DavidAlanFrankMD

PubMed

• Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration.
  Amrendra K Ajay, Li Zhao, Shruti Vig, Mai Fujiwara, Sudhir Thakurela, Shreyas Jadhav, Andrew Cho, I-Jen Chiu, Yan Ding, Krithika Ramachandran, Arushi Mithal, Aanal Bha...> ;Cell reports. 2022 Mar 8
• 6 citations
  STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications.
  Isidora Tošić, David A. Frank> ;Neoplasia. 2021 Oct 29
• 3 citations
  Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability.
  Li Wang, Matteo Astone, Sk Kayum Alam, Zhu Zhu, Wuhong Pei, David A. Frank, Shawn M. Burgess, Luke H. Hoeppner> ;Disease Models & Mechanisms. 2021 Sep 20
• IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway.
  Felipe Valença-Pereira, Qian Fang, Isabelle Marie, Emily Giddings, Karen A. Fortner, Rui Yang, Alejandro V. Villarino, Yina H. Huang, David A. Frank, Haitao Wen, David...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Sep 14
• 11 citations
  "It's like 'liquid handcuffs": The effects of take-home dosing policies on Methadone Maintenance Treatment (MMT) patients' lives.
  David A. Frank, Pedro Mateu-Gelabert, David C. Perlman, Suzan M. Walters, Laura Curran, Honoria Guarino> ;Harm Reduction Journal. 2021 Aug 14
• 1 citations
  "I'm pretty sure it's either food poisoning or Covid-19": Lived experience versus medical knowledge in diagnosing substance use problems.
  David A. Frank> ;International Journal of Drug Policy. 2021 Jun 14
• 1 citations
  Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM).
  Moshe Lapidot, Abigail E Case, Ellen Weisberg, Chengcheng Meng, Sarah R. Walker, Swati Garg, Wei Ni, Klaus Podar, Yin P Hung, Ruben D. Carrasco, Aine Knott, Prafulla C...> ;British Journal of Cancer. 2021 Jun 4
• 3 citations
  Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer.
  Suhu Liu, Helen I. Gandler, Isidora Tošić, Darwin Q. Ye, Zachary T. Giaccone, David A. Frank> ;Molecular Cancer Research. 2021 Apr 30
• 14 citations
  Socially-supportive norms and mutual aid of people who use opioids: An analysis of Reddit during the initial COVID-19 pandemic.
  Amanda M. Bunting, David A. Frank, Joshua Arshonsky, Marie A. Bragg, Samuel R. Friedman, Noa Krawczyk> ;Drug and Alcohol Dependence. 2021 May 1
• A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML.
  Bo-Rui Chen, Anagha Deshpande, Karina Barbosa, Maria Kleppe, Xue Lei, Narayana Yeddula, Pablo Sanchez Vela, Alexandre Rosa Campos, Robert J. Wechsler-Reya, Anindya Bag...> ;Blood. 2021 Jun 17
• 13 citations
  "How will I get my next week's script?" Reactions of Reddit opioid forum users to changes in treatment access in the early months of the coronavirus pandemic.
  Noa Krawczyk, Amanda M. Bunting, David A. Frank, Joshua Arshonsky, Yuanqi Gu, Samuel R. Friedman, Marie A. Bragg> ;International Journal of Drug Policy. 2021 Feb 5
• 3 citations
  Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid-coated Layer-by-Layer Nanoparticles
  Isidora Tošić, Lisa N. Heppler, Susana P. Egusquiaguirre, Natalie Boehnke, Santiago Correa, Daniel F. Costa, Elizabeth A. Grossman Moore, Sharmistha Pal, Douglas S. Ri...> ;Molecular Cancer Therapeutics. 2021 Feb 3
• 6 citations
  Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses.
  Jennifer R. Brown, Sarah R. Walker, Lisa N. Heppler, Svitlana Tyekucheva, Erik A. Nelson, Josephine L. Klitgaard, Maria Nicolais, Yasmin Kroll, Michael Xiang, Jennifer...> ;American Journal of Hematology. 2021 Apr 1
