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Office
132 Abigail Ln
Port Matilda, PA 16870Phone+1 814-272-7100- Is this information wrong?
Education & Training
Sidney Kimmel Medical College at Thomas Jefferson University/Deborah Heart and Lung CenterFellowship, Cardiovascular Disease, 2008 - 2011
Philadelphia College of Osteopathic MedicineChief Residency, Internal Medicine, 2007 - 2008- Philadelphia College of Osteopathic MedicineResidency, Internal Medicine, 2005 - 2008
- Philadelphia College of Osteopathic MedicineClass of 2005
Certifications & Licensure
PA State License 2005 - 2026
NJ State License 2008 - 2011- AOA Board of Internal Medicine Cardiology
- American College of CardiologyCardiologist
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2013
Publications & Presentations
PubMed
- 370 citationsInduction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cellMarco Ruella, Jun Xu, David M. Barrett, Joseph A. Fraietta, Tyler J. Reich, David E Ambrose, Michael Klichinsky, Olga Shestova, Prachi R. Patel, Irina Kulikovskaya, Fa...> ;Nature Medicine. 2018 Oct 1
- Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T Cell Therapy of Chronic Lymphocytic LeukemiaDavid L Porter, Bruce L Levine, David E Ambrose, Alexander C Huang, F Brad Johnson, Noelle V Frey, Carl H June, Donald L Siegel> ;Nature.
- 347 citationsPD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR.Elise A. Chong, J. Joseph Melenhorst, Simon F. Lacey, David E Ambrose, Vanessa E. Gonzalez, Bruce L. Levine, Carl H. June, Stephen J. Schuster> ;Blood. 2017 Feb 23
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Journal Articles
- Induction of Resistance to Chimeric Antigen Receptor T Cell Therapy by Transduction of a Single Leukemic B CellVijay G Bhoj, David M Barrett, Carl H June, Stephan A Grupp, David E Ambrose, Saar I Gill, Marco Ruella, Bruce L Levine, Shannon L Maude, Nature
Professional Memberships
- Member
- Fellow
- Fellow
Hospital Affiliations
Geisinger Medical CenterDanville, Pennsylvania- Mount Nittany Medical CenterState College, Pennsylvania
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