DavidJIrwinMD

PubMed

• Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice.
  Aaron J Barbour, Sarah Gourmaud, Eunjoo Lancaster, Xiaofan Li, David A Stewart, Keegan F Hoag, Delia M Talos, David J Irwin, Frances E Jensen> ;Brain. 2024 Apr 25
• Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease.
  Katheryn A Q Cousins, Jeffrey S Phillips, Sandhitsu R Das, Kyra O'Brien, Leslie M Shaw, Dawn Mechanic-Hamilton, Corey T McMillan, Thomas F Tropea, Alice Chen-Plotkin, ...> ;Alzheimer's & Dementia. 2024 Apr 21
• Gene specific effects on brain volume and cognition ofin frontotemporal lobar degeneration.
  Marijne Vandebergh, Eliana Marisa Ramos, Nick Corriveau-Lecavalier, Vijay K Ramanan, John Kornak, Carly Mester, Tyler Kolander, Danielle Brushaber, Adam M Staffaroni, ...> ;Medrxiv. 2024 Apr 5
• 1 citations
  Disparities in Genetic Testing for Neurologic Disorders.
  Aaron Baldwin, Juliette Copeland, Meron Azage, Laynie Dratch, Kelsey Johnson, Rachel A Paul, Defne A Amado, Michael Baer, Andres Deik, Lauren B Elman, Michael Guo, Ali...> ;Neurology. 2024 Mar 26
• Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia.
  Lianne M Reus, Iris E Jansen, Betty M Tijms, Pieter Jelle Visser, Niccoló Tesi, Sven J van der Lee, Lisa Vermunt, Carel F W Peeters, Lisa A De Groot, Yanaika S Hok-A-H...> ;Brain. 2024 Mar 25
• Tau-neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in Alzheimer's continuum.
  Xueying Lyu, Michael Tran Duong, Long Xie, Robin de Flores, Hayley Richardson, Gyujoon Hwang, Laura E M Wisse, Michael DiCalogero, Corey T McMillan, John L Robinson, S...> ;Alzheimer's & Dementia. 2024 Mar 1
• Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies".
  Frederike C Oertel, Daniel Casillas, Yann Cobigo, Shivany Condor Montes, Hilary W Heuer, Makenna Chapman, Alexandra Beaudry-Richard, Henriette Reinsberg, Ahmed Abdelha...> ;Acta Neuropathologica. 2024 Feb 3
• 2 citations
  Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-an...
  Marianne Chapleau, Renaud La Joie, Keir Yong, Federica Agosta, Isabel Elaine Allen, Liana Apostolova, John Best, Baayla D C Boon, Sebastian Crutch, Massimo Filippi, Gi...> ;The Lancet. Neurology. 2024 Feb 1
• Evaluation of ATNFramework and Biofluid Markers to Predict Cognitive Decline in Early Parkinson Disease.
  Cousins, K., Irwin, D., Tropea, T., Rhodes, E., Phillips, J., Chen-Plotkin, A., Brumm, M., Coffey, C., Kang, J., Simuni, T., Foroud, T., Toga, A., Tanner, C., Kieburtz...> ;Neurology. 2024 Feb 1
• Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration.
  Nevler, N., Cho, S., Cousins, K., Ash, S., Olm, C., Shellikeri, S., Agmon, G., Gonzalez-Recober, C., Xie, S., Barker, M., Manoochehri, M., Mcmillan, C., Irwin, D., Mas...> ;Neurology. 2024 Jan 23
• Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease.
  Sanaz Arezoumandan, Katheryn A Q Cousins, Daniel T Ohm, MaKayla Lowe, Min Chen, James Gee, Jeffrey S Phillips, Corey T McMillan, Kelvin C Luk, Andres Deik, Meredith A ...> ;Annals of Clinical and Translational Neurology. 2024 Mar 1
• Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum.
  Shen, T., Vogel, J., Duda, J., Phillips, J., Cook, P., Gee, J., Massimo, L., Grossman, M., McMillan, C., Elman, L., Quinn, C., Amado, D., Baer, M., Irwin, D.> ;Translational Neurodegeneration. 2023 Dec 7
• Digital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorders.
  Sanjana Shellikeri, Sunghye Cho, Sharon Ash, Carmen Gonzalez-Recober, Corey T Mcmillan, Lauren Elman, Colin Quinn, Defne A Amado, Michael Baer, David J Irwin, Lauren M...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2024 May 1
• Polypathologic Associations with Gray Matter Atrophy in Neurodegenerative Disease.
