DanielleKSandsmarkMD

Neurology • Philadelphia, PA

Neurocritical Care

Assistant Professor at Hospital of the University of Pennsylvania

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Office
3400 Civic Center Blvd
2nd Floor, South Pavilion
Philadelphia, PA 19104
Phone+1 215-662-3606
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Education & Training

University of Pennsylvania Health SystemFellowship, Neurocritical Care, 2012 - 2014
University of Pennsylvania Health SystemResidency, Neurology, 2009 - 2012
Washington University/B-JH/SLCH ConsortiumInternship, Internal Medicine, 2008 - 2009
Washington University in St. Louis School of MedicineClass of 2008

Certifications & Licensure

PA State Medical License 2009 - 2024
American Board of Psychiatry and Neurology Neurology

Publications & Presentations

PubMed

The Importance of Social Contact on Brain Atrophy Among Older Individuals.
Alexa E Walter, Danielle K Sandsmark> ;Neurology. 2023 Sep 12
Patients' Perspectives on Life and Recovery 1 Year After COVID-19 Hospitalization.
Carolyn P Chow, Christopher F Chesley, Michaela Ward, Rebecca Neergaard, Taara V Prasad, Erich M Dress, Sara Reagan, Priyanka Kalyani, Nathan Smyk, Alexandra P Turner,...> ;Journal of General Internal Medicine. 2023 Aug 1
Imaging Approach to Concussion.
Jeffrey B Ware, Danielle K Sandsmark> ;Neuroimaging Clinics of North America. 2023 May 1
6 citations
Clinical Updates in Mild Traumatic Brain Injury (Concussion).
Megan Moore, Danielle K Sandsmark> ;Neuroimaging Clinics of North America. 2023 May 1
1 citations
Associations of Microvascular Injury-Related Biomarkers With Traumatic Brain Injury Severity and Outcomes: A Transforming Research and Clinical Knowledge in Traumatic ...
Andrea L C Schneider, J Russell Huie, Sonia Jain, Xiaoying Sun, Adam R Ferguson, Cillian Lynch, John K Yue, Geoffrey T Manley, Kevin K W Wang, Danielle K Sandsmark, Ch...> ;Journal of Neurotrauma. 2023 Aug 1
2 citations
Structural brain network deviations predict recovery after traumatic brain injury.
James J Gugger, Nishant Sinha, Yiming Huang, Alexa E Walter, Cillian Lynch, Priyanka Kalyani, Nathan Smyk, Danielle Sandsmark, Ramon Diaz-Arrastia, Kathryn A Davis> ;Neuroimage. Clinical. 2023 Jan 1
Adherence to Established Blood Pressure Targets and Associated Complications in Patients Presenting with Acute Intracerebral Hemorrhage.
Nicole A Leshko, Raymond F Lamore, Megan K Zielke, Danielle K Sandsmark, Lauren E Schmidt> ;Neurocritical Care. 2023 Oct 1
Plasma von Willebrand Factor Is Elevated Hyperacutely After Mild Traumatic Brain Injury.
Rachel Thomas, Cillian E Lynch, Jeff Debad, Christopher Campbell, Onyinyechi Chidomere, Joseph Kilianski, Kan Ding, Christopher Madden, Danielle K Sandsmark, Ramon Dia...> ;Neurotrauma Reports. 2023 Jan 1
1 citations
Neurotrauma.
Grace Niziolek, Danielle K Sandsmark, Jose L Pascual> ;Current Opinion in Critical Care. 2022 Dec 1
1 citations
Longitudinal Abnormalities in White Matter Extracellular Free Water Volume Fraction and Neuropsychological Functioning in Patients with Traumatic Brain Injury.
James J Gugger, Alexa E Walter, Drew Parker, Nishant Sinha, Justin Morrison, Jeffrey Ware, Andrea L C Schneider, Dmitriy Petrov, Danielle K Sandsmark, Ragini Verma, Ra...> ;Journal of Neurotrauma. 2023 Apr 1
2 citations
Dynamic contrast enhanced MRI for characterization of blood-brain-barrier dysfunction after traumatic brain injury.
Jeffrey B Ware, Saurabh Sinha, Justin Morrison, Alexa E Walter, James J Gugger, Andrea L C Schneider, Cian Dabrowski, Hannah Zamore, Leroy Wesley, Brigid Magdamo, Dmit...> ;Neuroimage. Clinical. 2022 Jan 1
11 citations
Six-Month Impairment in Cognition, Mental Health, and Physical Function Following COVID-19-Associated Respiratory Failure.
Jason H Maley, Danielle K Sandsmark, Alison Trainor, Geoffrey D Bass, Cian L Dabrowski, Brigid A Magdamo, Bridget Durkin, Margaret M Hayes, Richard M Schwartzstein, Je...> ;Critical Care Explorations. 2022 Apr 1
17 citations
