbot, Michael S. Aboodi, Adrienne Baughman, Samuel M. Brown, Jonathan D Casey, Heidi L Erickson, Matthew C. Exline, ...> ;Clinical Infectious Diseases. 2021 Oct 20
281 citations
Comparative Effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) Vaccines in Preventing COVID-19 Hospitalizations Among Adults Without Immunocomp...
Wesley H. Self, Mark W Tenforde, Jillian P. Rhoads, Manjusha Gaglani, Adit A. Ginde, David J. Douin, Samantha M. Olson, H. Keipp Talbot, Jonathan D Casey, Nicholas M. ...> ;MMWR. Morbidity and Mortality Weekly Report. 2021 Sep 24
4 citations
Activity Levels in Survivors of the ICU
Sheetal Gandotra, D. Clark Files, Katherine L. Shields, Michael J. Berry, Rita N. Bakhru> ;Physical Therapy. 2021 Sep 1
145 citations
Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults - United States, March-July 2021.
Mark W Tenforde, Wesley H. Self, Eric A. Naioti, Adit A. Ginde, David J. Douin, Samantha M. Olson, H. Keipp Talbot, Jonathan D Casey, Nicholas M. Mohr, Anne Zepeski, M...> ;MMWR. Morbidity and Mortality Weekly Report. 2021 Aug 27
7 citations
Influenza vaccine acceptance and hesitancy among adults hospitalized with severe acute respiratory illnesses, United States 2019-2020.
Kelsey L Lytle, Sean P. Collins, Leora R. Feldstein, Adrienne Baughman, Samuel M. Brown, Jonathan D Casey, Heidi L Erickson, Matthew C. Exline, D. Clark Files, Kevin W...> ;Vaccine. 2021 Aug 7
88 citations
Effectiveness of SARS-CoV-2 mRNA Vaccines for Preventing Covid-19 Hospitalizations in the United States.
Mark W Tenforde, Manish M. Patel, Adit A. Ginde, David J. Douin, H. Keipp Talbot, Jonathan D Casey, Nicholas M. Mohr, Anne Zepeski, Manjusha Gaglani, Tresa McNeal, She...> ;Clinical Infectious Diseases. 2021 Aug 6
2 citations
Adults Hospitalized With Coronavirus Disease 2019 (COVID-19)-United States, March-June and October-December 2020: Implications for the Potential Effects of COVID-19 Ti...
Samira Sami, Mark W Tenforde, H. Keipp Talbot, Christopher J. Lindsell, Jay S. Steingrub, Nathan I. Shapiro, Adit A. Ginde, David J. Douin, Matthew E. Prekker, Heidi L...> ;Clinical Infectious Diseases. 2021 Jul 15
91 citations
Effectiveness of SARS-CoV-2 mRNA Vaccines for Preventing Covid-19 Hospitalizations in the United States
Mark W Tenforde, Manish M. Patel, Adit A. Ginde, David J. Douin, H. Keipp Talbot, Jonathan D Casey, Nicholas M. Mohr, Anne Zepeski, Manjusha Gaglani, Tresa McNeal, She...> ;Medrxiv. 2021 Jul 8
6 citations
Long-Term Outcomes in Acute Respiratory Distress Syndrome: Epidemiology, Mechanisms, and Patient Evaluation
Jessica A. Palakshappa, Jennifer Krall, Lanazha T. Belfield, D. Clark Files> ;Critical Care Clinics. 2021 May 27
4 citations
Modeling the impacts of clinical influenza testing on influenza vaccine effectiveness estimates.
Leora R. Feldstein, Jill M. Ferdinands, Wesley H. Self, Adrienne G. Randolph, Michael S. Aboodi, Adrienne Baughman, Samuel M. Brown, Matthew C. Exline, D. Clark Files,...> ;The Journal of Infectious Diseases. 2021 May 20
23 citations
A Pilot Study to Assess the Circulating Renin-Angiotensin-System in COVID-19 Acute Respiratory Failure.
D. Clark Files, Kevin W Gibbs, Chris L. Schaich, Sean P. Collins, TanYa M. Gwathmey, Jonathan D Casey, Wesley H. Self, Mark C. Chappell> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2021 May 19
7 citations
A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure
Raymond J. Langley, Marie E. Migaud, Lori Flores, J. Will Thompson, Elizabeth A. Kean, Murphy M. Mostellar, Matthew Mowry, Patrick Luckett, Lina Purcell, James Lovato,...> ;Scientific Reports. 2021 May 18
10 citations
Activated mast cells in skeletal muscle can be a potential mediator for cancer-associated cachexia.
D. Brooke Widner, Chun Liu, Qingxia Zhao, Sarah Sharp, Matthew R. Eber, Sun H. Park, D. Clark Files, Yusuke Shiozawa> ;Journal of Cachexia, Sarcopenia and Muscle. 2021 May 18
198 citations
Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Among Hospitalized Adults Aged ≥65 Years - United States, January-March 2021.
Mark W Tenforde, Samantha M. Olson, Wesley H. Self, H. Keipp Talbot, Christopher J. Lindsell, Jay S. Steingrub, Nathan I. Shapiro, Adit A. Ginde, David J. Douin, Matth...> ;MMWR. Morbidity and Mortality Weekly Report. 2021 May 7
6 citations
Macrophages augment the skeletal muscle proinflammatory response through TNFα following LPS-induced acute lung injury
Joseph J. Bivona, Hanna M. Crymble, Blas A. Guigni, Renee D. Stapleton, D. Clark Files, Michael J. Toth, Matthew E. Poynter, Benjamin T. Suratt> ;FASEB Journal. 2021 Apr 1
3 citations
Detection of Cognitive Impairment after Critical Illness with the Medicare Annual Wellness Visit: A Cohort Study
Jessica A. Palakshappa, Kathryn E. Callahan, Nicholas M. Pajewski, Daniel Clark Files, James J Willard, Jeff D. Williamson> ;Annals of the American Thoracic Society. 2021 Oct 1
22 citations
ICU Bed Utilization During the Coronavirus Disease 2019 Pandemic in a Multistate Analysis-March to June 2020.
David J. Douin, Michael J. Ward, Christopher J. Lindsell, Michelle P Howell, Catherine L. Hough, Matthew C. Exline, Michelle N. Gong, Michael S. Aboodi, Mark W Tenford...> ;Critical Care Explorations. 2021 Mar 12
17 citations
Symptoms and recovery among adult outpatients with and without COVID-19 at 11 healthcare facilities-July 2020, United States.
Kiva A Fisher, Samantha M. Olson, Mark W Tenforde, Wesley H. Self, Michael Wu, Christopher J. Lindsell, Nathan I. Shapiro, D. Clark Files, Kevin W Gibbs, Heidi L Erick...> ;Influenza and Other Respiratory Viruses. 2021 Jan 6
280 citations
Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
Wesley H. Self, Matthew W. Semler, Lindsay M. Leither, Jonathan D Casey, Derek C. Angus, Roy G. Brower, Steven Y. Chang, Sean P. Collins, John Eppensteiner, Michael R....> ;JAMA. 2020 Dec 1
101 citations
Decline in SARS-CoV-2 Antibodies After Mild Infection Among Frontline Health Care Personnel in a Multistate Hospital Network-12 States, April-August 2020
Wesley H. Self, Mark W Tenforde, William B. Stubblefield, Leora R. Feldstein, Jay S. Steingrub, Nathan I. Shapiro, Adit A. Ginde, Matthew E. Prekker, Samuel M. Brown, ...> ;MMWR. Morbidity and Mortality Weekly Report. 2020 Nov 27
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