DavidRHowlettMD

Family Medicine • East Granby, CT

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Office
13 Church Rd
East Granby, CT 06026
Phone+1 860-653-4526

Fax+1 860-653-5209
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Education & Training

University of ConnecticutResidency, Family Medicine, 1981 - 1983
Albany Medical CenterInternship, Family Medicine, 1980 - 1981
Uconn School Of MedicineClass of 1980

Certifications & Licensure

CT State Medical License 1982 - 2024
American Board of Family Medicine Family Medicine

Awards, Honors, & Recognition

Physician Practice Connections Recognition Program National Committee for Quality Assurance, 2011-2014
Patient-Centered Medical Home Recognition Program National Committee for Quality Assurance, 2011-2014
Diabetes Recognition Program National Committee for Quality Assurance, 2010-2013

Publications & Presentations

PubMed

55 citations
Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.
Carla J. Cox, Fahd Choudhry, Eleanor Peacey, Michael S. Perkinton, Jill C. Richardson, David R. Howlett, Stefan F. Lichtenthaler, Paul T. Francis, Robert J. Williams> ;Neurobiology of Aging. 2015 Jan 1
89 citations
Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment.
David Whitfield, Julie Vallortigara, Amani Alghamdi, David R. Howlett, Tibor Hortobágyi, Mary Johnson, Johannes Attems, Stephen Newhouse, Clive Ballard, Alan J. Thomas...> ;Neurobiology of Aging. 2014 Dec 1
3 citations
Decreased immunoreactivities of neocortical AMPA receptor subunits correlate with motor disability in Lewy body dementias
Nur-Ezan Mohamed, David R. Howlett, Lu Ma, Paul T. Francis, Dag Aarsland, Clive Ballard, Ian G. McKeith, Christopher Chen, Mitchell K.P. Lai> ;Journal of Neural Transmission. 2014 Jan 1
Systemic disease involvement of the hand: manifestations on plain radiograph.
Sellon E, Liakos A, Sallomi D, Anderson H, Panthakalam S, Howlett D> ;Br J Hosp Med (Lond). 2013-05-01
6 citations
Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model.
Elisa Dassie, Melissa R. Andrews, Jean-Charles Bensadoun, Matthias Cacquevel, Bernard L. Schneider, Patrick Aebischer, Fred S. Wouters, Jill C. Richardson, Ishrut Huss...> ;Neurobiology of Aging. 2013 May 1
30 citations
Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice
Fahd Choudhry, David R. Howlett, Jill C. Richardson, Paul T. Francis, Robert J. Williams> ;Neurobiology of Aging. 2012 May 1
Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice.
Martin Broadstock, Rikke Lewinsky, Emma L. Jones, Cathy Mitchelmore, David R. Howlett, Paul T. Francis> ;Journal of Neural Transmission. 2012 Apr 1
83 citations
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.
Paul J. Meakin, Alex J. Harper, D. Lee Hamilton, Jennifer E. Gallagher, Alison D. McNeilly, Laura A Burgess, Lobke M. Vaanholt, Kirsten A. Bannon, Judy Latcham, Ishrut...> ;The Biochemical Journal. 2012 Jan 1
14 citations
APP transgenic mice and their application to drug discovery.
David R. Howlett> ;Histology and Histopathology. 2011 Dec 1
21 citations
Characterisation of amyloid-induced inflammatory responses in the rat retina.
David R. Howlett, Simon T. Bate, Sarah Collier, A. Lawman, T Chapman, Tracey Ashmeade, Ian C B Marshall, Peter J. B. Anderson, Karen Louise Philpott, Jill C. Richardso...> ;Experimental Brain Research. 2011 Aug 18
Maintaining medical professionalism at the heart of radiology.
Thomas R, Bigland C, Burke C, Howlett D> ;Br J Hosp Med (Lond). 2011-07-01
