David BrentPolkMDAGAF

Pediatric Gastroenterology • San Diego, CA

Chief, Division of Gastroenterology, Hepatology & Nutrition, Rady Children's Hospital-San Diego; Executive Vice Chair, Department of Pediatrics and Martin Brotman Professor of Pediatrics, UC San Diego School of Medicine

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Office
3030 Children's Way
 2nd Floor
San Diego, CA 92123
Phone+1 858-966-4003
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Education & Training

Stanford Health Care-Sponsored Stanford UniversityFellowship, Gastroenterology, 1987 - 1988
University of Arkansas for Medical Sciences (UAMS) College of MedicineResidency, Pediatrics, 1984 - 1987
University of Arkansas For Medical Sciences College of MedicineClass of 1984

Certifications & Licensure

CA State Medical License 2010 - 2025
AR State Medical License 1984 - 2025
TN State Medical License 1990 - 2015
American Board of Pediatrics Pediatric Gastroenterology

Awards, Honors, & Recognition

Elected Member Association of American Physicians, 2017
Elected Member Alpha Omega Alpha, 2017
Fellow American Association for the Advancement of Science, 2016
Fellow Royal College of Physicians, 2016
Fellow (AGAF) American Gastroenterological Association, 2008
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Publications & Presentations

PubMed

10 citations
Transitional Anal Cells Mediate Colonic Re-epithelialization in Colitis.
Cambrian Y Liu, Nandini Girish, Marie L Gomez, Philip E Dubé, M Kay Washington, Benjamin D Simons, D Brent Polk> ;Gastroenterology. 2022 Jun 1
12 citations
Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease
Nandini Girish, Cambrian Y. Liu, Safina Gadeock, Marie L Gomez, Ying Huang, Zohreh Sharifkhodaei, M. Kay Washington, D. Brent Polk> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2021 Jul 14
11 citations
NRG4-ErbB4 signaling represses proinflammatory macrophage activity
Michael A. Schumacher, Isabella C Dennis, Cambrian Y. Liu, Cache Robinson, Judie Shang, Jessica K. Bernard, M. Kay Washington, D. Brent Polk, Mark R. Frey> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2021 Jun 1
8 citations
Exposure to p40 in Early Life Prevents Intestinal Inflammation in Adulthood Through Inducing a Long-Lasting Epigenetic Imprint on TGFβ.
Yilin Deng, Oliver G. McDonald, Anna L. Means, Richard M. Peek, M. Kay Washington, Sari Acra, D. Brent Polk, Fang Yan> ;Cellular and Molecular Gastroenterology and Hepatology. 2021 Jan 19
9 citations
TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice.
Cambrian Y. Liu, Sharon S. Tam, Ying Huang, Philip E. Dubé, Rabea Alhosh, Nandini Girish, Shivesh Punit, Shirin Nataneli, Fan Li, Jeffrey M. Bender, M. Kay Washington,...> ;Cell Reports. 2020 Oct 20
9 citations
Cellular maps of gastrointestinal organs: getting the most from tissue clearing.
Cambrian Y. Liu, D. Brent Polk> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2020 May 18
13 citations
Challenges in IBD Research: Novel Technologies.
Manish Dhyani, Nitin Joshi, Willem A. Bemelman, Michael S. Gee, Vijay Yajnik, André D'Hoore, Giovanni Traverso, Mark Donowitz, Gustavo Mostoslavsky, Timothy K. Lu, Nei...> ;Inflammatory Bowel Diseases. 2019 May 16
Microbiomes through the Looking Glass: What Do UC?
Cambrian Y. Liu, D. Brent Polk> ;Cell Host & Microbe. 2018 Oct 10
12 citations
Pharmacological activation of epidermal growth factor receptor signaling inhibits colitis-associated cancer in mice.
Philip E. Dubé, Cambrian Y. Liu, Nandini Girish, M. Kay Washington, D. Brent Polk> ;Scientific Reports. 2018 Jun 14
35 citations
Supplementation of p40, a Lactobacillus rhamnosus GG-derived protein, in early life promotes epidermal growth factor receptor-dependent intestinal development and long...
Xi Shen, Liping Liu, Richard M. Peek, Sari Acra, Daniel J. Moore, Keith T. Wilson, Fang He, D. Brent Polk, Fang Yan> ;Mucosal Immunology. 2018 Jun 6
23 citations
Activation of Epidermal Growth Factor Receptor in Macrophages Mediates Feedback Inhibition of M2 Polarization and Gastrointestinal Tumor Cell Growth.
