DanielMRosenbaumMD

Neurology • Brooklyn, NY

Spinal Disorder, Vascular Neurology

Visiting Professor, Neurology, Albert Einstein College of Medicine

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Office
450 Clarkson Ave
Brooklyn, NY 11203
Phone+1 718-270-2051

Fax+1 718-270-3840
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Education & Training

University of Texas Health Science Center at HoustonFellowship, Vascular Neurology, 1986 - 1987
Montefiore Medical Center/Albert Einstein College of MedicineResidency, Neurology, 1983 - 1986
One Brooklyn Health System/Brookdale University Hospital and Medical CenterInternship, Internal Medicine, 1982 - 1983
Albert Einstein College of MedicineClass of 1982

Certifications & Licensure

NY State Medical License 1984 - 2025
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Vascular Neurology

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com

Publications & Presentations

PubMed

5 citations
Molecular basis for ligand modulation of the cannabinoid CB1 receptor.
Karthik Ramesh, Daniel M. Rosenbaum> ;British Journal of Pharmacology. 2021 Aug 12
16 citations
Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing.
Daniel L. Kober, Arun Radhakrishnan, Joseph L. Goldstein, Michael S. Brown, Lindsay Clark, Xiao Chen Bai, Daniel M. Rosenbaum> ;Cell. 2021 Jul 8
75 citations
Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes
Peng Xiao, Wei Yan, Lu Gou, Ya Ni Zhong, Liangliang Kong, Chao Wu, Xin Wen, Yuan Yuan, Sheng Cao, Changxiu Qu, Xin Yang, Chuan Cheng Yang, Anjie Xia, Zhenquan Hu, Qian...> ;Cell. 2021 Feb 18
138 citations
Structural and functional diversity calls for a new classification of ABC transporters.
Christoph Thomas, Stephen G. Aller, Konstantinos Beis, Elisabeth P. Carpenter, Geoffrey Chang, Lei Chen, Elie Dassa, Michael Dean, Franck Duong Van Hoa, Damian C. Ekie...> ;FEBS Letters. 2020 Dec 1
19 citations
Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis.
Daniel L. Kober, Shimeng Xu, Shili Li, Bilkish Bajaj, Guosheng Liang, Daniel M. Rosenbaum, Arun Radhakrishnan> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Nov 10
7 citations
Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor.
Jakub Gunera, Jillian G. Baker, Niek van Hilten, Daniel M. Rosenbaum, Peter Kolb> ;Journal of Medicinal Chemistry. 2020 Oct 8
26 citations
Structure-based development of a subtype-selective orexin 1 receptor antagonist
Jan Hellmann, Matthäus Drabek, Jie Yin, Jakub Gunera, Theresa Pröll, Frank Kraus, Christopher J. Langmead, Harald Hübner, Dorothee Weikert, Peter Kolb, Daniel M. Rosen...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Jul 28
111 citations
Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane
Jie Yin, Kuang Yui M. Chen, Mary J. Clark, Mahdi Hijazi, Punita Kumari, Xiao Chen Bai, Roger K. Sunahara, Patrick Barth, Daniel M. Rosenbaum> ;Nature. 2020 Jun 11
100 citations
Structure of an allosteric modulator bound to the CB1 cannabinoid receptor.
Zhenhua Shao, Wei Yan, Karen M. Chapman, Karthik Ramesh, Aaron J. Ferrell, Jie Yin, Xuehui Wang, Qingping Xu, Daniel M. Rosenbaum> ;Nature Chemical Biology. 2019 Oct 28
8 citations
Improved strategy for isoleucine 1 H/ 13 C methyl labeling in Pichia pastoris
Rustam Ali, Lindsay Clark, Jacob A. Zahm, Andrew Lemoff, Karthik Ramesh, Daniel M. Rosenbaum, Michael K. Rosen> ;Journal of Biomolecular NMR. 2019 Sep 20
48 citations
An improved yeast surface display platform for the screening of nanobody immune libraries.
