DavidAlanFrankMD

PubMed

• Oncogenic STAT Transcription Factors as Targets for Cancer Therapy: Innovative Strategies and Clinical Translation.
  Weiyuan Wang, Melanie Cristina Lopez McDonald, Rajashree Hariprasad, Tiara Hamilton, David A Frank> ;Cancers. 2024 Mar 31
• 1 citations
  Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens.
  Jennifer I Brown, Rosanne Persaud, Petar Iliev, Ujjwala Karmacharya, Sanaz Attarha, Henok Sahile, Jonas E Olsen, Danielle Hanke, Temilolu Idowu, David A Frank, Adam Fr...> ;European Journal of Medicinal Chemistry. 2024 Jan 15
• 1 citations
  Prolactin levels and breast cancer risk by tumor expression of prolactin-related markers.
  Cassandra A Hathaway, Megan S Rice, Laura C Collins, Dilys Chen, David A Frank, Sarah Walker, Charles V Clevenger, Rulla M Tamimi, Shelley S Tworoger, Susan E Hankinson> ;Breast Cancer Research. 2023 Mar 7
• 2 citations
  Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.
  Jennifer I Brown, Peng Wang, Alan Y L Wong, Boryana Petrova, Rosanne Persaud, Sepideh Soukhtehzari, Melanie Lopez McDonald, Danielle Hanke, Josephine Christensen, Peta...> ;Metabolites. 2023 Jan 19
• 1 citations
  The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies.
  Weiyuan Wang, Melanie Cristina Lopez McDonald, Christine Kim, Mirielle Ma, Zetao Tommy Pan, Charlotte Kaufmann, David A Frank> ;Frontiers in Immunology. 2023 Jan 1
• 2 citations
  Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates.
  Evan C Chen, Helen Gandler, Isidora Tošić, Geoffrey G Fell, Ashlee Fiore, Olga Pozdnyakova, Daniel J DeAngelo, Ilene Galinsky, Marlise R Luskin, Martha Wadleigh, Eric ...> ;Clinical Cancer Research. 2023 Mar 1
• 13 citations
  JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States.
  Laura E Stevens, Guillermo Peluffo, Xintao Qiu, Daniel Temko, Anne Fassl, Zheqi Li, Anne Trinh, Marco Seehawer, Bojana Jovanović, Maša Alečković, Callahan M Wilde, Ren...> ;Cancer Research. 2023 Jan 18
• 3 citations
  Increased MYBL2 expression in aggressive hormone-sensitive prostate cancer.
  Yuki Yoshikawa, Konrad H Stopsack, Xin Victoria Wang, Yu-Hui Chen, Ying Z Mazzu, Foster Burton, Goutam Chakraborty, Sai Harisha Rajanala, Rahim Hirani, Subhiksha Nanda...> ;Molecular Oncology. 2022 Dec 1
• 18 citations
  Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration.
  Amrendra K Ajay, Li Zhao, Shruti Vig, Mai Fujiwara, Sudhir Thakurela, Shreyas Jadhav, Andrew Cho, I-Jen Chiu, Yan Ding, Krithika Ramachandran, Arushi Mithal, Aanal Bha...> ;Cell Reports. 2022 Mar 8
• 11 citations
  The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.
  Lisa N Heppler, Sanaz Attarha, Rosanne Persaud, Jennifer I Brown, Peng Wang, Boryana Petrova, Isidora Tošić, Foster B Burton, Yael Flamand, Sarah R Walker, Jennifer E ...> ;The Journal of Biological Chemistry. 2022 Feb 1
• 39 citations
  STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications.
  Isidora Tošić, David A. Frank> ;Neoplasia. 2021 Oct 29
• 22 citations
  Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability.
  Li Wang, Matteo Astone, Sk Kayum Alam, Zhu Zhu, Wuhong Pei, David A. Frank, Shawn M. Burgess, Luke H. Hoeppner> ;Disease Models & Mechanisms. 2021 Sep 20
• 11 citations
  IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway.
  Felipe Valença-Pereira, Qian Fang, Isabelle Marie, Emily Giddings, Karen A. Fortner, Rui Yang, Alejandro V. Villarino, Yina H. Huang, David A. Frank, Haitao Wen, David...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Sep 14
• 61 citations
  "It's like 'liquid handcuffs": The effects of take-home dosing policies on Methadone Maintenance Treatment (MMT) patients' lives.
