DanielAdolfoLlanoMDPhD

Neurology • Urbana, IL

Associate Professor in Molecular and Integrative Physiology and the Beckman Institute

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Office
611 W. Park St.
Urbana, IL 61801
Phone+1 217-383-3440

Fax+1 217-326-0160
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Clinical Expertise

Speech and language disorders, Cognitive disorders, Alzheimer's disease, Movement disorders

Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Neurology, 2003 - 2006
Massachusetts General HospitalInternship, Internal Medicine, 2002 - 2003
University of Illinois College of MedicineClass of 2002

Certifications & Licensure

IL State Medical License 2006 - 2026
MO State Medical License 2021 - 2023
MA State Medical License 2004 - 2007
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

Presidential Early Career Award for Scientists and Engineers (PECASE) 2019
Helen Corley Petit Scholar University of Illinois Urbana-Champaign, 2017
Advances in Medicine Award Carle Hospital, 2016
Golden Apple Teaching Award University of Illinois College of Medicine, 2015
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Publications & Presentations

PubMed

3 citations
Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.
Madan Ghimire, Rui Cai, Lynne Ling, Kevin A Brownell, Troy A Hackett, Daniel A Llano, Donald M Caspary> ;The Journal of Physiology. 2023 Jun 1
1 citations
Role of auditory-somatosensory corticothalamic circuit integration in analgesia.
Dimitri L Brunelle, Daniel A Llano> ;Cell Calcium. 2023 May 1
5 citations
CSF peptides from VGF and other markers enhance prediction of MCI to AD progression using the ATN framework.
Daniel A Llano, Priya Devanarayan, Viswanath Devanarayan> ;Neurobiology of Aging. 2023 Jan 1
Functional Neurological Symptom Disorder Manifesting as Auditory Verbal Agnosia in a 19-Year-Old Patient.
Suzanna Kitten, Neel D Jani, Daniel A Llano> ;Cureus. 2022 Aug 1
Disrupted Value-Directed Strategic Processing in Individuals with Mild Cognitive Impairment: Behavioral and Neural Correlates.
Lydia T Nguyen, Elizabeth A Lydon, Shraddha A Shende, Daniel A Llano, Raksha A Mudar> ;Geriatrics. 2022 May 11
4 citations
Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity.
Jennifer M Walters, Eung Chang Kim, Jiaren Zhang, Han Gil Jeong, Archit Bajaj, Brian C Baculis, Gregory C Tracy, Baher Ibrahim, Catherine A Christian-Hinman, Daniel A ...> ;Epilepsia. 2022 May 1
5 citations
Alzheimer's Disease, Hearing Loss, and Deviance Detection.
David Pérez-González, Thomas G Schreiner, Daniel A Llano, Manuel S Malmierca> ;Frontiers in Neuroscience. 2022 Jan 1
2 citations
Patterns of Unilateral and Bilateral Projections From Layers 5 and 6 of the Auditory Cortex to the Inferior Colliculus in Mouse
Nathiya Vaithiyalingam Chandra Sekaran, Meena S Deshpande, Baher A. Ibrahim, Gang Xiao, Yoshitaka Shinagawa, Daniel A. Llano> ;Frontiers in Systems Neuroscience. 2021 Oct 21
6 citations
Evidence for Layer-Specific Connectional Heterogeneity in the Mouse Auditory Corticocollicular System.
Georgiy Yudintsev, Alexander R. Asilador, Stacy K. Sons, Nathiya Vaithiyalingam Chandra Sekaran, Macey Coppinger, Kavya Nair, Masumi Prasad, Gang Xiao, Baher A. Ibrahi...> ;The Journal of Neuroscience. 2021 Oct 20
8 citations
Reported Hearing Loss in Alzheimer's Disease Is Associated With Loss of Brainstem and Cerebellar Volume.
Daniel A. Llano, Susanna S. Kwok, Viswanath Devanarayan> ;Frontiers in Human Neuroscience. 2021 Sep 24
2 citations
The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection.
Kendra D. Maclaine, Kevin A. Stebbings, Daniel A. Llano, Justin C. Havird> ;BMC Genomic Data. 2021 Jun 30
Nicotinic ganglionic acetylcholine receptor autoantibodies associated with paraneoplastic disease in a neuropsychiatric patient.
Daniel A. Llano, Suzanna Kitten, Catherine Stauffer> ;BMJ Case Reports. 2021 May 27
3 citations
Corticothalamic gating of population auditory thalamocortical transmission in mouse.
Baher A. Ibrahim, Caitlin A Murphy, Georgiy Yudintsev, Yoshitaka Shinagawa, Matthew I. Banks, Daniel A. Llano> ;Elife. 2021 May 24
