DarrelNKottonMD

PubMed

• Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels.
  Madeline K Eiken, Charlie J Childs, Lindy K Brastrom, Tristan Frum, Eleanor M Plaster, Orren Shachaf, Suzanne Pfeiffer, Justin E Levine, Konstantinos-Dionysios Alysand...> ;Biorxiv. 2024 Mar 19
• Lung repair and regeneration: Advanced models and insights into human disease.
  Maria C Basil, Edward E Morrisey, Konstantinos-Dionysios Alysandratos, Darrell N Kotton> ;Cell Stem Cell. 2024 Apr 4
• Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report.
  Kaminski, N., Montesi, S., Gomez, C., Beers, M., Brown, R., Chattopadhyay, I., Flaherty, K., Garcia, C., Gomperts, B., Hariri, L., Hogaboam, C., Jenkins, R., Kaminski,...> ;American Journal of Respiratory and Critical Care Medicine. 2024 Feb 15
• Human pluripotent stem cell modeling of alveolar type 2 cell dysfunction caused by ABCA3 mutations.
  Hennessey, E., Heins, H., Yang, P., Villacorta-Martin, C., Kwan, J., Gopalan, K., James, M., Emili, A., Cole, F., Wambach, J., Sun, Y., Kotton, D.> ;The Journal of Clinical Investigation. 2024 Jan 16
• 1 citations
  Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality.
  Hume, A., Olejnik, J., White, M., Huang, J., Turcinovic, J., Heiden, B., Bawa, P., Williams, C., Gorham, N., Alekseyev, Y., Connor, J., Mühlberger, E., Kotton, D.> ;Pathogens. 2024 Jan 9
• scTOP: physics-inspired order parameters for cellular identification and visualization.
  Maria Yampolskaya, Michael J Herriges, Laertis Ikonomou, Darrell N Kotton, Pankaj Mehta> ;Development. 2023 Nov 1
• The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells.
  Rhiannon B Werder, Kayleigh A Berthiaume, Carly Merritt, Marissa Gallagher, Carlos Villacorta-Martin, Feiya Wang, Pushpinder Bawa, Vidhi Malik, Shawn M Lyons, Maria C ...> ;American Journal of Human Genetics. 2023 Oct 5
• 9 citations
  Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells.
  Liang Ma, Bibek R Thapa, Jake A Le Suer, Andrew Tilston-Lünel, Michael J Herriges, Andrew Berical, Mary Lou Beermann, Feiya Wang, Pushpinder S Bawa, Anat Kohn, Alexand...> ;Cell Stem Cell. 2023 Sep 7
• 5 citations
  Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice.
  Michael J Herriges, Maria Yampolskaya, Bibek R Thapa, Jonathan Lindstrom-Vautrin, Feiya Wang, Jessie Huang, Cheng-Lun Na, Liang Ma, McKenna M Montminy, Pushpinder Bawa...> ;Cell Stem Cell. 2023 Sep 7
• 2 citations
  Human alveolar hydrogels promote morphological and transcriptional differentiation in iPSC-derived alveolar type 2 epithelial cells.
  Evan T Hoffman, Juan J Uriarte, Franziska E Uhl, Korin Eckstrom, Alicia E Tanneberger, Chloe Becker, Chloe Moulin, Loredana Asarian, Laertis Ikonomou, Darrell N Kotton...> ;Scientific Reports. 2023 Jul 25
• 4 citations
  Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme.
  Andrea B Alber, Hector A Marquez, Liang Ma, George Kwong, Bibek R Thapa, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Pushpinder Bawa, Feiya Wang, Yongfeng Lu...> ;Nature Communications. 2023 Jun 13
• 2 citations
  Generation of Pulmonary Ionocytes from Normal and Cystic Fibrosis Human Induced Pluripotent Stem Cells.
  Ruobing Wang, Chantelle Simone-Roach, Jonathan Lindstrom-Vautrin, Feiya Wang, Stuart Rollins, Pushpinder Singh Bawa, Junjie Lu, Yang Tang, Mary Lou Beermann, Thorsten ...> ;American Journal of Respiratory and Critical Care Medicine. 2023 May 1
• 44 citations
  Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.