Extracellular vesicles as distinct biomarker reservoirs for mild traumatic brain injury diagnosis.
Kryshawna Beard, Zijian Yang, Margalit Haber, Miranda Flamholz, Ramon Diaz-Arrastia, Danielle K. Sandsmark, David F. Meaney, David Issadore> ;Brain Communications. 2021 Jul 1
7 citations
Devastating Neurological Injury as a Result of Treatment of "Chronic Lyme Disease"
Sarah Frankl, Peter N. Hadar, Aleksandra Yakhkind, Adam Edward Lang, Danielle K. Sandsmark> ;Mayo Clinic Proceedings. 2021 Jul 1
4 citations
Arterial Spin Labeling Reveals Elevated Cerebral Blood Flow with Distinct Clusters of Hypo- and Hyperperfusion after Traumatic Brain Injury.
Linda Xu, Jeffrey B. Ware, Junghoon Kim, Pashtun Shahim, Erika Silverman, Brigid Magdamo, Cian Dabrowski, Leroy Wesley, My Duyen Le, Justin Morrison, Hannah Zamore, Ci...> ;Journal of Neurotrauma. 2021 Jun 10
10 citations
Imaging biomarkers of vascular and axonal injury are spatially distinct in chronic traumatic brain injury.
Margalit Haber, Franck Amyot, Cillian E Lynch, Danielle K. Sandsmark, Kimbra Kenney, John K Werner, Carol Moore, Kelley Flesher, Sarah Woodson, Erika Silverman, Yiyu C...> ;Journal of Cerebral Blood Flow and Metabolism. 2021 Jan 14
7 citations
Advances in traumatic brain injury research in 2020.
Danielle K. Sandsmark, Ramon Diaz-Arrastia> ;The Lancet. Neurology. 2021 Jan 1
48 citations
Multi-Dimensional Mapping of Brain-Derived Extracellular Vesicle MicroRNA Biomarker for Traumatic Brain Injury Diagnostics.
Jina Ko, Matthew A. Hemphill, Zijian Yang, Kryshawna Beard, Emily Sewell, Jamie Shallcross, Melissa Schweizer, Danielle K. Sandsmark, Ramon Diaz-Arrastia, Junhyong Kim...> ;Journal of Neurotrauma. 2020 Oct 28
2 citations
Unravelling the mechanisms of blood–brain barrier dysfunction in repetitive mild head injury
Jeffrey B. Ware, Danielle K. Sandsmark, Ramon Diaz-Arrastia> ;Brain. 2020 Jun 1
20 citations
Unsupervised Machine Learning Reveals Novel Traumatic Brain Injury Patient Phenotypes with Distinct Acute Injury Profiles and Long-Term Outcomes.
Kaitlin A. Folweiler, Danielle K. Sandsmark, Ramon Diaz-Arrastia, Akiva S. Cohen, Aaron J. Masino> ;Journal of Neurotrauma. 2020 May 27
8 citations
Molecular biomarkers in the neurological ICU: is there a role?
Ramon Diaz-Arrastia, Pashtun Shahim, Danielle K. Sandsmark> ;Current Opinion in Critical Care. 2020 Apr 1
68 citations
Cerebral Microvascular Injury: A Potentially Treatable Endophenotype of Traumatic Brain Injury-Induced Neurodegeneration.
Danielle K. Sandsmark, Asma Bashir, Cheryl L. Wellington, Ramon Diaz-Arrastia> ;Neuron. 2019 Aug 7
16 citations
Changes in Plasma von Willebrand Factor and Cellular Fibronectin in MRI-Defined Traumatic Microvascular Injury
Danielle K. Sandsmark, Tanya Bogoslovsky, Bao-Xi Qu, Margalit Haber, Martin R Cota, Cora Davis, John A. Butman, Lawrence L. Latour, Ramon Diaz-Arrastia> ;Frontiers in Neurology. 2019 Mar 26
34 citations
Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles
Jina Ko, Matthew A. Hemphill, Zijian Yang, Emily Sewell, Yj. Na, Danielle K. Sandsmark, Margalit Haber, Stephen A. Fisher, E. A. Torre, Kirsten C. Svane, Anton Omelche...> ;Lab on a Chip. 2018 Nov 20
16 citations
Vascular Abnormalities within Normal Appearing Tissue in Chronic Traumatic Brain Injury.
Margalit Haber, Franck Amyot, Kimbra Kenney, Tawny Meredith-Duliba, Carol Moore, Erika Silverman, Jamie E Podell, Yi Yu Chou, Dzung L. Pham, John A. Butman, Hanzhang L...> ;Journal of Neurotrauma. 2018 Sep 24
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Press Mentions

New Brain Scans May Show if a Concussion Has Not yet HealedMarch 22nd, 2023
Philadelphia Doctor Discusses Risk of Repeated Brain InjuriesSeptember 30th, 2022
Coming Together to Help COVID-19 “Long–Haulers”June 22nd, 2021
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Hospital Affiliations

Hospital of the University of PennsylvaniaPhiladelphia, Pennsylvania
Penn Presbyterian Medical CenterPhiladelphia, Pennsylvania
Pennsylvania HospitalPhiladelphia, Pennsylvania