DavidAllenBrennerMD

Gastroenterology • La Jolla, CA

Vice Chancellor ofr Health Sciences and Dean, School of Medicine at UC San Diego

Join to view full profile

Dr. Brenner is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Brenner's full profile

Already have an account?

Office
9300 Campus Point Dr
La Jolla, CA 92037
Phone+1 858-657-8381

Fax+1 858-822-0084
Is this information wrong?

Education & Training

University of California (San Diego) Medical CenterFellowship, Gastroenterology, 1985 - 1988
University of California (San Diego) Medical CenterResidency, Internal Medicine, 1985 - 1986
NIH Clinical CenterPost-Doctoral Fellowship, research associate, 1982 - 1985
Yale-New Haven Medical CenterResidency, Internal Medicine, 1979 - 1982
Yale School of MedicineClass of 1979

Certifications & Licensure

CA State Medical License 1985 - 2025
NY State Medical License 2003 - 2009
NC State Medical License 1993 - 2004
MD State Medical License 1982 - 1986
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Bomedical Scholar Pew Foundation, 1986
Fellow (FACP) American College of Physicians, 2005
Whos Who in Medicine and Healthcare Marquis Whos Who

Clinical Trials

Alpha-1 Antitrypsin Deficiency Adult Liver Study Start of enrollment: 2013 Dec 01
Active, not recruiting