  David A. Frank, Pedro Mateu-Gelabert, David C. Perlman, Suzan M. Walters, Laura Curran, Honoria Guarino> ;Harm Reduction Journal. 2021 Aug 14
• 5 citations
  A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML.
  Bo-Rui Chen, Anagha Deshpande, Karina Barbosa, Maria Kleppe, Xue Lei, Narayana Yeddula, Pablo Sanchez Vela, Alexandre Rosa Campos, Robert J. Wechsler-Reya, Anindya Bag...> ;Blood. 2021 Jun 17
• 4 citations
  "I'm pretty sure it's either food poisoning or Covid-19": Lived experience versus medical knowledge in diagnosing substance use problems.
  David A. Frank> ;The International Journal on Drug Policy. 2021 Jun 14
• 4 citations
  Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM).
  Moshe Lapidot, Abigail E Case, Ellen Weisberg, Chengcheng Meng, Sarah R. Walker, Swati Garg, Wei Ni, Klaus Podar, Yin P Hung, Ruben D. Carrasco, Aine Knott, Prafulla C...> ;British Journal of Cancer. 2021 Jun 4
• 14 citations
  Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer.
  Suhu Liu, Helen I. Gandler, Isidora Tošić, Darwin Q. Ye, Zachary T. Giaccone, David A. Frank> ;Molecular Cancer Research. 2021 Apr 30
• 40 citations
  Socially-supportive norms and mutual aid of people who use opioids: An analysis of Reddit during the initial COVID-19 pandemic.
  Amanda M. Bunting, David A. Frank, Joshua Arshonsky, Marie A. Bragg, Samuel R. Friedman, Noa Krawczyk> ;Drug and Alcohol Dependence. 2021 May 1
• 33 citations
  "How will I get my next week's script?" Reactions of Reddit opioid forum users to changes in treatment access in the early months of the coronavirus pandemic.
  Noa Krawczyk, Amanda M. Bunting, David A. Frank, Joshua Arshonsky, Yuanqi Gu, Samuel R. Friedman, Marie A. Bragg> ;The International Journal on Drug Policy. 2021 Feb 5
• 4 citations
  Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid-coated Layer-by-Layer Nanoparticles
  Isidora Tošić, Lisa N. Heppler, Susana P. Egusquiaguirre, Natalie Boehnke, Santiago Correa, Daniel F. Costa, Elizabeth A. Grossman Moore, Sharmistha Pal, Douglas S. Ri...> ;Molecular Cancer Therapeutics. 2021 Feb 3
• 17 citations
  Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses.
  Jennifer R. Brown, Sarah R. Walker, Lisa N. Heppler, Svitlana Tyekucheva, Erik A. Nelson, Josephine L. Klitgaard, Maria Nicolais, Yasmin Kroll, Michael Xiang, Jennifer...> ;American Journal of Hematology. 2021 Apr 1
• 12 citations
  Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM).
  Moshe Lapidot, Abigail E Case, Dalia Larios, Helen I. Gandler, Chengcheng Meng, Isidora Tošić, Ellen Weisberg, Michael J. Poitras, Prafulla C. Gokhale, Cloud P. Pawele...> ;Cancers. 2020 Dec 22
• 8 citations
  Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
  Li Wang, Matteo Astone, Sk Kayum Alam, Zhu Zhu, Wuhong Pei, David A. Frank, Shawn M. Burgess, Luke H. Hoeppner> ;Biorxiv. 2020 Oct 28
• 3 citations
  Retraction Note: Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation
  Jixiao Niu, Yang Sun, Baoen Chen, Baohui Zheng, Gopala K. Jarugumilli, Sarah R. Walker, Aaron N. Hata, Mari Mino-Kenudson, David A. Frank, Xu Wu> ;Nature. 2020 Jul 1
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Journal Articles

• Study of Cathepsin B Inhibition in VEGFR TKI Treated Human Renal Cell Carcinoma Xenografts  
  David A Frank, Rupal S Bhatt, Seth L Alper, Prateek Khanna, Nature

Abstracts/Posters

• Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical, Clinical, and Correlative Studies
  David A. Frank, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019