DavidGutsteinMD

Nuclear Cardiology

Vice President, Strategic Program Direction, Hematology, Regeneron Pharmaceuticals; Adjunct Professor of Medicine, New York University Medical Center

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Office
777 Old Saw Mill River Rd
Tarrytown, NY 10591
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Education & Training

Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalFellowship, Cardiovascular Disease, 1995 - 1999
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1991 - 1994
Northwestern University The Feinberg School of MedicineClass of 1991

Certifications & Licensure

NY State Medical License 1995 - 2024

Awards, Honors, & Recognition

Louis N. and Arnold M. Katz Basic Science Research Prize American Heart Association, 2000

Publications & Presentations

PubMed

2 citations
A Study to Assess the Proarrhythmic Potential of Mirtazapine Using Concentration‐QTc (C‐QTc) Analysis
Sevgi Gurkan, Fang Liu, Anne Chain, David E. Gutstein> ;Clinical Pharmacology in Drug Development. 2019 May 1
1 citations
Pharmacokinetics and Pharmacodynamics of Anacetrapib in Black and White Healthy Subjects
Rajesh Krishna, Ferdous Gheyas, Christy Corr, Josee Cote, Yang Liu, John A. Wagner, David E. Gutstein> ;Journal of Clinical Pharmacology. 2018 Dec 1
35 citations
Chronic Administration of Anacetrapib Is Associated With Accumulation in Adipose and Slow Elimination.
Rajesh Krishna, Ferdous Gheyas, Yang Liu, David Hagen, Brittany Walker, Akshita Chawla, Josee Cote, Robert O. Blaustein, David E. Gutstein> ;Clinical Pharmacology and Therapeutics. 2017 Nov 1
57 citations
CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects
Tiffany Thomas, Haihong Zhou, Wahida Karmally, Rajasekhar Ramakrishnan, Stephen Holleran, Yang Liu, Patricia Jumes, John A. Wagner, Brian K. Hubbard, Stephen F. Previs...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2017 Jul 20
15 citations
Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms
Deborah A. Howatt, Maya Dajee, Xiaojie Xie, Jessica J. Moorleghen, Debra L. Rateri, Anju Balakrishnan, Valdeci Da Cunha, Douglas G. Johns, David E. Gutstein, Alan Daug...> ;Circulation Journal. 2017 May 25
18 citations
Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E.
John S. Millar, Michael E. Lassman, Tiffany Thomas, Rajasekhar Ramakrishnan, Patricia Jumes, Richard L. Dunbar, Emile M. deGoma, Amanda Baer, Wahida Karmally, Daniel S...> ;Journal of Lipid Research. 2017 Mar 17
6 citations
Inhibition of Factor XIa Reduces the Frequency of Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits.
Xinkang Wang, Stan Kurowski, Weizhen Wu, Gino Castriota, Xueping Zhou, Lin Chu, Kenneth P. Ellsworth, Donald Chu, Scott D. Edmondson, Amjad Ali, Patrick Andre, Dietmar...> ;The Journal of Pharmacology and Experimental Therapeutics. 2017 Mar 1
9 citations
Factor XIIa as a Novel Target for Thrombosis: Target Engagement Requirement and Efficacy in a Rabbit Model of Microembolic Signals.
Christopher M. Barbieri, Xinkang Wang, Weizhen Wu, Xueping Zhou, Aimie M. Ogawa, Kim O’Neill, Donald Chu, Gino Castriota, Dietmar Seiffert, David E. Gutstein, Zhu Chen> ;The Journal of Pharmacology and Experimental Therapeutics. 2017 Mar 1
6 citations
A rabbit model of cerebral microembolic signals for translational research: preclinical validation for aspirin and clopidogrel.
Xueping Zhou, Stanley Kurowski, Weizhen Wu, K. Desai, Lin Chu, David E. Gutstein, Dietmar Seiffert, Xinkang Wang> ;Journal of Thrombosis and Haemostasis. 2016 Sep 1
3 citations
Apixaban Inhibits Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits.
Xueping Zhou, Weizhen Wu, Lin Chu, David E. Gutstein, Dietmar Seiffert, Xinkang Wang> ;The Journal of Pharmacology and Experimental Therapeutics. 2016 Sep 1
5 citations
Discovery and Clinical Evaluation of MK‐8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release
Clayton D. Knox, Pieter‐Jan de Kam, Karim Azer, Peggy H. Wong, Antwan G. Ederveen, Diane Shevell, Christopher J. Morabito, Alan G. Meehan, Wen Liu, Tom Reynders, Jean ...> ;Journal of the American Heart Association. 2016 Sep 1
14 citations
Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice.
