DanielJLindnerMDPhD

General Surgery • Cleveland, OH

Assistant Professor, Molecular Medicine, Case Western Reserve University School of Medicine

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Office
Cleveland Clinic Main Campus
9500 Euclid Avenue
Cleveland, OH 44195
Phone+1 216-445-0548
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Education & Training

Georgetown University School of MedicineClass of 1981

Publications & Presentations

PubMed

Retraction: Identification and characterization of GRIM-1, a cell-death-associated gene product.
Edward R. Hofmann, Shreeram C. Nallar, Limei Lin, Jonathan D'Cunha, Daniel J. Lindner, Xiao Weihua, Dhananjaya V. Kalvakolanu> ;Journal of Cell Science. 2021 Nov 15
7 citations
PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation.
Xiaorong Gu, Francis Enane, Rita Tohme, Caroline Schuerger, Tomas Radivoyevitch, Yvonne Parker, Eric Zuberi, Bartlomiej P Przychodzen, Babal K. Jha, Daniel J. Lindner,...> ;Cell Reports. 2021 Sep 21
10 citations
Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma.
Metis Hasipek, Dale Grabowski, Yihong Guan, Raghunandan Reddy Alugubelli, Anand D. Tiwari, Xiaorong Gu, Gabriel DeAvila, Ariosto S. Silva, Mark B. Meads, Yvonne Parker...> ;Cancers. 2021 May 28
5 citations
Vascular Patterning as Integrative Readout of Complex Molecular and Physiological Signaling by VESsel GENeration Analysis.
Mark Lagatuz, Ruchi J. Vyas, Marina Predovic, Shiyin Lim, Nicole M. Jacobs, Miguel Martinho, Hamed Valizadegan, David L. Kao, Nikunj C. Oza, Corey A. Theriot, Susana B...> ;Journal of Vascular Research. 2021 Apr 9
6 citations
A pilot clinical trial of oral tetrahydrouridine/decitabine for noncytotoxic epigenetic therapy of chemoresistant lymphoid malignancies.
Brian T. Hill, Deepa Jagadeesh, Brad Pohlman, Robert M. Dean, Neetha Parameswaran, Joel Chen, Tomas Radivoyevitch, Ashley Morrison, Sherry Fada, Meredith Dever, Shelle...> ;Seminars in Hematology. 2021 Jan 1
4 citations
Nitric Oxide Inhibits NF-κB-mediated Survival Signaling: Possible Role in Overcoming TRAIL Resistance.
Joseph A. Bauer, Joseph A. Lupica, Joseph A. DiDonato, Daniel J. Lindner> ;Anticancer Research. 2020 Dec 7
3 citations
A Therapeutic Strategy for Preferential Targeting of TET2 Mutant and TET-dioxygenase Deficient Cells in Myeloid Neoplasms.
Yihong Guan, Anand D Tiwari, James G Phillips, Metis Hasipek, Dale R Grabowski, Simona Pagliuca, Priyanka Gopal, Cassandra M Kerr, Vera Adema, Tomas Radivoyevitch, Yvo...> ;Blood Cancer Discovery. 2021 Mar 1
7 citations
CBL0137 increases the targeting efficacy of Rovalpituzumab tesirine against tumour-initiating cells in small cell lung cancer
Daniel J. Lindner, Gary Wildey, Yvonne Parker, Afshin Dowlati, George R. Stark, Sarmishtha De> ;British Journal of Cancer. 2021 Mar 2
1 citations
Comment on the importance of using nitric oxide gas in the synthesis of nitrosylcobalamin and ICH-validated methods to assess purity and stability.
Annette M. Sysel, Michael J Dunphy, Daniel J. Lindner, Joseph A. DiDonato, Joseph A. Lupica, Joseph A. Bauer> ;The Journal of Biological Chemistry. 2020 Oct 23
7 citations
Pharmacologic Inhibition of Ezrin-Radixin-Moesin Phosphorylation is a Novel Therapeutic Strategy in Rhabdomyosarcoma.
Austin M. Proudfit, Nabanita Bhunia, Debasis Pore, Yvonne Parker, Daniel J. Lindner, Neetu Gupta> ;Sarcoma. 2020 Sep 9
13 citations
A pilot clinical trial of the cytidine deaminase inhibitor tetrahydrouridine combined with decitabine to target DNMT1 in advanced, chemorefractory pancreatic cancer.
Davendra Sohal, Smitha S. Krishnamurthi, Rita Tohme, Xiaorong Gu, Daniel J. Lindner, Terry H. Landowski, John J. Pink, Tomas Radivoyevitch, Sherry Fada, Zhenghong Lee,...> ;American Journal of Cancer Research. 2020 Sep 1
1 citations
Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism
Maryam Zamanian-Daryoush, Daniel J. Lindner, Jennifer A. Buffa, Banu Gopalan, Jie Na, Stanley L. Hazen, Joseph A. DiDonato> ;Oncotarget. 2020 May 12
Withdrawal: Suppression of NF-κB survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL.
Mamta Chawla-Sarkar, Joseph A Bauer, Joseph A Lupica, Bei H Morrison, Zhuo Tang, Rhonda K Oates, Alex Almasan, Joseph A DiDonato, Ernest C Borden, Daniel J Lindner> ;The Journal of Biological Chemistry. 2019 Nov 29
26 citations
MiR-644a Disrupts Oncogenic Transformation and Warburg Effect by Direct Modulation of Multiple Genes of Tumor-Promoting Pathways.
Jey Sabith Ebron, Eswar Shankar, Jagjit Singh, Kavleen Sikand, Crystal M. Weyman, Sanjay Gupta, Daniel J. Lindner, Xiaoqi Liu, Moray J. Campbell, Girish C. Shukla> ;Cancer Research. 2019 Apr 15
3 citations
Chronic myeloid leukemia: Two mysteries.
Tomas Radivoyevitch, Trine N. Jørgensen, Daniel J. Lindner, Jaroslaw P. Maciejewski, Yasushi Miyazaki, Robert Peter Gale> ;Leukemia Research. 2019 Feb 12
34 citations
The FACT inhibitor CBL0137 Synergizes with Cisplatin in Small-Cell Lung Cancer by Increasing NOTCH1 Expression and Targeting Tumor-Initiating Cells
Sarmishtha De, Daniel J. Lindner, Claire J. Coleman, Gary Wildey, Afshin Dowlati, George Stark Stark> ;Cancer Research. 2018 Jan 1
57 citations
Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis
Keiichi Asano, Courtney M. Nelson, Sumeda Nandadasa, Noriko Aramaki-Hattori, Daniel J. Lindner, Tyler J. Alban, Junko Inagaki, Takashi Ohtsuki, Toshitaka Oohashi, Sune...> ;Scientific Reports. 2017 Dec 8
13 citations
PRO 140 Monoclonal Antibody to CCR5 Prevents Acute Xenogeneic Graft-versus-Host Disease in NOD-scid IL-2Rynull Mice
Denis R. Burger, Yvonne Parker, Kathryn M Guinta, Daniel J. Lindner> ;Biology of Blood and Marrow Transplantation. 2018 Feb 1
47 citations
Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1-Mediated Macrophage Infiltration.
Khalid Sossey-Alaoui, Elzbieta Pluskota, Katarzyna Bialkowska, Dorota Szpak, Yvonne Parker, Chevaun D. Morrison, Daniel J. Lindner, William P Schiemann, Edward F. Plow> ;Cancer Research. 2017 Sep 15
53 citations
CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors.
Caner Saygin, Andrew Wiechert, Vinay S. Rao, Ravi Kumar Alluri, Elizabeth V. Connor, Praveena S. Thiagarajan, James S. Hale, Yan Li, Anastasia Chumakova, Awad Jarrar, ...> ;The Journal of Experimental Medicine. 2017 Sep 4
31 citations
Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis.
Peng Yao, Jiangbin Wu, Daniel J. Lindner, Paul L. Fox> ;Nucleic Acids Research. 2017 Jul 27
23 citations
Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer
Maryam Zamanian-Daryoush, Daniel J. Lindner, Joseph A. DiDonato, Matthew A. Wagner, Jennifer A. Buffa, Patricia Rayman, John S. Parks, Marit Westerterp, Alan R. Tall, ...> ;Oncotarget. 2017 Jun 27
5 citations
Peginterferon Beta-1a Shows Antitumor Activity as a Single Agent and Enhances Efficacy of Standard of Care Cancer Therapeutics in Human Melanoma, Breast, Renal, and Co...
Antonio Boccia, Cyrus Virata, Daniel J. Lindner, Nicki English, Nuzhat Pathan, Margot Brickelmaier, Xiao Hu, Jennifer L. Gardner, Liaomin Peng, Xinzhong Wang, Xiamei Z...> ;Journal of Interferon & Cytokine Research. 2017 Jan 1
19 citations
Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming
Praveena S. Thiagarajan, Xiaoliang Wu, Wei Zhang, Ivy Shi, Rakesh Bagai, Patrick Leahy, Yan Feng, Marty L Veigl, Daniel J. Lindner, David Danielpour, Lihong Yin, Rafae...> ;Oncotarget. 2016 Nov 11
35 citations
MEK inhibition abrogates sunitinib resistance in a renal cell carcinoma patient-derived xenograft model.
C. Marcela Diaz-Montero, Frances Mao, John Barnard, Yvonne Parker, Maryam Zamanian-Daryoush, John J. Pink, James H. Finke, Brian I. Rini, Daniel J. Lindner> ;British Journal of Cancer. 2016 Aug 25
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Abstracts/Posters