• 7 citations
  Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM).
  Moshe Lapidot, Abigail E Case, Dalia Larios, Helen I. Gandler, Chengcheng Meng, Isidora Tošić, Ellen Weisberg, Michael J. Poitras, Prafulla C. Gokhale, Cloud P. Pawele...> ;Cancers. 2020 Dec 22
• 1 citations
  Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
  Li Wang, Matteo Astone, Sk Kayum Alam, Zhu Zhu, Wuhong Pei, David A. Frank, Shawn M. Burgess, Luke H. Hoeppner> ;bioRxiv. 2020 Oct 28
• 1 citations
  Retraction Note: Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation
  Jixiao Niu, Yang Sun, Baoen Chen, Baohui Zheng, Gopala K. Jarugumilli, Sarah R. Walker, Aaron N. Hata, Mari Mino-Kenudson, David A. Frank, Xu Wu> ;Nature. 2020 Jul 1
• An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling.
  Yue Yin, David A. Frank, Weijie Zhou, Neena Kaur, Jarrod B. French, Nick Carpino> ;Journal of Biological Chemistry. 2020 May 5
• 7 citations
  Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors.
  Robert A. Cerulli, Livia Shehaj, Isidora Tošić, Kevin Jiang, Jing Wang, David A. Frank, Joshua A. Kritzer> ;Bioorganic & Medicinal Chemistry. 2020 May 4
• 8 citations
  CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3
  Susana P. Egusquiaguirre, Suhu Liu, Isidora Tošić, Kevin Jiang, Sarah R. Walker, Maria Nicolais, Tzuen Yih Saw, Michael Xiang, Katarina Bartel, Erik A. Nelson, David A...> ;Neoplasia. 2020 Jan 1
• 14 citations
  Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation.
  Alexandra M. Stevens, Michael Xiang, Lisa N. Heppler, Isidora Tošić, Kevin Jiang, Jaime O. Munoz, Amos Gaikwad, Terzah M. Horton, Xin Long, Padmini Narayanan, Elizabet...> ;Blood Advances. 2019 Dec 23
• 5 citations
  Inhibit versus Destroy: Are PROTAC Degraders the Solution to Targeting STAT3?
  Lisa N. Heppler, David A. Frank> ;Cancer Cell. 2019 Nov 11
• 29 citations
  Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.
  Jixiao Niu, Yang Sun, Baoen Chen, Baohui Zheng, Gopala K. Jarugumilli, Sarah R. Walker, Aaron N. Hata, Mari Mino-Kenudson, David A. Frank, Xu Wu> ;Nature. 2019 Aug 28
• 2 citations
  Cancer Biomarkers for Integrative Oncology
  Aniruddha Ganguly, David A. Frank, Nagi B. Kumar, Yung-Chi Cheng, Edward Chu> ;Current Oncology Reports. 2019 Mar 5
• 15 citations
  Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts.
  Chun-Hau Chen, Swati Bhasin, Prateek Khanna, Joshi M, Joslin Pm, Ruchi Saxena, Amin S, Liu S, Sindhu S, Walker, Paul J. Catalano, David A. Frank, Seth L. Alper, Manoj ...> ;Oncogenesis. 2019 Feb 22
• 14 citations
  The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.
  Suhu Liu, Anna E. Marneth, Gabriela Alexe, Sarah R. Walker, Helen I. Gandler, Darwin Q. Ye, Katherine Labella, Radhika Mathur, Patricia A. Toniolo, Michelle Tillgren, ...> ;Blood Advances. 2018 Dec 11
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Journal Articles

• Study of Cathepsin B Inhibition in VEGFR TKI Treated Human Renal Cell Carcinoma Xenografts  
  David A Frank, Rupal S Bhatt, Seth L Alper, Prateek Khanna, Nature

Abstracts/Posters

• Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical, Clinical, and Correlative Studies
  David A. Frank, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019