Georgy Hartmann, Sanjeev Kumar, Douglas G. Johns, Ferdous Gheyas, David E. Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Ch...> ;Drug Metabolism and Disposition. 2016 Mar 1
29 citations
Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Decreases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholester...
Gissette Reyes-Soffer, John S. Millar, Colleen Ngai, Patricia Jumes, Ellie Coromilas, Bela F. Asztalos, Amy O. Johnson-Levonas, John A. Wagner, Daniel S. Donovan, Wahi...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2016 Jan 1
31 citations
Practical Immunoaffinity-Enrichment LC-MS for Measuring Protein Kinetics of Low-Abundance Proteins
Michael E. Lassman, Thomas McAvoy, Anita Y. H. Lee, Derek L Chappell, Oitak Wong, Haihong Zhou, Gissette Reyes-Soffer, Henry N. Ginsberg, John S. Millar, Daniel J. Rad...> ;Clinical Chemistry. 2014 Sep 1
16 citations
Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS
Yi Pan, Haihong Zhou, Ablatt Mahsut, Rory J. Rohm, Olga Berejnaia, Olga Price, Ying Chen, Jose Castro-Perez, Michael E. Lassman, David G. McLaren, James Conway, Kristi...> ;Journal of Lipid Research. 2014 Jun 1
14 citations
Effects of Rifampin, a Potent Inducer of Drug-Metabolizing Enzymes and an Inhibitor of OATP1B1/3 Transport, on the Single Dose Pharmacokinetics of Anacetrapib
Matt S. Anderson, Josee Cote, Yang Liu, Daria Stypinski, Patrice Auger, Anne Hohnstein, Scott Rasmussen, Amy O. Johnson-Levonas, David E. Gutstein> ;Journal of Clinical Pharmacology. 2013 Jul 1
28 citations
Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry
Haihong Zhou, Jose Castro-Perez, Michael E. Lassman, Tiffany Thomas, Wenyu Li, Theresa McLaughlin, Xie Dan, Patricia Jumes, John A. Wagner, David E. Gutstein, Brian K....> ;Rapid Communications in Mass Spectrometry. 2013 Jun 30
43 citations
The evaluation and management of drug effects on cardiac conduction (PR and QRS Intervals) in clinical development
Adel Nada, Gary Gintant, Robert Kleiman, David E. Gutstein, Christer Gottfridsson, Eric L. Michelson, Colette Strnadova, Matthew Killeen, Mary Jane Geiger, Mónica L. F...> ;American Heart Journal. 2013 Apr 1
39 citations
MK-0448, a specific Kv1.5 inhibitor: safety, pharmacokinetics, and pharmacodynamic electrophysiology in experimental animal models and humans.
Behzad B. Pavri, Howard E. Greenberg, Walter K. Kraft, Nicole Lazarus, Joseph J. Lynch, Joseph J. Salata, Mark T. Bilodeau, Christopher P. Regan, Gary L. Stump, Li Fan...> ;Circulation. Arrhythmia and Electrophysiology. 2012 Dec 1
13 citations
Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction
Jennifer B. Christian, John Finkle, Bonnie Ky, Pamela S. Douglas, David E. Gutstein, Paul D. Hockings, Pierre Lainee, Daniel J. Lenihan, Jay W. Mason, Philip T. Sager,...> ;American Heart Journal. 2012 Dec 1
1 citations
Quantifying monocyte infiltration in response to intradermal tetanus toxoid injection.
Joanna Z. Peng, David E. Gutstein, Lisa A. Beck, Lisa Hickey, Carolyn M. Hustad, Smita Abbi, Ajay Nirula, Julie DeMartino, Paul Rothenberg, Keith Gottesdiener, Daniel ...> ;Biomarkers in Medicine. 2012 Aug 23
13 citations
Quantification of circulating D-dimer by peptide immunoaffinity enrichment and tandem mass spectrometry.
Weixun Wang, Nykia D. Walker, Li-Ji Zhu, Weizhen Wu, Lan Ge, David E. Gutstein, Nathan A. Yates, Ronald C. Hendrickson, Martin L. Ogletree, Michele A. Cleary, Gregory ...> ;Analytical Chemistry. 2012 Jul 19
125 citations
Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells
Eri Taniguchi Ishikawa, Daniel González-Nieto, Gabriel Ghiaur, Susan K. Dunn, Ashley M. Ficker, Bhuvana Murali, Malav Madhu, David E. Gutstein, Glenn I. Fishman, Luis ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Jun 5
71 citations
Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors
Daniel González-Nieto, Lina Li, Anja Köhler, Gabriel Ghiaur, Eri Ishikawa, Amitava Sengupta, Malav Madhu, Jorden Arnett, Rebecca A. Santho, Susan K. Dunn, Glenn I. Fis...> ;Blood. 2012 May 31
44 citations
Anacetrapib, a Novel CETP Inhibitor: Pursuing a New Approach to Cardiovascular Risk Reduction
David E. Gutstein, Rajesh Krishna, Douglas G. Johns, Howard K. Surks, H M Dansky, Sonia Shah, Yale B. Mitchel, J Arena, John A. Wagner> ;Clinical Pharmacology and Therapeutics. 2012 Jan 1
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