DarlaKLilesMD

Oncology • Greenville, NC

Hematologic Oncology

Professor of Medicine, E Carolina University

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Office
600 Moye Blvd
Ecu Physicians - Leo Jenkins Cancer Services
Greenville, NC 27834
Phone+1 252-816-2273

Fax+1 252-744-7005
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Education & Training

University of North Carolina HospitalsFellowship, Hematology and Medical Oncology, 1990 - 1994
Vidant Medical Center/East Carolina UniversityInternship, Internal Medicine, 1986 - 1990
University of Missouri Kansas City School of MedicineClass of 1986

Certifications & Licensure

NC State Medical License 1990 - 2024
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises Start of enrollment: 2013 Jul 01
Completed
Phase 2
A Efficacy and Safety Study of R935788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) Start of enrollment: 2014 Jul 14
Completed
Phase 3
A Multi-Center Study of Riociguat in Patients With Sickle Cell Diseases Start of enrollment: 2017 Apr 11
Completed
Phase 2
A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia Start of enrollment: 2018 Nov 01
Completed
Phase 3
Rofecoxib Efficacy and Safety Evaluation Trial in Hemophilic Arthropathy Start of enrollment: 2021 Jun 02
Terminated
Phase 3
Roles: Contact, Principal Investigator
A Study of TAK-981 Given With Rituximab in Adults With Relapsed or Refractory CD20-Positive Non-Hodgkin Lymphoma Start of enrollment: 2019 Oct 15
Terminated
Phase 1, Phase 2
Roles: Principal Investigator
A Study of SHP655 (rADAMTS13) in Sickle Cell Disease Start of enrollment: 2019 Oct 21
Completed
Phase 1
Roles: Principal Investigator
Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications Start of enrollment: 2020 Aug 12
Completed
Not Applicable
Roles: Contact
A Study of TAK-755 (rADAMTS13) With Little to No Plasma Exchange (PEX) Treatment in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) Start of enrollment: 2023 Mar 21
Recruiting
Phase 2
Roles: Principal Investigator
AB1 in Adult Patients With Sickle Cell Disease (SCD) Start of enrollment: 2022 Dec 05
Recruiting
Phase 1, Phase 2
Roles: Contact
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Publications & Presentations