Gang Zhao, Liping Liu, Richard M. Peek, Xishan Hao, D. Brent Polk, Hui Li, Fang Yan> ;The Journal of Biological Chemistry. 2016 Sep 23
An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells.
Wang Y, Liu L, Moore DJ, Shen X, Peek RM, Acra SA, Li H, Ren X, Polk DB, Yan F> ;Mucosal immunology. 2016-06-29
Neonatal colonization of mice with LGG promotes intestinal development and decreases susceptibility to colitis in adulthood.
Yan F, Liu L, Cao H, Moore DJ, Washington MK, Wang B, Peek RM, Acra SA, Polk DB> ;Mucosal immunology. 2016-04-20
49 citations
Preserving viability of Lactobacillus rhamnosus GG in vitro and in vivo by a new encapsulation system
Ran Li, Yufeng Zhang, D. Brent Polk, Peggy M. Tomasula, Fang Yan, LinShu Liu> ;Journal of Controlled Release. 2016 May 28
90 citations
Epidermal growth factor receptor–stimulated intestinal epithelial cell migration requires phospholipase C activity
D. Brent Polk> ;Gastroenterology. 1998 Mar 1
40 citations
Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8+ T Cells in Mice With Colitis
Shivesh Punit, Philip E. Dubé, Cambrian Y. Liu, Nandini Girish, M. Kay Washington, D. Brent Polk> ;Gastroenterology. 2015 Oct 1
16 citations
Optical reconstruction of murine colorectal mucosa at cellular resolution
Cambrian Y. Liu, Philip E. Dubé, Nandini Girish, Ajay Thota Reddy, D. Brent Polk> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2015 May 1
26 citations
Redeeming an old foe: protective as well as pathophysiological roles for tumor necrosis factor in inflammatory bowel disease
Philip E. Dubé, Shivesh Punit, D. Brent Polk> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2015 Feb 1
81 citations
Predicting Persistence of Functional Abdominal Pain From Childhood Into Young Adulthood
Sara N. Horst, Grace D. Shelby, Julia Anderson, Sari Acra, D. Brent Polk, Benjamin R. Saville, Judy Garber, Lynn S. Walker> ;Clinical Gastroenterology and Hepatology. 2014 Dec 1
Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis.
Ahmad, R.,Chaturvedi, R.,Olivares-Villagómez, D.,Habib, T.,Asim, M.,Shivesh, P.,Polk, D. B.,Wilson, K. T.,Washington, M. K.,Van Kaer, L.,Dhawan, P.,Singh, A. B.> ;Mucosal Immunol. 2014 Mar 29
69 citations
Activation of EGFR and ERBB2 by Helicobacter pylori Results in Survival of Gastric Epithelial Cells With DNA Damage
Rupesh Chaturvedi, Mohammad Asim, M. Blanca Piazuelo, Fang Yan, Daniel P. Barry, Johanna C. Sierra, Alberto G. Delgado, Salisha Hill, Robert A. Casero, Luis Eduardo Br...> ;Gastroenterology. 2014 Jun 1
22 citations
Lactobacillus rhamnosus GG: An Updated Strategy to Use Microbial Products to Promote Health.
Fang Yan, D. Brent Polk> ;Functional Food Reviews. 2012 Jun 1
28 citations
Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells
Johanna C. Sierra, Stuart S. Hobbs, Rupesh Chaturvedi, Fang Yan, Keith T. Wilson, Richard M. Peek, D. Brent Polk> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2013 Jul 15
50 citations
Berberine Inhibits Proliferation and Down-Regulates Epidermal Growth Factor Receptor through Activation of Cbl in Colon Tumor Cells
Lihong Wang, Hailong Cao, Ning Lu, Liping Liu, Bangmao Wang, Tianhui Hu, Dawn A. Israel, Richard M. Peek, D. Brent Polk, Fang Yan> ;Plos One. 2013 Feb 14
11 citations
Mycophenolate Mofetil-Related Enterocolitis and Weight Loss: A Pediatric Case Series
Dana M. H. Dykes, Sean R. Moore, D. Brent Polk, Michael J. Rosen, Marcia L. Wills, Brian Morris, Jeanine S Maclin, Janaina B. Nogueira, Avi Katz, Tracey E. Hunley, Jud...> ;Case Reports in Pediatrics. 2012 Oct 23
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Professional Memberships

American Gastroenterological Association - AGA
Fellow
American Pediatric Society
Member
Society for Pediatric Research
Member
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
Member
Association of Medical School Pediatric Department Chairs
Member
Sigma Xi
Fellow
Association of American Physicians
Fellow

Hospital Affiliations

Rady Children's Hospital - San DiegoSan Diego, California