50 citations
CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases.
Ritchie Williamson, Lidy van Aalten, David M. A. Mann, Bettina Platt, Florian Plattner, Lynn Bedford, John E. Mayer, David R. Howlett, Alessia Usardi, Calum Sutherland...> ;Journal of Alzheimer's Disease. 2011 Jan 1
Current applications of interventional radiology.
Shaw A, Speirs AJD, Howlett D> ;Br J Hosp Med (Lond). 2010-11-01
The role of plain films in imaging major trauma.
Burke CJ, Thomas RH, Owens E, Howlett D> ;Br J Hosp Med (Lond). 2010-11-01
7 citations
Neurochemical changes in a double transgenic mouse model of Alzheimer's disease fed a pro-oxidant diet
Elizabeth S. Ash, Mohammad S. Alavijeh, Alan M. Palmer, Cathy Mitchelmore, David R. Howlett, Paul T. Francis, Martin Broadstock, Jill C. Richardson> ;Neurochemistry International. 2010 Nov 1
Cranial computed tomography 2: use in clinical practice.
Thomas RH, Burke CJ, Howlett D> ;Br J Hosp Med (Lond). 2010-09-01
Cranial computed tomography 1: technical aspects for clinicians.
Thomas RH, Burke CJ, Howlett D> ;Br J Hosp Med (Lond). 2010-08-01
Imaging of stroke and transient ischaemic attack.
Thomas RH, Burke CJ, Howlett D> ;Br J Hosp Med (Lond). 2010-07-01
304 citations
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
Madhav Thambisetty, Andrew Simmons, Latha Velayudhan, Abdul Hye, James Campbell, Yi Zhang, Lars-Olof Wahlund, Eric Westman, Anna Kinsey, Andreas Güntert, Petroula Proi...> ;Archives of General Psychiatry. 2010 Jul 1
74 citations
Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP × PS1 mice using MRI
Satheesh Maheswaran, Hervé Barjat, Daniel Rueckert, Simon T. Bate, David R. Howlett, Lorna Tilling, Sean C. Smart, Andreas Pohlmann, Jill C. Richardson, Thomas Hartken...> ;Brain Research. 2009 May 13
49 citations
The pathology of APP transgenic mice: a model of Alzheimer's disease or simply overexpression of APP?
David R. Howlett, Jill C. Richardson> ;Histology and Histopathology. 2009 Jan 1
53 citations
Aβ1–42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors
Jonathan J. Abbott, David R. Howlett, Paul T. Francis, Robert J. Williams> ;Neurobiology of Aging. 2008 Jul 1
59 citations
Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.
David R. Howlett, Katie E. Bowler, Peter Ernest Soden, D. Riddell, John B. Davis, Jill C. Richardson, S.A. Burbidge, M.I. Gonzalez, Elaine A. Irving, A. Lawman, G. Mig...> ;Histology and Histopathology. 2008 Jan 1
128 citations
MAPK-activated Protein Kinase 2 Deficiency in Microglia Inhibits Pro-inflammatory Mediator Release and Resultant Neurotoxicity RELEVANCE TO NEUROINFLAMMATION IN A TRAN...
Ainsley A. Culbert, Stephen D. Skaper, David R. Howlett, Nicholas A. Evans, Laura Facci, Peter Ernest Soden, Zoe Seymour, Florence Guillot, Matthias Gaestel, Jill C. R...> ;The Journal of Biological Chemistry. 2006 Aug 18
104 citations
Imaging and spatial distribution of β-amyloid peptide and metal ions in Alzheimer’s plaques by laser ablation–inductively coupled plasma–mass spectrometry
Robert W. Hutchinson, Alan G. Cox, Cameron W. McLeod, Peter S. Marshall, Alex J. Harper, Emma L. Dawson, David R. Howlett> ;Analytical Biochemistry. 2005 Nov 15
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Press Mentions

Performance Indicators for Radiation Protection Management: Suggestions from the European Society of RadiologyDecember 9th, 2020
New AAFP Policy Pushes Payers to Accept Supplemental DataAugust 29th, 2019