16 citations
Serum Phosphatidylethanolamine and Lysophosphatidylethanolamine Levels Differentiate Alzheimer's Disease from Controls and Predict Progression from Mild Cognitive Impa...
Daniel A. Llano, Viswanath Devanarayan, Alzheimer’s Disease Neuroimaging Initiative> ;Journal of Alzheimer's Disease. 2021 Jan 1
21 citations
Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections.
Alexander R. Asilador, Daniel A. Llano> ;Frontiers in Neural Circuits. 2021 Jan 22
5 citations
Developmental PCB Exposure Disrupts Synaptic Transmission and Connectivity in the Rat Auditory Cortex, Independent of Its Effects on Peripheral Hearing Threshold.
Christopher M. Lee, Renee N. Sadowski, Susan L. Schantz, Daniel A. Llano> ;Eneuro. 2021 Jan 1
2 citations
A novel dynamic network imaging analysis method reveals aging-related fragmentation of cortical networks in mouse.
Daniel A. Llano, Chihua Ma, Umberto Di Fabrizio, Aynaz Taheri, Kevin A. Stebbings, Georgiy Yudintsev, Gang Xiao, Robert V. Kenyon, Tanya Y. Berger-Wolf> ;Network Neuroscience. 2021 Jan 1
1 citations
Hitting The Right Spot: NMDA Receptors in the Auditory Thalamus May Hold the Key to Understanding Schizophrenia
Gang Xiao, Daniel A. Llano> ;The International Journal of Neuropsychopharmacology. 2020 Dec 3
13 citations
Hearing Loss in Alzheimer's Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles.
Daniel A. Llano, Lina K Issa, Priya Devanarayan, Viswanath Devanarayan, Alzheimer's Disease Neuroimaging Initiative Adni> ;Cells. 2020 Nov 28
1 citations
Simultaneous two-photon activation and imaging of neural activity based on spectral–temporal modulation of supercontinuum light
Yuan-Zhi Liu, Carlos Renteria, Connor D. Courtney, Baher A. Ibrahim, Sixian You, Eric J. Chaney, Ronit Barkalifa, Rishyashring R. Iyer, Mantas Zurauskas, Haohua Tu, Da...> ;Neurophotonics. 2020 Nov 3
16 citations
TRPM8 as the rapid testosterone signaling receptor: Implications in the regulation of dimorphic sexual and social behaviors.
Adithya Mohandass, Vivek Krishnan, Ekaterina Gribkova, Swapna Asuthkar, Padmamalini Baskaran, Yelena Nersesyan, Zahir Hussain, Leslie Wise, Robert George, Nadarra Stok...> ;FASEB Journal. 2020 Aug 1
33 citations
Does hearing loss lead to dementia? A review of the literature
Yosra Nadhimi, Daniel A. Llano> ;Hearing Research. 2021 Mar 15
16 citations
Circuit Mechanisms Underlying the Segregation and Integration of Parallel Processing Streams in the Inferior Colliculus.
Alexandria M.H. Lesicko, Stacy K. Sons, Daniel A. Llano> ;The Journal of Neuroscience. 2020 Aug 12
5 citations
Investigating EEG theta and alpha oscillations as measures of value-directed strategic processing in cognitively normal younger and older adults.
Lydia T. Nguyen, Francesco Marini, Shraddha A. Shende, Daniel A. Llano, Raksha A. Mudar> ;Behavioural Brain Research. 2020 May 24
7 citations
Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging.
Kendra D. Maclaine, Kevin A. Stebbings, Daniel A. Llano, Justin S. Rhodes> ;Plos One. 2020 Mar 2
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Journal Articles

Thalamocortical and Intracortical Inputs Differentiate Layer-Specific Mouse Auditory Corticocollicular Neurons
Daniel Llano, MD, The Journal of Neuroscience

Grant Support

Diminished cortical GABAergic inhibition in mouse model of Alzheimer DiseaseAlzheimer Association2012–Present
Changes in Auditory Cortical Circuitry in Aging: Exploration of the Links between Aging and the Cortical Circuitry of AttentionAmerican Federation for Aging Research2011–Present
Functional organization of the auditory corticocollicular systemNIDCD2014–2019
CRCNS: Community Dynamic Imaging of Corticothalamic ProjectionsNSF2015–2018
Age-Related Changes In Gabaergic Influence On Auditory Corticothalamic ProjectionNational Institute On Deafness And Other Communication Disorders2011
Functional Organization Of Auditory Corticothalamic Projection SystemsNational Institute On Deafness And Other Communication Disorders2006–2007