Hypomethylating Agent 5-Azacytidine Sensitizes Peripheral T-Cell Lymphoma to SLAMF7-Targeting Therapeutic Antibody, Elotuzumab
Daniel Lindner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
TET Dioxygenase Inhibition As a Therapeutic Strategy in TET2 Mutant Myeloid Neoplasia
Daniel Lindner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

Development of a Novel Class of Agents Targeting the RNA-Splicing Machinery in Myeloid Malignancies
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

The Kindlin2-p53-SerpinB2 Signaling Axis Is Required for Cellular Senescence in Breast CancerJuly 15th, 2020
CytoDyn Initiates Pre-Clinical Study of Leronlimab (PRO 140) to Prevent NASH with the Cleveland Clinic’s Dr. Daniel J. Lindner, M.D., Ph.D.May 13th, 2019
ASH 2018: Dec 1-4December 1st, 2017
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Grant Support

Nitrosylcobalamin - A Novel Chemotherapeutic AgentNational Cancer Institute2004–2007
Inositol Hexakisphosphate Kinase 2:Apoptosis RegulatorNational Cancer Institute2004–2006
Inositol Hexakisphosphate Kinase 2:Apoptosis RegulatorNational Cancer Institute2003

Hospital Affiliations

Cleveland ClinicCleveland, Ohio