DavidBarrettMD

Pediatric Hematology & Oncology • Philadelphia, PA

Assistant Professor, Pediatrics, Perelman School of Medicine

Join to view full profile

Are you Dr. Barrett?

Join over one million U.S. Physicians, Nurse Practitioners and PAs, already on Doximity.

Connect with colleagues in the same hospital or clinic
You already have 77 invites waiting!
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

Claim this profile

Not you? Find your profile

Office
3401 Civic Center Blvd
Children's Hospital Of Philadelphia - Hem/Onc
Philadelphia, PA 19104
Phone+1 215-590-3535

Fax+1 215-590-3992
Is this information wrong?

Summary

Dr. David Barrett, MD is a pediatric hematologist/oncologist in Philadelphia, Pennsylvania. He is currently licensed to practice medicine in Pennsylvania. He is affiliated with Children's Hospital of Philadelphia and Veterans Affairs Maryland Health Care System-Baltimore Division.

Education & Training

Children's Hospital of PhiladelphiaFellowship, Pediatric Hematology/Oncology, 2007 - 2010
Children's Hospital of PhiladelphiaResidency, Pediatrics, 2004 - 2007
Virginia Commonwealth University School of MedicineClass of 2004

Certifications & Licensure

PA State Medical License 2006 - 2022

Clinical Trials

Caspofungin Acetate, Fluconazole, or Voriconazole in Preventing Fungal Infections in Patients Following Donor Stem Cell Transplant Start of enrollment: 2013 Mar 21
Completed
Phase 3