Publications & Presentations

PubMed

Review article: New developments in biomarkers and clinical drug development in alpha-1 antitrypsin deficiency-related liver disease.
Rohit Loomba, Ginger Clark, Jeff Teckman, Veeral Ajmera, Cynthia Behling, Mark Brantly, David Brenner, Jeanine D'Armiento, Michael W Fried, Janani S Iyer, Mattias Mand...> ;Alimentary Pharmacology & Therapeutics. 2024 Mar 22
2 citations
FUS mutations dominate TBK1 mutations in FUS/TBK1 double-mutant ALS/FTD pedigrees
David A. Brenner, Kathrin Muller, Serena Lattante, Rüstem Yilmaz, Antje Knehr, Axel Freischmidt, Albert C. Ludolph, Peter M. Andersen, Jochen H. Weishaupt> ;Neurogenetics. 2021 Sep 13
8 citations
Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice.
Jacopo Baglieri, Cuili Zhang, Shuang Liang, Xiao Liu, Takahiro Nishio, Sara Brin Rosenthal, Debanjan Dhar, Hua Su, Min Cong, Jidong Jia, Mojgan Hosseini, Michael Karin...> ;The American Journal of Pathology. 2021 Sep 1
11 citations
Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
Takahiro Nishio, Yukinori Koyama, Xiao Liu, Sara Brin Rosenthal, Gen Yamamoto, Hiroaki Fuji, Jacopo Baglieri, Na Li, Laura N. Brenner, Keiko Iwaisako, Kojiro Taura, Ja...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Jul 20
3 citations
Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice.
Francisco I. Ramirez-Perez, Makenzie L Woodford, Mariana Morales-Quinones, Zachary I. Grunewald, Francisco J Cabral-Amador, Tadashi Yoshida, David A. Brenner, Camila M...> ;American Journal of Physiology. Heart and Circulatory Physiology. 2021 Jul 9
16 citations
Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet
Souradipta Ganguly, German R. Aleman Muench, Linshan Shang, Sara Brin Rosenthal, Gibraan Rahman, Ruoyu Wang, Yanhan Wang, Hyeok Choon Kwon, Anthony M. Diomino, Tatiana...> ;Cellular and Molecular Gastroenterology and Hepatology. 2021 May 29
105 citations
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis.
Tae Gyu Oh, Susy M Kim, Cyrielle Caussy, Ting Fu, Jian Guo, Shirin Bassirian, Seema Singh, Egbert V Madamba, Ricki Bettencourt, Lisa Richards, Ruth T Yu, Annette R Atk...> ;Cell Metabolism. 2020 Nov 3
23 citations
Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis.
Bernat Baeza-Raja, Andrew Goodyear, Xiao Liu, Kevin Lam, Lynn Yamamoto, Yingwu Li, G. Steven Dodson, Toshi Takeuchi, Tatiana Kisseleva, David A. Brenner, Karim Dabbagh> ;Plos One. 2020 Jun 3
12 citations
Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder
Bei Gao, Atoosa Emami, Rongrong Zhou, Sonja Lang, Yi Duan, Yanhan Wang, Lu Jiang, Rohit Loomba, David A. Brenner, Peter Stärkel, Bernd Schnabl> ;Frontiers in Physiology. 2020 Apr 24
7 citations
Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative...
Vincenzo Pizza, Paola Antonini, Rossella Marino, Giovanni D’Arena, Serena Grazia Lucibello, Marianna Rizzo, David A. Brenner, Dilip V. Jeste, Salvatore Di Somma> ;Medicina. 2020 May 5
88 citations
Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution
Xiao Liu, Jun Xu, Sara Brin Rosenthal, Ling-juan Zhang, Ryan McCubbin, Nairika Meshgin, Linshan Shang, Yukinori Koyama, Hsiao-Yen Ma, Sonia Sharma, Sven Heinz, Christo...> ;Gastroenterology. 2020 May 1
93 citations
IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease.
Hsiao-Yen Ma, Gen Yamamoto, Jun Xu, Xiao Liu, Daniel Karin, Ju Youn Kim, Ludmil B. Alexandrov, Yukinori Koyama, Takahiro Nishio, Christopher Benner, Sven Heinz, Sara B...> ;Journal of Hepatology. 2020 May 1
16 citations
Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles.
Xiao Liu, Sara Brin Rosenthal, Nairika Meshgin, Jacopo Baglieri, Sami G. Musallam, Karin Diggle, Kevin Lam, Raymond Wu, Stephanie Q. Pan, Yibu Chen, Ken Dorko, Sharon ...> ;Hepatology Communications. 2020 Apr 1
23 citations
Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs
Mingjun Zhang, Michael Haughey, Nai-Yu Wang, Kate Blease, Ann M. Kapoun, Suzana Couto, Igor Belka, Timothy Hoey, Matthew C. Groza, James Hartke, Brydon L. Bennett, Jen...> ;Plos One. 2020 Mar 11
21 citations
SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden
Rüstem Yilmaz, Kathrin Muller, David A. Brenner, Alexander E Volk, Guntram Borck, Andreas Hermann, Thomas Meitinger, Tim M. Strom, Karin M Danzer, Albert C. Ludolph, P...> ;Neurobiology of Aging. 2020 Mar 1
25 citations
Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice
Jun Xu, Hsiao-Yen Ma, Xiao Liu, Sara Brin Rosenthal, Jacopo Baglieri, Ryan McCubbin, Mengxi Sun, Yukinori Koyama, Cédric G. Geoffroy, Kaoru Saijo, Linshan Shang, Takah...> ;JCI Insight. 2020 Feb 13
157 citations
Mechanisms of liver fibrosis and its role in liver cancer
Debanjan Dhar, Jacopo Baglieri, Tatiana Kisseleva, David A. Brenner> ;Experimental Biology and Medicine. 2020 Jan 10
100 citations
Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis
Xiaoli Sun, Jason S. Seidman, Peng Zhao, Ty D. Troutman, Nathanael J. Spann, Xuchu Que, Fangli Zhou, Zhongji Liao, Martina P. Pasillas, Xiaohong Yang, Jason A. Magida,...> ;Cell Metabolism. 2020 Jan 7
8 citations
Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity.
Lori B. Daniels, Paula Antonini, Rossella Marino, Marianna Rizzo, Silvia Navarin, Serena Grazia Lucibello, Alan S. Maisel, Vincenzo Pizza, David A. Brenner, Dilip V. J...> ;Journal of Cardiovascular Medicine. 2020 Feb 1
1 citations
Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations.
David A. Brenner, Angela Rosenbohm, Rüstem Yilmaz, Kathrin Muller, Torsten Grehl, Susanne Petri, Thomas F. Meyer, Julian Grosskreutz, Patrick Weydt, Wolfgang Ruf, Chri...> ;Brain. 2019 Dec 1
16 citations
The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease.
Tatiana Kisseleva, David A. Brenner> ;Cell Metabolism. 2019 Nov 5
43 citations
Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease.
Cyrielle Caussy, Veeral Ajmera, Puneet Puri, Cynthia Hsu, Shirin Bassirian, S Singh, Claire Faulkner, Mark A. Valasek, Emily Rizo, Lisa Richards, David A. Brenner, Cla...> ;Gut. 2019 Oct 1
40 citations
Update on amyotrophic lateral sclerosis genetics.
David A. Brenner, Jochen H. Weishaupt> ;Current Opinion in Neurology. 2019 Oct 1
23 citations
YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
Lirui Wang, Magdalena Mazagova, Chuyue Pan, Song Yang, Katharina Brandl, Jun Liu, Shannon M. Reilly, Yanhan Wang, Zhaorui Miao, Rohit Loomba, Na Lu, Qinglong Guo, Jihu...> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 Jul 23
75 citations
Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice.
Takahiro Nishio, Ronglin Hu, Yukinori Koyama, Shuang Liang, Sara Brin Rosenthal, Gen Yamamoto, Daniel Karin, Jacopo Baglieri, Hsiao-Yen Ma, Jun Xu, Xiao Liu, Debanjan ...> ;Journal of Hepatology. 2019 Sep 1
Join now to see all

Press Mentions

Jacobs Medical Center Marks Fifth Anniversary, Achievements and MilestonesOctober 12th, 2021
UC San Diego Health Launches New Center to Spur Patient-Centered TechnologiesSeptember 2nd, 2021
After Discussions and Delays, San Diego Joins Blue Shield’s Statewide Vaccine ProgramMarch 20th, 2021
Join now to see all