DavidAD'AlessioMD

PubMed

• 5 citations
  Extreme elevations of low-density lipoprotein cholesterol with very low carbohydrate, high fat diets.
  Anna E Schaffer, David A. D'Alessio, John R. Guyton> ;Journal of Clinical Lipidology. 2021 May 1
• 54 citations
  GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells.
  Kimberley El, Sarah M. Gray, Megan E. Capozzi, E. R. Knuth, E. Jin, Berit Svendsen, A. Clifford, J. L. Brown, Sara E. Encisco, Bryanna M. Chazotte, Kyle W. Sloop, Dere...> ;Science Advances. 2021 Mar 1
• Correction to: Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes
  Kimberly M. Alonge, David A. D'Alessio, Michael W. Schwartz> ;Diabetologia. 2021 Jan 1
• 5 citations
  Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes.
  Kimberly M. Alonge, David A. D'Alessio, Michael W. Schwartz> ;Diabetologia. 2021 Jan 1
• 6 citations
  A Lesson From 2020: Public Health Matters for Both COVID-19 and Diabetes.
  Matthew C. Riddle, George L. Bakris, Lawrence Blonde, Andrew J.M. Boulton, David A. D'Alessio, Linda A. DiMeglio, Linda Gonder-Frederick, Korey K. Hood, Frank B. Hu, S...> ;Diabetes Care. 2021 Jan 1
• 157 citations
  Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
  Francis S. Willard, Jonathan D. Douros, Maria Buur Nordskov Gabe, Aaron D. Showalter, David B. Wainscott, Todd M. Suter, Megan E. Capozzi, Wijnand J.C. van der Velden,...> ;JCI Insight. 2020 Sep 3
• 33 citations
  Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia.
  Caslin A. Gilroy, Megan E. Capozzi, Anastasia K. Varanko, Jenny Tong, David A. D'Alessio, Jonathan E. Campbell, Ashutosh Chilkoti> ;Science Advances. 2020 Aug 26
• 23 citations
  Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells.
  Sarah M. Gray, Yurong Xin, Elizabeth C. Ross, Bryanna M. Chazotte, Megan E. Capozzi, Kimberley El, Berit Svendsen, Peter Ravn, Kyle W. Sloop, Jenny Tong, Jesper Gromad...> ;The Journal of Biological Chemistry. 2020 Jun 18
• 2 citations
  Preliminary evidence of effects of potassium chloride on a metabolomic path to diabetes and cardiovascular disease.
  Ranee Chatterjee, Clemontina A. Davenport, Lydia Coulter Kwee, David A. D'Alessio, Laura P. Svetkey, Pao-Hwa Lin, Cris A. Slentz, Olga Ilkayeva, Johanna L. Johnson, Da...> ;Metabolomics. 2020 Jun 18
• 100 citations
  Erratum. 2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Associati...
  John B. Buse, Deborah J. Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A. D'Alessio, Melanie J. Davies> ;Diabetes Care. 2020 May 22
• 2 citations
  Thermic effect of food and resting energy expenditure after sleeve gastrectomy for weight loss in adolescent females.
  Bonnie J. Brehm, Suzanne S. Summer, Todd M. Jenkins, David A. D'Alessio, Thomas H. Inge> ;Surgery for Obesity and Related Diseases. 2020 Feb 4
• 9 citations
  Rapid hepatic metabolism blunts the endocrine action of portally infused GLP-1 in male rats.
  Benedikt A. Aulinger, Marta Perabo, Randy J. Seeley, Klaus G. Parhofer, David A. D'Alessio> ;American Journal of Physiology. Endocrinology and Metabolism. 2020 Feb 1
• 32 citations
  Pharmacological antagonism of the incretin system protects against diet-induced obesity.
  Berit Svendsen, Megan E. Capozzi, Jingjing Nui, Sarah A. Hannou, Brian Finan, Jacqueline Naylor, Peter Ravn, David A. D'Alessio, Jonathan E. Campbell> ;Molecular Metabolism. 2020 Feb 1
• 12 citations
  THE EFFECTS OF PERIOPERATIVE DEXAMETHASONE ON GLYCEMIC CONTROL AND POSTOPERATIVE OUTCOMES
  Rebecca Herbst, Onala Telford, John Hunting, W. Michael Bullock, Erin L. Manning, Beatrice D. Hong, David A. D'Alessio, Tracy L. Setji> ;Endocrine Practice. 2020 Feb 1
• 30 citations
  The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition
  Megan E. Capozzi, Reilly W. Coch, Jepchumba Koech, Inna Astapova, Jacob B. Wait, Sara E. Encisco, Jonathan D. Douros, Kimberly El, Brian Finan, Mark A. Herman, David A...> ;Diabetes. 2020 Jan 29
• 18 citations
  Efficacy and Safety of the Glucagon Receptor Antagonist RVT-1502 in Type 2 Diabetes Uncontrolled on Metformin Monotherapy: A 12-Week Dose-Ranging Study
  Jeremy Pettus, David A. D'Alessio, Juan P. Frias, Eric G. Vajda, James D. Pipkin, Julio Rosenstock, Gretchen Williamson, Miriam A. Zangmeister, Lin Zhi, Keith B. Marschke> ;Diabetes Care. 2020 Jan 1
• 47 citations
  The Effects of Bariatric Surgery on Islet Function, Insulin Secretion, and Glucose Control.