Publications & Presentations

PubMed

12 citations
Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors.
Jessica B Foster, Crystal Griffin, Jo Lynne Rokita, Allison Stern, Cameron Brimley, Komal Rathi, Maria V Lane, Samantha N Buongervino, Tiffany Smith, Peter J Madsen, D...> ;Journal for Immunotherapy of Cancer. 2022 Sep 1
10 citations
Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19.
Caroline Diorio, Rawan Shraim, Regina Myers, Edward M Behrens, Scott Canna, Hamid Bassiri, Richard Aplenc, Chakkapong Burudpakdee, Fang Chen, Amanda M DiNofia, Saar Gi...> ;Clinical Cancer Research. 2022 Sep 1
Correction for Bagashev et al., "CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum".
Asen Bagashev, Elena Sotillo, Chih-Hang Anthony Tang, Kathryn L Black, Jessica Perazzelli, Steven H Seeholzer, Yair Argon, David M Barrett, Stephan A Grupp, Chih-Chi A...> ;Molecular and Cellular Biology. 2022 Sep 15
48 citations
Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL.
Zhiliang Bai, Steven Woodhouse, Ziran Zhao, Rahul Arya, Kiya Govek, Dongjoo Kim, Stefan Lundh, Alev Baysoy, Hongxing Sun, Yanxiang Deng, Yang Xiao, David M Barrett, Re...> ;Science Advances. 2022 Jun 10
36 citations
Impact of high-risk cytogenetics on outcomes for children and young adults receiving CD19-directed CAR T-cell therapy.
Allison Barz Leahy, Kaitlin J Devine, Yimei Li, Hongyan Liu, Regina Myers, Amanda DiNofia, Lisa Wray, Susan R Rheingold, Colleen Callahan, Diane Baniewicz, Maria Patin...> ;Blood. 2022 Apr 7
10 citations
Combined use of emapalumab and ruxolitinib in a patient with refractory hemophagocytic lymphohistiocytosis was safe and effective.
Michael P Triebwasser, David M. Barrett, Hamid Bassiri, Nancy Bunin, Caitlin W Elgarten, Jason L. Freedman, Abdallah S Geera, Dimitri S. Monos, Michele P. Lambert, Tim...> ;Pediatric Blood & Cancer. 2021 Mar 22
Improving and Maintaining Responses in Pediatric B-Cell Acute Lymphoblastic Leukemia Chimeric Antigen Receptor-T Cell Therapy.
Rahul Arya, David M. Barrett, Stephan A. Grupp, J. Joseph Melenhorst> ;Cancer Journal. 2021 Mar 1
72 citations
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma.
Babak Moghimi, Sakunthala Muthugounder, Samy Jambon, Rachelle Tibbetts, Long Hung, Hamid Bassiri, Michael D. Hogarty, David M. Barrett, Hiroyuki Shimada, Shahab Asghar...> ;Nature Communications. 2021 Jan 21
89 citations
Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical ...
Stephan Kadauke, Regina M. Myers, Yimei Li, Richard Aplenc, Diane Baniewicz, David M. Barrett, Allison Barz Leahy, Colleen Callahan, Joseph G Dolan, Julie C. Fitzgeral...> ;Journal of Clinical Oncology. 2021 Jan 8
1 citations
High Expression of TIM 3 and Galectin 9 on Immunohistochemistry Staining of Tumor Specimen at Diagnosis in Pediatric Patients with Ewing Sarcoma.
Stephanie J Si, Gerald B Wertheim, David M Barrett> ;Journal of Cancer Immunology. 2021 Jan 1
254 citations
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2.
Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Ba...> ;The Journal of Clinical Investigation. 2020 Nov 2
25 citations
Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children.
Caroline Diorio, Pamela A. Shaw, Edward Pequignot, Alena Orlenko, Fang Chen, Richard Aplenc, David M. Barrett, Hamid Bassiri, Edward M. Behrens, Amanda M. DiNofia, Van...> ;Blood Advances. 2020 Oct 27
35 citations
Lingering effects of chemotherapy on mature T cells impair proliferation.
Rajat K. Das, Roddy S. O’Connor, Stephan A. Grupp, David M. Barrett> ;Blood Advances. 2020 Oct 13
1 citations
Thoracic duct lymphatic fluid harbors phenotypically naive T cells for use in adoptive T-cell therapy.
Jessica B. Foster, Yoav Dori, Stephan A. Grupp, David M. Barrett> ;Cytotherapy. 2020 Oct 1
11 citations
Human Adenovirus 7-Associated Hemophagocytic Lymphohistiocytosis-Like Illness: Clinical and Virological Characteristics in a Cluster of Five Pediatric Cases
William R Otto, Edward M. Behrens, David T. Teachey, Daryl M. Lamson, David M. Barrett, Hamid Bassiri, Michelle P Lambert, Suzanne Mount, Whitney Petrosa, Neil Romberg...> ;Clinical Infectious Diseases. 2021 Oct 5
240 citations
The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
Lim, K., Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, ...> ;Cell. 2020 Apr 16
53 citations
Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19.
Mukta Asnani, Katharina E. Hayer, Ammar S. Naqvi, Sisi Zheng, Scarlett Y. Yang, Derek A. Oldridge, Fadia Ibrahim, Manolis Maragkakis, Matthew R. Gazzara, Kathryn L. Bl...> ;Leukemia. 2020 Apr 1
13 citations
Dissecting the tumor-immune landscape in chimeric antigen receptor T-cell therapy: key challenges and opportunities for a systems immunology approach
Gregory M. Chen, Andrew Azzam, Yang-Yang Ding, David M. Barrett, Stephan A. Grupp, Kai Tan> ;Clinical Cancer Research. 2020 Mar 3
2 citations
Partially CD3+-Depleted Unrelated and Haploidentical Donor Peripheral Stem Cell Transplantation Has Favorable Graft-versus-Host Disease and Survival Rates in Pediatric...
Alix E. Seif, Yimei Li, Dimitri S. Monos, Stephanie C. Heidemann, Richard Aplenc, David M. Barrett, James T. Casper, Jason L. Freedman, Stephan A. Grupp, David A. Marg...> ;Biology of Blood and Marrow Transplantation. 2020 Mar 1
24 citations
A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor–positive cells
Marco Ruella, David M. Barrett, Olga Shestova, Jessica Perazzelli, Avery D. Posey, Seok Jae Hong, Miroslaw Kozlowski, Simon F. Lacey, J. Joseph Melenhorst, Carl H. Jun...> ;Blood. 2020 Feb 13
42 citations
Cellular therapy: Immune‐related complications
Joseph H. Oved, David M. Barrett, David T. Teachey> ;Immunological Reviews. 2019 Jul 1
174 citations
Tocilizumab for the treatment of chimeric antigen receptor T cell-induced cytokine release syndrome
Chelsea Kotch, David M. Barrett, David T. Teachey> ;Expert Review of Clinical Immunology. 2019 Jun 20
7 citations
Improving CAR T cell immunotherapy–mediated remissions for pediatric leukemia
David M. Barrett> ;The Journal of Clinical Investigation. 2019 May 1
137 citations
Naïve T-cell Deficits at Diagnosis and after Chemotherapy Impair Cell Therapy Potential in Pediatric Cancers.
Rajat K. Das, Lauren Vernau, Stephan A. Grupp, David M. Barrett> ;Cancer Discovery. 2019 Apr 1
41 citations
The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution
Deanne Taylor, Bruce J. Aronow, Kai Tan, Kathrin M. Bernt, Nathan Salomonis, Casey S. Greene, Alina Frolova, Sarah E. Henrickson, Andrew D. Wells, Liming Pei, Jyoti K....> ;Developmental Cell. 2019 Apr 8
Join now to see all

Hospital Affiliations

Veterans Affairs Maryland Health Care System-Baltimore DivisionBaltimore, Maryland
Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania