DavidGailaniMD

PubMed

• Targeting factor XI and factor XIa to prevent thrombosis.
  Andras Gruber, David Gailani> ;Blood. 2024 Apr 11
• 1 citations
  A mechanism for hereditary angioedema caused by a methionine-379-to-lysine substitution in kininogens.
  S Kent Dickeson, Sunil Kumar, Mao-Fu Sun, Maxim Litvak, Tracey Z He, Dennis R Phillips, Elijah T Roberts, Edward P Feener, Ruby H P Law, David Gailani> ;Blood. 2024 Feb 15
• 3 citations
  Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placeb...
  Sharma, M., Molina, C., Toyoda, K., Bereczki, D., Bangdiwala, S., Kasner, S., Lutsep, H., Tsivgoulis, G., Ntaios, G., Czlonkowska, A., Shuaib, A., Amarenco, P., Endres...> ;The Lancet. Neurology. 2024 Jan 1
• Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia.
  Kohs, T., Vu, H., Jordan, K., Parra-Izquierdo, I., Hinds, M., Shatzel, J., Kievit, P., Morgan, T., Yunga, S., Ngo, T., Aslan, J., Wallisch, M., Lorentz, C., Tucker, E....> ;Research and Practice in Thrombosis and Haemostasis. 2024 Jan 1
• 1 citations
  Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Patients With Cancer Undergoing Central Line Placement: A Phase 2 Clinical Trial.
  Michael A Pfeffer, Tia C L Kohs, Helen H Vu, Kelley R Jordan, Christina U Lorentz, Erik I Tucker, Cristina Puy, Sven R Olson, Thomas G DeLoughery, Monica T Hinds, Ravi...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2024 Jan 1
• Chromogenic and Clot-Based Bivalirudin Assays for Monitoring Anticoagulation.
  Prashant Raghavendran, Benjamin F Tillman, Allison P Wheeler, David Gailani> ;The Journal of Applied Laboratory Medicine. 2023 Nov 2
• High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation.
  Bassem M Mohammed, Mao-Fu Sun, Qiufang Cheng, Maxim Litvak, Keith R McCrae, Jonas Emsley, Owen J T McCarty, David Gailani> ;Journal of Thrombosis and Haemostasis. 2024 Jan 1
• Factor XI Inhibition With Heparin Reduces Clot Formation in Simulated Pediatric Extracorporeal Membrane Oxygenation.
  Andrew D Meyer, Catherine R Thorpe, Tamara Fraker, Tomas Cancio, Jeanette Rocha, R Patrick Willis, Andrew P Cap, David Gailani, Joseph J Shatzel, Erik I Tucker, Owen J...> ;ASAIO Journal. 2023 Dec 1
• Kininogen debuts on apple (domain) disks.
  Bassem M Mohammed, David Gailani> ;Journal of Thrombosis and Haemostasis. 2023 Sep 1
• 2 citations
  Pharmacological targeting of coagulation factor XI attenuates experimental autoimmune encephalomyelitis in mice.
  Tia C L Kohs, Meghan E Fallon, Ethan C Oseas, Laura D Healy, Erik I Tucker, David Gailani, Owen J T McCarty, Arthur A Vandenbark, Halina Offner, Norah G Verbout> ;Metabolic Brain Disease. 2023 Oct 1
• 3 citations
  Factor XII Structure-Function Relationships.
  Aleksandr Shamanaev, Maxim Litvak, Ivan Ivanov, Priyanka Srivastava, Mao-Fu Sun, S Kent Dickeson, Sunil Kumar, Tracey Z He, David Gailani> ;Seminars in Thrombosis and Hemostasis. 2023 Jun 5
• 3 citations
  A site on factor XII required for productive interactions with polyphosphate.
  Aleksandr Shamanaev, Maxim Litvak, Qiufang Cheng, Michal Ponczek, S Kent Dickeson, Stephanie A Smith, James H Morrissey, David Gailani> ;Journal of Thrombosis and Haemostasis. 2023 Jun 1
• 3 citations
  Recommendation on the nomenclature for anticoagulants: updated communication from the International Society on Thrombosis and Haemostasis Scientific and Standardizatio...
  Geoffrey D Barnes, Walter Ageno, Lana A Castellucci, Thita Chiasakul, Renee Eslick, José L Ferreiro, David Gailani, Diana A Gorog, Gregory Y H Lip, Leslie Raffini, Sue...> ;Journal of Thrombosis and Haemostasis. 2023 May 1
• 7 citations
  Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease.
  Erica M Sparkenbaugh, Michael W Henderson, Megan Miller-Awe, Christina Abrams, Anton Ilich, Fatima Trebak, Nirupama Ramadas, Shantel Vital, Dillon Bohinc, Kara L Bane,...> ;Blood. 2023 Apr 13
• 1 citations
  Mechanisms involved in hereditary angioedema with normal C1-inhibitor activity.
  Aleksandr Shamanaev, S Kent Dickeson, Ivan Ivanov, Maxim Litvak, Mao-Fu Sun, Sunil Kumar, Quifang Cheng, Priyanka Srivastava, Tracey Z He, David Gailani> ;Frontiers in Physiology. 2023 Jan 1
• 4 citations
  Titanium is a potent inducer of contact activation: implications for intravascular devices.
  Maxim Litvak, Aleksandr Shamanaev, Sandip Zalawadiya, Anton Matafonov, Anton Kobrin, Edward P Feener, Michael Wallisch, Erik I Tucker, Owen J T McCarty, David Gailani> ;Journal of Thrombosis and Haemostasis. 2023 May 1
• A demonstration of factor XI contributing to hemostasis in the absence of factor XII.
  Bassem M Mohammed, Qiufang Cheng, David Gailani> ;Research and Practice in Thrombosis and Haemostasis. 2022 Nov 1
• 23 citations
  Rationale and design of the AXIOMATIC-SSP phase II trial: Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute Thromboembolic events for...
  Mukul Sharma, Carlos A Molina, Kazunori Toyoda, Daniel Bereczki, Scott E Kasner, Helmi L Lutsep, Georgios Tsivgoulis, George Ntaios, Anna Czlonkowska, Ashfaq Shuaib, P...> ;Journal of Stroke and Cerebrovascular Diseases. 2022 Oct 1
• 11 citations
  Revised model of the tissue factor pathway of thrombin generation: Role of the feedback activation of FXI.
  Hari Hara Sudhan Lakshmanan, Aldrich Estonilo, Stéphanie E Reitsma, Alexander R Melrose, Jayaram Subramanian, Tony J Zheng, Jeevan Maddala, Erik I Tucker, David Gailan...> ;Journal of Thrombosis and Haemostasis. 2022 Jun 1
• 7 citations
  Pharmacological reduction of coagulation factor XI reduces macrophage accumulation and accelerates deep vein thrombosis resolution in a mouse model of venous thrombosis.
  Kelley R Jordan, Cory R Wyatt, Meghan E Fallon, Randy Woltjer, Edward A Neuwelt, Quifang Cheng, David Gailani, Christina Lorentz, Erik I Tucker, Owen J T McCarty, Moni...> ;Journal of Thrombosis and Haemostasis. 2022 Sep 1
• 10 citations
  Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains.
  Aleksandr Shamanaev, Ivan Ivanov, Mao-Fu Sun, Maxim Litvak, Priyanka Srivastava, Bassem M Mohammed, Rabia Shaban, Ashoka Maddur, Ingrid M Verhamme, Owen J T McCarty, R...> ;Blood Advances. 2022 May 24
• 11 citations
  A mechanism for hereditary angioedema caused by a lysine 311-to-glutamic acid substitution in plasminogen.
  S Kent Dickeson, Sunil Kumar, Mao-Fu Sun, Bassem M Mohammed, Dennis R Phillips, James C Whisstock, Adam J Quek, Edward P Feener, Ruby H P Law, David Gailani> ;Blood. 2022 May 5
• 1 citations
  A Common Missense Variant Causing Factor XI Deficiency and Increased Bleeding Tendency in Maine Coon Cats.
  Henrike Kuder, S Kent Dickeson, Marjory B Brooks, Alexandra Kehl, Elisabeth Müller, David Gailani, Urs Giger> ;Genes. 2022 Apr 28
• 3 citations
  Making anticoagulation safer.
  David Gailani> ;Lancet. 2022 Apr 9
• 4 citations
  Factor XI as a target for preventing venous thromboembolism.
  David Gailani> ;Journal of Thrombosis and Haemostasis. 2022 Mar 1
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Journal Articles

• Factor XI Promotes Hemostasis in Factor IX Deficient Mice  
  David Gailani, MD, Journal of Thrombosis and Haemostasis
• Peptidoglycan Induces Disseminated Intravascular Coagulation in Baboons Through Activation of Both Coagulation Pathways  
  David Gailani, MD, Blood