David Bushart MD PhD

PubMed

• Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1.
  Logan M Morrison, Haoran Huang, Hillary P Handler, Min Fu, Deborah M Jones
  Human Molecular Genetics. 2024-12-06
• Increased intrinsic membrane excitability is associated with hypertrophic olivary degeneration in spinocerebellar ataxia type 1.
  Logan M Morrison, Haoran Huang, Hillary P Handler, Min Fu, David D Bushart
  Biorxiv. 2023-10-23
• 16 citations
  Compartmentalized Actions of the Plasminogen Activator Inhibitors, PAI-1 and Nsp, in Ischemic Stroke.
  Daniel Torrente, Enming Joseph Su, Linda Fredriksson, Mark Warnock, David Bushart
  Translational Stroke Research. 2022-10-01

Journal Articles

• Vulnerability of human cerebellar neurons to degeneration in ataxia-causing channelopathies  
  Bushart DD, Shakkottai VG, Frontiers in Systems Neuroscience, 6/9/2022
• Preliminary study on the effects of vibrotactile feedback-augmented at-home balance and coordination training in individuals with cerebellar ataxia  
  Jabri S, Bushart DD, Kinnaird C, Bao T, Bu A, Shakkottai VG, Sienko KH, Sensors, 5/5/2022
• Compartmentalized actions of the plasminogen activator inhibitors, PAI-1 and Nsp, in ischemic stroke  
  Torrente D, Su EJ, Fredriksson L, Warnock M, Bushart D, Mann KM, Emal CD, Lawrence DA, Translational Stroke Research, 10/2022
• A chlorzoxazone-baclofen combination improves cerebellar impairment in spinocerebellar ataxia type 1  
  Bushart DD, Huang H, Man LJ, Morrison LM, Shakkottai VG, Movement Disorders, 11/5/2020
• Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1  
  Chopra R*, Bushart DD*, Cooper JP, Yellajoshyula D, Morrison LM, Huang H, Handler HP, Man LJ, Dansithong W, Scoles DR, Pulst SM, Orr HT, Shakkottai VG, Human Molecular Genetics, 10/1/2020
• Antisense oligonucleotide therapy targeted against ATXN3 improves potassium channel-mediated Purkinje neuron dysfunction in spinocerebellar ataxia type 3  
  Bushart DD*, Zalon AJ*, Zhang H, Morrison LM, Guan Y, Paulson HL, Shakkottai VG, McLoughlin HS, Cerebellum, 8/13/2020
• Nicotinamide pathway-dependent Sirt1 activation restores calcium homeostasis to achieve neuroprotection in spinocerebellar ataxia type 7  
  Stoyas CA*, Bushart DD*, Switonski PM, Ward JM, Alaghatta A, Tang MB, Niu C, Wadhwa M, Huang H, Savchenko A, Gariani K, Xie F, Delaney JR, Gaasterland T, Auwerx J, Sha..., Neuron, 2/19/2020
• Synthetic high-density lipoprotein nanoparticles for the treatment of Neimann-Pick diseases  
  Schultz ML, Fawaz MV, Azaria RD, Hollon TC, Liu EA, Kunkel TJ, Halseth TA, Krus KL, Ming R, Morin EE, McLoughlin HS, Bushart DD, Paulson HL, Shakkottai VG, Orringer DA..., BMC Medicine, 11/11/2019
• Antisense oligonucleotide therapy rescues aggresome formation in a novel spinocerebellar ataxia type 3 human embryonic stem cell line  
  Moore LR, Keller L, Bushart DD, Delatorre RG, Li D, McLoughlin HS, do Carmo Costa M, Shakkottai VG, Smith GD, Paulson HL, Stem Cell Research, 8/2019
• Ion channel dysfunction in cerebellar ataxia  
  Bushart DD, Shakkottai VG, Neuroscience Letters, 1/1/2019
• Dendritic potassium channel dysfunction may contribute to dendrite degeneration in spinocerebellar ataxia type 1  
  Chopra R, Bushart DD, Shakkottai VG, PLoS One, 5/30/2018
• Targeting potassium channels to treat cerebellar ataxia  
  Bushart DD, Chopra R, Singh V, Murphy GG, Wulff H, Shakkottai VG, Annals of Clinical and Translation Neurology, 1/22/2018
• Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease  
  Bushart DD, Murphy GG, Shakottai VG, Annals of Translational Medicine, 1/27/2016
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