Tomasz Uchański, Thomas Zögg, Jie Yin, Daopeng Yuan, Alexandre Wohlkonig, Baptiste Fischer, Daniel M. Rosenbaum, Brian K. Kobilka, Els Pardon, Jan Steyaert> ;Scientific Reports. 2019 Jan 23
5 citations
Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics.
Igor Dikiy, Lindsay Clark, Kevin H. Gardner, Daniel M. Rosenbaum> ;Methods in Enzymology. 2019 Jan 1
23 citations
Crystal structure of the human NK1 tachykinin receptor.
Jie Yin, Karen M. Chapman, Lindsay Clark, Zhenhua Shao, Dominika Borek, Qingping Xu, Junmei Wang, Daniel M. Rosenbaum> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Dec 26
28 citations
On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies.
Lindsay Clark, Igor Dikiy, Daniel M. Rosenbaum, Kevin H. Gardner> ;Journal of Biomolecular NMR. 2018 Aug 1
46 citations
Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
Ryoji Suno, Kanako Terakado Kimura, Takanori Nakane, Keitaro Yamashita, Junmei Wang, Takaaki Fujiwara, Yasuaki Yamanaka, Dohyun Im, Shoichiro Horita, Hirokazu Tsujimot...> ;Structure. 2018 Jan 2
60 citations
Ligand modulation of sidechain dynamics in a wild-type human GPCR.
Lindsay Clark, Igor Dikiy, Karen M. Chapman, Karin E J Rödström, James M. Aramini, Michael V. LeVine, George Khelashvili, Søren G. F. Rasmussen, Kevin H. Gardner, Dani...> ;Elife. 2017 Oct 6
26 citations
The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits
Jin Zhou, Jie Li, Daniel M. Rosenbaum, Jian Zhuang, Carrie Poon, Pu Qin, Katrina Rivera, John J. Lepore, Robert N. Willette, Erding Hu, Frank C. Barone> ;Plos One. 2017 Sep 7
3 citations
The Human Orexin/Hypocretin Receptor Crystal Structures.
Jie Yin, Daniel M. Rosenbaum> ;Current Topics in Behavioral Neurosciences. 2016 Dec 27
275 citations
High-resolution crystal structure of the human CB1 cannabinoid receptor
Zhenhua Shao, Jie Yin, Karen M. Chapman, Magdalena Grzemska, Lindsay Clark, Junmei Wang, Daniel M. Rosenbaum> ;Nature. 2016 Dec 22
15 citations
Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS*
Yinxin Zhang, Kwang Min Lee, Lisa N. Kinch, Lindsay Clark, Nick V. Grishin, Daniel M. Rosenbaum, Michael S. Brown, Joseph L. Goldstein, Arun Radhakrishnan> ;The Journal of Biological Chemistry. 2016 Jun 10
191 citations
Crystal structure of the human sterol transporter ABCG5/ABCG8
Jyh-Yeuan Lee, Lisa N. Kinch, Dominika Borek, Jin Wang, Junmei Wang, Ina L. Urbatsch, Xiao Song Xie, Nikolai V. Grishin, Jonathan C. Cohen, Zbyszek Otwinowski, Helen H...> ;Nature. 2016 May 26
95 citations
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
Jie Yin, Kerim Babaoglu, Chad A. Brautigam, Lindsay Clark, Zhenhua Shao, Thomas H. Scheuermann, Charles M. Harrell, Anthony L. Gotter, Anthony J. Roecker, Christopher ...> ;Nature Structural & Molecular Biology. 2016 Apr 1
Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris
Lindsay Clark, Jacob A. Zahm, Rustam Ali, Maciej Kukula, Liangqiao Bian, Steven M. Patrie, Kevin H. Gardner, Michael K. Rosen, Daniel M. Rosenbaum> ;Journal of Biomolecular NMR. 2016 Feb 19
33 citations
Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris
Lindsay Clark, Jacob A. Zahm, Rustam Ali, Maciej Kukula, Liangqiao Bian, Steven M. Patrie, Kevin H. Gardner, Michael K. Rosen, Daniel M. Rosenbaum> ;Journal of Biomolecular NMR. 2015 May 30
151 citations
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Jie Yin, Juan Carlos Mobarec, Peter Kolb, Daniel M. Rosenbaum> ;Nature. 2015 Mar 12
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