  Jonathan D. Douros, Jenny Tong, David A. D'Alessio> ;Endocrine Reviews. 2019 Oct 1
• One small step for mice, one giant leap for GWAS?
  Mark A. Herman, Jonathan E. Campbell, David A. D'Alessio> ;The Journal of Clinical Investigation. 2019 Oct 1
• 18 citations
  Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes.
  Edith Angellotti, David A. D'Alessio, Bess Dawson-Hughes, Yan Chu, Jason Nelson, Peter J Hu, Robert M. Cohen, Anastassios G. Pittas> ;Clinical Nutrition. 2019 Oct 1
• 12 citations
  Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery
  Marzieh Salehi, Amalia Gastaldelli, David A. D'Alessio> ;Gut. 2019 Oct 1
• 632 citations
  Glucagon-like peptide 1 (GLP-1)
  Timo D. Müller, Brian Finan, Stephen R. Bloom, David A. D'Alessio, Daniel J. Drucker, Peter R. Flatt, Andreas Fritsche, Fiona M. Gribble, Harvey J. Grill, Joel F. Habe...> ;Molecular Metabolism. 2019 Sep 30
• 11 citations
  Intraislet Ghrelin Signaling Does Not Regulate Insulin Secretion From Adult Mice.
  Sarah M. Gray, Jingjing Niu, Amanda Zhang, Berit Svendsen, Jonathan E. Campbell, David A. D'Alessio, Jenny Tong> ;Diabetes. 2019 Sep 1
• 83 citations
  Glucagon lowers glycemia when β-cells are active.
  Megan E. Capozzi, Jacob B. Wait, Jepchumba Koech, Andrew Gordon, Reilly W. Coch, Berit Svendsen, Brian Finan, David A. D'Alessio, Jonathan E. Campbell> ;JCI Insight. 2019 Aug 22
• 12 citations
  Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control.
  Jonathan D. Douros, Jingjing Niu, Sophia M. Sdao, Trillian Gregg, Matthew J. Merrins, Jonathan E. Campbell, Jenny Tong, David A. D'Alessio> ;Molecular Metabolism. 2019 Jul 5
• 7 citations
  Role of vagal activation in postprandial glucose metabolism after gastric bypass in individuals with and without hypoglycaemia
  Marzieh Salehi, Amalia Gastaldelli, David A. D'Alessio> ;Diabetes, Obesity & Metabolism. 2019 Jun 1
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Journal Articles

• Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans  
  Zhang CJ, Bidlingmaier M, Altaye M, Page LC, D'Alessio D, Tschop MH, Tong J, Eur J Endocrinol, 1/1/2017
• Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress  
  Ghosal S, Packard AE, Mahbod P, McKlveen JM, Seeley RJ, Myers B, Ulrich-Lai Y, Smith EP, D'Alessio DA, Herman JP, J Neurosci, 1/1/2017
• The incretin effect in obese adolescents with and without type 2 diabetes: Impaired or intact?  
  Aulinger BA, Vahl TP, Prigeon RL, D'Alessio DA, Elder DA, Am J Physiol Endocrinol Metab, 1/1/2016
• Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1  
  Tong J, Davis HW, Gastaldelli A, D'Alessio D, J Clin Endocrinol Metab, 1/1/2016
• Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation  
  Alzaman NS, Dawson-Hughes B, Nelson J, D'Alessio D, Pittas AG, Am J Clin Nutr, 1/1/2016
• Baseline factors associated with glycaemic response to treatment with weekly dulaglutide in patients with type 2 diabetes  
  Wysham C, Guerci B, D'Alessio D, Jia N, Botros FT, Diabetes Obes Metab, 1/1/2016
• Is GLP-1 a hormone: Whether and When?  
  D'Alessio D, J Diabetes Investig, 1/1/2016
• Bariatric Surgery: A Potential Treatment for Type 2 Diabetes in Youth  
  Shah AS, D'Alessio D, Ford-Adams ME, Desai AP, Inge TH, Diabetes Care, 1/1/2016
• Bariatric/metabolic surgery for diabetes: Incorporating a powerful treatment into standard care  
  Wolfe BM, D'Alessio DA, Obesity, 1/1/2016
• Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe  
  Salehi M, D'Alessio DA, Surg Obes Relat Dis, 1/1/2016
• Comparison of insulin glargine and liraglutide added to oral agents in patients with poorly controlled type 2 diabetes  
  D'Alessio D, Häring HU, Charbonnel B, de Pablos-Velasco P, Candelas C, Dain MP, Vincent M, Pilorget V, Yki-Jarvinen H, Diabetes Obes Metab, 1/1/2015
• Rapid deterioration of insulin secretion in obese adolescents preceding the onset of type 2 diabetes  
  Elder DA, Hornung LN, Herbers PM, Prigeon R, Woo JG, D'Alessio DA, J Pediatr, 1/1/2015
• Insulin detemir is transported from blood to cerebrospinal fluid and has prolonged central anorectic action relative to NPH insulin  
  Begg D, May A, Mul JD, Liu M, D'Alessio DA, Seeley RJ, Woods SC, Diabetes, 1/1/2015
• Exenatide protects against glucose and lipid-induced endothelial dysfunction: Evidence for direct vasodilation effect of GLP-1 receptor agonists in humans  
  Koska J, Sands M, Burciu C, D'Souza K, Raravikar K, Liu J, Truran S, Franco DA, Schwartz EA, Schwenke DC, D'Alessio D, Migrino RQ, Reaven PD, Diabetes, 1/1/2015
• Beta-cell sensitivity to GLP-1 in healthy humans is variable and proportional to insulin sensitivity  
  Aulinger BA, Vahl TP, Wilson-Perez HE, Prigeon RL, D'Alessio DA, J Clin Endocrinol Metab, 1/1/2015
• Diet-Induced Obese Mice Retain Endogenous Leptin Action  
  Ottaway N, Mahbod P, Rivero B, Norman LA, Gertler A, D'Alessio DA, Perez-Tilve D, Cell Metab, 1/1/2015
• Ghrelin  
  Muller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebte..., Mol Metab, 1/1/2015
• Mouse handling limits the impact of stress on metabolic endpoints  
  Ghosal S, Nunley A, Mahbod P, Lewis AG, Smith EP, Tong J, D'Alessio DA, Herman JP, Physiol Behav, 1/1/2015
• Gastric bypass alters both glucose-dependent and glucose-independent regulation of islet hormone secretion  
  Salehi M, Woods SC, D'Alessio DA, Obesity, 1/1/2015
• Insulin Sensitivity and beta-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents  
  Inge TH, Prigeon RL, Elder DA, Jenkins TM, Cohen RM, Xanthakos SA, Benoit SC, Dolan LM, Daniels SR, D'Alessio DA, J Pediatr, 1/1/2015
• Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes ...  
  Gibb RD, McRorie JW Jr, Russell DA, Hasselblad V, D'Alessio DA, Am J Clin Nutr, 1/1/2015
• Physiology of Proglucagon Peptides: The role of glucagon and GLP-1 in health and disease  
  Sandoval D and D’Alessio DA, Phys Rev, 1/1/2015
• Ghrelin and hypothalamic development: too little and too much of a good thing  
  Tong J, D'Alessio D, J Clin Invest, 1/1/2015
• Controversial Issues: When the drugs don't work, can surgery provide a different outcome for diabetic adolescents?  
  Beamish AJ, D'Alessio DA, Inge TH, Surg Obes Relat Dis, 1/1/2015
• An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes  
  Rosario W, D'Alessio D, Diabetes, 1/1/2015
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Books/Book Chapters

• Textbook of Diabetes 
  Chapter: Glucagon in Islet and Metabolic Regulation 
  Page 103.0 - 113.0Sandoval D, Tong J, D’Alessio DEditors: Holt, Cockram, Flyvbjerg Goldstein.JohnWiley and Sons, Ltd, Chichester, West Sussex, UKEdition 5th,2017
• Therapy for Diabetes Mellitus and Related Disorders 
  Chapter: GLP-1 based drugs 
  Diab D, D’Alessio DAEditors: G Umpierrez.Alexandria, VAEdition 6th,2014
• Manual of Obstetrics 
  Chapter: Endocrine Disorders: Thyroid, Parathyroid, Adrenal, and Pituitary Disease 
  Valent AM, D’Alessio DAEditors: AT Evans.Philadelphia, PAEdition 8th,2014
• Obesity 
  Chapter: Environmental factors influencing obesity 
  Brehm, B. and D’Alessio, DEditors: M. Weickert.2014
• Goodman and Gilman’s The Pharmacologic Basis of Therapeutics 
  Chapter: Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia 
  Page 1237. - 1274.Powers AC, D’Alessio DAEditors: Brunton, Chabner, Knollman.New York, NYEdition 12th,2013
• Diabetes: Translating Research into Practice 
  Chapter: The incretin effect: Regulation of insulin secretion and glucose tolerance by GI hormones 
  D’Alessio DA, Aulinger BA, Salehi MEditors: CJ Greenbaum and CH Harrison.New York, NY2008
• Ellenberg and Rifkin’s Diabetes Mellitus 
  Chapter: Incretins: Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like peptide 1 
  Page 85.0 - 96.0D’Alessio DAEditors: Baron, Porte Jr. and Sherwin.New York, NY2002
• The insulinotropic hormone Glucagon-like peptide 1 
  Chapter: The regulation of islet hormone secretion by GLP-1 in humans 
  Page 132.0 - 141.0D’Alessio DA, Ensinck JWEditors: Fehman, Goke and Goke.Basel1996
• Frontiers in Diabetes Research, Lessons from animal diabetes 
  Chapter: Consequences of human IAPP expression in transgenic mice 
  Verchere CB, D'Alessio DA, Kahn SEEditors: Shafrir and Renold.London1994
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