  Da-Yuan Chen, Chue Vin Chin, Devin Kenney, Alexander H Tavares, Nazimuddin Khan, Hasahn L Conway, GuanQun Liu, Manish C Choudhary, Hans P Gertje, Aoife K O'Connell, Sc...> ;Nature. 2023 Mar 1
• Author Correction: SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.
  John Kee, Samuel Thudium, David M Renner, Karl Glastad, Katherine Palozola, Zhen Zhang, Yize Li, Yemin Lan, Joseph Cesare, Andrey Poleshko, Anna A Kiseleva, Rachel Tru...> ;Nature. 2023 Feb 1
• scTOP: physics-inspired order parameters for cellular identification and visualization.
  Maria Yampolskaya, Michael Herriges, Laertis Ikonomou, Darrell Kotton, Pankaj Mehta> ;Biorxiv. 2023 Jan 25
• 5 citations
  Generation of human alveolar epithelial type I cells from pluripotent stem cells.
  Claire L Burgess, Jessie Huang, Pushpinder Bawa, Konstantinos-Dionysios Alysandratos, Kasey Minakin, Michael P Morley, Apoorva Babu, Carlos Villacorta-Martin, Anne Hin...> ;Biorxiv. 2023 Jan 20
• 17 citations
  Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells.
  Konstantinos-Dionysios Alysandratos, Carolina Garcia-de-Alba, Changfu Yao, Patrizia Pessina, Jessie Huang, Carlos Villacorta-Martin, Olivia T Hix, Kasey Minakin, Clair...> ;JCI Insight. 2023 Jan 10
• Publisher Correction: SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.
  John Kee, Samuel Thudium, David M Renner, Karl Glastad, Katherine Palozola, Zhen Zhang, Yize Li, Yemin Lan, Joseph Cesare, Andrey Poleshko, Anna A Kiseleva, Rachel Tru...> ;Nature. 2023 Jan 1
• 8 citations
  Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo.
  James A Torchia, Alexander H Tavares, Laura S Carstensen, Da-Yuan Chen, Jessie Huang, Tianshu Xiao, Sonia Mukherjee, Patrick M Reeves, Hua Tu, Ann E Sluder, Bing Chen,...> ;Science Advances. 2022 Dec 9
• 3 citations
  Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia.
  Arun Pradhan, Lixiao Che, Vladimir Ustiyan, Abid A Reza, Nicole M Pek, Yufang Zhang, Andrea B Alber, Timothy R Kalin, Jennifer A Wambach, Mingxia Gu, Darrell N Kotton,...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Apr 15
• 2 citations
  Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity.
  Joseph E Kaserman, Rhiannon B Werder, Feiya Wang, Taylor Matte, Michelle I Higgins, Mark Dodge, Jonathan Lindstrom-Vautrin, Pushpinder Bawa, Anne Hinds, Esther Bullitt...> ;Cell Reports. 2022 Dec 6
• 51 citations
  SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.
  John Kee, Samuel Thudium, David M Renner, Karl Glastad, Katherine Palozola, Zhen Zhang, Yize Li, Yemin Lan, Joseph Cesare, Andrey Poleshko, Anna A Kiseleva, Rachel Tru...> ;Nature. 2022 Oct 1
• 6 citations
  CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells.
  Rhiannon B Werder, Tao Liu, Kristine M Abo, Jonathan Lindstrom-Vautrin, Carlos Villacorta-Martin, Jessie Huang, Anne Hinds, Nathan Boyer, Esther Bullitt, Marc Liesa, E...> ;Science Advances. 2022 Jul 15
• 23 citations
  CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information.
  Shou-Wen Wang, Michael J Herriges, Kilian Hurley, Darrell N Kotton, Allon M Klein> ;Nature Biotechnology. 2022 Jul 1
• Generation of Airway Epithelial Cell Air-Liquid Interface Cultures from Human Pluripotent Stem Cells.
  Andrew Berical, Mary Lou Beermann, Shingo Suzuki, Jake LeSuer, Taylor Matte, Brian Davis, Darrell Kotton, Finn Hawkins> ;Journal of Visualized Experiments. 2022 Jun 14
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