  Jeffrey S Phillips, John L Robinson, Katheryn A Q Cousins, David A Wolk, Edward B Lee, Corey T McMillan, John Q Trojanowski, Murray Grossman, David J Irwin> ;The Journal of Neuroscience. 2024 Feb 7
• 1 citations
  Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts.
  Laynie Dratch, Meron Azage, Aaron Baldwin, Kelsey Johnson, Rachel A Paul, Tanya M Bardakjian, Sara-Claude Michon, Defne A Amado, Michael Baer, Andres F Deik, Lauren B ...> ;Journal of Neurology. 2024 Feb 1
• 1 citations
  ATN cerebrospinal fluid biomarkers in dementia with Lewy bodies: Initial results from the United States Dementia with Lewy Bodies Consortium.
  Lavanya Jain, Maria Khrestian, Shane Formica, Elizabeth D Tuason, Jagan A Pillai, Stephen Rao, Odinachi Oguh, Carol F Lippa, Oscar L Lopez, Sarah B Berman, Debby W Tsu...> ;Alzheimer's & Dementia. 2024 Jan 1
• Alzheimer Disease Biomarkers: Moving from CSF to Plasma for Reliable Detection of Amyloid and tau Pathology.
  Ju Hee Kang, Magdalena Korecka, Edward B Lee, Katheryn A Q Cousins, Thomas F Tropea, Alice A Chen-Plotkin, David J Irwin, David Wolk, Magdalena Brylska, Yang Wan, Lesl...> ;Clinical Chemistry. 2023 Nov 2
• 5 citations
  CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease.
  Marta Del Campo, Lisa Vermunt, Carel F W Peeters, Anne Sieben, Yanaika S Hok-A-Hin, Alberto Lleó, Daniel Alcolea, Mirrelijn van Nee, Sebastiaan Engelborghs, Juliette L...> ;Nature Communications. 2023 Sep 13
• 1 citations
  Racial Differences in Clinical Presentation in Individuals Diagnosed With Frontotemporal Dementia.
  Hannah A Jin, Corey T McMillan, Isabel Yannatos, Lauren Fisher, Emma Rhodes, Sarah F Jacoby, David J Irwin, Lauren Massimo> ;JAMA Neurology. 2023 Nov 1
• Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration.
  Lucia Aa Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke Jm Rozemuller, , John C van Swie...> ;Acta Neuropathologica Communications. 2023 Aug 2
• 5 citations
  CSF proteomics in autosomal dominant Alzheimer's disease highlights parallels with sporadic disease.
  Emma L van der Ende, Sjors G J G In 't Veld, Iris Hanskamp, Sven van der Lee, Janna I R Dijkstra, Yanaika S Hok-A-Hin, Elena R Blujdea, John C van Swieten, David J Irw...> ;Brain. 2023 Nov 2
• 1 citations
  Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research.
  Jack Carson Taylor, Hilary W Heuer, Annie L Clark, Amy B Wise, Masood Manoochehri, Leah Forsberg, Carly Mester, Meghana Rao, Daniell Brushaber, Joel Kramer, Ariane E W...> ;Alzheimer's & Dementia. 2023 May 9
• 8 citations
  Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies.
  Alexandra L Young, Jacob W Vogel, John L Robinson, Corey T McMillan, Rik Ossenkoppele, David A Wolk, David J Irwin, Lauren Elman, Murray Grossman, Virginia M Y Lee, Ed...> ;Brain. 2023 Jul 3
• 6 citations
  Fluid and Biopsy Based Biomarkers in Parkinson's Disease.
  David G Coughlin, David J Irwin> ;Neurotherapeutics. 2023 Jul 1
• Creating the Pick's disease International Consortium: Association study ofH2 haplotype with risk of Pick's disease.
  White, C. L., White, C. L., Rebecca R Valentino, William J Scotton, Shanu F Roemer, Tammaryn Lashley, Michael G Heckman, Maryam Shoai, Alejandro Martinez-Carrasco, Nic...> ;Medrxiv. 2023 Apr 24
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Journal Articles

• Prevalence of Amyloid‐Β Pathology in Distinct Variants of Primary Progressive Aphasia  
  Gil D Rabinovici, William Seeley, Edmond Teng, David J Irwin, David A Wolk, Annals of Neurology
• Neurodegenerative Disease Concomitant Proteinopathies Are Prevalent, Age-Related and APOE4-Associated  
  David Wolk, Steven E Arnold, Edward B Lee, David J Irwin, Leo McCluskey, Howard I Hurtig, Lauren Elman, Bruce Miller, Murray Grossman, John E Duda, John Q Trojanowski,..., Brain