PubMed

4 citations
Pharmacokinetics, pharmacodynamics, safety, and efficacy of crizanlizumab in patients with sickle cell disease.
Julie Kanter, R Clark Brown, Cynthia Norris, Santosh M Nair, Abdullah Kutlar, Deepa Manwani, Nirmish Shah, Chiaki Tanaka, Shankaranand Bodla, Gessami Sanchez-Olle, Urs...> ;Blood Advances. 2023 Mar 28
10 citations
Race, rituximab, and relapse in TTP.
Shruti Chaturvedi, Ana G Antun, Andrew M Farland, Ryan Woods, Ara Metjian, Yara A Park, Gustaaf de Ridder, Briana Gibson, Raj S Kasthuri, Darla K Liles, Frank Akwaa, T...> ;Blood. 2022 Sep 22
5 citations
A randomised controlled provider-blinded trial of community health workers in sickle cell anaemia: effects on haematologic variables and hydroxyurea adherence.
Wally R. Smith, Donna K. McClish, Richard Lottenberg, India Sisler, Daniel Sop, Shirley Johnson, Anthony Villella, Darla K. Liles, Elizabeth Yang, Ian A. Chen> ;British Journal of Haematology. 2021 Nov 16
4 citations
Long-term biological effects in sickle cell disease: insights from a post-crizanlizumab study.
Darla K. Liles, Nirmish Shah, Brigid Scullin, Victor R. Gordeuk, Wally R. Smith, Julie Kanter, Maureen Achebe, Ralph V. Boccia, Shelley E. Crary, Walter K. Kraft, Nata...> ;British Journal of Haematology. 2021 Oct 5
24 citations
Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia.
Margaret Nelson, Kelsey L. McLaughlin, James T Hagen, Hannah S Coalson, Cameron A. Schmidt, Miki Kassai, Kimberly A. Kew, Joseph M. McClung, P. Darrell Neufer, Patrici...> ;Elife. 2021 Jun 16
4 citations
Peripheral blood interleukin 6, interleukin 10, and T lymphocyte levels are associated with checkpoint inhibitor induced pneumonitis: a case report.
Abdul Rafeh Naqash, Mona A. Marie, Druid C Atwell, Mahvish Muzaffar, Nitika Sharma, Suneetha Amara, Darla K. Liles, Paul R. Walker, Li V. Yang> ;Acta Oncologica. 2021 May 3
1 citations
Sipuleucel-T associated inflammatory cardiomyopathy: a case report and observations from a large pharmacovigilance database
Melissa Y.Y. Moey, Rahim Jiwani, Kotaro Takeda, Karyn Prenshaw, R. Wayne Kreeger, John Inzerillo, Darla K. Liles, C. Bogdan Marcu, Bénédicte Lebrun-Vignes, D Lynn Morr...> ;ESC Heart Failure. 2021 May 2
11 citations
Comparing the Effectiveness of Education Versus Digital Cognitive Behavioral Therapy for Adults With Sickle Cell Disease: Protocol for the Cognitive Behavioral Therapy...
Sherif M. Badawy, Kaleab Z. Abebe, Charlotte A Reichman, Grace Checo, Megan Hamm, Jennifer Stinson, Chitra Lalloo, P. Carroll, Santosh L. Saraf, Victor R. Gordeuk, Pay...> ;JMIR Research Protocols. 2021 May 14
5 citations
Concomitant use of renin-angiotensin-aldosterone system inhibitors prevent trastuzumab-induced cardiotoxicity in HER2+ breast cancer patients: an institutional retrosp...
Melissa Y.Y. Moey, Darla K. Liles, Blase A. Carabello> ;Cardio-Oncology. 2019 Jul 8
25 citations
Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
Abdul Rafeh Naqash, Ebenezer Ofori Appah, Li V. Yang, Mahvish Muzaffar, Mona A. Marie, Justin D. McCallen, Shravanti Macherla, Darla K. Liles, Paul R. Walker> ;Journal for Immunotherapy of Cancer. 2019 Jul 5
67 citations
Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis
Abdullah Kutlar, Julie Kanter, Darla K. Liles, Ofelia A. Alvarez, Rodolfo D. Cançado, Joao Ricardo Friedrisch, Jennifer Knight-Madden, Andreas Bruederle, Michael Shi, ...> ;American Journal of Hematology. 2019 Jan 1
6 citations
Exploring behaviors, treatment beliefs, and barriers to oral chemotherapy adherence among adult leukemia patients in a rural outpatient setting.
C. Suzanne Lea, Sulochana Bohra, Tiffanie Nicole Moore, Chelsea Passwater, Darla K. Liles> ;BMC Research Notes. 2018 Nov 29
12 citations
The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study.
Mahvish Muzaffar, Helen M. Johnson, Nasreen A. Vohra, Darla K. Liles, Jan H. Wong> ;International Journal of Breast Cancer. 2018 Jun 3
Acute Inflammatory Demyelinating Polyradiculoneuropathy Secondary to Ifosfamide.
Mahvish Muzaffar, Prashanti Atluri, Darla K. Liles> ;American Journal of Therapeutics. 2017 Nov 1
11 citations
Hemophagocytic lymphohistiocytosis (HLH) secondary to Ehrlichia chaffeensis with bone marrow involvement.
Abdul Rafeh Naqash, Meera Yogarajah, Bethany Dawn Vallangeon, Maida Hafiz, Deval Patel, Evelina Kolychev, Dora Lebron, Darla K. Liles> ;Annals of Hematology. 2017 Jul 31
4 citations
Vitamin D Deficiency in Adult Sickle Cell Patients.
Peter Boettger, Charles Knupp, Darla K. Liles, Kaitlyn Walker> ;Journal of the National Medical Association. 2017 Mar 1
490 citations
Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease.
Kenneth I. Ataga, Abdullah Kutlar, Julie Kanter, Darla K. Liles, Rodolfo D. Cançado, Joao Ricardo Friedrisch, Troy H. Guthrie, Jennifer Knight-Madden, Ofelia A. Alvare...> ;The New England Journal of Medicine. 2017 Feb 2
4 citations
Acute Pancreatitis Associated With Ado-Trastuzumab Emtansine.
Mahvish Muzaffar, Jingquan Jia, Darla K. Liles, Musharraf Naveed, Anita Kumari> ;American Journal of Therapeutics. 2016 Mar 1
38 citations
Sleep disorders in adult sickle cell patients.
Sunil Sharma, Jimmy T. Efird, Charles Knupp, Renuka Kadali, Darla K. Liles, Kristin Y. Shiue, Peter Boettger, Stuart F. Quan> ;Journal of Clinical Sleep Medicine. 2015 Mar 15
3 citations
Edmonton Symptom Assessment System for outpatient symptom monitoring of sickle cell disease.
Gabriel Lopez, Darla K. Liles, Charles Knupp> ;Southern Medical Journal. 2014 Dec 1
15 citations
Randomized Phase II Trial of Irinotecan/Docetaxel or Irinotecan/Docetaxel Plus Cetuximab for Metastatic Pancreatic Cancer: An Eastern Cooperative Oncology Group Study.
Barbara Burtness, Mark Powell, Paul J. Catalano, Jordan Berlin, Darla K. Liles, Andrew E. Chapman, Edith P. Mitchell, Al B. Benson> ;American Journal of Clinical Oncology. 2016 Aug 1
8 citations
Pulmonary artery occlusion pressure may overdiagnose pulmonary artery hypertension in sickle cell disease.
Sunil Sharma, Jimmy T. Efird, Renuka Kadali, Sanjay Mehra, Hadi Chohan, Ramesh Daggubati, Darla K. Liles, Catherine A. Gouge, Peter Boettger, Charles Knupp> ;Clinical Cardiology. 2013 Sep 1
2 citations
Daytime pulse oximetry measurements may not predict nocturnal desaturations in adult sickle cell patients.
Hiren Mehta, Jimmy T. Efird, Renuka Kadali, Peter Boettger, Darla K. Liles, Charles Knupp, Sunil Sharma> ;Annals of Hematology. 2013 Feb 23
18 citations
Outbreak of Mycobacterium mucogenicum Bloodstream Infections among Patients with Sickle Cell Disease in an Outpatient Setting
Muhammad Salman Ashraf, Marian Swinker, Kerri L. Augustino, Delores L. Nobles, Charles Knupp, Darla K. Liles, John D. Christie, Keith M. Ramsey> ;Infection Control and Hospital Epidemiology. 2012 Oct 5
7 citations
A Comparison of White and African American Outcomes from a Three-Arm, Randomized, Phase III Multicenter Trial of Advanced or Metastatic Non-small Cell Lung Cancer
Coleman K. Obasaju, Rafat Ansari, Mark A. Socinski, Ruqin Chen, Matthew J. Monberg, Robert B. Catalano, Donna M. Marinucci, Darla K. Liles, Maria-Jose Ribeiro, Robert ...> ;Journal of Thoracic Oncology. 2010 Jul 1
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Journal Articles

Acute Pancreatitis Associated With Ado-Trastuzumab Emtansine.
Muzaffar M1, Jia J, Liles D, Naveed M, Kumari A., Am J Ther., 1/7/2014

Abstracts/Posters

Differential Effect of Rituximab on Relapse-Free Survival in De Novo and Relapsed Immune Thrombotic Thrombocytopenic Purpura in African-American and Caucasian Populations
Darla K Liles, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
The Effect of Patient Navigators on Laboratory Parameters of Hydroxyurea Adherence in Sickle Cell Anemia: The SHIP-HU Study
Darla K Liles, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
The Effect of Patient Navigators on Laboratory Parameters of Hydroxyurea Adherence in Sickle Cell Anemia: The SHIP-HU Study
Darla K Liles, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Crizanlizumab 5.0 Mg/Kg Exhibits a Favorable Safety Profile in Patients with Sickle Cell Disease: Pooled Data from Two Phase II Studies
Darla K Liles, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
African American Race Is Associated with Decreased Relapse-Free Survival in Immune Thrombotic Thrombocytopenic Purpura
Darla K Liles, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

Established Prevention of Vaso-Occlusive Crises with Crizanlizumab Is Further Improved in Patients Who Follow the Standard Treatment Regimen: Post-Hoc Analysis of the ...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

East Carolina University: CANCER CLINICAL TRIALSJuly 29th, 2021
Vidant EastCare Becomes One of First Flight Programs in State to Carry O Negative Whole BloodJune 2nd, 2021
Financial Barriers Stand in the Way of Research at Rural HospitalsApril 13th, 2021
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